Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0152 | 0.92 | 1 |
Onchocerca volvulus | 0.0012 | 0 | 0.5 | |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0012 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.92 | 0.92 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.9197 | 0.9197 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.92 | 0.92 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.92 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.92 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.9197 | 0.9197 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.92 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.92 | 0.92 |
Brugia malayi | P38 map kinase family protein 2 | 0.0152 | 0.92 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.9197 | 0.9997 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.92 | 0.92 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.92 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.92 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0012 | 0 | 0.5 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0012 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.92 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.121 uM | Inhibitory activity against TGF-beta type I receptor | ChEMBL. | 15177480 |
IC50 (binding) | = 0.121 uM | Inhibitory activity against TGF-beta type I receptor | ChEMBL. | 15177480 |
IC50 (functional) | = 0.304 uM | Inhibitory activity against TGF-beta dependentluciferase production in mink lung cells p3TP Lux | ChEMBL. | 15177480 |
IC50 (functional) | = 0.397 uM | Inhibitory activity tested in NIH 3T3 cells | ChEMBL. | 15177480 |
IC50 (functional) | = 0.397 uM | Inhibitory activity tested in NIH 3T3 cells | ChEMBL. | 15177480 |
IC50 (binding) | = 4.6 uM | Inhibitory activity against Mitogen-activated protein kinase p38 | ChEMBL. | 15177480 |
IC50 (binding) | = 4.6 uM | Inhibitory activity against Mitogen-activated protein kinase p38 | ChEMBL. | 15177480 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 15177480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.