Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | thymidylate synthase | 0.0318 | 0.6365 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0318 | 0.6365 | 1 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0285 | 0.5132 | 0.8063 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0285 | 0.5132 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0318 | 0.6365 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0318 | 0.6365 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0318 | 0.6365 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0318 | 0.6365 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0318 | 0.6365 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0318 | 0.6365 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0154 | 0.0112 | 0.0176 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0285 | 0.5132 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0318 | 0.6365 | 1 |
Brugia malayi | thymidylate synthase | 0.0318 | 0.6365 | 1 |
Onchocerca volvulus | 0.0318 | 0.6365 | 0.5 | |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0318 | 0.6365 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0154 | 0.0112 | 0.0176 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0318 | 0.6365 | 1 |
Trichomonas vaginalis | thymidine kinase, putative | 0.0285 | 0.5132 | 1 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0318 | 0.6365 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0318 | 0.6365 | 1 |
Entamoeba histolytica | thymidine kinase, putative | 0.0285 | 0.5132 | 0.5 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0285 | 0.5132 | 0.8063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.