Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Schistosoma mansoni | aldo-keto reductase | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2032 | 1 | 0.5 |
Trypanosoma cruzi | aldo/keto reductase, putative | 0.2032 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2032 | 1 | 0.5 |
Leishmania major | aldo-keto reductase-like protein | 0.2032 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.2032 | 1 | 1 |
Onchocerca volvulus | 0.2032 | 1 | 0.5 | |
Leishmania major | prostaglandin f synthase, putative | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Onchocerca volvulus | 0.2032 | 1 | 0.5 | |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2032 | 1 | 0.5 |
Leishmania major | prostaglandin f2-alpha synthase/D-arabinose dehydrogenase | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2032 | 1 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Trypanosoma brucei | prostaglandin f synthase | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Trypanosoma brucei | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Brugia malayi | oxidoreductase, aldo/keto reductase family protein | 0.2032 | 1 | 0.5 |
Schistosoma mansoni | pol-related | 0.2032 | 1 | 0.5 |
Onchocerca volvulus | 0.2032 | 1 | 0.5 | |
Trichomonas vaginalis | aldo/keto reductase, putative | 0.2032 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | dihydrodiol dehydrogenase, putative | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.2032 | 1 | 0.5 |
Onchocerca volvulus | 0.2032 | 1 | 0.5 | |
Echinococcus granulosus | aldo keto reductase | 0.2032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.2032 | 1 | 0.5 |
Giardia lamblia | Aldose reductase | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Mycobacterium ulcerans | oxidoreductase | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Schistosoma mansoni | aldo-keto reductase | 0.2032 | 1 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.2032 | 1 | 0.5 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Entamoeba histolytica | aldose reductase, putative | 0.2032 | 1 | 0.5 |
Toxoplasma gondii | aldose reductase, putative | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Mycobacterium leprae | PROBABLE OXIDOREDUCTASE | 0.2032 | 1 | 1 |
Onchocerca volvulus | 0.2032 | 1 | 0.5 | |
Giardia lamblia | Aldose reductase | 0.2032 | 1 | 0.5 |
Onchocerca volvulus | 0.2032 | 1 | 0.5 | |
Trypanosoma cruzi | aldo-keto reductase | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Leishmania major | aldehyde reductase, putative,oxidoreductase, putative | 0.2032 | 1 | 0.5 |
Echinococcus granulosus | aldo keto reductase | 0.2032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Trichomonas vaginalis | aldo-keto reductase, putative | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase | 0.2032 | 1 | 1 |
Entamoeba histolytica | aldose reductase, putative | 0.2032 | 1 | 0.5 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Echinococcus granulosus | aldo keto reductase family 1 member B4 | 0.2032 | 1 | 1 |
Echinococcus multilocularis | aldo keto reductase family 1, member B4 | 0.2032 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibitory activity of the compound against partially purified rat liver HMG CoA reductase at 0.625 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 0 % | Inhibitory activity of the compound against partially purified rat liver HMG CoA reductase at 0.625 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 8 % | Inhibitory activity of the compound against partially purified rat liver HMG CoA reductase at 3.125 ug/ml concentration | ChEMBL. | 3973903 |
Inhibition (binding) | = 8 % | Inhibitory activity of the compound against partially purified rat liver HMG CoA reductase at 3.125 ug/ml concentration | ChEMBL. | 3973903 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.