Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | thymidylate synthase | 0.254 | 0.0957 | 0.0957 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.9721 | 0.6117 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.9721 | 0.6117 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9721 | 0.6117 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 1.5123 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.9721 | 0.6117 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.9721 | 0.6117 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1208 | 0 | 0.5 |
Onchocerca volvulus | 0.254 | 0.0957 | 0.5 | |
Chlamydia trachomatis | dihydrofolate reductase | 1.5123 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.254 | 0.0957 | 0.0957 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 1.5123 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 1.5123 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.9721 | 0.6117 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 1.5123 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 1.5123 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 1.5123 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 1.5123 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 1.5123 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.