Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | 0.1212 | 0.3044 | 0.303 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0615 | 0.1321 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.1212 | 0.3044 | 0.303 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0615 | 0.1321 | 0.0142 |
Echinococcus multilocularis | voltage dependent calcium channel subunit | 0.036 | 0.0586 | 0.0568 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0615 | 0.1321 | 0.0142 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.1212 | 0.3044 | 0.3044 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0572 | 0.1196 | 0.1179 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0615 | 0.1321 | 0.1321 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0615 | 0.1321 | 0.1304 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.1212 | 0.3044 | 0.303 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.064 | 0.1394 | 0.0225 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1212 | 0.3044 | 0.2099 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.1212 | 0.3044 | 0.303 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.1212 | 0.3044 | 0.2099 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0615 | 0.1321 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0615 | 0.1321 | 0.1321 |
Schistosoma mansoni | nuclear hormone receptor | 0.0572 | 0.1196 | 0.1196 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0615 | 0.1321 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.1394 | 0.0225 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0615 | 0.1321 | 0.5 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.1212 | 0.3044 | 0.2099 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.1212 | 0.3044 | 0.2099 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.1212 | 0.3044 | 0.303 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0615 | 0.1321 | 0.1304 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1212 | 0.3044 | 0.2099 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | hypothetical protein | 0.0615 | 0.1321 | 0.0142 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.1212 | 0.3044 | 0.303 |
Onchocerca volvulus | 0.0615 | 0.1321 | 0.0142 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0615 | 0.1321 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | nuclear hormone receptor | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.064 | 0.1394 | 0.1394 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.3623 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0615 | 0.1321 | 0.1321 |
Onchocerca volvulus | 0.0615 | 0.1321 | 0.0142 | |
Schistosoma mansoni | zinc finger protein | 0.0572 | 0.1196 | 0.1196 |
Plasmodium falciparum | transporter, putative | 0.0615 | 0.1321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1321 | 0.0142 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1321 | 0.0142 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.064 | 0.1394 | 0.1394 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1321 | 0.0142 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.064 | 0.1394 | 0.1377 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.064 | 0.1394 | 0.0225 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0615 | 0.1321 | 0.1304 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0615 | 0.1321 | 0.1304 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.1212 | 0.3044 | 0.2099 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0572 | 0.1196 | 0.1179 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1212 | 0.3044 | 0.303 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.1212 | 0.3044 | 0.3044 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.1212 | 0.3044 | 0.303 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0615 | 0.1321 | 0.1321 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 0.3044 | 0.2099 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1212 | 0.3044 | 0.303 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0615 | 0.1321 | 0.1304 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.1212 | 0.3044 | 0.3044 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0615 | 0.1321 | 0.1321 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.3623 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0615 | 0.1321 | 0.5 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0615 | 0.1321 | 0.0142 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.1212 | 0.3044 | 0.2099 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0615 | 0.1321 | 0.0142 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.064 | 0.1394 | 0.0225 |
Toxoplasma gondii | hypothetical protein | 0.0615 | 0.1321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 0.3044 | 0.2099 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.1212 | 0.3044 | 0.2099 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0615 | 0.1321 | 0.1304 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.064 | 0.1394 | 0.1377 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.1394 | 0.0225 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.1212 | 0.3044 | 0.303 |
Schistosoma mansoni | nuclear receptor | 0.0572 | 0.1196 | 0.1196 |
Echinococcus granulosus | voltage dependent calcium channel subunit | 0.036 | 0.0586 | 0.0568 |
Onchocerca volvulus | Bile acid receptor homolog | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0615 | 0.1321 | 0.1321 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0572 | 0.1196 | 0.1179 |
Echinococcus granulosus | serotonin transporter | 0.3623 | 1 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0615 | 0.1321 | 0.1304 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0572 | 0.1196 | 0.1179 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.1212 | 0.3044 | 0.303 |
Brugia malayi | ecdysteroid receptor | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0615 | 0.1321 | 0.1321 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0572 | 0.1196 | 0.1196 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | nuclear receptor | 0.0572 | 0.1196 | 0.1196 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.1394 | 0.0225 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0572 | 0.1196 | 0.1179 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0572 | 0.1196 | 0.1179 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.1212 | 0.3044 | 0.3044 |
Loa Loa (eye worm) | steroid hormone receptor | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | nuclear receptor RXR | 0.064 | 0.1394 | 0.0225 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1212 | 0.3044 | 0.2099 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.1212 | 0.3044 | 0.303 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1321 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.1212 | 0.3044 | 0.3044 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.1212 | 0.3044 | 0.303 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.1212 | 0.3044 | 0.303 |
Brugia malayi | steroid hormone receptor | 0.1212 | 0.3044 | 0.2099 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0572 | 0.1196 | 0.1179 |
Loa Loa (eye worm) | norepinephrine transporter | 0.3623 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.1212 | 0.3044 | 0.2099 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0615 | 0.1321 | 0.1304 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1321 | 0.0142 |
Brugia malayi | nuclear receptor NHR-88 | 0.1212 | 0.3044 | 0.2099 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0615 | 0.1321 | 0.1304 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 0.3044 | 0.2099 |
Plasmodium vivax | amine transporter, putative | 0.0615 | 0.1321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.1394 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.1212 | 0.3044 | 0.3044 |
Loa Loa (eye worm) | hypothetical protein | 0.3623 | 1 | 1 |
Loa Loa (eye worm) | serotonin transporter b | 0.3623 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0572 | 0.1196 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.1394 | 0.0225 |
Echinococcus granulosus | FTZ F1 alpha | 0.1212 | 0.3044 | 0.303 |
Plasmodium falciparum | amino acid transporter, putative | 0.0615 | 0.1321 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 0.3044 | 0.2099 |
Onchocerca volvulus | 0.1212 | 0.3044 | 0.2099 | |
Echinococcus multilocularis | serotonin transporter | 0.3623 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0572 | 0.1196 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 0.3044 | 0.2099 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.1212 | 0.3044 | 0.303 |
Loa Loa (eye worm) | hypothetical protein | 0.1212 | 0.3044 | 0.2099 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.1212 | 0.3044 | 0.303 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0572 | 0.1196 | 0.1179 |
Plasmodium vivax | hypothetical protein, conserved | 0.0615 | 0.1321 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.1212 | 0.3044 | 0.3044 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0572 | 0.1196 | 0.1196 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.1212 | 0.3044 | 0.2099 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0615 | 0.1321 | 0.1304 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0572 | 0.1196 | 0.1196 |
Schistosoma mansoni | thyroid hormone receptor | 0.1212 | 0.3044 | 0.3044 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0615 | 0.1321 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0572 | 0.1196 | 0.1196 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0615 | 0.1321 | 0.0142 |
Schistosoma mansoni | thyroid hormone receptor | 0.1212 | 0.3044 | 0.3044 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0615 | 0.1321 | 0.1321 |
Echinococcus multilocularis | FTZ F1 alpha | 0.1212 | 0.3044 | 0.303 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0615 | 0.1321 | 0.1321 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.1212 | 0.3044 | 0.3044 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0572 | 0.1196 | 0.1179 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | hypothetical protein | 0.064 | 0.1394 | 0.0225 |
Onchocerca volvulus | 0.3623 | 1 | 1 | |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.1212 | 0.3044 | 0.3044 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0572 | 0.1196 | 0.1179 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1321 | 0.0142 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.1212 | 0.3044 | 0.2099 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.1212 | 0.3044 | 0.2099 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0615 | 0.1321 | 0.1321 |
Onchocerca volvulus | 0.0615 | 0.1321 | 0.0142 | |
Schistosoma mansoni | retinoic acid receptor RXR | 0.1212 | 0.3044 | 0.3044 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0615 | 0.1321 | 0.1304 |
Brugia malayi | hypothetical protein | 0.064 | 0.1394 | 0.0225 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1321 | 0.0142 |
Schistosoma mansoni | nuclear hormone receptor | 0.1212 | 0.3044 | 0.3044 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.3623 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3623 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3623 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.3623 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
pKB (functional) | = 5.96 | Antagonist activity tested against Cysteinyl leukotriene D4 receptor | ChEMBL. | 1313876 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.