Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.1489 | 0.1489 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.008 | 0.375 | 0.375 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.375 | 0.375 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.375 | 1 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1412 | 0.412 |
Leishmania major | ATP-binding cassette protein subfamily G, member 6, putative | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.11 | 0.11 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.11 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.004 | 0.1489 | 0.4393 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.008 | 0.375 | 0.375 |
Plasmodium vivax | hypothetical protein, conserved | 0.0033 | 0.11 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0018 | 0.0251 | 0.0251 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0108 | 0.5308 | 0.5308 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0033 | 0.11 | 1 |
Trypanosoma brucei | ATP-binding cassette protein, putative | 0.0013 | 0 | 0.5 |
Echinococcus granulosus | GPCR family 2 | 0.0018 | 0.0251 | 0.0251 |
Echinococcus multilocularis | geminin | 0.0192 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0251 | 0.0251 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0033 | 0.11 | 0.11 |
Giardia lamblia | PHD finger protein 15 | 0.0033 | 0.11 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.008 | 0.375 | 0.375 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.1412 | 0.1412 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0033 | 0.11 | 0.11 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0018 | 0.0251 | 0.0251 |
Echinococcus granulosus | jumonji domain containing protein | 0.0046 | 0.1824 | 0.1824 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0033 | 0.11 | 1 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.004 | 0.1489 | 0.1489 |
Brugia malayi | Bromodomain containing protein | 0.0033 | 0.11 | 0.1679 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.2413 | 0.7671 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0251 | 0.0251 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0033 | 0.11 | 0.3012 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0251 | 0.0251 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.004 | 0.1489 | 0.1489 |
Brugia malayi | jmjC domain containing protein | 0.004 | 0.1489 | 0.2448 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0033 | 0.11 | 0.11 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0251 | 0.0251 |
Trypanosoma cruzi | ABC transporter, putative | 0.0013 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.375 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.1412 | 0.2296 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0018 | 0.0251 | 0.0251 |
Leishmania major | ATP-binding cassette protein subfamily G, member 4, putative | 0.0013 | 0 | 0.5 |
Brugia malayi | PHD-finger family protein | 0.0033 | 0.11 | 0.1679 |
Brugia malayi | hypothetical protein | 0.008 | 0.375 | 0.6919 |
Echinococcus multilocularis | peregrin | 0.0033 | 0.11 | 0.11 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.2413 | 0.7671 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0251 | 0.0251 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.375 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0108 | 0.5308 | 0.5308 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.375 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0086 | 0.4063 | 0.4063 |
Brugia malayi | jmjC domain containing protein | 0.0108 | 0.5308 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0046 | 0.1824 | 0.1824 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.004 | 0.1489 | 0.1489 |
Trypanosoma brucei | ABC transporter, putative | 0.0013 | 0 | 0.5 |
Trypanosoma cruzi | ATP-binding cassette protein, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0068 | 0.3069 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.2413 | 0.4275 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.2421 | 0.7701 |
Mycobacterium ulcerans | transmembrane ABC transporter ATP-binding protein | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.11 | 0.3012 |
Echinococcus granulosus | peregrin | 0.0033 | 0.11 | 0.11 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.2413 | 0.4275 |
Onchocerca volvulus | Alhambra homolog | 0.0033 | 0.11 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 15.5 uM | Concentration required for 50% toxicity in metastatic lung carcinoma (MV522) cells. | ChEMBL. | 11000013 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.