Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0071 | 0.0023 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1172 | 1 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0049 | 0.0297 | 0.029 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0151 | 0.0152 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0151 | 0.0152 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0071 | 0.0012 |
Brugia malayi | MH2 domain containing protein | 0.0062 | 0.0403 | 0.0401 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0151 | 0.0158 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0151 | 0.0158 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0005 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0049 | 0.0297 | 0.0243 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0023 | 0.0066 | 0.0063 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1172 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0049 | 0.0297 | 0.029 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0071 | 0.0063 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.0071 | 0.0069 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0282 | 0.2304 | 0.2253 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0049 | 0.0297 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.0151 | 0.009 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0023 | 0.0066 | 0.0063 |
Onchocerca volvulus | 0.1122 | 0.9573 | 1 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1172 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0071 | 0.0063 |
Entamoeba histolytica | thymidine kinase, putative | 0.0282 | 0.2304 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1122 | 0.9573 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1122 | 0.9573 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0534 | 0.4485 | 0.4449 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0005 | 0.0005 |
Echinococcus multilocularis | dna polymerase eta | 0.0023 | 0.0071 | 0.0069 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.0071 | 0.0069 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0071 | 0.0069 |
Echinococcus granulosus | thymidine kinase | 0.0573 | 0.4823 | 0.5036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Giardia lamblia | Thymidine kinase | 0.0282 | 0.2304 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0049 | 0.0297 | 0.0243 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0151 | 0.0137 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0146 | 0.0152 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.8335 | 0.8707 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0236 | 0.0179 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0023 | 0.0066 | 0.0057 |
Schistosoma mansoni | DNA polymerase eta | 0.0023 | 0.0071 | 0.0005 |
Brugia malayi | hypothetical protein | 0.0534 | 0.4485 | 0.4675 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0071 | 0.0005 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0151 | 0.009 |
Trypanosoma brucei | thymidine kinase | 0.0282 | 0.2304 | 0.2298 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0151 | 0.0152 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0071 | 0.0053 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0151 | 0.0152 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0282 | 0.2304 | 0.5065 |
Echinococcus granulosus | Thymidine kinase 2 mitochondrial | 0.0573 | 0.4823 | 0.5036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0534 | 0.4485 | 0.4649 |
Trypanosoma brucei | RNA helicase, putative | 0.0042 | 0.0236 | 0.0228 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0282 | 0.2304 | 0.5065 |
Leishmania major | thymidine kinase, putative | 0.0282 | 0.2304 | 0.2253 |
Echinococcus granulosus | thymidylate synthase | 0.1122 | 0.9573 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0005 |
Echinococcus granulosus | dihydrofolate reductase | 0.0049 | 0.0297 | 0.0305 |
Echinococcus granulosus | lamin | 0.0033 | 0.0151 | 0.0152 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.0071 | 0.0069 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0151 | 0.0137 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1172 | 1 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1122 | 0.9573 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.002 | 0.0021 |
Loa Loa (eye worm) | thymidylate synthase | 0.1122 | 0.9573 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.1122 | 0.9573 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1122 | 0.9573 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0062 | 0.0403 | 0.0421 |
Echinococcus multilocularis | thymidine kinase | 0.0573 | 0.4823 | 0.5036 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0005 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.0066 | 0.0048 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0005 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0071 | 0.0074 |
Brugia malayi | thymidylate synthase | 0.1122 | 0.9573 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0049 | 0.0297 | 0.0243 |
Schistosoma mansoni | lamin | 0.0033 | 0.0151 | 0.009 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0151 | 0.0158 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.0066 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.0071 | 0.0005 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0.0071 | 0.0005 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0.0071 | 0.0063 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.0071 | 0.0005 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0023 | 0.0066 | 0.0069 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0282 | 0.2304 | 0.2253 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0005 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0.0071 | 0.0005 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.0071 | 0.0063 |
Echinococcus multilocularis | thymidine kinase | 0.0573 | 0.4823 | 0.5036 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0049 | 0.0297 | 0.031 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0049 | 0.0297 | 0.0305 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0062 | 0.0403 | 0.0421 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0.0071 | 0.0005 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1172 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.0071 | 0.0005 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0151 | 0.0152 |
Schistosoma mansoni | thymidine kinase | 0.0573 | 0.4823 | 0.5004 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.0071 | 0.0063 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Echinococcus multilocularis | transfer RNA-Ile | 0.0573 | 0.4823 | 0.5036 |
Echinococcus granulosus | thymidine kinase | 0.0573 | 0.4823 | 0.5036 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.0071 | 0.0074 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.0071 | 0.0005 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.0066 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0071 | 0.0053 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.0071 | 0.0023 |
Echinococcus granulosus | dna polymerase eta | 0.0023 | 0.0071 | 0.0069 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.0071 | 0.0005 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0282 | 0.2304 | 0.5065 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0534 | 0.4485 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0071 | 0.0012 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.0071 | 0.0063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.