Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1581 | 0.839 |
Onchocerca volvulus | Putative thymidylate kinase | 0.0075 | 0.1639 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.6628 | 1 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0075 | 0.1639 | 0.1582 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0063 | 0.128 | 0.128 |
Echinococcus multilocularis | thymidylate kinase | 0.0075 | 0.1639 | 1 |
Brugia malayi | thymidylate kinase | 0.0075 | 0.1639 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0075 | 0.1639 | 0.2396 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0.0284 | 0.0329 |
Trypanosoma brucei | ingi protein (ORF1) | 0.003 | 0.0308 | 0.0242 |
Trypanosoma brucei | DNA polymerase alpha catalytic subunit | 0.0023 | 0.0098 | 0.0031 |
Leishmania major | thymidylate kinase-like protein | 0.0075 | 0.1639 | 0.2396 |
Echinococcus multilocularis | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0989 | 0.5863 |
Loa Loa (eye worm) | thymidylate kinase | 0.0075 | 0.1639 | 1 |
Brugia malayi | Galactosyltransferase family protein | 0.0063 | 0.128 | 0.7713 |
Schistosoma mansoni | thymidylate kinase | 0.0075 | 0.1639 | 0.1639 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0075 | 0.1639 | 1 |
Echinococcus multilocularis | Metazoa galactosyltransferase | 0.0063 | 0.128 | 0.7713 |
Trypanosoma cruzi | DNA polymerase I alpha catalytic subunit, putative | 0.0023 | 0.0098 | 0.0046 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.003 | 0.0284 | 0.0329 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0243 | 0.6628 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0243 | 0.6628 | 1 |
Chlamydia trachomatis | thymidylate kinase | 0.0075 | 0.1639 | 0.5 |
Plasmodium vivax | thymidylate kinase, putative | 0.0075 | 0.1639 | 1 |
Trypanosoma cruzi | UMP-CMP kinase, mitochondrial, putative | 0.003 | 0.0284 | 0.0329 |
Mycobacterium ulcerans | thymidylate kinase | 0.0075 | 0.1639 | 0.5 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.6628 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0075 | 0.1639 | 0.2396 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0154 | 0.3984 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.1639 | 0.1639 |
Leishmania major | thymidine kinase, putative | 0.0243 | 0.6628 | 1 |
Trypanosoma brucei | unspecified product | 0.003 | 0.0308 | 0.0242 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0243 | 0.6628 | 1 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0045 | 0.0747 | 0.1035 |
Toxoplasma gondii | DNA polymerase (pol2) superfamily protein | 0.0043 | 0.069 | 0.3962 |
Trypanosoma brucei | ingi protein (ORF1) | 0.003 | 0.0308 | 0.0242 |
Echinococcus granulosus | Ribosomal protein L34a | 0.0047 | 0.0788 | 0.4584 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0068 | 0.0068 |
Echinococcus granulosus | thymidylate kinase | 0.0075 | 0.1639 | 1 |
Giardia lamblia | CDC8 | 0.0075 | 0.1639 | 0.2396 |
Schistosoma mansoni | thymidylate kinase | 0.0075 | 0.1639 | 0.1639 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0075 | 0.1639 | 1 |
Echinococcus granulosus | Metazoa galactosyltransferase | 0.0063 | 0.128 | 0.7713 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0075 | 0.1639 | 0.2396 |
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0023 | 0.0098 | 0.0046 |
Schistosoma mansoni | beta-14-galactosyltransferase | 0.0063 | 0.128 | 0.128 |
Echinococcus multilocularis | Ribosomal protein L34a | 0.0047 | 0.0788 | 0.4584 |
Plasmodium falciparum | thymidylate kinase | 0.0075 | 0.1639 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0357 | 1 | 1 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.003 | 0.0308 | 0.0242 |
Mycobacterium leprae | probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) | 0.0075 | 0.1639 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.003 | 0.0308 | 0.0242 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0073 | 0.1581 | 0.9632 |
Echinococcus multilocularis | Metazoa galactosyltransferase | 0.0053 | 0.099 | 0.5866 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0068 | 0.0068 |
Schistosoma mansoni | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0989 | 0.0989 |
Schistosoma mansoni | phosphoglucomutase | 0.0022 | 0.0068 | 0.0068 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0075 | 0.1639 | 0.2396 |
Trypanosoma brucei | thymidine kinase | 0.0243 | 0.6628 | 0.6605 |
Giardia lamblia | Thymidine kinase | 0.0243 | 0.6628 | 1 |
Echinococcus granulosus | DNA polymerase alpha catalytic subunit | 0.0053 | 0.0989 | 0.5863 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0075 | 0.1639 | 0.1582 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0243 | 0.6628 | 1 |
Toxoplasma gondii | thymidylate kinase | 0.0075 | 0.1639 | 1 |
Brugia malayi | DNA polymerase alpha catalytic subunit | 0.0043 | 0.069 | 0.3962 |
Leishmania major | DNA polymerase I alpha catalytic subunit, putative | 0.0023 | 0.0098 | 0.0046 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0023 | 0.0098 | 0.0046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.