Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kelch-like ECH-associated protein 1 | References | |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Kelch motif family protein | kelch-like ECH-associated protein 1 | 624 aa | 565 aa | 31.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Kelch motif family protein | 0 | 0.0003 | 0.0007 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0 | 0.0003 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 10 | 0 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Echinococcus multilocularis | kelch protein 12 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3781 | 0.3781 |
Brugia malayi | Kelch motif family protein | 0 | 0.0003 | 0.0007 |
Echinococcus granulosus | kelch protein 10 | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3781 | 0.3792 |
Echinococcus multilocularis | kelch protein 3 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3781 | 0.3781 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0114 | 0.9972 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0114 | 0.9972 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 18 | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 18 | 0 | 0.0003 | 0.0003 |
Brugia malayi | Kelch-like protein X | 0 | 0.0003 | 0.0007 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0043 | 0.3781 | 1 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 0.9972 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3781 | 0.3781 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 0.9972 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | Klhl5 protein | 0 | 0.0003 | 1 |
Echinococcus granulosus | kelch protein 3 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 12 | 0 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 1 |
Loa Loa (eye worm) | ring canal kelch protein | 0 | 0.0003 | 1 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0 | 0.0003 | 0.0003 |
Brugia malayi | BTB/POZ domain containing protein | 0 | 0.0003 | 0.0007 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 15 uM | Inhibition of kelch domain of Keap1 (unknown origin) interaction to high affinity ETGE motif from Nrf2 by fluorescence polarization assay | ChEMBL. | 26348784 |
FC (binding) | = 2.24 | Activation of Nrf2 in mouse Hepa1c1c7 cells assessed as induction of NQO1 production at 10 uM after 24 hrs by MTT colorimetric assay relative to control | ChEMBL. | 26348784 |
Inhibition (binding) | = 67.2 % | Inhibition of kelch domain of Keap1 (unknown origin) interaction to high affinity ETGE motif from Nrf2 unknown origin) at 100 uM by fluorescence polarization assay | ChEMBL. | 26348784 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.