Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Angiotensin II type 1a (AT-1a) receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Duration (functional) | > 3.5 hr | Time to produce onset of action for inhibition of Angiotensin II pressor response in conscious, normotensive rats at 1 mg/kg po | ChEMBL. | 8246227 |
Duration (functional) | > 3.5 hr | Time to produce onset of action for inhibition of Angiotensin II pressor response in conscious, normotensive rats at 0.3 mg/kg po | ChEMBL. | 8246227 |
Duration (functional) | ~ 4 hr | Time to produce onset of action for inhibition of Angiotensin II pressor response in conscious, normotensive rats at 0.3 mg/kg iv | ChEMBL. | 8246227 |
Duration (functional) | > 6 hr | Time to produce onset of action for inhibition of Angiotensin II pressor response in conscious, normotensive rats at 1 mg/kg iv | ChEMBL. | 8246227 |
IC50 (functional) | = 0.67 nM | Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1 | ChEMBL. | 8246227 |
IC50 (functional) | = 0.67 nM | Evaluation of Angiotensin II antagonistic activity by displacement of [125I]-Sar Ile-AII at the rabbit aorta Angiotensin II receptor, type 1 | ChEMBL. | 8246227 |
Inhibition (functional) | = 57 % | Peak percent inhibition of Angiotensin II pressor response in conscious, normotensive rats at 0.3 mg/kg po | ChEMBL. | 8246227 |
Inhibition (functional) | = 71 % | Peak percent inhibition of Angiotensin II pressor response in conscious, normotensive rats at 1 mg/kg po | ChEMBL. | 8246227 |
Inhibition (functional) | = 77 % | Peak percent inhibition of Angiotensin II pressor response in conscious, normotensive rats at 0.3 mg/kg iv | ChEMBL. | 8246227 |
Inhibition (functional) | = 100 % | Peak percent inhibition of Angiotensin II pressor response in conscious, normotensive rats at 1 mg/kg iv | ChEMBL. | 8246227 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.