Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dihydrofolate reductase | 0.6126 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.048 | 0.0725 | 0.0725 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0049 | 0.0017 | 0.0017 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.0007 | 0.0101 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.3894 | 0.6335 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0266 | 0.0374 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0001 | 0.0001 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0247 | 0.0343 | 0.0343 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.0143 | 0.0143 |
Brugia malayi | hypothetical protein | 0.0247 | 0.0343 | 0.0343 |
Schistosoma mansoni | survival motor neuron protein | 0.005 | 0.002 | 0.002 |
Echinococcus multilocularis | kinesin family 1 | 0.2049 | 0.3302 | 0.3302 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.007 | 0.0052 | 0.0052 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0102 | 0.0105 | 0.0105 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.3894 | 0.6335 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.1009 | 0.1594 | 0.1594 |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0001 | 0.0001 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0059 | 0.1566 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.3894 | 0.6335 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0141 | 0.0169 | 0.0169 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0266 | 0.0374 | 0.0591 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.0143 | 0.0143 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0247 | 0.0343 | 0.0343 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0001 | 0.0022 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0145 | 0.0176 | 0.0176 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.0007 | 0.0101 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.6126 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0.002 | 0.002 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0102 | 0.0105 | 0.0105 |
Echinococcus granulosus | dihydrofolate reductase | 0.6126 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0264 | 0.037 | 0.037 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.0001 | 0.0001 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0145 | 0.0176 | 0.0176 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.1009 | 0.1594 | 0.1594 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0233 | 0.0233 |
Loa Loa (eye worm) | hypothetical protein | 0.0247 | 0.0343 | 0.0343 |
Echinococcus multilocularis | geminin | 0.018 | 0.0233 | 0.0233 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0.0017 | 0.0017 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0059 | 0.1566 |
Schistosoma mansoni | kinesin eg-5 | 0.0266 | 0.0374 | 0.0374 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3894 | 0.6335 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.048 | 0.0725 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0125 | 0.0143 | 0.0143 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.3894 | 0.6335 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.1009 | 0.1594 | 0.1594 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0264 | 0.037 | 0.037 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0125 | 0.0143 | 0.0143 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0017 | 0.0017 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0125 | 0.0143 | 0.0226 |
Loa Loa (eye worm) | acetyltransferase | 0.0145 | 0.0176 | 0.0176 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.0059 | 0.0059 |
Giardia lamblia | Kinesin-5 | 0.0266 | 0.0374 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0001 | 0.0001 |
Onchocerca volvulus | 0.1009 | 0.1594 | 1 | |
Brugia malayi | hypothetical protein | 0.048 | 0.0725 | 0.0725 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0125 | 0.0143 | 0.0143 |
Onchocerca volvulus | 0.005 | 0.002 | 0.0126 | |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.0007 | 0.0012 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | thymidylate synthase | 0.1009 | 0.1594 | 0.1594 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.0059 | 0.0059 |
Echinococcus granulosus | geminin | 0.018 | 0.0233 | 0.0233 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0017 | 0.0017 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0007 | 0.0007 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.0059 | 0.0059 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.0059 | 0.0059 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0001 | 0.0001 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0145 | 0.0176 | 0.0176 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0125 | 0.0143 | 0.0143 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.3894 | 0.6335 | 1 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.0233 | 0.0233 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0017 | 0.0017 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0266 | 0.0374 | 0.0374 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0049 | 0.0017 | 0.0017 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.0001 | 0.0001 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.007 | 0.0052 | 0.0052 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.6126 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.6126 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.6126 | 1 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0001 | 0.0001 |
Brugia malayi | Dihydrofolate reductase | 0.6126 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.6126 | 1 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0125 | 0.0143 | 0.0143 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0001 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0059 | 0.1566 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0017 | 0.0017 |
Plasmodium falciparum | kinesin-5 | 0.0266 | 0.0374 | 0.0589 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0001 | 0.0009 |
Brugia malayi | thymidylate synthase | 0.1009 | 0.1594 | 0.1594 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.0052 | 0.0052 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.0007 | 0.0012 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.0007 | 0.0012 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.0001 | 0.0009 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0049 | 0.0017 | 0.0017 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0049 | 0.0017 | 0.0017 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.0001 | 0.0009 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0001 | 0.0001 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0102 | 0.0105 | 0.0105 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0001 | 0.0001 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1009 | 0.1594 | 0.1594 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.048 | 0.0725 | 0.1145 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.6126 | 1 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.005 | 0.002 | 0.002 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.0059 | 0.1566 |
Plasmodium vivax | kinesin-5 | 0.0266 | 0.0374 | 0.0591 |
Echinococcus granulosus | thymidylate synthase | 0.1009 | 0.1594 | 0.1594 |
Brugia malayi | Kinesin motor domain containing protein | 0.0266 | 0.0374 | 0.0374 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0244 | 0.0339 | 0.0339 |
Schistosoma mansoni | hypothetical protein | 0.1782 | 0.2865 | 0.2865 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.1009 | 0.1594 | 0.1594 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0125 | 0.0143 | 0.0143 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0125 | 0.0143 | 0.0226 |
Echinococcus granulosus | kinesin family 1 | 0.2049 | 0.3302 | 0.3302 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0105 | 0.0105 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Release (binding) | = 90 % | 4-methoxyaniline yield was measured from 4 fold reduced forms of compound at pH 7.4 | ChEMBL. | 9986704 |
Release (binding) | = 90 % | 4-methoxyaniline yield was measured from 8 fold reduced forms of compound at pH 7.4 | ChEMBL. | 9986704 |
T1/2 (ADMET) | < 1 min | The reaction of half life of compound was measured on 4 fold reduced forms at PH 7.4 | ChEMBL. | 9986704 |
T1/2 (ADMET) | < 1 min | The reaction of half life of compound was measured on 8 fold reduced forms at PH 7.4 | ChEMBL. | 9986704 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.