Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0076 | 0.2963 | 0.2963 |
Echinococcus multilocularis | peroxidasin | 0.0076 | 0.2963 | 0.2959 |
Echinococcus granulosus | lamin | 0.0026 | 0.0645 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0228 | 1 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.05 | 0.0638 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.05 | 0.0356 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0645 | 0.0645 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.2963 | 0.2901 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0645 | 0.064 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.05 | 0.0356 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.05 | 0.0417 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.05 | 0.0417 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0645 | 0.0645 |
Onchocerca volvulus | 0.0076 | 0.2963 | 1 | |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.05 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.1595 | 0.1803 |
Mycobacterium ulcerans | isopentenyl pyrophosphate isomerase | 0.0064 | 0.2418 | 0.2909 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0041 | 0.1344 | 0.1339 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.05 | 0.0356 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.05 | 0.0356 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.05 | 0.05 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0645 | 0.064 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0014 | 0.0086 | 0.0086 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0645 | 0.0645 |
Onchocerca volvulus | 0.0076 | 0.2963 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0623 | 0.0623 |
Echinococcus multilocularis | flap endonuclease 1 | 0.0033 | 0.0948 | 0.0943 |
Echinococcus granulosus | peroxidasin | 0.0076 | 0.2963 | 0.2959 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0041 | 0.1344 | 1 |
Onchocerca volvulus | 0.0035 | 0.1049 | 0.3528 | |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0047 | 0.1613 | 0.1838 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0041 | 0.1344 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.05 | 0.0356 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0228 | 1 | 1 |
Onchocerca volvulus | 0.0026 | 0.0645 | 0.2163 | |
Plasmodium vivax | flap endonuclease 1, putative | 0.0033 | 0.0948 | 0.6435 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.2963 | 0.2901 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0136 | 0.5731 | 0.5729 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.05 | 0.0417 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0232 | 0.0232 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.05 | 0.0411 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.05 | 0.2049 |
Leishmania major | isopentenyl-diphosphate delta-isomerase, putative,isomerase, putative | 0.0064 | 0.2418 | 1 |
Onchocerca volvulus | 0.0023 | 0.05 | 0.1671 | |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1595 | 0.1803 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0038 | 0.1186 | 0.3577 |
Plasmodium vivax | DNA repair protein RAD2, putative | 0.0038 | 0.1175 | 0.8478 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0038 | 0.1186 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Onchocerca volvulus | Peroxidase homolog | 0.0076 | 0.2963 | 1 |
Treponema pallidum | hypothetical protein | 0.018 | 0.7746 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0076 | 0.2963 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.014 | 0.5913 | 0.5913 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.05 | 0.0411 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0645 | 0.064 |
Onchocerca volvulus | Peroxidasin homolog | 0.0076 | 0.2963 | 1 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0013 | 0.0022 | 0.0017 |
Loa Loa (eye worm) | flap endonuclease-1 | 0.0033 | 0.0948 | 0.0948 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0645 | 0.0564 |
Leishmania major | flap endonuclease-1 (FEN-1), putative | 0.0033 | 0.0948 | 0.3906 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0041 | 0.1344 | 1 |
Mycobacterium tuberculosis | Possible L-lactate dehydrogenase (cytochrome) LldD2 | 0.018 | 0.7746 | 1 |
Schistosoma mansoni | xp-G/rad2 DNA repair endonuclease family | 0.0038 | 0.1175 | 0.1006 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0232 | 0.0232 |
Brugia malayi | Blistered cuticle protein 3 | 0.0076 | 0.2963 | 0.2901 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.2963 | 0.2901 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0013 | 0.0022 | 0.0017 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.014 | 0.5913 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0645 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1175 | 0.1175 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Brugia malayi | hypoxia-induced factor 1 | 0.0145 | 0.6164 | 0.6131 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Brugia malayi | Peroxidasin | 0.0076 | 0.2963 | 0.2901 |
Entamoeba histolytica | isopentenyl-diphosphate delta-isomerase, putative | 0.0064 | 0.2418 | 1 |
Loa Loa (eye worm) | aryl Hydrocarbon receptor Associated protein family member | 0.0012 | 0.0005 | 0.0005 |
Toxoplasma gondii | XPG N-terminal domain-containing protein | 0.0038 | 0.1175 | 0.5731 |
Brugia malayi | XPG N-terminal domain containing protein | 0.0032 | 0.0906 | 0.0828 |
Plasmodium falciparum | flap endonuclease 1 | 0.0033 | 0.0948 | 0.7505 |
Onchocerca volvulus | Dual oxidase homolog | 0.0076 | 0.2963 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0232 | 0.0057 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.05 | 0.0356 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0038 | 0.1186 | 1 |
Onchocerca volvulus | 0.0047 | 0.1595 | 0.5374 | |
Echinococcus multilocularis | transfer RNA-Lys | 0.0035 | 0.1049 | 0.1044 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0645 | 0.064 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0232 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.05 | 0.05 |
Echinococcus multilocularis | DNA repair protein complementing XP G cells | 0.0038 | 0.1175 | 0.117 |
Entamoeba histolytica | Flap nuclease, putative | 0.0033 | 0.0948 | 0.2337 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.05 | 0.0638 |
Schistosoma mansoni | flap endonuclease-1 | 0.0027 | 0.0707 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0232 | 0.0232 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.2963 | 0.2901 |
Echinococcus granulosus | flap endonuclease 1 | 0.0033 | 0.0948 | 0.0943 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.6729 | 0.6729 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.05 | 0.2049 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0005 | 0.0005 |
Onchocerca volvulus | 0.0076 | 0.2963 | 1 | |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0145 | 0.6164 | 0.6164 |
Mycobacterium leprae | POSSIBLE L-LACTATE DEHYDROGENASE (CYTOCHROME) LLDD2 | 0.018 | 0.7746 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.2963 | 0.2963 |
Mycobacterium ulcerans | putative regulatory protein | 0.0035 | 0.1049 | 0.1087 |
Trypanosoma cruzi | flap endonuclease-1 (FEN-1), putative | 0.0033 | 0.0948 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Schistosoma mansoni | single-minded | 0.0047 | 0.1613 | 0.1838 |
Brugia malayi | Flap endonuclease-1 | 0.0033 | 0.0948 | 0.0869 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0038 | 0.1175 | 0.8736 |
Echinococcus granulosus | DNA repair protein complementing XP G cells | 0.0038 | 0.1175 | 0.117 |
Brugia malayi | PAS domain containing protein | 0.0047 | 0.1613 | 0.154 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.2963 | 0.2963 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0041 | 0.1344 | 1 |
Brugia malayi | hypothetical protein | 0.0158 | 0.6729 | 0.67 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Trypanosoma brucei | isopentenyl-diphosphate delta-isomerase (type II) | 0.0064 | 0.2418 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0041 | 0.1344 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.014 | 0.5913 | 0.5877 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.05 | 0.05 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.2963 | 0.2963 |
Plasmodium falciparum | DNA repair protein RAD2, putative | 0.0038 | 0.1175 | 0.9888 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.05 | 0.2049 |
Onchocerca volvulus | 0.0026 | 0.0645 | 0.2163 | |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0645 | 0.0564 |
Onchocerca volvulus | Peroxidase homolog | 0.0076 | 0.2963 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0076 | 0.2963 | 0.2901 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Schistosoma mansoni | peroxidasin | 0.0076 | 0.2963 | 0.4399 |
Brugia malayi | bHLH-PAS transcription factor | 0.0035 | 0.1049 | 0.0971 |
Entamoeba histolytica | DNA-repair protein, putative | 0.0038 | 0.1175 | 0.3521 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0076 | 0.2963 | 0.2963 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.014 | 0.5913 | 0.5911 |
Trichomonas vaginalis | flap endonuclease-1, putative | 0.0033 | 0.0948 | 0.7039 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.05 | 0.0356 |
Schistosoma mansoni | peroxidasin | 0.0076 | 0.2963 | 0.4399 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.1595 | 0.1522 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0232 | 0.0232 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0232 | 1 |
Echinococcus granulosus | single minded 2 | 0.0035 | 0.1049 | 0.1044 |
Onchocerca volvulus | Peroxidasin homolog | 0.0076 | 0.2963 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0022 | 0.0022 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD1 | 0.0064 | 0.2418 | 0.2909 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.2963 | 0.2963 |
Mycobacterium ulcerans | L-lactate dehydrogenase (cytochrome) LldD2 | 0.018 | 0.7746 | 1 |
Brugia malayi | hypothetical protein | 0.0076 | 0.2963 | 0.2901 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.301 | Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells | ChEMBL. | 14695817 |
IC50 (binding) | = 4.377 | Inhibitory activity against cyclin-dependent kinase 5/p25 | ChEMBL. | 14695817 |
IC50 (binding) | = 4.638 | Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes | ChEMBL. | 14695817 |
Log IC50 (binding) | = 3.301 | Inhibitory activity against glycogen synthase kinase-3 beta purified from insect sf9 cells | ChEMBL. | 14695817 |
Log IC50 (binding) | = 4.377 | Inhibitory activity against cyclin-dependent kinase 5/p25 | ChEMBL. | 14695817 |
Log IC50 (binding) | = 4.638 | Inhibitory activity against cyclin dependent kinase 1-cyclinB extracted from M phase starfish (Marthasterias glacialis) oocytes | ChEMBL. | 14695817 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.