Detailed information for compound 2090350

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 406.925 | Formula: C9H6Cl6O3S
  • H donors: 0 H acceptors: 1 LogP: 3.24 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S1OC[C@@H]2[C@H](CO1)[C@]1(C([C@]2(Cl)C(=C1Cl)Cl)(Cl)Cl)Cl
  • InChi: 1S/C9H6Cl6O3S/c10-5-6(11)8(13)4-2-18-19(16)17-1-3(4)7(5,12)9(8,14)15/h3-4H,1-2H2/t3-,4+,7-,8+,19?
  • InChiKey: RDYMFSUJUZBWLH-AZVNHNRSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0013 0.0004
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0105 0.0195 0.0186
Leishmania major carbonic anhydrase family protein, putative 0.1241 0.3902 1
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0105 0.0195 0.0195
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0013 0.0013
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0057 0.0036 0.0027
Loa Loa (eye worm) hypothetical protein 0.0057 0.0036 0.0027
Echinococcus multilocularis carbonic anhydrase 0.0537 0.1604 0.1596
Echinococcus multilocularis mitogen activated protein kinase 11 0.0131 0.0278 0.0269
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0105 0.0195 0.0186
Entamoeba histolytica aldose reductase, putative 0.0099 0.0174 0.0358
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1111 0.3479 0.3473
Brugia malayi Peroxidasin 0.3108 1 1
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0163 0.0382 0.0373
Echinococcus granulosus aldehyde reductase 0.007 0.0081 0.0071
Mycobacterium ulcerans oxidoreductase 0.0099 0.0174 0.0383
Onchocerca volvulus 0.0105 0.0195 0.0195
Schistosoma mansoni programmed cell death protein 0.007 0.008 0.008
Echinococcus multilocularis carbonic anhydrase II 0.1111 0.3479 0.3473
Echinococcus granulosus FTZ F1 alpha 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0085 0.0129 0.012
Brugia malayi Cytochrome P450 family protein 0.006 0.0047 0.0038
Brugia malayi nuclear receptor NHR-88 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0099 0.0174 0.0165
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0095 0.0086
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Toxoplasma gondii hypothetical protein 0.0537 0.1604 0.7856
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0004
Onchocerca volvulus Protein ultraspiracle homolog 0.005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0057 0.0036 0.0027
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0163 0.0382 0.0373
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0105 0.0195 0.0186
Brugia malayi GCC2 and GCC3 family protein 0.0671 0.2042 0.2035
Plasmodium falciparum carbonic anhydrase 0.0537 0.1604 1
Onchocerca volvulus 0.0049 0.0009 0.0009
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0163 0.0382 0.0374
Echinococcus multilocularis aldo keto reductase 0.0099 0.0174 0.0165
Brugia malayi EGF-like domain containing protein 0.0085 0.0129 0.012
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Echinococcus granulosus fibrillin 2 0.0085 0.0129 0.0119
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0099 0.0174 0.0222
Schistosoma mansoni carbonic anhydrase 0.0537 0.1604 0.1604
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0537 0.1604 0.1596
Echinococcus granulosus integrin alpha ps 0.0069 0.0075 0.0066
Onchocerca volvulus 0.0671 0.2042 0.2042
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus granulosus protein jagged 1 0.0671 0.2042 0.2034
Onchocerca volvulus 0.0069 0.0075 0.0075
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Entamoeba histolytica ankyrin, putative 0.0072 0.0084 0.0126
Echinococcus granulosus aldo keto reductase 0.0099 0.0174 0.0165
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0163 0.0382 0.0382
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Brugia malayi Integrin beta pat-3 precursor 0.2642 0.848 0.8478
Echinococcus granulosus glycine receptor subunit beta 0.0163 0.0382 0.0373
Brugia malayi EGF-like domain containing protein 0.0671 0.2042 0.2035
Loa Loa (eye worm) animal heme peroxidase 0.3108 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0013 0.0004
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Onchocerca volvulus Peroxidase homolog 0.3108 1 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0049 0.0009 0.0009
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0057 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0036 0.0027
Loa Loa (eye worm) oxidoreductase 0.0099 0.0174 0.0165
Schistosoma mansoni peroxidasin 0.3108 1 1
Brugia malayi EGF-like domain containing protein 0.0085 0.0129 0.012
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1241 0.3902 1
Echinococcus multilocularis integrin alpha 3 0.0117 0.0234 0.0225
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0131 0.0278 0.0269
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Echinococcus multilocularis slit 2 protein 0.0671 0.2042 0.2034
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0013 0.0004
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus granulosus peroxidasin 0.3108 1 1
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Schistosoma mansoni hypothetical protein 0.0172 0.0413 0.0413
Onchocerca volvulus 0.3108 1 1
Loa Loa (eye worm) Notch2 0.0671 0.2042 0.2035
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0131 0.0278 0.0269
Schistosoma mansoni nAChR subunit 0.0105 0.0195 0.0195
Onchocerca volvulus 0.0105 0.0195 0.0195
Schistosoma mansoni notch 0.0671 0.2042 0.2042
Loa Loa (eye worm) oxidoreductase 0.0099 0.0174 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Brugia malayi Delta serrate ligand family protein 0.0671 0.2042 0.2035
Schistosoma mansoni hypothetical protein 0.0537 0.1604 0.1604
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0691 0.2107 0.6839
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0535 0.1597 0.159
Loa Loa (eye worm) hypothetical protein 0.0537 0.1604 0.1596
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Onchocerca volvulus 0.0099 0.0174 0.0174
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0013 0.0013
Brugia malayi phosphoinositide-dependent protein kinase I 0.0292 0.0804 0.0795
Brugia malayi follicle stimulating hormone receptor 0.0245 0.0651 0.0643
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Onchocerca volvulus 0.0099 0.0174 0.0174
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.024 0.0634 0.2057
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0449 0.1317 0.1309
Brugia malayi Calcium binding EGF domain containing protein 0.0671 0.2042 0.2035
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0152 0.0347 0.0338
Onchocerca volvulus 0.0105 0.0195 0.0195
Schistosoma mansoni notch 0.0671 0.2042 0.2042
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Loa Loa (eye worm) hypothetical protein 0.0116 0.0229 0.022
Echinococcus granulosus aldo keto reductase 0.0099 0.0174 0.0165
Schistosoma mansoni aldo-keto reductase 0.0099 0.0174 0.0174
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0246 0.0654 0.0654
Echinococcus granulosus integrin alpha 3 0.0117 0.0234 0.0225
Brugia malayi EGF-like domain containing protein 0.0671 0.2042 0.2035
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0013 0.0004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0013 0.0004
Echinococcus multilocularis aldehyde reductase 0.007 0.0081 0.0071
Onchocerca volvulus 0.3108 1 1
Loa Loa (eye worm) hypothetical protein 0.0476 0.1404 0.1396
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0013 0.0013
Echinococcus multilocularis fibrillin 2 0.0085 0.0129 0.0119
Onchocerca volvulus 0.0099 0.0174 0.0174
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0099 0.0174 0.0222
Trypanosoma cruzi aldo/keto reductase, putative 0.0099 0.0174 0.0476
Onchocerca volvulus 0.0105 0.0195 0.0195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0013 0.0004
Brugia malayi Cation transporter family protein 0.0163 0.0382 0.0374
Brugia malayi Animal haem peroxidase family protein 0.3108 1 1
Trypanosoma brucei aldo-keto reductase, putative 0.0099 0.0174 0.0476
Brugia malayi notch-like transmembrane receptor 0.0671 0.2042 0.2035
Echinococcus multilocularis protein jagged 1 0.0671 0.2042 0.2034
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Schistosoma mansoni programmed cell death protein 0.007 0.008 0.008
Loa Loa (eye worm) runx1 0.0067 0.007 0.0061
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0195 0.0186
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0537 0.1604 0.1596
Schistosoma mansoni pol-related 0.0099 0.0174 0.0174
Loa Loa (eye worm) cytochrome P450 family protein 0.006 0.0047 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0013 0.0004
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0106 0.0197 0.0188
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1111 0.3479 0.3473
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Echinococcus granulosus glycine receptor subunit beta 0.0163 0.0382 0.0373
Loa Loa (eye worm) hypothetical protein 0.0057 0.0036 0.0027
Schistosoma mansoni carbonic anhydrase-related 0.0537 0.1604 0.1604
Onchocerca volvulus 0.0105 0.0195 0.0195
Toxoplasma gondii aldose reductase, putative 0.0099 0.0174 0.0854
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0163 0.0382 0.0373
Brugia malayi EGF-like domain containing protein 0.0671 0.2042 0.2035
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0131 0.0278 0.0774
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0246 0.0654 0.0645
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0105 0.0195 0.0186
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Mycobacterium ulcerans transferase 0.0069 0.0075 0.0165
Schistosoma mansoni thyroid hormone receptor 0.0202 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Onchocerca volvulus Peroxidase homolog 0.3108 1 1
Echinococcus granulosus adam 0.0085 0.0129 0.0119
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0013 0.0013
Schistosoma mansoni nAChR subunit 0.0105 0.0195 0.0195
Schistosoma mansoni notch 0.0671 0.2042 0.2042
Trichomonas vaginalis aldo/keto reductase, putative 0.0099 0.0174 0.0222
Schistosoma mansoni lipoxygenase 0.0084 0.0124 0.0124
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0013 0.0004
Onchocerca volvulus 0.0049 0.0009 0.0009
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0114 0.0224 0.0215
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Entamoeba histolytica aldose reductase, putative 0.0099 0.0174 0.0358
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1111 0.3479 0.3473
Loa Loa (eye worm) hypothetical protein 0.0246 0.0654 0.0645
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0013 0.0004
Loa Loa (eye worm) LGC-31 protein 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0085 0.0129 0.012
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0166 0.0393 0.1277
Brugia malayi Cation transporter family protein 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0535 0.1597 0.159
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Plasmodium vivax hypothetical protein, conserved 0.007 0.008 0.409
Trichomonas vaginalis AGC family protein kinase 0.0292 0.0804 0.1626
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0099 0.0174 0.0165
Echinococcus multilocularis glycine receptor subunit beta 0.0163 0.0382 0.0373
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Schistosoma mansoni nAChR subunit 0.0105 0.0195 0.0195
Schistosoma mansoni acetylcholine receptor subunit beta 0.0049 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0013 0.0004
Echinococcus multilocularis aldo keto reductase 0.0099 0.0174 0.0165
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0105 0.0195 0.0186
Echinococcus multilocularis neural cadherin 0.0671 0.2042 0.2034
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0057 0.0036 0.0027
Toxoplasma gondii hypothetical protein 0.0085 0.0129 0.063
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.005 0.0013 0.0013
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1111 0.3479 0.3479
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Echinococcus granulosus mitogen activated protein kinase 14 0.0131 0.0278 0.0269
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0131 0.0278 0.0774
Trichomonas vaginalis conserved hypothetical protein 0.144 0.4555 1
Schistosoma mansoni integrin beta subunit 0.1556 0.4932 0.4932
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0245 0.0651 0.0643
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus granulosus protein jagged 2 0.0671 0.2042 0.2034
Schistosoma mansoni septate junction protein 0.0671 0.2042 0.2042
Onchocerca volvulus Putative sulfate transporter 0.0208 0.0529 0.0529
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0163 0.0382 0.0373
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0105 0.0195 0.0186
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0537 0.1604 0.1596
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0099 0.0174 0.0165
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0671 0.2042 0.2042
Brugia malayi Calcium binding EGF domain containing protein 0.0671 0.2042 0.2035
Brugia malayi Cadherin domain containing protein 0.0671 0.2042 0.2035
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus multilocularis protein jagged 2 0.0671 0.2042 0.2034
Brugia malayi Animal haem peroxidase family protein 0.3108 1 1
Schistosoma mansoni nAChR subunit 0.0105 0.0195 0.0195
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0013 0.0004
Loa Loa (eye worm) ACC-1 protein 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0085 0.0129 0.012
Onchocerca volvulus 0.0057 0.0036 0.0036
Echinococcus granulosus cytochrome c oxidase subunit II 0.0151 0.0345 0.0336
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1111 0.3479 1
Onchocerca volvulus Slit protein homolog 0.0671 0.2042 0.2042
Schistosoma mansoni nuclear hormone receptor 0.005 0.0013 0.0013
Echinococcus multilocularis programmed cell death protein 4 0.007 0.008 0.0071
Onchocerca volvulus 0.0057 0.0036 0.0036
Onchocerca volvulus Chorion peroxidase homolog 0.3108 1 1
Brugia malayi Calcium binding EGF domain containing protein 0.0671 0.2042 0.2035
Brugia malayi Kelch motif family protein 0.0401 0.1162 0.1154
Echinococcus granulosus integrin beta 2 0.1957 0.6243 0.6239
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Schistosoma mansoni sodium/chloride dependent transporter 0.0246 0.0654 0.0654
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0105 0.0195 0.0186
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0013 0.0004
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1111 0.3479 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0106 0.0197 0.0188
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0004
Schistosoma mansoni cytochrome c oxidase subunit II 0.0124 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.012 0.0243 0.0234
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0013 0.0004
Loa Loa (eye worm) norepinephrine transporter 0.0246 0.0654 0.0645
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0013 0.0004
Echinococcus granulosus carbonic anhydrase II 0.1111 0.3479 0.3473
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0105 0.0195 0.0186
Brugia malayi hypothetical protein 0.0401 0.1162 0.1154
Echinococcus multilocularis peroxidasin 0.3108 1 1
Schistosoma mansoni aldo-keto reductase 0.0099 0.0174 0.0174
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0105 0.0195 0.0195
Brugia malayi nuclear hormone receptor 0.005 0.0013 0.0004
Echinococcus granulosus neurogenic locus notch protein 0.0671 0.2042 0.2034
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0498 0.1475 0.1468
Loa Loa (eye worm) hypothetical protein 0.0498 0.1475 0.1468
Onchocerca volvulus Peroxidasin homolog 0.3108 1 1
Schistosoma mansoni acetylcholine receptor-related 0.0049 0.0009 0.0009
Echinococcus granulosus nAChR subunit 0.0105 0.0195 0.0186
Echinococcus multilocularis mitogen activated protein kinase 11 0.0131 0.0278 0.0269
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0537 0.1604 0.1596
Echinococcus multilocularis fibrillin 1 0.0085 0.0129 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0013 0.0004
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0131 0.0278 0.0774
Schistosoma mansoni neurotransmitter gated ion channel 0.0049 0.0009 0.0009
Onchocerca volvulus 0.0671 0.2042 0.2042
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0195 0.0186
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0013 0.0004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0013 0.0004
Brugia malayi Muscle positioning protein 4 0.0671 0.2042 0.2035
Echinococcus multilocularis thyroid hormone receptor alpha 0.0202 0.0509 0.0501
Onchocerca volvulus 0.0049 0.0009 0.0009
Schistosoma mansoni carbonic anhydrase 0.1241 0.3902 0.3902
Onchocerca volvulus 0.0208 0.0529 0.0529
Echinococcus multilocularis neurogenic locus notch protein 0.0671 0.2042 0.2034
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0195 0.0186
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0105 0.0195 0.0186
Toxoplasma gondii MAPEG family protein 0.0114 0.0222 0.1088
Echinococcus granulosus slit 2 protein 0.0671 0.2042 0.2034
Echinococcus granulosus geminin 0.0172 0.0413 0.0404
Brugia malayi EGF-like domain containing protein 0.0671 0.2042 0.2035
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Brugia malayi Cadherin domain containing protein 0.0671 0.2042 0.2035
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Onchocerca volvulus 0.0099 0.0174 0.0174
Schistosoma mansoni thyroid hormone receptor 0.0202 0.0509 0.0509
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0195 0.0186
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0004
Echinococcus multilocularis serotonin transporter 0.0246 0.0654 0.0645
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0292 0.0804 0.0795
Brugia malayi EGF-like domain containing protein 0.0085 0.0129 0.012
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0152 0.0347 0.0338
Mycobacterium ulcerans carbonic anhydrase 0.144 0.4555 1
Schistosoma mansoni hypothetical protein 0.0671 0.2042 0.2042
Schistosoma mansoni nAChR subunit 0.0105 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Echinococcus granulosus serotonin transporter 0.0246 0.0654 0.0645
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0013 0.0013
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0013 0.0004
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0537 0.1604 0.1596
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0013 0.0004
Brugia malayi EGF-like domain containing protein 0.0671 0.2042 0.2035
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0292 0.0804 0.0795
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0671 0.2042 0.2042
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0116 0.0229 0.022
Entamoeba histolytica carbonic anhydrase, putative 0.1241 0.3902 1
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0131 0.0278 0.069
Echinococcus granulosus aldo keto reductase 0.0099 0.0174 0.0165
Onchocerca volvulus 0.3108 1 1
Brugia malayi Protein kinase domain containing protein 0.0292 0.0804 0.0795
Echinococcus multilocularis protein jagged 1 0.0671 0.2042 0.2034
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0099 0.0174 0.0425
Echinococcus granulosus mitogen activated protein kinase 11 0.0131 0.0278 0.0269
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0072 0.0084 0.0273
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Loa Loa (eye worm) hypothetical protein 0.0085 0.0129 0.012
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Echinococcus granulosus neurogenic locus notch protein 0.0671 0.2042 0.2034
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.0242 0.0233
Echinococcus multilocularis integrin alpha ps 0.0069 0.0075 0.0066
Brugia malayi Cation transporter family protein 0.0105 0.0195 0.0186
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1111 0.3479 0.3479
Giardia lamblia High cysteine protein 0.0671 0.2042 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0013 0.0004
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Onchocerca volvulus Neurogenic locus notch homolog 0.0671 0.2042 0.2042
Loa Loa (eye worm) hypothetical protein 0.0401 0.1162 0.1154
Echinococcus multilocularis Protein lozenge 0.0067 0.007 0.006
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0099 0.0174 0.0222
Loa Loa (eye worm) serotonin transporter b 0.0246 0.0654 0.0645
Echinococcus granulosus programmed cell death protein 4 0.007 0.008 0.0071
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0106 0.0197 0.0188
Echinococcus multilocularis neurogenic locus protein delta 0.0671 0.2042 0.2034
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Echinococcus granulosus hypothetical protein 0.0099 0.0174 0.0165
Echinococcus multilocularis geminin 0.0172 0.0413 0.0404
Schistosoma mansoni hypothetical protein 0.0671 0.2042 0.2042
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Treponema pallidum sodium- and chloride- dependent transporter 0.0246 0.0654 0.5
Brugia malayi Integrin alpha pat-2 precursor 0.0153 0.0351 0.0342
Schistosoma mansoni notch 0.0671 0.2042 0.2042
Echinococcus multilocularis integrin beta 2 0.1957 0.6243 0.6239
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Leishmania major carbonic anhydrase-like protein 0.1111 0.3479 0.8913
Echinococcus granulosus delta-like protein 1 0.0671 0.2042 0.2034
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0151 0.0345 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0099 0.0174 0.0165
Schistosoma mansoni integrin alpha 0.0153 0.0351 0.0351
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0013 0.0013
Schistosoma mansoni neurotransmitter gated ion channel 0.0057 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0105 0.0195 0.0186
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0105 0.0195 0.0186
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0105 0.0195 0.0186
Giardia lamblia Aldose reductase 0.0099 0.0174 0.0239
Trypanosoma brucei carbonic anhydrase-like protein 0.1111 0.3479 1
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Brugia malayi P38 map kinase family protein 2 0.0131 0.0278 0.0269
Schistosoma mansoni notch 0.0671 0.2042 0.2042
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0246 0.0654 0.0645
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Brugia malayi steroid hormone receptor 0.005 0.0013 0.0004
Schistosoma mansoni nAChR subunit 0.0049 0.0009 0.0009
Echinococcus granulosus protein jagged 1 0.0671 0.2042 0.2034
Onchocerca volvulus 0.0099 0.0174 0.0174
Loa Loa (eye worm) ACC-1 protein 0.0105 0.0195 0.0186
Toxoplasma gondii MA3 domain-containing protein 0.007 0.008 0.0392
Loa Loa (eye worm) hypothetical protein 0.0537 0.1604 0.1596
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Echinococcus granulosus dynactin 5 p25 0.0072 0.0084 0.0075
Mycobacterium leprae Conserved hypothetical protein 0.007 0.0081 0.0014
Schistosoma mansoni carbonic anhydrase-related 0.0537 0.1604 0.1604
Echinococcus multilocularis aldo keto reductase 0.0099 0.0174 0.0165
Echinococcus multilocularis carbonic anhydrase 0.0537 0.1604 0.1596
Loa Loa (eye worm) GABA receptor subunit 0.0114 0.0224 0.0215
Brugia malayi ecdysteroid receptor 0.005 0.0013 0.0004
Onchocerca volvulus 0.0535 0.1597 0.1597
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Mycobacterium ulcerans carbonic anhydrase 0.1241 0.3902 0.8567
Onchocerca volvulus 0.0671 0.2042 0.2042
Loa Loa (eye worm) animal heme peroxidase 0.3108 1 1
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0497 0.1472 0.1472
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0095 0.0086
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.007 0.008 0.0499
Toxoplasma gondii EGF family domain-containing protein 0.0671 0.2042 1
Onchocerca volvulus Peroxidasin homolog 0.3108 1 1
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0099 0.0174 0.0425
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0671 0.2042 0.2035
Echinococcus multilocularis fat cadherin tumor suppressor 0.0671 0.2042 0.2034
Trypanosoma brucei prostaglandin f synthase 0.0099 0.0174 0.0476
Brugia malayi EGF-like domain containing protein 0.0671 0.2042 0.2035
Echinococcus multilocularis fibropellin Ia 0.0671 0.2042 0.2034
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0099 0.0174 0.0259
Mycobacterium ulcerans epoxide hydrolase EphA 0.0166 0.0393 0.0864
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0105 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Onchocerca volvulus 0.0085 0.0129 0.0129
Trichomonas vaginalis aldo/keto reductase, putative 0.0099 0.0174 0.0222
Echinococcus granulosus protein jagged 2 0.0671 0.2042 0.2034
Schistosoma mansoni slit 0.0671 0.2042 0.2042
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0106 0.0197 0.0188
Giardia lamblia Aldose reductase 0.0099 0.0174 0.0239
Echinococcus granulosus glycine receptor subunit alpha 1 0.0163 0.0382 0.0373
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0013 0.0004
Onchocerca volvulus 0.0105 0.0195 0.0195
Loa Loa (eye worm) blistered cuticle protein 3 0.3108 1 1
Trichomonas vaginalis AGC family protein kinase 0.0292 0.0804 0.1626
Schistosoma mansoni hypothetical protein 0.0671 0.2042 0.2042
Echinococcus multilocularis glycine receptor subunit beta 0.0163 0.0382 0.0373
Brugia malayi excitatory GABA receptor EXP-1A 0.0105 0.0195 0.0186
Schistosoma mansoni coup transcription factor 0.005 0.0013 0.0013
Schistosoma mansoni microsomal glutathione s-transferase 0.0114 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus multilocularis carbonic anhydrase 0.0537 0.1604 0.1596
Loa Loa (eye worm) hypothetical protein 0.0114 0.0224 0.0215
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0163 0.0382 0.0382
Onchocerca volvulus 0.0671 0.2042 0.2042
Onchocerca volvulus Putative cubilin 0.0671 0.2042 0.2042
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0013 0.0004
Loa Loa (eye worm) animal heme peroxidase 0.3108 1 1
Brugia malayi EGF-like domain containing protein 0.0085 0.0129 0.012
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0537 0.1604 0.1596
Loa Loa (eye worm) solute carrier family 6 member 4 0.0246 0.0654 0.0645
Echinococcus multilocularis mitogen activated protein kinase 14 0.0131 0.0278 0.0269
Entamoeba histolytica acetyltransferase, putative 0.0072 0.0084 0.0124
Trichomonas vaginalis hypothetical protein 0.0085 0.0129 0.0119
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Schistosoma mansoni peroxidasin 0.3108 1 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0163 0.0382 0.0373
Schistosoma mansoni carbonic anhydrase-related 0.0537 0.1604 0.1604
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Schistosoma mansoni hypothetical protein 0.0671 0.2042 0.2042
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0105 0.0195 0.0186
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0671 0.2042 0.2042
Leishmania major prostaglandin f synthase, putative 0.0099 0.0174 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0013 0.0004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Loa Loa (eye worm) integrin alpha pat-2 0.0236 0.0622 0.0613
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0105 0.0195 0.0186
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0004
Loa Loa (eye worm) oxidoreductase 0.0099 0.0174 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0013 0.0004
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0057 0.0036 0.0027
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0106 0.0196 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Loa Loa (eye worm) hypothetical protein 0.0057 0.0036 0.0027
Onchocerca volvulus Dual oxidase homolog 0.3108 1 1
Echinococcus multilocularis neurogenic locus notch protein 0.0671 0.2042 0.2034
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0292 0.0804 0.0795
Brugia malayi Animal haem peroxidase family protein 0.3108 1 1
Echinococcus granulosus neurogenic locus notch protein 4 0.0671 0.2042 0.2034
Schistosoma mansoni serine/threonine protein kinase 0.0292 0.0804 0.0804
Loa Loa (eye worm) hypothetical protein 0.0084 0.0126 0.0118
Loa Loa (eye worm) oxidoreductase 0.0099 0.0174 0.0165
Schistosoma mansoni nAChR subunit 0.0049 0.0009 0.0009
Onchocerca volvulus Bile acid receptor homolog 0.005 0.0013 0.0013
Echinococcus granulosus fibrillin 1 0.0085 0.0129 0.0119
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0105 0.0195 0.0186
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0013 0.0004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0099 0.0174 0.0165
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0105 0.0195 0.0186
Brugia malayi Blistered cuticle protein 3 0.3108 1 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0105 0.0195 0.0186
Echinococcus granulosus neurogenic locus protein delta 0.0671 0.2042 0.2034
Trichomonas vaginalis conserved hypothetical protein 0.144 0.4555 1
Onchocerca volvulus 0.0099 0.0174 0.0174
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.0989 0.3081 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0004
Echinococcus multilocularis neurogenic locus notch protein 4 0.0671 0.2042 0.2034
Schistosoma mansoni laminin gamma-3 chain 0.0671 0.2042 0.2042
Schistosoma mansoni lipoxygenase 0.012 0.0242 0.0242
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Loa Loa (eye worm) hypothetical protein 0.0246 0.0654 0.0645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0013 0.0004
Echinococcus granulosus notch 0.0671 0.2042 0.2034
Echinococcus multilocularis notch 0.0671 0.2042 0.2034
Onchocerca volvulus 0.0246 0.0654 0.0654
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0013 0.0013
Echinococcus granulosus carbonic anhydrase 0.0537 0.1604 0.1596
Loa Loa (eye worm) hypothetical protein 0.1138 0.3568 0.3563
Schistosoma mansoni notch 0.0671 0.2042 0.2042
Echinococcus granulosus microsomal glutathione S transferase 3 0.0114 0.0222 0.0213
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0057 0.0036 0.0036
Loa Loa (eye worm) oxidoreductase 0.0099 0.0174 0.0165
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Echinococcus multilocularis nAChR subunit 0.0057 0.0036 0.0027
Trichomonas vaginalis aldo/keto reductase, putative 0.0099 0.0174 0.0222
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0013 0.0004
Brugia malayi Animal haem peroxidase family protein 0.3108 1 1
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0789 0.2429 0.7882
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0013 0.0004
Echinococcus multilocularis aldo keto reductase 0.0099 0.0174 0.0165
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0114 0.0222 0.0213
Trypanosoma cruzi aldo-keto reductase 0.0099 0.0174 0.0476
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.0242 0.0233
Brugia malayi hypothetical protein 0.0535 0.1597 0.159
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0292 0.0804 0.1626
Onchocerca volvulus 0.0671 0.2042 0.2042
Leishmania major aldo-keto reductase-like protein 0.0099 0.0174 0.0425
Entamoeba histolytica protein kinase, putative 0.0292 0.0804 0.1986
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0099 0.0174 0.0222
Echinococcus multilocularis nAChR subunit 0.0105 0.0195 0.0186
Schistosoma mansoni hypothetical protein 0.0671 0.2042 0.2042
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0099 0.0174 0.0165
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0049 0.0009 0.002
Schistosoma mansoni lozenge 0.0067 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0671 0.2042 0.2042
Brugia malayi EGF-like domain containing protein 0.0671 0.2042 0.2035
Echinococcus granulosus glycine receptor subunit alpha 1 0.0163 0.0382 0.0373
Loa Loa (eye worm) integrin beta-2 0.2642 0.848 0.8478
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Loa Loa (eye worm) hypothetical protein 0.005 0.0013 0.0004
Brugia malayi Animal haem peroxidase family protein 0.3108 1 1
Echinococcus granulosus carbonic anhydrase 0.0537 0.1604 0.1596
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0105 0.0195 0.0186
Schistosoma mansoni nAChR subunit 0.0105 0.0195 0.0195
Entamoeba histolytica aldose reductase, putative 0.0099 0.0174 0.0358
Loa Loa (eye worm) hypothetical protein 0.0163 0.0382 0.0374
Schistosoma mansoni cell polarity protein 0.0671 0.2042 0.2042
Schistosoma mansoni hypothetical protein 0.0172 0.0413 0.0413
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0105 0.0195 0.0186
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0013 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0163 0.0382 0.0373
Schistosoma mansoni hypothetical protein 0.0152 0.0347 0.0347
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0013 0.0004
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Schistosoma mansoni integrin alpha-ps 0.0069 0.0075 0.0075
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0085 0.0129 0.0119
Echinococcus granulosus carbonic anhydrase 0.0537 0.1604 0.1596
Loa Loa (eye worm) hypothetical protein 0.3108 1 1
Mycobacterium leprae Probable transmembrane transport protein 0.024 0.0634 0.146
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0013 0.0004
Onchocerca volvulus Putative nachr subunit 0.0105 0.0195 0.0195
Loa Loa (eye worm) animal heme peroxidase 0.3108 1 1
Schistosoma mansoni nAChR subunit 0.0105 0.0195 0.0195
Echinococcus multilocularis integrin alpha ps 0.0069 0.0075 0.0066
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus granulosus neural cadherin 0.0671 0.2042 0.2034
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0013 0.0004
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0174 0.0566
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0105 0.0195 0.0186
Echinococcus multilocularis adam 0.0085 0.0129 0.0119
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0105 0.0195 0.0186
Echinococcus granulosus nAChR subunit 0.0057 0.0036 0.0027
Loa Loa (eye worm) hypothetical protein 0.0671 0.2042 0.2035
Echinococcus granulosus fibropellin Ia 0.0671 0.2042 0.2034
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0105 0.0195 0.0186
Loa Loa (eye worm) hypothetical protein 0.0057 0.0036 0.0027
Echinococcus multilocularis protein jagged 2 0.0085 0.0129 0.0119
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0163 0.0382 0.0382
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0099 0.0174 0.0165
Onchocerca volvulus 0.005 0.0013 0.0013
Loa Loa (eye worm) carbonic anhydrase 3 0.1111 0.3479 0.3473
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0013 0.0004
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0292 0.0804 0.0795
Loa Loa (eye worm) hypothetical protein 0.0057 0.0036 0.0027
Echinococcus multilocularis neurogenic locus protein delta 0.0671 0.2042 0.2034
Loa Loa (eye worm) notch protein 0.0671 0.2042 0.2035
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0401 0.1162 0.1154

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 48.9662 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the AP-1 signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 54.941 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.1306 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 61.6448 uM PubChem BioAssay: Tox21. qHTS assay for small molecule activators of the heat shock response signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 68.5896 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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