Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | muscleblind protein | 0.0156 | 0.0605 | 0.0605 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0216 | 0.1556 | 0.1012 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0745 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Leishmania major | prostaglandin f synthase, putative | 0.0745 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.0745 | 1 | 1 |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0216 | 0.1556 | 0.1012 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0216 | 0.1556 | 0.1556 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0745 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0216 | 0.1556 | 0.1556 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Plasmodium vivax | aldehyde reductase, putative | 0.0216 | 0.1556 | 0.5 |
Brugia malayi | NADH-dependent xylose reductase | 0.0216 | 0.1556 | 0.1012 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0216 | 0.1556 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Mycobacterium ulcerans | oxidoreductase | 0.0745 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0529 | 0.6557 | 0.5922 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.0745 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0745 | 1 | 1 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0216 | 0.1556 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0216 | 0.1556 | 0.1556 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.0745 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0156 | 0.0605 | 0.0605 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.0745 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0529 | 0.6557 | 0.6557 |
Schistosoma mansoni | aldo-keto reductase | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.0745 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.0745 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.0745 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0216 | 0.1556 | 0.1556 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.0745 | 1 | 1 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0216 | 0.1556 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Onchocerca volvulus | 0.0745 | 1 | 1 | |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.0745 | 1 | 1 |
Schistosoma mansoni | pol-related | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0529 | 0.6557 | 0.6557 |
Echinococcus granulosus | muscleblind protein | 0.0156 | 0.0605 | 0.0605 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.0745 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase | 0.0745 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Km (binding) | = 44 uM | Compound was evaluated in vitro for its inhibitory effect Vitamin K dependent carboxylase of Phe-Leu-Glu-Glu-Leu in rat microsomal protein | ChEMBL. | 6332196 |
Km (binding) | < 50 uM | Compound was evaluated in vitro for its inhibitory effect Vitamin K dependent carboxylase of Phe-Leu-Glu-Glu-Leu in rat microsomal protein | ChEMBL. | 6332196 |
Km (binding) | < 50 uM | Compound was evaluated in vitro for its inhibitory effect Vitamin K dependent carboxylase of Phe-Leu-Glu-Glu-Leu in rat microsomal protein | ChEMBL. | 6332196 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.