Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cytochrome P450 family protein | 0.0077 | 0.0385 | 0.3386 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0074 | 0.0369 | 0.2535 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.0937 | 0.4189 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0059 | 0.0264 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0155 | 0.0693 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0124 | 0.1031 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.0056 | 0.0419 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.0111 | 0.0576 | 0.2573 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0031 | 0.0124 | 0.0555 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0059 | 0.0445 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0155 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0059 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0059 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0056 | 0.0251 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0111 | 0.0576 | 0.2573 |
Plasmodium vivax | SET domain protein, putative | 0.0031 | 0.0124 | 1 |
Toxoplasma gondii | melibiase subfamily protein | 0.0111 | 0.0576 | 0.0536 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0124 | 0.0555 |
Brugia malayi | Pre-SET motif family protein | 0.0031 | 0.0124 | 0.1036 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.0698 | 0.5005 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0059 | 0.0264 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0074 | 0.0369 | 0.1648 |
Brugia malayi | cytochrome P450 | 0.0018 | 0.0056 | 0.0424 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0155 | 0.0693 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0111 | 0.0576 | 0.2573 |
Onchocerca volvulus | 0.0031 | 0.0124 | 0.0084 | |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0124 | 0.0552 |
Brugia malayi | hypothetical protein | 0.0151 | 0.0798 | 0.7102 |
Echinococcus multilocularis | geminin | 0.0176 | 0.0937 | 0.4189 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0111 | 0.0576 | 0.2573 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.0937 | 0.4189 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0059 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0059 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0115 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0798 | 0.71 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0155 | 0.1315 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0059 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0074 | 0.0369 | 0.1648 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0124 | 0.0555 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0155 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.001 | 0.0044 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.1119 | 1 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.1801 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0111 | 0.0576 | 0.2573 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.0056 | 0.0424 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0031 | 0.0124 | 0.0082 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0155 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0059 | 0.5 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0114 | 0.0943 |
Echinococcus granulosus | dnaJ subfamily B | 0.0409 | 0.2237 | 1 |
Echinococcus multilocularis | 0.0018 | 0.0056 | 0.0251 | |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.1801 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0155 | 0.0693 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0124 | 0.0552 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0031 | 0.0124 | 0.0555 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0062 | 0.03 | 0.1342 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0031 | 0.0124 | 0.0555 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.0111 | 0.0576 | 0.2573 |
Echinococcus granulosus | Alpha N acetylgalactosaminidase | 0.0111 | 0.0576 | 0.2573 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0114 | 0.0511 |
Schistosoma mansoni | cytochrome P450 | 0.0018 | 0.0056 | 0.0251 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.0056 | 0.0424 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0018 | 0.0056 | 0.0251 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0016 | 0.0042 | 0.0188 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0059 | 0.0003 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0059 | 0.0264 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0124 | 0.0552 |
Onchocerca volvulus | 0.0151 | 0.0798 | 0.5862 | |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0114 | 0.0948 |
Brugia malayi | hypothetical protein | 0.0133 | 0.0698 | 0.6202 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0698 | 0.6199 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0155 | 0.0693 |
Onchocerca volvulus | Huntingtin homolog | 0.0133 | 0.0698 | 0.5005 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0056 | 0.0264 | 0.0223 |
Brugia malayi | Melibiase family protein | 0.0074 | 0.0369 | 0.3238 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0059 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0059 | 0.0017 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.1801 | 1 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0059 | 0.0264 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0077 | 0.0385 | 0.3383 |
Loa Loa (eye worm) | cytochrome P450 | 0.0018 | 0.0056 | 0.0419 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0018 | 0.0056 | 0.0419 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0155 | 1 |
Echinococcus granulosus | geminin | 0.0176 | 0.0937 | 0.4189 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0124 | 0.0552 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0031 | 0.0124 | 0.0555 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.001 | 0.0044 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.0056 | 0.0424 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0018 | 0.0056 | 0.0014 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0059 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0.0059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0369 | 0.3234 |
Loa Loa (eye worm) | hypothetical protein | 0.0133 | 0.0698 | 0.6199 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0018 | 0.0056 | 0.0419 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0059 | 0.0451 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0031 | 0.0124 | 0.0555 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0409 | 0.2237 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0409 | 0.2237 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 0.128 | 1 |
Onchocerca volvulus | 0.0238 | 0.128 | 1 | |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.1119 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 18 nM | Potency to inhibit A1-adenosine receptor mediated cAMP accumulation in DDT1 MF-2 cells | ChEMBL. | 9934487 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.