Detailed information for compound 208682

Basic information

Technical information
  • TDR Targets ID: 208682
  • Name: 4-(4-amino-3-methoxyphenyl)disulfanyl-2-metho xyaniline
  • MW: 308.419 | Formula: C14H16N2O2S2
  • H donors: 2 H acceptors: 0 LogP: 2.61 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(SSc2ccc(c(c2)OC)N)ccc1N
  • InChi: 1S/C14H16N2O2S2/c1-17-13-7-9(3-5-11(13)15)19-20-10-4-6-12(16)14(8-10)18-2/h3-8H,15-16H2,1-2H3
  • InChiKey: FZOHAJVWFPMQRW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(4-amino-3-methoxy-phenyl)disulfanyl-2-methoxy-aniline
  • 4-(4-azanyl-3-methoxy-phenyl)disulfanyl-2-methoxy-aniline
  • [4-(4-amino-3-methoxy-phenyl)disulfanyl-2-methoxy-phenyl]amine
  • 29811-61-8
  • 4,4'-Dithiobis(O-anisidine)
  • 4-[(4-Amino-3-methoxyphenyl)disulfanyl]-2-methoxyphenylamine
  • NSC136554
  • (4-((4-Amino-3-methoxyphenyl)dithio)-2-methoxyphenyl)amine
  • NSC 136554
  • AIDS-032778
  • AIDS032778
  • {4-[(4-Amino-3-methoxyphenyl)dithio]-2-methoxyphenyl}amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0009 0.0002 0.0002
Loa Loa (eye worm) orotate phosphoribosyltransferase 0.0021 0.0206 0.0258
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.3614 0.3614
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0629 1 1
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0091 0.1328 0.5867
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0064 0.0272
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.013 0.1962 0.1962
Mycobacterium tuberculosis Conserved protein 0.0021 0.0206 0.0206
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0009 0.0002 0.0002
Leishmania major xanthine phosphoribosyltransferase 0.0091 0.1328 0.5867
Schistosoma mansoni lamin 0.0054 0.0726 0.0726
Mycobacterium ulcerans bifunctional Mta/Sah nucleosidase Mtn 0.013 0.1962 0.1962
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0002 0.0002
Echinococcus granulosus purine nucleoside phosphorylase 0.0629 1 1
Echinococcus granulosus purine nucleoside phosphorylase 0.0629 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0865 0.0865
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0387 0.1704
Echinococcus multilocularis adenine phosphoribosyltransferase 0.0021 0.0206 0.0206
Mycobacterium ulcerans hypothetical protein 0.002 0.0183 0.0183
Echinococcus granulosus thioredoxin glutathione reductase 0.0094 0.1376 0.1376
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0676 0.0676
Brugia malayi PAS domain containing protein 0.0048 0.0635 0.0633
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0009 0.0002 0.0002
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0002 0.0002
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0387 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0064 0.0064
Echinococcus granulosus lamin 0.0054 0.0726 0.0726
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0387 0.0387
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0387 0.0385
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0465 0.0463
Echinococcus granulosus methylthioadenosine phosphorylase 0.013 0.1962 0.1962
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0726 0.0916
Mycobacterium ulcerans adenine phosphoribosyltransferase 0.0021 0.0206 0.0206
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0009 0.0002 0.0002
Echinococcus multilocularis uridine phosphorylase 1 0.013 0.1962 0.1962
Plasmodium falciparum thioredoxin reductase 0.0033 0.0387 0.1704
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.0331
Schistosoma mansoni DNA helicase recq1 0.0037 0.0465 0.0465
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0387 0.1704
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0091 0.0091
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0387 0.1704
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0238 0.3699 0.3699
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0789 0.0789
Mycobacterium ulcerans hypothetical protein 0.0009 0.0002 0.0002
Brugia malayi hypothetical protein 0.0233 0.3614 0.3613
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.1104 0.5619
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0037 0.0465 0.0465
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0162 0.0823
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0093 0.0093
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0064 0.0064
Toxoplasma gondii endonuclease IV APN 0.0075 0.1079 0.4763
Trypanosoma brucei uridine phosphorylase 0.013 0.1962 0.8671
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0094 0.1376 0.1376
Onchocerca volvulus 0.0054 0.0726 0.0724
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0291 0.0291
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0162 0.0162
Brugia malayi Bloom's syndrome protein homolog 0.0062 0.0866 0.0863
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0009 0.0002 0.0002
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0149 0.2263 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0387 0.1704
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0064 0.0064
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.013 0.1962 0.1962
Treponema pallidum pfs protein (pfs) 0.013 0.1962 1
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0012 0.0064 0.0064
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.046 0.0458
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0387 0.1704
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0162 0.0162
Echinococcus multilocularis purine nucleoside phosphorylase 0.0629 1 1
Leishmania major nucleoside phosphorylase-like protein 0.013 0.1962 0.8671
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0012 0.0064 0.0078
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.1031 0.1031
Giardia lamblia UPL-1 0.013 0.1962 0.196
Mycobacterium tuberculosis Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase) 0.0021 0.0206 0.0206
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.046 0.2334
Treponema pallidum thioredoxin reductase (trxB) 0.0009 0.0002 0.0012
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0387 0.1704
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0009 0.0002 0.0002
Toxoplasma gondii orotate phosphoribosyltransferase 0.0021 0.0206 0.0902
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0064 0.0064
Loa Loa (eye worm) adenine phosphoribosyltransferase 0.0021 0.0206 0.0258
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0789 0.0789
Mycobacterium leprae Possible regulatory protein 0.0012 0.0064 0.0064
Brugia malayi Adenine phosphoribosyltransferase 0.0021 0.0206 0.0204
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.046 0.2024
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0214 0.3314 0.3314
Onchocerca volvulus 0.0028 0.0319 0.0316
Trypanosoma cruzi nucleoside phosphorylase, putative 0.013 0.1962 0.8671
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0009 0.0002 0.0002
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0629 1 1
Echinococcus granulosus cpg binding protein 0.003 0.0345 0.0345
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0387 0.1704
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.013 0.1962 0.196
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0387 0.0387
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.017 0.0741
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0064 0.0272
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0009 0.0002 0.0022
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0039 0.0039
Mycobacterium ulcerans hypothetical protein 0.0021 0.0206 0.0206
Treponema pallidum phosphoribosylpyrophosphate synthetase 0.0021 0.0206 0.1051
Trichomonas vaginalis ribose-phosphate pyrophosphokinase, putative 0.0021 0.0206 0.0206
Echinococcus multilocularis purine nucleoside phosphorylase 0.0629 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0062 0.0866 0.0866
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.013 0.1962 0.1962
Entamoeba histolytica recQ family helicase, putative 0.0018 0.0158 0.0795
Brugia malayi thymidylate synthase 0.0106 0.1568 0.1566
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0064 0.0272
Giardia lamblia Sgs1 DNA helicase, putative 0.0037 0.0465 0.0463
Echinococcus granulosus aryl hydrocarbon receptor 0.0012 0.0064 0.0064
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.013 0.1962 1
Echinococcus multilocularis uridine 5' monophosphate synthase 0.0021 0.0206 0.0206
Schistosoma mansoni hypothetical protein 0.0167 0.2551 0.2551
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.1104 1
Brugia malayi hypothetical protein 0.012 0.1794 0.1792
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0828 0.0828
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.013 0.1962 0.1962
Mycobacterium ulcerans ferredoxin reductase 0.0009 0.0002 0.0002
Mycobacterium ulcerans dehydrogenase 0.0009 0.0002 0.0002
Onchocerca volvulus 0.006 0.0828 0.0826
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.013 0.1962 0.8671
Loa Loa (eye worm) dihydrofolate reductase 0.0043 0.0558 0.0704
Mycobacterium tuberculosis Conserved protein 0.0021 0.0206 0.0206
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.013 0.1962 1
Echinococcus granulosus bloom syndrome protein 0.0062 0.0866 0.0866
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0162 0.0704
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.046 0.046
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0075 0.1079 0.1077
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0042 0.0548 0.2413
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0012 0.0012
Mycobacterium leprae probable uridine phosphorylase 0.013 0.1962 0.1962
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0387 0.1704
Loa Loa (eye worm) hypothetical protein 0.0026 0.028 0.0351
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0021 0.0206 0.0206
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0009 0.0002 0.0002
Mycobacterium tuberculosis Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) 0.0629 1 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.1104 0.4872
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.046 0.046
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0037 0.0035
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0021 0.0206 0.0206
Schistosoma mansoni uracil phosphoribosyltransferase 0.0021 0.0206 0.0206
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.013 0.1962 0.2481
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0091 0.0113
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0091 0.1328 0.1328
Brugia malayi Uncoordinated protein 44 0.0014 0.0091 0.0089
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0091 0.0089
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0033 0.0387 0.0387
Echinococcus granulosus purine nucleoside phosphorylase 0.0629 1 1
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase, putative 0.0091 0.1328 0.5867
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0009 0.0002 0.0002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0828 0.0828
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0009 0.0002 0.0022
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0106 0.1568 0.1568
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.013 0.1962 1
Brugia malayi dihydrofolate reductase family protein 0.0043 0.0558 0.0556
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0149 0.2263 1
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.013 0.1962 1
Trichomonas vaginalis conserved hypothetical protein 0.013 0.1962 0.1962
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Mycobacterium ulcerans hypoxanthine-guanine phosphoribosyltransferase Hpt 0.0091 0.1328 0.1328
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.002 0.0183 0.0181
Onchocerca volvulus 0.0091 0.1328 0.1326
Loa Loa (eye worm) hypothetical protein 0.0499 0.7901 1
Echinococcus granulosus death domain containing protein 0.0014 0.0091 0.0091
Schistosoma mansoni hypothetical protein 0.0014 0.0091 0.0091
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0091 0.1328 0.5867
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.013 0.1962 0.1962
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0162 0.0704
Echinococcus granulosus purine nucleoside phosphorylase 0.0629 1 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0629 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.1104 0.1104
Mycobacterium ulcerans purine nucleoside phosphorylase 0.0629 1 1
Toxoplasma gondii phosphorylase family protein 0.013 0.1962 0.8671
Loa Loa (eye worm) hypothetical protein 0.0075 0.1079 0.1363
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0214 0.3314 0.3314
Schistosoma mansoni DNA helicase recq5 0.0037 0.0465 0.0465
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.1104 0.1104
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.046 0.0458
Plasmodium vivax thioredoxin reductase, putative 0.0094 0.1376 0.6078
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0465 0.2046
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0726 0.0917
Treponema pallidum oxidoreductase 0.0009 0.0002 0.0012
Echinococcus multilocularis musashi 0.0054 0.0726 0.0726
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0033 0.0387 0.0387
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0629 1 1
Mycobacterium tuberculosis Hypothetical protein 0.013 0.1962 0.1962
Mycobacterium tuberculosis Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor 0.007 0.0985 0.0985
Plasmodium vivax orotate phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Schistosoma mansoni glutamate synthase 0.0009 0.0002 0.0002
Schistosoma mansoni lamin 0.0054 0.0726 0.0726
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0037 0.0465 0.0585
Trypanosoma cruzi nucleoside phosphorylase, putative 0.013 0.1962 0.8671
Leishmania major methylthioadenosine phosphorylase, putative 0.013 0.1962 0.8671
Schistosoma mansoni hypothetical protein 0.0403 0.6351 0.6351
Schistosoma mansoni ap endonuclease 0.0019 0.0162 0.0162
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.046 0.046
Echinococcus multilocularis lamin dm0 0.0054 0.0726 0.0726
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0387 0.1704
Plasmodium falciparum purine nucleoside phosphorylase 0.013 0.1962 0.8671
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.002 0.0183 0.0229
Onchocerca volvulus 0.0106 0.1568 0.1566
Schistosoma mansoni cpg binding protein 0.003 0.0345 0.0345
Mycobacterium leprae PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE) 0.0021 0.0206 0.0206
Brugia malayi uridine phosphorylase family protein 0.013 0.1962 0.196
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0789 0.0787
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0628 0.0626
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.1104 0.4872
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0162 0.0812
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0091 0.0091
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0024 0.0248 0.0246
Onchocerca volvulus 0.0471 0.7454 0.7453
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0676 0.0676
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0012
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.013 0.1962 0.8671
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0312 0.4895 0.6195
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.1104 0.1104
Entamoeba histolytica hypothetical protein 0.013 0.1962 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0387 0.1704
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0009 0.0002 0.0002
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0091 0.1328 0.5867
Schistosoma mansoni Adenine phosphoribosyltransferase 0.0021 0.0206 0.0206
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0002 0.0002
Plasmodium vivax SET domain protein, putative 0.006 0.0828 0.3654
Brugia malayi Probable ClpP-like protease 0.0077 0.1104 0.1102
Mycobacterium ulcerans glutamate synthase subunit beta 0.0009 0.0002 0.0002
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0039 0.0047
Toxoplasma gondii Purine nucleoside phosphorylase 0.013 0.1962 0.8671
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0387 0.1704
Echinococcus multilocularis purine nucleoside phosphorylase 0.0499 0.7901 0.7901
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0828 0.0828
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0002 0.0002
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0635 0.0635
Echinococcus granulosus uridine phosphorylase 1 0.013 0.1962 0.1962
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0214 0.3314 0.3314
Loa Loa (eye worm) RecQ helicase 0.0062 0.0866 0.1093
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.017 0.0741
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0091 0.0091
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0319 0.0401
Schistosoma mansoni purine nucleoside phosphorylase 0.0629 1 1
Schistosoma mansoni uridine phosphorylase 0.013 0.1962 0.1962
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0162 0.0704
Trypanosoma cruzi trypanothione reductase, putative 0.0094 0.1376 0.6078
Loa Loa (eye worm) hypothetical protein 0.006 0.0828 0.1046
Plasmodium vivax purine nucleoside phosphorylase, putative 0.013 0.1962 0.8671
Trichomonas vaginalis Ribose-phosphate pyrophosphokinase, putative 0.0021 0.0206 0.0206
Echinococcus multilocularis dihydrofolate reductase 0.0043 0.0558 0.0558
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.002 0.0183 0.0181
Echinococcus granulosus dihydrofolate reductase 0.0043 0.0558 0.0558
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Echinococcus granulosus purine nucleoside phosphorylase 0.0629 1 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0062 0.0866 0.0866
Mycobacterium tuberculosis Probable reductase 0.0214 0.3314 0.3314
Trypanosoma brucei trypanothione reductase 0.0094 0.1376 0.6078
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0091 0.1328 0.1328
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0038 0.0476 0.2096
Brugia malayi Death domain containing protein 0.0014 0.0091 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.046 0.0579
Schistosoma mansoni methylthioadenosine phosphorylase 0.013 0.1962 0.1962
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0012 0.0064 0.0064
Trypanosoma brucei orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0789 0.0789
Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT 0.0091 0.1328 0.5867
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.013 0.1962 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.1031 0.1031
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0009 0.0002 0.0002
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0291 0.1481
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.013 0.1962 0.196
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0548 0.0548
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0434 0.0432
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0149 0.2263 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0012 0.0064 0.0272
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0387 0.1704
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0033 0.0387 0.0387
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1789 0.2262
Mycobacterium ulcerans orotate phosphoribosyltransferase 0.0021 0.0206 0.0206
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0434 0.0434
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0012 0.0064 0.0272
Leishmania major adenine phosphoribosyltransferase 0.0021 0.0206 0.0902
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0012
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0674 0.2972
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0674 0.0674
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.013 0.1962 1
Chlamydia trachomatis AMP nucleosidase 0.013 0.1962 1
Schistosoma mansoni hypothetical protein 0.0047 0.0628 0.0628
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.36 0.4554
Brugia malayi CXXC zinc finger family protein 0.0028 0.0319 0.0316
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.2251 0.2847
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0206 0.0206
Trypanosoma cruzi orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0828 0.3654
Echinococcus multilocularis lamin 0.0054 0.0726 0.0726
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.046 0.046
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.013 0.1962 0.1962
Echinococcus multilocularis glutamate synthase 0.0009 0.0002 0.0002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0002 0.0002
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0009 0.0002 0.0002
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0042 0.0548 0.2413
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0009 0.0002 0.0002
Schistosoma mansoni blooms syndrome DNA helicase 0.0043 0.0559 0.0559
Brugia malayi hypothetical protein 0.0161 0.2452 0.245
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0387 0.1704
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0037 0.0465 0.2046
Echinococcus multilocularis purine nucleoside phosphorylase 0.0629 1 1
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0091 0.1328 0.1328
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.1079 0.4763
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.3614 0.3614
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0064 0.0064
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.046 0.2024
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0264 0.0331
Brugia malayi Pre-SET motif family protein 0.006 0.0828 0.0826
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0149 0.2263 1
Onchocerca volvulus 0.0047 0.0628 0.0626
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.0014 0.0091 0.0089
Echinococcus multilocularis thymidylate synthase 0.0106 0.1568 0.1568
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0387 0.1704
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0091 0.1328 0.1328
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0162 0.0159
Schistosoma mansoni survival motor neuron protein 0.0047 0.0628 0.0628
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0075 0.1079 0.1079
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0075 0.1079 0.4763
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.6351 0.6351
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0075 0.1079 0.1079
Echinococcus multilocularis purine nucleoside phosphorylase 0.0499 0.7901 0.7901
Trypanosoma cruzi Adenine phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Treponema pallidum uridine phosphorylase (udp) 0.013 0.1962 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0387 0.1704
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0009 0.0002 0.0002
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0091 0.1328 0.5867
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0387 0.1704
Trichomonas vaginalis glutamate synthase, putative 0.0009 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0828 0.0828
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0009 0.0002 0.0002
Echinococcus granulosus geminin 0.0167 0.2551 0.2551
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0214 0.3314 0.3314
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0789 0.3479
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0002 0.0002
Trypanosoma brucei Adenine phosphoribosyltransferase, putative 0.0021 0.0206 0.0902
Trypanosoma cruzi nucleoside phosphorylase, putative 0.013 0.1962 0.8671
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1789 0.2262
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0783 0.0783
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.046 0.2024
Schistosoma mansoni glutamate synthase 0.0009 0.0002 0.0002
Trichomonas vaginalis hypoxanthine-guanine phosphoribosyltransferase, putative 0.0091 0.1328 0.1328
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0009 0.0002 0.0002
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0009 0.0002 0.0002
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0002 0.0002
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0043 0.0558 0.0558
Schistosoma mansoni sulfide quinone reductase 0.0009 0.0002 0.0002
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.046 0.046
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0387 0.3511
Brugia malayi intermediate filament protein 0.0054 0.0726 0.0724
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0291 0.1275
Brugia malayi Thioredoxin reductase 0.0094 0.1376 0.1374
Schistosoma mansoni orotidine 5'-phosphate decarboxylase 0.0021 0.0206 0.0206
Loa Loa (eye worm) thymidylate synthase 0.0106 0.1568 0.1982
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0465 0.0463
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.013 0.1962 0.1962
Loa Loa (eye worm) hypothetical protein 0.0054 0.0726 0.0916
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0037 0.0465 0.2046
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0033 0.0387 0.0387
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0018 0.0158 0.0689
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0162 0.0159
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0009 0.0002 0.0002
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0037 0.0465 0.0465
Echinococcus multilocularis methylthioadenosine phosphorylase 0.013 0.1962 0.1962
Echinococcus multilocularis purine nucleoside phosphorylase 0.0629 1 1
Mycobacterium tuberculosis Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase) 0.0021 0.0206 0.0206
Plasmodium vivax glutathione reductase, putative 0.0094 0.1376 0.6078
Toxoplasma gondii exonuclease III APE 0.0019 0.0162 0.0704
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0238 0.3699 0.3699
Echinococcus granulosus single minded 2 0.0035 0.0434 0.0434
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0037 0.0465 0.0585
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0387 0.1704
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.028 0.028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0761 0.3358
Echinococcus granulosus inosine guanosine and xanthosine phosphorylase 0.0499 0.7901 0.7901
Loa Loa (eye worm) hypothetical protein 0.0014 0.0093 0.0115
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0676 0.0676
Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase, putative 0.0091 0.1328 0.5867
Brugia malayi Dihydrofolate reductase 0.0043 0.0558 0.0556
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0387 0.0387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0828 0.0828
Schistosoma mansoni hypoxanthine-guanine phosphoribosyltransferase 0.0021 0.0206 0.0206
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.1104 0.5624
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0009 0.0002 0.0002
Echinococcus multilocularis bloom syndrome protein 0.0062 0.0866 0.0866
Leishmania major trypanothione reductase 0.0094 0.1376 0.6078
Loa Loa (eye worm) hypothetical protein 0.0014 0.0091 0.0113
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0726 0.0724
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.046 0.046
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.017 0.017
Schistosoma mansoni cpg binding protein 0.003 0.0345 0.0345
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0828 0.0828
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0149 0.2263 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0002 0.0002
Onchocerca volvulus Adenine phosphoribosyltransferase homolog 0.0021 0.0206 0.0204
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0012 0.0012
Treponema pallidum ATP-dependent DNA helicase 0.0019 0.017 0.0866
Leishmania major protein kinase, putative 0.0012 0.0064 0.0272
Loa Loa (eye worm) hypothetical protein 0.0161 0.2452 0.3101
Treponema pallidum hypothetical protein 0.0021 0.0206 0.1051
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0002 0.0002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0291 0.1275
Loa Loa (eye worm) thioredoxin reductase 0.0094 0.1376 0.1739
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0434 0.0434
Schistosoma mansoni methylthioadenosine phosphorylase 0.013 0.1962 0.1962
Loa Loa (eye worm) hypothetical protein 0.0053 0.071 0.0896
Plasmodium falciparum orotate phosphoribosyltransferase 0.0021 0.0206 0.0902
Treponema pallidum NADH oxidase 0.0033 0.0387 0.1975
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0009 0.0002 0.0002
Schistosoma mansoni uridine phosphorylase 0.013 0.1962 0.1962
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0009 0.0002 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0387 0.1704
Echinococcus granulosus purine nucleoside phosphorylase 0.0629 1 1
Trypanosoma cruzi hypoxanthine-guanine phosphoribosyltransferase, putative 0.0091 0.1328 0.5867
Leishmania major hypoxanthine-guanine phosphoribosyltransferase 0.0091 0.1328 0.5867
Plasmodium falciparum glutathione reductase 0.0033 0.0387 0.1704
Echinococcus multilocularis aryl hydrocarbon receptor 0.0012 0.0064 0.0064
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.046 0.046
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0162 0.0201
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.1104 0.1104
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.046 0.2024
Mycobacterium tuberculosis Probable pyrimidine operon regulatory protein PyrR 0.0021 0.0206 0.0206
Brugia malayi glutathione reductase 0.0094 0.1376 0.1374
Schistosoma mansoni methylthioadenosine phosphorylase 0.013 0.1962 0.1962
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.013 0.1962 0.1962
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0057 0.0783 0.3453
Brugia malayi follicle stimulating hormone receptor 0.0232 0.36 0.3598
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0387 0.1704
Onchocerca volvulus 0.0054 0.0726 0.0724
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0789 0.0789
Loa Loa (eye worm) hypothetical protein 0.0044 0.0571 0.072
Chlamydia trachomatis dihydrofolate reductase 0.0043 0.0558 0.2836
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0214 0.3314 0.3314
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.1104 0.4872
Brugia malayi Phosphoribosyl transferase domain containing protein 0.0091 0.1328 0.1326
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.1104 0.5619
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0162 0.1464
Mycobacterium leprae conserved hypothetical protein 0.002 0.0183 0.0183
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.1104 0.1104
Toxoplasma gondii phosphorylase family protein 0.013 0.1962 0.8671
Echinococcus multilocularis cpg binding protein 0.003 0.0345 0.0345
Echinococcus granulosus thymidylate synthase 0.0106 0.1568 0.1568
Mycobacterium tuberculosis Probable oxidoreductase 0.0238 0.3699 0.3699
Echinococcus granulosus dnaJ subfamily B 0.0403 0.6351 0.6351
Brugia malayi MH2 domain containing protein 0.012 0.1789 0.1787
Mycobacterium tuberculosis Conserved hypothetical protein 0.013 0.1962 0.1962
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0726 0.0916
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0387 0.0387
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.013 0.1962 1
Schistosoma mansoni dihydrofolate reductase 0.0043 0.0558 0.0558
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0033 0.0387 0.3511
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0043 0.0558 0.0558
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0387 0.1704
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.046 0.046
Brugia malayi Pre-SET motif family protein 0.0414 0.6532 0.6531
Mycobacterium ulcerans thymidylate synthase 0.0106 0.1568 0.1568
Brugia malayi MTAP 0.013 0.1962 0.196
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0009 0.0002 0.0022
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.013 0.1962 0.8671
Loa Loa (eye worm) uridine phosphorylase 0.013 0.1962 0.2481
Onchocerca volvulus 0.0035 0.0434 0.0432
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0162 0.0704
Echinococcus granulosus uridine 5' monophosphate synthase 0.0021 0.0206 0.0206
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0039 0.0488 0.2148
Plasmodium falciparum glutathione reductase 0.0094 0.1376 0.6078
Schistosoma mansoni single-minded 0.0048 0.0635 0.0635
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0789 0.0789
Echinococcus granulosus adenine phosphoribosyltransferase 0.0021 0.0206 0.0206
Wolbachia endosymbiont of Brugia malayi orotate phosphoribosyltransferase 0.0021 0.0206 0.1869
Mycobacterium ulcerans endonuclease IV 0.0075 0.1079 0.1079
Trichomonas vaginalis set domain proteins, putative 0.0471 0.7452 0.7452
Schistosoma mansoni disulfide oxidoreductase 0.0009 0.0002 0.0002
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.046 0.046
Mycobacterium ulcerans monoxygenase 0.0009 0.0002 0.0002
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.046 0.046
Wolbachia endosymbiont of Brugia malayi amidophosphoribosyltransferase 0.0021 0.0206 0.1869
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0789 0.0789
Loa Loa (eye worm) glutathione reductase 0.0094 0.1376 0.1739
Mycobacterium leprae Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho 0.007 0.0985 0.0985
Mycobacterium tuberculosis Probable bifunctional MTA/SAH nucleosidase Mtn: 5'-methylthioadenosine nucleosidase (methylthioadenosine methylthioribohydrolase 0.013 0.1962 0.1962
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0106 0.1568 0.1568
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0162 0.0162
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0091 0.0091
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0162 0.0704
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0009 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0674 0.0674
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0325 0.0409
Echinococcus multilocularis purine nucleoside phosphorylase 0.0629 1 1
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0009 0.0002 0.0002
Echinococcus granulosus Ankyrin 0.0014 0.0093 0.0093
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0106 0.1568 0.1568
Echinococcus granulosus glutamate synthase 0.0009 0.0002 0.0002
Mycobacterium ulcerans amidophosphoribosyltransferase 0.0021 0.0206 0.0206
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0183 0.0183
Entamoeba histolytica recQ family DNA helicase 0.0019 0.017 0.0854
Schistosoma mansoni glutamate synthase 0.0009 0.0002 0.0002
Treponema pallidum adenine phosphoribosyltransferase 0.0021 0.0206 0.1051
Echinococcus granulosus purine nucleoside phosphorylase 0.0629 1 1
Chlamydia trachomatis endonuclease IV 0.0075 0.1079 0.5493
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0828 0.0828
Entamoeba histolytica recQ family helicase, putative 0.0042 0.0548 0.2782
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.002 0.0183 0.0183
Brugia malayi hypothetical protein 0.005 0.0674 0.0672
Mycobacterium ulcerans epimerase 0.002 0.0183 0.0183
Echinococcus granulosus hypoxanthine guanine phosphoribosyltransferase 0.0091 0.1328 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0064 0.0064
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0037 0.0465 0.0465
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0064 0.0272
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0039 0.0039
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0037 0.0465 0.0465
Brugia malayi hypoxia-induced factor 1 0.0148 0.2251 0.225
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0012 0.0064 0.0064
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.046 0.046
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0077 0.1104 0.1394
Echinococcus granulosus intermediate filament protein 0.0054 0.0726 0.0726
Brugia malayi orotate phosphoribosyltransferase family protein 0.0021 0.0206 0.0204
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0091 0.0089
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0149 0.2263 1
Mycobacterium tuberculosis Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase) 0.0021 0.0206 0.0206
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0629 1 1
Leishmania major protein kinase, putative 0.0012 0.0064 0.0272
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0012 0.0064 0.0313
Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase 0.0091 0.1328 0.5867
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0043 0.0558 0.0558
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0387 0.1704
Schistosoma mansoni hypothetical protein 0.0167 0.2551 0.2551
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0387 0.1704
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0009 0.0002 0.0002
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0387 0.1704
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0009 0.0002 0.0002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0094 0.1376 0.1376
Schistosoma mansoni cpg binding protein 0.0028 0.0319 0.0319
Echinococcus granulosus lamin dm0 0.0054 0.0726 0.0726
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.1104 0.1104
Mycobacterium ulcerans NADH dehydrogenase 0.0009 0.0002 0.0002
Mycobacterium ulcerans bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 0.0021 0.0206 0.0206
Trypanosoma brucei hypoxanthine-guanine phosphoribosyltransferase 0.0091 0.1328 0.5867
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0002 0.0002
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0012 0.0064 0.0064
Echinococcus multilocularis geminin 0.0167 0.2551 0.2551
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0009 0.0002 0.0002
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0091 0.0091
Onchocerca volvulus 0.0012 0.0064 0.0061
Loa Loa (eye worm) hypothetical protein 0.0019 0.017 0.0212
Schistosoma mansoni purine nucleoside phosphorylase 0.0629 1 1
Echinococcus multilocularis Ankyrin 0.0014 0.0093 0.0093
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0024 0.0248 0.0246
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0009 0.0002 0.0002
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0387 0.1965
Toxoplasma gondii thioredoxin reductase 0.0094 0.1376 0.6078
Schistosoma mansoni intermediate filament proteins 0.0054 0.0726 0.0726
Loa Loa (eye worm) hypothetical protein 0.0233 0.3614 0.4573
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0325 0.0323
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0238 0.3699 0.3699
Giardia lamblia Adenine phosphoribosyltransferase 0.0021 0.0206 0.0204
Giardia lamblia NADH oxidase lateral transfer candidate 0.0033 0.0387 0.0385
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0012 0.0064 0.0272
Trichomonas vaginalis conserved hypothetical protein 0.013 0.1962 0.1962
Leishmania major orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative 0.0021 0.0206 0.0902
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0676 0.0676
Schistosoma mansoni netrin receptor unc5 0.0014 0.0091 0.0091
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.1104 0.4872
Plasmodium falciparum thioredoxin reductase 0.0094 0.1376 0.6078
Trichomonas vaginalis adenylate cyclase, putative 0.0012 0.0064 0.0064
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.028 0.028
Echinococcus multilocularis hypoxanthine guanine phosphoribosyltransferase 0.0091 0.1328 0.1328
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0162 0.0162
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0676 0.0676
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0019 0.017 0.0741
Schistosoma mansoni ap endonuclease 0.0019 0.0162 0.0162
Giardia lamblia Guanine phosphoribosyltransferase 0.0091 0.1328 0.1326
Mycobacterium leprae AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE) 0.0021 0.0206 0.0206
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.6532 0.8267
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0042 0.0548 0.2413
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0162 0.0704
Mycobacterium tuberculosis Probable dehydrogenase 0.0214 0.3314 0.3314
Loa Loa (eye worm) hypothetical protein 0.0012 0.0064 0.0078
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0012 0.0064 0.0064
Trichomonas vaginalis apoptosis inducing factor, putative 0.0009 0.0002 0.0002
Echinococcus granulosus purine nucleoside phosphorylase 0.0629 1 1
Trichomonas vaginalis guanylate cyclase, putative 0.0012 0.0064 0.0064
Toxoplasma gondii hypothetical protein 0.0027 0.0291 0.1275

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Inhibition of HIV-1 replication in human T-cell by using XTT assay; Inactive ChEMBL. 8809151
IC50 (functional) = 26.4 Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay. ChEMBL. 8809151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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