Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2529 | 0.7734 | 1 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0037 | 0.0033 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0016 | 0.0006 | 0.0006 |
Echinococcus granulosus | smad | 0.0016 | 0.0006 | 0.0002 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0176 | 0.0499 | 0.0632 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0036 | 0.0036 |
Toxoplasma gondii | GAF domain-containing protein | 0.0029 | 0.0047 | 0.0047 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0037 | 0.0037 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0064 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0096 | 0.0251 | 0.0247 |
Schistosoma mansoni | lamin | 0.0026 | 0.0037 | 0.0033 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.0011 | 0.0011 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0016 | 0.0006 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0021 | 0.0021 |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0092 | 0.0241 | 0.0298 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0092 | 0.0241 | 0.0298 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.0251 | 0.0247 |
Trichomonas vaginalis | PIKK family atypical protein kinase | 0.0024 | 0.0032 | 0.0169 |
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.0251 | 0.0247 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0092 | 0.0241 | 0.0298 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0106 | 0.0106 |
Echinococcus granulosus | thymidylate synthase | 0.086 | 0.2601 | 0.2598 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0233 | 0.0673 | 0.0673 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0409 | 0.1215 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0176 | 0.0499 | 0.0496 |
Entamoeba histolytica | hypothetical protein | 0.0024 | 0.0032 | 0.3837 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0006 | 0.0006 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.0251 | 0.0247 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0029 | 0.0047 | 0.0301 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2529 | 0.7734 | 1 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0041 | 0.0082 | 0.0591 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0106 | 0.0106 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2529 | 0.7734 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.0046 | 0.0045 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.086 | 0.2601 | 0.2566 |
Echinococcus multilocularis | cAMP and cAMP inhibited cGMP 3',5' cyclic | 0.0041 | 0.0082 | 0.0079 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0096 | 0.0251 | 0.0251 |
Trichomonas vaginalis | set domain proteins, putative | 0.023 | 0.0664 | 0.5425 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0096 | 0.0251 | 0.0251 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0046 | 0.0046 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3266 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0409 | 0.1215 | 0.1173 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2529 | 0.7734 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0176 | 0.0499 | 0.0499 |
Brugia malayi | Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative | 0.0041 | 0.0082 | 0.0082 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.0251 | 0.0247 |
Echinococcus granulosus | dihydrofolate reductase | 0.3266 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0037 | 0.0033 |
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.0251 | 0.0247 |
Schistosoma mansoni | hypothetical protein | 0.0096 | 0.0251 | 0.0247 |
Leishmania major | carbonic anhydrase-like protein | 0.0176 | 0.0499 | 0.0632 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0059 | 0.0059 |
Loa Loa (eye worm) | thymidylate synthase | 0.086 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0016 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | MH2 domain containing protein | 0.0233 | 0.0673 | 0.0673 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0251 | 0.0251 |
Echinococcus granulosus | Smad4 | 0.0016 | 0.0006 | 0.0002 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0037 | 0.0033 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.0046 | 0.0042 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0006 | 0.0002 |
Toxoplasma gondii | hypothetical protein | 0.0081 | 0.0206 | 0.0253 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0016 | 0.0006 | 0.0002 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0011 | 0.0011 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0096 | 0.0251 | 0.0251 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0063 | 0.0151 | 0.1158 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.0046 | 0.0042 |
Onchocerca volvulus | 0.0029 | 0.0046 | 0.0034 | |
Brugia malayi | thymidylate synthase | 0.086 | 0.2601 | 0.2601 |
Loa Loa (eye worm) | Smad1 | 0.0016 | 0.0006 | 0.0006 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0082 | 0.0082 |
Onchocerca volvulus | 0.086 | 0.2601 | 1 | |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.0041 | 0.0082 | 0.0082 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0176 | 0.0499 | 0.0632 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0037 | 0.0037 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0024 | 0.0032 | 0.0032 |
Trichomonas vaginalis | cGMP-inhibited 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0096 | 0.0251 | 0.0251 |
Echinococcus multilocularis | FKBP12 rapamycin complex associated protein | 0.0018 | 0.0011 | 0.0007 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.0046 | 0.0046 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2529 | 0.7734 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0006 | 0.0002 |
Echinococcus granulosus | dual 3'5' cyclic AMP and GMP phosphodiesterase | 0.0092 | 0.0241 | 0.0237 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Trichomonas vaginalis | cAMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Brugia malayi | Smad1 | 0.0016 | 0.0006 | 0.0006 |
Trypanosoma brucei | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0032 | 0.0026 |
Echinococcus granulosus | cAMP and cAMP inhibited cGMP 3'5' cyclic | 0.0041 | 0.0082 | 0.0079 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0064 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.086 | 0.2601 | 0.2566 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.0206 | 0.162 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.0206 | 0.162 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0092 | 0.0241 | 0.0298 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Echinococcus multilocularis | smad | 0.0016 | 0.0006 | 0.0002 |
Echinococcus granulosus | FKBP12 rapamycin complex associated protein | 0.0018 | 0.0011 | 0.0007 |
Chlamydia trachomatis | dihydrofolate reductase | 0.3266 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.3266 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.3266 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3266 | 1 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.0578 | 0.0578 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0018 | 0.0011 | 0.0011 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.0046 | 0.0042 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0046 | 0.0042 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0233 | 0.0673 | 0.0673 |
Echinococcus granulosus | carbonic anhydrase | 0.0096 | 0.0251 | 0.0247 |
Schistosoma mansoni | lamin | 0.0026 | 0.0037 | 0.0033 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.086 | 0.2601 | 0.2566 |
Plasmodium vivax | hypothetical protein, conserved | 0.0029 | 0.0047 | 0.0002 |
Echinococcus granulosus | lamin | 0.0026 | 0.0037 | 0.0033 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0015 | 0.0004 | 0.0004 |
Schistosoma mansoni | cgmp-dependent 35-cyclic phosphodiesterase | 0.0041 | 0.0082 | 0.0079 |
Echinococcus multilocularis | dual 3',5' cyclic AMP and GMP phosphodiesterase | 0.0092 | 0.0241 | 0.0237 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0016 | 0.0006 | 0.0002 |
Brugia malayi | hypothetical protein | 0.0409 | 0.1215 | 0.1215 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0041 | 0.0082 | 0.0591 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.0578 | 0.0578 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0096 | 0.0251 | 0.0247 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0059 | 0.0055 |
Plasmodium falciparum | carbonic anhydrase | 0.0096 | 0.0251 | 0.0264 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0041 | 0.0082 | 0.0591 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0043 | 0.0039 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0064 | 0.006 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0006 | 0.0006 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0064 | 0.006 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0016 | 0.0006 | 0.0002 |
Giardia lamblia | GTOR | 0.0018 | 0.0011 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2529 | 0.7734 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0409 | 0.1215 | 0.1559 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0064 | 1 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm) | 0.0024 | 0.0032 | 0.0028 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0176 | 0.0499 | 0.0496 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0176 | 0.0499 | 0.0496 |
Trichomonas vaginalis | cGMP-dependent 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Schistosoma mansoni | smad1 5 8 and | 0.0016 | 0.0006 | 0.0002 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0096 | 0.0251 | 0.0251 |
Trichomonas vaginalis | cone cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Echinococcus multilocularis | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.0011 | 0.0007 |
Brugia malayi | MH1 domain containing protein | 0.0016 | 0.0006 | 0.0006 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0176 | 0.0499 | 0.0632 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.0251 | 0.0247 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0064 | 0.006 |
Trichomonas vaginalis | cAMP-specific phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Schistosoma mansoni | camp/cgmp cyclic nucleotide phosphodiesterase | 0.0092 | 0.0241 | 0.0237 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0018 | 0.0011 | 0.0011 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3266 | 1 | 1 |
Echinococcus multilocularis | serine protein kinase ATM | 0.0024 | 0.0032 | 0.0028 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0021 | 0.0021 | 0.0013 |
Toxoplasma gondii | FATC domain-containing protein | 0.0024 | 0.0032 | 0.0026 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0047 | 0.0047 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0015 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0047 | 0.0047 |
Trichomonas vaginalis | high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Trichomonas vaginalis | cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative | 0.0063 | 0.0151 | 0.1158 |
Trichomonas vaginalis | rod cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Trichomonas vaginalis | cGMP-specific 3,5-cyclic phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0106 | 0.0106 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Trichomonas vaginalis | cAMP/cGMP cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Echinococcus granulosus | serine protein kinase ATM | 0.0024 | 0.0032 | 0.0028 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.086 | 0.2601 | 0.2598 |
Trypanosoma cruzi | phosphatidylinositol kinase related protein, putative | 0.0024 | 0.0032 | 0.0026 |
Toxoplasma gondii | hypothetical protein | 0.0096 | 0.0251 | 0.031 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0037 | 0.0037 |
Echinococcus multilocularis | thymidylate synthase | 0.086 | 0.2601 | 0.2598 |
Echinococcus multilocularis | carbonic anhydrase | 0.0096 | 0.0251 | 0.0247 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0176 | 0.0499 | 0.0499 |
Toxoplasma gondii | hypothetical protein | 0.0029 | 0.0047 | 0.0047 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0064 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0176 | 0.0499 | 0.0499 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3266 | 1 | 1 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0064 | 0.0064 |
Trichomonas vaginalis | calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Schistosoma mansoni | phosphatidylinositol 3-and 4-kinase | 0.0018 | 0.0011 | 0.0007 |
Brugia malayi | MH2 domain containing protein | 0.0016 | 0.0006 | 0.0006 |
Onchocerca volvulus | 0.023 | 0.0664 | 0.2445 | |
Trypanosoma brucei | cAMP-specific phosphodiesterase | 0.0092 | 0.0241 | 0.0298 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.0046 | 0.0042 |
Trypanosoma cruzi | cAMP specific phosphodiesterase, putative | 0.0063 | 0.0151 | 0.018 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0059 | 0.0059 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0037 | 0.0033 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0081 | 0.0206 | 0.162 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.0251 | 0.0251 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0046 | 0.0042 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0176 | 0.0499 | 0.0496 |
Trichomonas vaginalis | cyclic nucleotide phosphodiesterase, putative | 0.0092 | 0.0241 | 0.1911 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0092 | 0.0241 | 0.1911 |
Echinococcus multilocularis | Smad4 | 0.0016 | 0.0006 | 0.0002 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0016 | 0.0006 | 0.0002 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0037 | 0.0033 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.0046 | 0.0042 |
Schistosoma mansoni | ataxia telangiectasia mutated (atm)-related | 0.0018 | 0.0011 | 0.0007 |
Schistosoma mansoni | Smad4 | 0.0016 | 0.0006 | 0.0002 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0176 | 0.0499 | 0.0499 |
Echinococcus granulosus | phosphatidylinositol 3 and 4 kinase | 0.0018 | 0.0011 | 0.0007 |
Schistosoma mansoni | smad | 0.0016 | 0.0006 | 0.0002 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0096 | 0.0251 | 0.0251 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0037 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0064 | 0.006 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0015 | 0.0004 | 0.0004 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0037 | 0.0037 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3266 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0106 | 0.0106 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CC50 (functional) | = 4 uM | Tested for cytotoxicity towards human MRC-5 cells | ChEMBL. | 12443785 |
CC50 (functional) | = 4 uM | Tested for cytotoxicity towards human MRC-5 cells | ChEMBL. | 12443785 |
CC50 (functional) | = 32 uM | Tested for cytotoxicity towards mouse peritoneal macrophages (MPM) | ChEMBL. | 12443785 |
ED50 (functional) | = 3 uM | Evaluated in vitro for antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 12443785 |
ED50 (functional) | = 3 uM | Evaluated in vitro for antitrypanosomal activity against Trypanosoma brucei | ChEMBL. | 12443785 |
ED50 (functional) | = 3 uM | Evaluated in vitro for antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 12443785 |
ED50 (functional) | = 3 uM | Evaluated in vitro for antitrypanosomal activity against Trypanosoma brucei | ChEMBL. | 12443785 |
ED50 (functional) | = 8 uM | Evaluated in vitro for antitrypanosomal activity against Leishmania infantum | ChEMBL. | 12443785 |
ED50 (functional) | = 8 uM | Evaluated in vitro for antitrypanosomal activity against Leishmania infantum | ChEMBL. | 12443785 |
IC50 (binding) | > 50 uM | Compound was tested for inhibition of trypanothione reductase from Trypanosoma cruzi | ChEMBL. | 12443785 |
IC50 (binding) | > 50 uM | Compound was tested for inhibition of trypanothione reductase from Trypanosoma cruzi | ChEMBL. | 12443785 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.