Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Echinococcus granulosus | aldehyde reductase | 0.0234 | 0.6923 | 0.6923 |
Echinococcus granulosus | hypothetical protein | 0.033 | 1 | 1 |
Loa Loa (eye worm) | cyclic AMP specific phosphodiesterase PDE4D5A | 0.0066 | 0.1501 | 0.1501 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.033 | 1 | 1 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Echinococcus multilocularis | aldehyde reductase | 0.0234 | 0.6923 | 0.6923 |
Schistosoma mansoni | pol-related | 0.033 | 1 | 1 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0073 | 0.1716 | 0.1716 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.033 | 1 | 1 |
Brugia malayi | NADH-dependent xylose reductase | 0.0096 | 0.2453 | 0.2453 |
Onchocerca volvulus | 0.0096 | 0.2453 | 0.2376 | |
Brugia malayi | glutamate-cysteine ligase modifier subunit | 0.0096 | 0.2453 | 0.2453 |
Schistosoma mansoni | aldo-keto reductase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.033 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0039 | 0.0616 | 0.0616 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel subunit | 0.0096 | 0.2453 | 0.2453 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0101 | 0.0101 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0023 | 0.0118 | 0.0118 |
Brugia malayi | follicle stimulating hormone receptor | 0.0231 | 0.6806 | 0.6806 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0223 | 0.0223 |
Echinococcus granulosus | aldo keto reductase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0616 | 0.0616 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0066 | 0.1501 | 0.1501 |
Plasmodium falciparum | aldo-keto reductase, putative | 0.0096 | 0.2453 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.033 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0046 | 0.0873 | 0.0873 |
Plasmodium falciparum | phd finger protein, putative | 0.0023 | 0.0101 | 0.0412 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0914 | 0.0914 |
Leishmania major | prostaglandin f synthase, putative | 0.033 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.033 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.033 | 1 | 1 | |
Schistosoma mansoni | jumonji domain containing protein | 0.0104 | 0.2726 | 0.2726 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Leishmania major | aldo-keto reductase-like protein | 0.033 | 1 | 1 |
Echinococcus multilocularis | peregrin | 0.0023 | 0.0101 | 0.0101 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.033 | 1 | 1 | |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0234 | 0.6919 | 0.6919 |
Plasmodium vivax | SET domain protein, putative | 0.0023 | 0.0118 | 0.0482 |
Trypanosoma cruzi | aldo-keto reductase | 0.033 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.033 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.033 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.033 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0226 | 0.6645 | 0.5 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase R153.1, putative | 0.0066 | 0.1501 | 0.1501 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0023 | 0.0101 | 0.0101 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0231 | 0.6806 | 0.6806 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0023 | 0.0118 | 0.0118 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0039 | 0.0616 | 0.0616 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0022 | 0.0091 | 0.0091 |
Echinococcus multilocularis | aldo keto reductase | 0.033 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0119 | 0.3214 | 0.3214 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Loa Loa (eye worm) | hypothetical protein | 0.033 | 1 | 1 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0119 | 0.3214 | 0.3214 |
Plasmodium vivax | hypothetical protein, conserved | 0.0023 | 0.0101 | 0.0412 |
Plasmodium falciparum | aldehyde reductase, putative | 0.0096 | 0.2453 | 1 |
Toxoplasma gondii | aldo-keto reductase | 0.0096 | 0.2453 | 0.2453 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0023 | 0.0118 | 0.0118 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0914 | 0.0914 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0161 | 0.4552 | 0.4552 |
Echinococcus multilocularis | aldo keto reductase | 0.033 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0026 | 0.0223 | 0.0223 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0084 | 0.2091 | 0.2091 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0031 | 0.0385 | 0.0385 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.033 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1, member B4 | 0.0096 | 0.2453 | 0.2453 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.0096 | 0.2453 | 0.2453 |
Loa Loa (eye worm) | oxidoreductase | 0.033 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.011 | 0.2927 | 0.0628 |
Onchocerca volvulus | 0.033 | 1 | 1 | |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0066 | 0.1501 | 0.1501 |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0084 | 0.2091 | 0.2091 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Echinococcus granulosus | aldo keto reductase | 0.033 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Echinococcus granulosus | aldo keto reductase | 0.033 | 1 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0023 | 0.0101 | 0.0101 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Echinococcus granulosus | cAMP specific 3'5' cyclic phosphodiesterase | 0.0084 | 0.2091 | 0.2091 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0023 | 0.0101 | 0.0101 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0023 | 0.0101 | 0.0101 |
Echinococcus granulosus | peregrin | 0.0023 | 0.0101 | 0.0101 |
Onchocerca volvulus | 0.0183 | 0.5268 | 0.5219 | |
Plasmodium vivax | oxidoreductase, aldo/keto reductase domain containing protein | 0.0096 | 0.2453 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.033 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0023 | 0.0101 | 0.0101 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0226 | 0.6645 | 0.6611 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0023 | 0.0118 | 0.0118 |
Echinococcus multilocularis | high affinity cAMP specific 3',5' cyclic | 0.0324 | 0.982 | 0.982 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.033 | 1 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0183 | 0.5268 | 0.3729 |
Toxoplasma gondii | aldo/keto reductase family oxidoreductase | 0.0096 | 0.2453 | 0.2453 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0039 | 0.0616 | 0.0616 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.033 | 1 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0073 | 0.1716 | 0.1716 |
Entamoeba histolytica | aldose reductase, putative | 0.033 | 1 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0023 | 0.0101 | 0.0101 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0073 | 0.1716 | 0.1716 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0118 | 0.0118 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Toxoplasma gondii | 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein | 0.0084 | 0.2091 | 0.2091 |
Mycobacterium ulcerans | oxidoreductase | 0.033 | 1 | 1 |
Brugia malayi | PHD-finger family protein | 0.0023 | 0.0101 | 0.0101 |
Onchocerca volvulus | 0.033 | 1 | 1 | |
Echinococcus multilocularis | cAMP specific 3',5' cyclic phosphodiesterase | 0.0084 | 0.2091 | 0.2091 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0234 | 0.6923 | 0.5922 |
Trypanosoma brucei | aldo/keto reductase, putative | 0.0096 | 0.2453 | 0.2453 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0914 | 0.0914 |
Loa Loa (eye worm) | glutamate-cysteine ligase modifier subunit | 0.0096 | 0.2453 | 0.2453 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.2091 | 0.2091 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.033 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.033 | 1 | 1 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.033 | 1 | 1 |
Toxoplasma gondii | oxidoreductase, aldo/keto reductase family protein | 0.0096 | 0.2453 | 0.2453 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Brugia malayi | hypothetical protein | 0.0234 | 0.6919 | 0.6919 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0073 | 0.1716 | 0.1716 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.033 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.011 | 0.2927 | 0.0628 |
Giardia lamblia | CAMP-specific 3,5-cyclic phosphodiesterase 4B | 0.0084 | 0.2091 | 0.201 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0234 | 0.6919 | 0.6919 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.033 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0161 | 0.4552 | 0.4552 |
Brugia malayi | Pre-SET motif family protein | 0.0023 | 0.0118 | 0.0118 |
Schistosoma mansoni | camp-specific 35-cyclic phosphodiesterase | 0.0084 | 0.2091 | 0.2091 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.033 | 1 | 1 |
Echinococcus multilocularis | voltage gated potassium channel subunit | 0.0096 | 0.2453 | 0.2453 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0223 | 0.0223 |
Plasmodium vivax | aldehyde reductase, putative | 0.0096 | 0.2453 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.033 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.0118 | 0.0018 | |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0023 | 0.0118 | 0.0118 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0023 | 0.0101 | 0.0101 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1009 | 0.1009 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0023 | 0.0118 | 0.0118 |
Giardia lamblia | Aldose reductase | 0.033 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0023 | 0.0118 | 0.0118 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0119 | 0.3214 | 0.3214 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.6919 | 0.6919 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.011 | 0.2927 | 0.0628 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0073 | 0.1716 | 0.1716 |
Onchocerca volvulus | 0.0048 | 0.0914 | 0.0822 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0226 | 0.6645 | 0.5555 |
Echinococcus multilocularis | aldo keto reductase | 0.033 | 1 | 1 |
Leishmania major | aldo/keto reductase, putative,aldo/keto reductase family-like protein | 0.0096 | 0.2453 | 0.2453 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0101 | 0.0101 |
Echinococcus granulosus | high affinity cAMP specific 3'5' cyclic | 0.0324 | 0.982 | 0.982 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0073 | 0.1716 | 0.1716 |
Giardia lamblia | Aldose reductase | 0.033 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.033 | 1 | 1 |
Schistosoma mansoni | potassium channel beta | 0.0096 | 0.2453 | 0.2453 |
Loa Loa (eye worm) | oxidoreductase | 0.033 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.033 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.033 | 1 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0023 | 0.0118 | 0.0118 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.033 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0031 | 0.0385 | 0.0385 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Compound was tested for inhibition of HIV-1 replication in human T-cell by using XTT assay; Moderately active | ChEMBL. | 8809151 |
Decrease in RFU (functional) | = 78.1 % | Tested against zinc finger of the recombinant HIV-1 p7NC protein by using Trp residue for fluorometric measurements | ChEMBL. | 8809151 |
EC50 (functional) | = 3.4 | Inhibition of HIV-1 replication in human T-cell by using XTT assay. | ChEMBL. | 8809151 |
EC50 (functional) | > 100 uM | Effective concentration required for 50% production of p24 production. | ChEMBL. | 8809151 |
IC50 (functional) | = 10.9 | Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay. | ChEMBL. | 8809151 |
IC50 (functional) | > 100 uM | Tested for cytoprotection against production of HIV-1 p24. | ChEMBL. | 8809151 |
increase in RFU (functional) | = 0.3 % | Tested against zinc finger of the recombinant HIV-1 p7NC toluenesulfonamide) residue for fluorometric measurements | ChEMBL. | 8809151 |
TI50 (functional) | = 3.2 | Inhibition of HIV-1 replication in human T-cell by using XTT assay. | ChEMBL. | 8809151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.