Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.002 | 0.0121 | 0.0374 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0053 | 0.0684 | 0.076 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0205 | 0.3235 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0547 | 0.9004 | 1 |
Echinococcus multilocularis | beta 1,4 N acetylgalactosaminyltransferase | 0.0014 | 0.0026 | 0.0029 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0205 | 0.3235 | 0.3235 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0014 | 0.0026 | 0.0029 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0045 | 0.0546 | 0.0606 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0014 | 0.0026 | 0.0029 |
Brugia malayi | hypothetical protein | 0.015 | 0.2318 | 0.2575 |
Echinococcus granulosus | thymidylate synthase | 0.0316 | 0.5103 | 0.5667 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.002 | 0.0121 | 0.0121 |
Echinococcus multilocularis | Ribosomal protein L34a | 0.0039 | 0.045 | 0.05 |
Echinococcus granulosus | beta 14 galactosyltransferase 7 | 0.0014 | 0.0026 | 0.0029 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0205 | 0.3235 | 1 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.002 | 0.0121 | 0.0374 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0045 | 0.0546 | 0.0606 |
Trypanosoma brucei | thymidine kinase | 0.0205 | 0.3235 | 0.3235 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0547 | 0.9004 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.015 | 0.2318 | 0.2318 |
Entamoeba histolytica | thymidine kinase, putative | 0.0205 | 0.3235 | 1 |
Echinococcus granulosus | Ribosomal protein L34a | 0.0039 | 0.045 | 0.05 |
Echinococcus multilocularis | Metazoa galactosyltransferase | 0.0053 | 0.0684 | 0.076 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0014 | 0.0026 | 0.0029 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0036 | 0.0403 | 0.0448 |
Echinococcus granulosus | Metazoa galactosyltransferase | 0.0053 | 0.0684 | 0.076 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0017 | 0.0074 | 0.0082 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0607 | 1 | 1 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0036 | 0.0403 | 0.0403 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0828 | 0.092 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0053 | 0.0684 | 0.076 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0038 | 0.043 | 0.133 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0607 | 1 | 1 |
Loa Loa (eye worm) | galactosyltransferase | 0.0014 | 0.0026 | 0.0029 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.002 | 0.0121 | 0.0121 |
Loa Loa (eye worm) | galactosyltransferase | 0.0053 | 0.0684 | 0.076 |
Mycobacterium tuberculosis | Hypothetical protein | 0.015 | 0.2318 | 0.0489 |
Brugia malayi | Galactosyltransferase family protein | 0.0053 | 0.0684 | 0.076 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0205 | 0.3235 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0607 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0547 | 0.9004 | 1 |
Schistosoma mansoni | phenylalanine decarboxylase | 0.0014 | 0.0026 | 0.0029 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0547 | 0.9004 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0205 | 0.3235 | 0.3235 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0547 | 0.9004 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0316 | 0.5103 | 0.445 |
Loa Loa (eye worm) | UDP-Galactose:b-N-acetylglucosamine b1,4-galactosyltransferase 4 | 0.0014 | 0.0026 | 0.0029 |
Brugia malayi | Galactosyltransferase family protein | 0.0014 | 0.0026 | 0.0029 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.1696 | 0.1883 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0062 | 0.0828 | 0.1623 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0316 | 0.5103 | 0.5667 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0045 | 0.0546 | 0.0606 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0607 | 1 | 1 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0014 | 0.0026 | 0.0029 |
Echinococcus multilocularis | thymidylate synthase | 0.0316 | 0.5103 | 0.5667 |
Echinococcus multilocularis | beta 1,4 galactosyltransferase 7 | 0.0014 | 0.0026 | 0.0029 |
Schistosoma mansoni | beta-14-galactosyltransferase 34-related | 0.0014 | 0.0026 | 0.0029 |
Onchocerca volvulus | 0.0316 | 0.5103 | 1 | |
Loa Loa (eye worm) | thymidylate synthase | 0.0316 | 0.5103 | 0.5667 |
Loa Loa (eye worm) | beta-1,4-galactosyltransferase VII | 0.0014 | 0.0026 | 0.0029 |
Plasmodium falciparum | DNA polymerase alpha catalytic subunit A | 0.0013 | 0.0005 | 0.0005 |
Leishmania major | thymidine kinase, putative | 0.0205 | 0.3235 | 0.3235 |
Giardia lamblia | Thymidine kinase | 0.0205 | 0.3235 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0014 | 0.0026 | 0.0026 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.002 | 0.0121 | 0.0121 |
Echinococcus granulosus | dihydrofolate reductase | 0.0547 | 0.9004 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0547 | 0.9004 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0547 | 0.9004 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0547 | 0.9004 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0607 | 1 | 1 |
Brugia malayi | thymidylate synthase | 0.0316 | 0.5103 | 0.5667 |
Trypanosoma brucei | RNA helicase, putative | 0.0113 | 0.1696 | 0.1696 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0014 | 0.0026 | 0.0029 |
Brugia malayi | beta-1,4-galactosyltransferase VII | 0.0014 | 0.0026 | 0.0029 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0036 | 0.0403 | 0.0403 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0547 | 0.9004 | 0.5 |
Echinococcus multilocularis | Metazoa galactosyltransferase | 0.0045 | 0.0546 | 0.0607 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0014 | 0.0026 | 0.0029 |
Echinococcus granulosus | beta 14 N acetylgalactosaminyltransferase | 0.0014 | 0.0026 | 0.0029 |
Entamoeba histolytica | DNA polymerase alpha catalytic subunit, putative | 0.0013 | 0.0005 | 0.0016 |
Trichomonas vaginalis | conserved hypothetical protein | 0.015 | 0.2318 | 0.7166 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.