Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | glucose-6-phosphate dehydrogenase | 0.0144 | 0.7557 | 1 |
Trypanosoma cruzi | glucose-6-phosphate 1-dehydrogenase, putative | 0.0144 | 0.7557 | 1 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0115 | 0.5308 | 0.5097 |
Schistosoma mansoni | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0115 | 0.5308 | 0.6844 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0144 | 0.7557 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0062 | 0.1132 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0115 | 0.5308 | 0.5097 |
Chlamydia trachomatis | glucose-6-phosphate 1-dehydrogenase | 0.0144 | 0.7557 | 0.5 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0115 | 0.5308 | 0.5097 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Echinococcus multilocularis | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Onchocerca volvulus | 0.0115 | 0.5308 | 1 | |
Loa Loa (eye worm) | ACC-1 protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0144 | 0.7557 | 0.5 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0115 | 0.5308 | 0.6844 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0062 | 0.1132 | 0.0984 |
Echinococcus multilocularis | glucose 6 phosphate 1 dehydrogenase | 0.0144 | 0.7557 | 0.7447 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0062 | 0.1132 | 0.0984 |
Schistosoma mansoni | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0115 | 0.5308 | 0.6844 |
Echinococcus granulosus | glucose 6 phosphate 1 dehydrogenase | 0.0144 | 0.7557 | 0.7447 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0115 | 0.5308 | 0.5097 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0144 | 0.7557 | 0.5 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0115 | 0.5308 | 0.5097 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0115 | 0.5308 | 0.6844 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0115 | 0.5308 | 0.5097 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0115 | 0.5308 | 0.6844 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0115 | 0.5308 | 0.5097 |
Onchocerca volvulus | 0.0115 | 0.5308 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Schistosoma mansoni | glucose-6-phosphate 1-dehydrogenase | 0.0144 | 0.7557 | 0.7447 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Cation transporter family protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Schistosoma mansoni | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0115 | 0.5308 | 0.5097 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0115 | 0.5308 | 0.5097 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0062 | 0.1132 | 0.0733 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Onchocerca volvulus | 0.0115 | 0.5308 | 1 | |
Echinococcus granulosus | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Cation transporter family protein | 0.0115 | 0.5308 | 0.6844 |
Schistosoma mansoni | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Onchocerca volvulus | 0.0115 | 0.5308 | 1 | |
Onchocerca volvulus | Putative nachr subunit | 0.0115 | 0.5308 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0115 | 0.5308 | 0.6844 |
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0144 | 0.7557 | 0.5 |
Trypanosoma brucei | glucose-6-phosphate 1-dehydrogenase | 0.0144 | 0.7557 | 0.5 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0144 | 0.7557 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0115 | 0.5308 | 0.6844 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0115 | 0.5308 | 0.6844 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | Cation transporter family protein | 0.0115 | 0.5308 | 0.6844 |
Onchocerca volvulus | 0.0062 | 0.1132 | 0.1438 | |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0062 | 0.1132 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Loa Loa (eye worm) | ACC-1 protein | 0.0115 | 0.5308 | 0.6844 |
Schistosoma mansoni | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Schistosoma mansoni | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0115 | 0.5308 | 0.5097 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0115 | 0.5308 | 0.6844 |
Onchocerca volvulus | 0.0115 | 0.5308 | 1 | |
Mycobacterium ulcerans | glucose-6-phosphate 1-dehydrogenase | 0.0144 | 0.7557 | 1 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0062 | 0.1132 | 0.0984 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0144 | 0.7557 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | glucose-6-phosphate dehydrogenase | 0.0144 | 0.7557 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0062 | 0.1132 | 0.0733 |
Onchocerca volvulus | 0.0115 | 0.5308 | 1 | |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0115 | 0.5308 | 0.5097 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0115 | 0.5308 | 0.6844 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0115 | 0.5308 | 0.5097 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0144 | 0.7557 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0115 | 0.5308 | 0.6844 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0115 | 0.5308 | 0.5097 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0062 | 0.1132 | 0.0984 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Echinococcus multilocularis | nAChR subunit | 0.0062 | 0.1132 | 0.0733 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0115 | 0.5308 | 0.5097 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0115 | 0.5308 | 0.5097 |
Leishmania major | glucose-6-phosphate 1-dehydrogenase, putative | 0.0144 | 0.7557 | 0.5 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0115 | 0.5308 | 0.6844 |
Loa Loa (eye worm) | LGC-31 protein | 0.0115 | 0.5308 | 0.6844 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0062 | 0.1132 | 0.0984 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0115 | 0.5308 | 0.5097 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0115 | 0.5308 | 0.6844 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0144 | 0.7557 | 0.5 |
Echinococcus multilocularis | geminin | 0.0175 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.1132 | 0.1438 | |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0115 | 0.5308 | 0.5097 |
Schistosoma mansoni | nAChR subunit | 0.0115 | 0.5308 | 0.5097 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) | 0.005 | 0.0176 | 0.5 |
Echinococcus granulosus | nAChR subunit | 0.0062 | 0.1132 | 0.0733 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.1132 | 0.0984 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0115 | 0.5308 | 0.5097 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0115 | 0.5308 | 0.5097 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.