Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kelch-like ECH-associated protein 1 | References | |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Kelch motif family protein | kelch-like ECH-associated protein 1 | 624 aa | 565 aa | 31.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectoderm neural cortex protein 1 | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.3781 | 0.3781 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Brugia malayi | Kelch motif family protein | 0 | 0.0003 | 0.0007 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.3781 | 0.3781 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 0.9972 |
Echinococcus granulosus | kelch protein 10 | 0 | 0.0003 | 0.0003 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | ring canal kelch protein | 0 | 0.0003 | 1 |
Echinococcus granulosus | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0114 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.3781 | 0.3781 |
Echinococcus granulosus | ectoderm neural cortex protein 1 | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0114 | 0.9972 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.3781 | 0.3792 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Echinococcus granulosus | kelch ECH associated protein 1 like | 0.0114 | 0.9972 | 1 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0043 | 0.3781 | 1 |
Brugia malayi | Kelch motif family protein | 0 | 0.0003 | 0.0007 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 12 | 0 | 0.0003 | 0.0003 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Echinococcus multilocularis | kelch protein 10 | 0 | 0.0003 | 0.0003 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0 | 0.0003 | 1 |
Loa Loa (eye worm) | Klhl5 protein | 0 | 0.0003 | 1 |
Onchocerca volvulus | 0 | 0 | 0.5 | |
Echinococcus multilocularis | kelch protein 18 | 0 | 0.0003 | 0.0003 |
Brugia malayi | Kelch-like protein X | 0 | 0.0003 | 0.0007 |
Brugia malayi | BTB/POZ domain containing protein | 0 | 0.0003 | 0.0007 |
Echinococcus granulosus | kelch protein 18 | 0 | 0.0003 | 0.0003 |
Schistosoma mansoni | hypothetical protein | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 12 | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch protein 3 | 0 | 0.0003 | 0.0003 |
Echinococcus granulosus | kelch protein 3 | 0 | 0.0003 | 0.0003 |
Echinococcus multilocularis | kelch ECH associated protein 1 | 0.0114 | 0.9972 | 0.9972 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.3781 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CD (binding) | = 0.7 uM | Activation of Nrf2 in mouse Hepa1c1c7 cells assessed as concentration required to 2 fold induction of NQO1 production after 24 hrs by MTT colorimetric assay | ChEMBL. | 26348784 |
EC50 (binding) | = 8.8 uM | Inhibition of kelch domain of Keap1 (unknown origin) interaction to high affinity ETGE motif from Nrf2 by fluorescence polarization assay | ChEMBL. | 26348784 |
Inhibition (binding) | = 60.4 % | Inhibition of kelch domain of Keap1 (unknown origin) interaction to high affinity ETGE motif from Nrf2 unknown origin) at 100 uM by fluorescence polarization assay | ChEMBL. | 26348784 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.