Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0059 | 0.0581 | 0.083 |
Brugia malayi | Spermidine synthase | 0.0201 | 0.3693 | 0.4216 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0094 | 0.1346 | 0.1922 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0297 | 0.5799 | 0.665 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0406 | 0.0419 |
Trypanosoma cruzi | spermidine synthase, putative | 0.0201 | 0.3693 | 0.4984 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0043 | 0.0146 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0631 | 0.0679 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0043 | 0.0062 |
Plasmodium vivax | SET domain protein, putative | 0.0062 | 0.0631 | 0.1708 |
Loa Loa (eye worm) | spermidine synthase | 0.0201 | 0.3693 | 0.4216 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0631 | 0.214 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2946 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0062 | 0.0631 | 0.0901 |
Leishmania major | spermidine synthase | 0.0201 | 0.3693 | 0.5275 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0062 | 0.0631 | 0.214 |
Trypanosoma cruzi | spermidine synthase, putative | 0.0201 | 0.3693 | 0.4984 |
Leishmania major | S-adenosylmethionine decarboxylase | 0.0352 | 0.7001 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.2946 | 1 |
Mycobacterium ulcerans | spermidine synthase | 0.0177 | 0.3158 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0062 | 0.0631 | 0.0901 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.072 | 0.0782 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0062 | 0.0631 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0056 | 0.0501 | 0.1701 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.072 | 0.0782 |
Brugia malayi | Pre-SET motif family protein | 0.043 | 0.8699 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0631 | 0.214 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0094 | 0.1346 | 0.1922 |
Schistosoma mansoni | jumonji domain containing protein | 0.0075 | 0.0921 | 0.3126 |
Brugia malayi | Pre-SET motif family protein | 0.0062 | 0.0631 | 0.0679 |
Echinococcus multilocularis | S adenosylmethionine decarboxylase proenzyme | 0.0352 | 0.7001 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0361 | 0.0367 |
Brugia malayi | hypothetical protein | 0.0066 | 0.072 | 0.0782 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0059 | 0.0582 | 0.0623 |
Plasmodium vivax | S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative | 0.0172 | 0.304 | 0.8233 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.072 | 0.0782 |
Trypanosoma cruzi | spermidine synthase, putative | 0.0201 | 0.3693 | 0.4984 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.043 | 0.8699 | 1 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0352 | 0.7001 | 1 |
Echinococcus multilocularis | spermidine synthase | 0.0201 | 0.3693 | 0.5275 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0297 | 0.5799 | 0.665 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0352 | 0.7001 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.5799 | 0.665 |
Echinococcus multilocularis | jumonji domain containing protein | 0.004 | 0.0157 | 0.0225 |
Echinococcus multilocularis | geminin | 0.0167 | 0.2946 | 0.4209 |
Brugia malayi | hypothetical protein | 0.0066 | 0.072 | 0.0782 |
Plasmodium falciparum | spermidine synthase | 0.0201 | 0.3693 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0094 | 0.1346 | 0.1505 |
Trichomonas vaginalis | set domain proteins, putative | 0.0489 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0297 | 0.5799 | 0.665 |
Entamoeba histolytica | arginine N-methyltransferase protein, putative | 0.0051 | 0.0406 | 0.5 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0043 | 0.0062 |
Plasmodium vivax | spermidine synthase, putative | 0.0201 | 0.3693 | 1 |
Trypanosoma brucei | spermidine synthase | 0.0201 | 0.3693 | 0.4984 |
Entamoeba histolytica | hypothetical protein | 0.0051 | 0.0406 | 0.5 |
Trypanosoma cruzi | spermidine synthase, putative | 0.0201 | 0.3693 | 0.4984 |
Mycobacterium tuberculosis | Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) | 0.0177 | 0.3158 | 0.5 |
Echinococcus granulosus | jumonji domain containing protein | 0.004 | 0.0157 | 0.0225 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0062 | 0.0631 | 0.214 |
Echinococcus granulosus | S adenosylmethionine decarboxylase proenzyme | 0.0352 | 0.7001 | 1 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0352 | 0.7001 | 1 |
Loa Loa (eye worm) | S-adenosylmethionine decarboxylase proenzyme | 0.0352 | 0.7001 | 0.8038 |
Brugia malayi | S-adenosylmethionine decarboxylase proenzyme | 0.0352 | 0.7001 | 0.8038 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0352 | 0.7001 | 1 |
Echinococcus granulosus | spermidine synthase | 0.0201 | 0.3693 | 0.5275 |
Echinococcus granulosus | geminin | 0.0167 | 0.2946 | 0.4209 |
Brugia malayi | hypothetical protein | 0.0051 | 0.0406 | 0.0419 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0062 | 0.0631 | 0.0901 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0352 | 0.7001 | 1 |
Onchocerca volvulus | 0.0066 | 0.072 | 0.0096 | |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0043 | 0.0146 |
Plasmodium falciparum | S-adenosylmethionine decarboxylase/ornithine decarboxylase | 0.0172 | 0.304 | 0.8233 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.