Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | DNA methyltransferase 2, putative | 0.0866 | 0.6943 | 0.6943 |
Echinococcus multilocularis | arginine glutamic acid dipeptide (RE) repeats | 0.0062 | 0.0159 | 0.0159 |
Brugia malayi | hypothetical protein | 0.0189 | 0.1233 | 0.1141 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0089 | 0.0383 | 0.0408 |
Toxoplasma gondii | C-5 cytosine-specific DNA methylase superfamily protein | 0.0866 | 0.6943 | 0.7154 |
Brugia malayi | jmjC domain containing protein | 0.0102 | 0.0495 | 0.0396 |
Trypanosoma cruzi | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.3859 |
Schistosoma mansoni | DNA (cytosine-5)-methyltransferase | 0.0866 | 0.6943 | 0.6898 |
Echinococcus multilocularis | histone h3 methyltransferase | 0.1228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0159 | 0.0075 |
Trypanosoma cruzi | Histone-lysine N-methyltransferase, H3 lysine-76 specific | 0.0156 | 0.095 | 0.7498 |
Echinococcus multilocularis | cpg binding protein | 0.0469 | 0.3591 | 0.3591 |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.0866 | 0.6943 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0465 | 0.3557 | 0.349 |
Echinococcus granulosus | PWWP domain containing protein 2A | 0.0189 | 0.1233 | 0.1233 |
Leishmania major | histone-lysine N-methyltransferase, putative | 0.0156 | 0.095 | 0.0865 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.1183 | 0.9626 | 1 |
Schistosoma mansoni | SET domain protein | 0.0192 | 0.1254 | 0.1127 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1233 | 0.1106 |
Schistosoma mansoni | phd finger protein | 0.0189 | 0.1233 | 0.1106 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.235 | 0.2284 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.1233 | 0.1158 |
Schistosoma mansoni | bromo adjacent homology domain containing | 0.0062 | 0.0159 | 0.0016 |
Schistosoma mansoni | metastasis-associated protein 1 (mta1) | 0.0062 | 0.0159 | 0.0016 |
Echinococcus multilocularis | metastasis associated protein MTA1 | 0.0062 | 0.0159 | 0.0159 |
Echinococcus granulosus | histone lysine N methyltransferase H3 lysine 36 | 0.0192 | 0.1254 | 0.1254 |
Echinococcus granulosus | metastasis associated protein MTA1 | 0.0062 | 0.0159 | 0.0159 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Echinococcus multilocularis | geminin | 0.0181 | 0.1162 | 0.1162 |
Echinococcus granulosus | S adenosylmethionine decarboxylase proenzyme | 0.0089 | 0.0383 | 0.0383 |
Toxoplasma gondii | DNA methyltransferase 2, putative | 0.0866 | 0.6943 | 0.7154 |
Schistosoma mansoni | hypothetical protein | 0.0062 | 0.0159 | 0.0016 |
Schistosoma mansoni | hepatoma derived growth factor | 0.0189 | 0.1233 | 0.1106 |
Echinococcus granulosus | polybromo 1 | 0.0062 | 0.0159 | 0.0159 |
Trypanosoma cruzi | histone-lysine N-methyltransferase, putative | 0.0156 | 0.095 | 0.7498 |
Onchocerca volvulus | 0.0189 | 0.1233 | 0.2599 | |
Onchocerca volvulus | 0.0539 | 0.4183 | 1 | |
Treponema pallidum | S-adenosylmethionine synthetase | 0.0107 | 0.0539 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0469 | 0.3591 | 0.3536 |
Trypanosoma brucei | Histone methylation protein DOT1, putative | 0.0156 | 0.095 | 0.1238 |
Entamoeba histolytica | hypothetical protein | 0.0189 | 0.1233 | 0.1651 |
Trypanosoma brucei | transcription elongation factor s-II, putative | 0.0189 | 0.1233 | 0.1651 |
Trypanosoma cruzi | MIZ/SP-RING zinc finger, putative | 0.0189 | 0.1233 | 1 |
Echinococcus multilocularis | PWWP domain containing protein 2A | 0.0189 | 0.1233 | 0.1233 |
Schistosoma mansoni | polybromo-1 | 0.0062 | 0.0159 | 0.0016 |
Echinococcus granulosus | peregrin | 0.022 | 0.1496 | 0.1496 |
Schistosoma mansoni | cpg binding protein | 0.0469 | 0.3591 | 0.3498 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Schistosoma mansoni | metastasis-associated protein 1 (mta1) | 0.0062 | 0.0159 | 0.0016 |
Trypanosoma cruzi | Histone methylation protein DOT1, putative | 0.0156 | 0.095 | 0.7498 |
Trypanosoma cruzi | Histone methylation protein DOT1, putative | 0.0156 | 0.095 | 0.7498 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1162 | 0.1033 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Brugia malayi | PWWP domain containing protein | 0.0189 | 0.1233 | 0.1141 |
Echinococcus multilocularis | bromo adjacent y domain containing 1 | 0.0062 | 0.0159 | 0.0159 |
Plasmodium vivax | DNA (cytosine-5)-methyltransferase, putative | 0.0866 | 0.6943 | 1 |
Trypanosoma cruzi | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.3859 |
Schistosoma mansoni | hypothetical protein | 0.0181 | 0.1162 | 0.1033 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Schistosoma mansoni | jumonji domain containing protein | 0.0081 | 0.0318 | 0.0177 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase | 0.0089 | 0.0383 | 0.0408 |
Leishmania major | S-adenosylmethionine synthetase | 0.0107 | 0.0539 | 0.0239 |
Brugia malayi | Disco-interacting protein 2 homolog | 0.0539 | 0.4183 | 0.4122 |
Leishmania major | modification methylase-like protein | 0.0866 | 0.6943 | 1 |
Echinococcus granulosus | histone h3 methyltransferase | 0.1228 | 1 | 1 |
Echinococcus granulosus | DNA methyltransferase 2, putative | 0.0866 | 0.6943 | 0.6943 |
Toxoplasma gondii | hypothetical protein | 0.1183 | 0.9626 | 1 |
Echinococcus multilocularis | hepatoma derived growth factor protein | 0.0189 | 0.1233 | 0.1233 |
Schistosoma mansoni | metastasis-associated protein 1 (mta1) | 0.0062 | 0.0159 | 0.0016 |
Trichomonas vaginalis | set domain proteins, putative | 0.0529 | 0.4099 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0067 | 0.0197 | 0.0095 |
Echinococcus granulosus | metastasis associated protein 1 mta1 | 0.0062 | 0.0159 | 0.0159 |
Schistosoma mansoni | cpg binding protein | 0.0469 | 0.3591 | 0.3498 |
Toxoplasma gondii | hypothetical protein | 0.0156 | 0.095 | 0.0799 |
Brugia malayi | ELM2 domain containing protein | 0.0062 | 0.0159 | 0.0056 |
Trichomonas vaginalis | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0539 | 0.4183 | 0.4133 |
Echinococcus granulosus | PWWP domain containing protein 2A | 0.0189 | 0.1233 | 0.1233 |
Brugia malayi | S-adenosylmethionine synthetase | 0.0107 | 0.0539 | 0.044 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0197 | 0.0055 |
Echinococcus multilocularis | metastasis associated protein 1 (mta1) | 0.0062 | 0.0159 | 0.0159 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0102 | 0.0495 | 0.0495 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0102 | 0.0495 | 0.0495 |
Echinococcus multilocularis | disco interacting protein 2 | 0.0539 | 0.4183 | 0.4183 |
Echinococcus multilocularis | peregrin | 0.022 | 0.1496 | 0.1496 |
Leishmania major | hypothetical protein, conserved | 0.0156 | 0.095 | 0.0865 |
Schistosoma mansoni | cpg binding protein | 0.0469 | 0.3591 | 0.3498 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0197 | 0.0055 |
Leishmania major | hypothetical protein, conserved | 0.0156 | 0.095 | 0.0865 |
Leishmania major | S-adenosylmethionine synthetase | 0.0107 | 0.0539 | 0.0239 |
Trichomonas vaginalis | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0965 |
Trypanosoma cruzi | transcription elongation factor-like protein, putative | 0.0189 | 0.1233 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase, H3 lysine 36 | 0.0192 | 0.1254 | 0.1254 |
Echinococcus granulosus | hepatoma derived growth factor protein | 0.0189 | 0.1233 | 0.1233 |
Trypanosoma brucei | histone-lysine n-methyltransferase | 0.0156 | 0.095 | 0.1238 |
Loa Loa (eye worm) | methionine adenosyltransferase | 0.0107 | 0.0539 | 0.0458 |
Leishmania major | hypothetical protein, conserved | 0.0189 | 0.1233 | 0.1296 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1233 | 0.1106 |
Echinococcus multilocularis | S adenosylmethionine decarboxylase proenzyme | 0.0089 | 0.0383 | 0.0383 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Giardia lamblia | S-adenosylmethionine synthetase | 0.0107 | 0.0539 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1228 | 1 | 1 |
Echinococcus multilocularis | PWWP domain containing protein 2A | 0.0189 | 0.1233 | 0.1233 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0159 | 0.0075 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0465 | 0.3557 | 0.3502 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0064 | 0.0176 | 0.0176 |
Onchocerca volvulus | 0.0469 | 0.3591 | 0.8514 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0067 | 0.0197 | 0.0055 |
Schistosoma mansoni | metastasis-associated protein 1 (mta1) | 0.0062 | 0.0159 | 0.0016 |
Brugia malayi | S-adenosylmethionine decarboxylase proenzyme | 0.0089 | 0.0383 | 0.0282 |
Onchocerca volvulus | 0.0529 | 0.4099 | 0.9791 | |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.0177 | 0.0093 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.0322 | 0.235 | 0.227 |
Onchocerca volvulus | 0.0189 | 0.1233 | 0.2599 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0189 | 0.1233 | 1 |
Brugia malayi | CXXC zinc finger family protein | 0.0469 | 0.3591 | 0.3524 |
Schistosoma mansoni | S-adenosylmethionine synthetase | 0.0107 | 0.0539 | 0.0402 |
Trichomonas vaginalis | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0965 |
Plasmodium falciparum | DNA (cytosine-5)-methyltransferase | 0.0866 | 0.6943 | 0.7047 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0067 | 0.0197 | 0.0197 |
Schistosoma mansoni | hepatoma derived growth factor | 0.0189 | 0.1233 | 0.1106 |
Plasmodium vivax | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0507 |
Brugia malayi | polybromodomain protein | 0.0062 | 0.0159 | 0.0056 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0067 | 0.0197 | 0.0197 |
Echinococcus multilocularis | S adenosylmethionine synthase type 1 | 0.0107 | 0.0539 | 0.0539 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0089 | 0.0383 | 0.2473 |
Echinococcus granulosus | cpg binding protein | 0.0469 | 0.3591 | 0.3591 |
Toxoplasma gondii | S-adenosyl methionine synthetase | 0.0107 | 0.0539 | 0.0363 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0067 | 0.0197 | 0.0197 |
Trichomonas vaginalis | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0197 | 0.0113 |
Trichomonas vaginalis | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.0103 | 0.0019 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Trichomonas vaginalis | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0965 |
Trypanosoma cruzi | transcription elongation factor s-II, putative | 0.0189 | 0.1233 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0067 | 0.0197 | 0.0055 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1233 | 0.1106 |
Echinococcus multilocularis | polybromo 1 | 0.0062 | 0.0159 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.235 | 0.2284 |
Trypanosoma brucei | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0089 | 0.0383 | 0.0408 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.0866 | 0.6943 | 1 |
Echinococcus granulosus | bromo adjacent y domain containing 1 | 0.0062 | 0.0159 | 0.0159 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0189 | 0.1233 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0159 | 0.0075 |
Brugia malayi | GATA zinc finger family protein | 0.0062 | 0.0159 | 0.0056 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Brugia malayi | SET domain containing protein | 0.0065 | 0.018 | 0.0077 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Trichomonas vaginalis | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0965 |
Trypanosoma brucei | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Wolbachia endosymbiont of Brugia malayi | S-adenosylmethionine synthetase | 0.0107 | 0.0539 | 0.5 |
Entamoeba histolytica | S-adenosylmethionine synthetase, putative | 0.0107 | 0.0539 | 0.0637 |
Mycobacterium ulcerans | S-adenosylmethionine synthetase | 0.0107 | 0.0539 | 0.5 |
Echinococcus granulosus | S adenosylmethionine synthase type 1 | 0.0107 | 0.0539 | 0.0539 |
Echinococcus granulosus | disco interacting protein 2 | 0.0539 | 0.4183 | 0.4183 |
Brugia malayi | hypothetical protein | 0.0189 | 0.1233 | 0.1141 |
Schistosoma mansoni | disco-interacting protein 2 (dip2) | 0.0539 | 0.4183 | 0.4098 |
Echinococcus granulosus | arginine glutamic acid dipeptide RE repeats | 0.0062 | 0.0159 | 0.0159 |
Loa Loa (eye worm) | PWWP domain-containing protein | 0.0189 | 0.1233 | 0.1158 |
Schistosoma mansoni | histone J3 methyltransferase | 0.1228 | 1 | 1 |
Trypanosoma brucei | Histone-lysine N-methyltransferase, H3 lysine-76 specific | 0.0156 | 0.095 | 0.1238 |
Loa Loa (eye worm) | S-adenosylmethionine decarboxylase proenzyme | 0.0089 | 0.0383 | 0.03 |
Echinococcus granulosus | geminin | 0.0181 | 0.1162 | 0.1162 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0322 | 0.235 | 0.2284 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0159 | 0.0075 |
Trypanosoma cruzi | S-adenosylmethionine decarboxylase proenzyme, putative | 0.0089 | 0.0383 | 0.2473 |
Toxoplasma gondii | hypothetical protein | 0.0189 | 0.1233 | 0.1099 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.