Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.2231 | 1 | 1 |
Giardia lamblia | Aldose reductase | 0.2231 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2231 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2231 | 1 | 0.5 |
Onchocerca volvulus | 0.2231 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2231 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.2231 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2231 | 1 | 1 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Leishmania major | prostaglandin f synthase, putative | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Onchocerca volvulus | 0.2231 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.2231 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2231 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.2231 | 1 | 0.5 |
Mycobacterium ulcerans | oxidoreductase | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.2231 | 1 | 0.5 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase | 0.2231 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | hypothetical protein | 0.2231 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.2231 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2231 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Onchocerca volvulus | 0.2231 | 1 | 0.5 | |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.2231 | 1 | 0.5 |
Onchocerca volvulus | 0.2231 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.2231 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Trypanosoma cruzi | aldo-keto reductase | 0.2231 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2231 | 1 | 1 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2231 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Trypanosoma brucei | prostaglandin f synthase | 0.2231 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2231 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2231 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Onchocerca volvulus | 0.2231 | 1 | 0.5 | |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.2231 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Toxoplasma gondii | aldose reductase, putative | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.2231 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2231 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2231 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2231 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2231 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2231 | 1 | 1 |
Onchocerca volvulus | 0.2231 | 1 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.2231 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2231 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 18 % | Inhibitory activity against partially purified rat liver HMG CoA reductase at 4 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 18 % | Inhibitory activity against partially purified rat liver HMG CoA reductase at 4 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 21 % | Inhibitory activity against partially purified rat liver HMG CoA reductase at 1 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 21 % | Inhibition of partially purified rat liver HMG CoA reductase at 10 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 21 % | Inhibitory activity against partially purified rat liver HMG CoA reductase at 1 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 21 % | Inhibition of partially purified rat liver HMG CoA reductase at 10 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 24 % | Inhibitory activity against partially purified rat liver HMG CoA reductase at 2 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 24 % | Inhibitory activity against partially purified rat liver HMG CoA reductase at 2 ug/ml concentration | ChEMBL. | 3973903 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.