Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Mycobacterium ulcerans | thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0195 | 0.5 | 0.5 |
Echinococcus granulosus | thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0195 | 0.5 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0195 | 0.5 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0195 | 0.5 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0195 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
k2' (functional) | = 0.12 min-1 | The time dependent reaction (k2'(1/min)) of compound was measured for inactivation of L1210 Thymidylate Synthase | ChEMBL. | 8246229 |
k2' (functional) | = 0.12 min-1 | The time dependent reaction (k2'(1/min)) of compound was measured for inactivation of L1210 Thymidylate Synthase | ChEMBL. | 8246229 |
k2' (functional) | = 0.36 min-1 | The time dependent reaction (k2''(1/min)) of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases | ChEMBL. | 8246229 |
k2' (functional) | = 0.36 min-1 | The time dependent reaction (k2''(1/min)) of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases | ChEMBL. | 8246229 |
k2'' (functional) | = 0.02 min-1 | The time dependent reaction (k2''(1/min)) of compound was measured for inactivation of L1210 Thymidylate Synthase | ChEMBL. | 8246229 |
k2'' (functional) | = 0.02 min-1 | The time dependent reaction (k2''(1/min)) of compound was measured for inactivation of L1210 Thymidylate Synthase | ChEMBL. | 8246229 |
k2'' (functional) | = 0.06 min-1 | The time dependent reaction (k2''(1/min)) of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthase | ChEMBL. | 8246229 |
k2'' (functional) | = 0.06 min-1 | The time dependent reaction (k2''(1/min)) of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthase | ChEMBL. | 8246229 |
Ki (binding) | = 0.07 uM | Apparent Ki value of the compound was measured by competitive inhibition of Thymidylate Synthase from L1210 cells of mouse | ChEMBL. | 8246229 |
Ki (binding) | = 0.07 uM | Apparent Ki value of the compound was measured by competitive inhibition of Thymidylate Synthase from L1210 cells of mouse | ChEMBL. | 8246229 |
Ki (binding) | = 0.14 uM | Apparent Ki value of the compound was measured by competitive inhibition of Thymidylate Synthase from Ehrlich Carcinoma cells of mouse | ChEMBL. | 8246229 |
Ki (binding) | = 0.14 uM | Apparent Ki value of the compound was measured by competitive inhibition of Thymidylate Synthase from Ehrlich Carcinoma cells of mouse | ChEMBL. | 8246229 |
Ki' (functional) | = 41 nM | The reaction rate(Ki') of compound was measured for inactivation of L1210 Thymidylate Synthase | ChEMBL. | 8246229 |
Ki' (functional) | = 41 nM | The reaction rate(Ki') of compound was measured for inactivation of L1210 Thymidylate Synthase | ChEMBL. | 8246229 |
Ki' (functional) | = 79 nM | The reaction rate(Ki') of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases | ChEMBL. | 8246229 |
Ki' (functional) | = 79 nM | The reaction rate(Ki') of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases | ChEMBL. | 8246229 |
Ki'' (functional) | = 46 nM | The reaction rate(Ki'') of compound was measured for inactivation of L1210 Thymidylate Synthase | ChEMBL. | 8246229 |
Ki'' (functional) | = 46 nM | The reaction rate(Ki'') of compound was measured for inactivation of L1210 Thymidylate Synthase | ChEMBL. | 8246229 |
Ki'' (functional) | = 49 nM | The reaction rate(Ki'') of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases | ChEMBL. | 8246229 |
Ki'' (functional) | = 49 nM | The reaction rate(Ki'') of compound was measured for inactivation of Ehrlich Carcinoma Thymidylate Synthases | ChEMBL. | 8246229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.