Detailed information for compound 2090462

Basic information

Technical information
  • TDR Targets ID: 2090462
  • Name: 2-ethyl-1-[3-(phenoxy)propyl]benzimidazole
  • MW: 280.364 | Formula: C18H20N2O
  • H donors: 0 H acceptors: 1 LogP: 4.23 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1nc2c(n1CCCOc1ccccc1)cccc2
  • InChi: 1S/C18H20N2O/c1-2-18-19-16-11-6-7-12-17(16)20(18)13-8-14-21-15-9-4-3-5-10-15/h3-7,9-12H,2,8,13-14H2,1H3
  • InChiKey: DEVIJAXYGJDTAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-Ethyl-1-(3-phenoxy-propyl)-1H-benzoimidazole
  • BAS 10319456

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus mothers against decapentaplegic 6 0.0019 0.0012 0.0017
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.0582 0.1397
Toxoplasma gondii hypothetical protein 0.0029 0.004 0.0348
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0031 0.0045 0.0032
Echinococcus multilocularis smad 0.0043 0.008 0.0146
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0019 0.0046
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0048 0.029
Toxoplasma gondii protein kinase, putative 0.0291 0.0795 1
Trypanosoma cruzi hexose transporter 0.0067 0.0151 0.6596
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0158 0.037
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0039 0.007 0.3072
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0024 0.0027 0.0122
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.0188 0.1774
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0048 0.0445
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0153 0.0288
Echinococcus multilocularis General substrate transporter 0.0186 0.0494 0.0953
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0048 0.0116
Echinococcus granulosus synaptic vesicle 2 protein 0.0031 0.0045 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0019 0.0073
Loa Loa (eye worm) hypothetical protein 0.0085 0.0203 0.0807
Brugia malayi Calcitonin receptor-like protein seb-1 0.0215 0.0575 0.2238
Echinococcus multilocularis short transient receptor potential channel 6 0.0128 0.0326 0.0625
Plasmodium vivax hexose transporter 0.0217 0.0582 0.4727
Schistosoma mansoni smad1 5 8 and 0.0043 0.008 0.0193
Echinococcus multilocularis neuropeptide receptor A26 0.0534 0.1494 0.2901
Schistosoma mansoni hypothetical protein 0.0023 0.0022 0.0054
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0164 0.0453
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0019 0.0027
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.0436 0.5412
Trypanosoma brucei metacaspase MCA3 0.0028 0.0038 0.1664
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0027 0.011
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0215 0.0575 0.2238
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0019 0.0073
Mycobacterium leprae Probable lipase LipE 0.0072 0.0164 0.0453
Leishmania major glucose transporter, lmgt3 0.0067 0.0151 0.6596
Echinococcus multilocularis transient receptor potential gamma protein 0.0194 0.0515 0.0993
Onchocerca volvulus 0.0031 0.0045 0.0219
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.0653
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0022 0.0075
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0199 0.1704
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0039 0.007 0.0579
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0039 0.007 0.028
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0151 0.6596
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0071 0.0743
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Onchocerca volvulus 0.0031 0.0045 0.0219
Loa Loa (eye worm) hypothetical protein 0.015 0.0389 0.1548
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0116 0.0268
Trypanosoma brucei glucose transporter, putative 0.0067 0.0151 0.6596
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0023 0.0093
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0164 0.7168
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0063 0.0151
Schistosoma mansoni sugar transporter 0.0031 0.0045 0.0109
Trypanosoma brucei Metacaspase-4 0.0028 0.0038 0.1664
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0007 0.0005
Brugia malayi hypothetical protein 0.0023 0.0022 0.0086
Trichomonas vaginalis glucosylceramidase, putative 0.0826 0.2334 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.0098
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0066 0.0147 0.0344
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0059 0.0138
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0199 0.1543
Echinococcus granulosus para nitrobenzyl esterase 0.015 0.0389 0.093
Echinococcus granulosus neuropeptide receptor A26 0.0534 0.1494 0.3606
Schistosoma mansoni loxhd1 0.0023 0.0022 0.0054
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0164 0.1384
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0199 0.0481
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0046 0.018
Loa Loa (eye worm) hypothetical protein 0.0122 0.0307 0.1223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0019 0.0075
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Brugia malayi Isocitrate dehydrogenase 0.0066 0.0147 0.0571
Trichomonas vaginalis glucose transporter, putative 0.0031 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0215 0.0575 0.229
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0019 0.0034
Onchocerca volvulus Putative transporter 0.0031 0.0045 0.0219
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.0582 0.1124
Onchocerca volvulus 0.0092 0.0221 0.1386
Onchocerca volvulus 0.0031 0.0045 0.0219
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0199 0.0378
Brugia malayi hypothetical protein 0.0023 0.0022 0.0086
Brugia malayi CXXC zinc finger family protein 0.0031 0.0046 0.0179
Loa Loa (eye worm) hypothetical protein 0.0043 0.0081 0.0324
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0063 0.0112
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0908 0.257 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Schistosoma mansoni rab6-interacting 0.0023 0.0022 0.0054
Echinococcus granulosus solute carrier family 22 0.0031 0.0045 0.0097
Brugia malayi beta-lactamase family protein 0.0072 0.0164 0.0638
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0158 0.0381
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0103 0.0253 0.2438
Schistosoma mansoni alpha-glucosidase 0.0136 0.0349 0.0845
Plasmodium falciparum protein kinase 6 0.0437 0.1216 1
Giardia lamblia Hexose transporter 0.0031 0.0045 0.0222
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0199 0.2374
Echinococcus granulosus family S9 non peptidase ue S09 family 0.015 0.0389 0.093
Trichomonas vaginalis myo-inositol transporter, putative 0.0031 0.0045 0.0128
Onchocerca volvulus 0.0031 0.0046 0.0225
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0058 0.0129
Brugia malayi Carboxylesterase family protein 0.0888 0.2512 0.9774
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0413 0.1643
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0084
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0043 0.008 0.0146
Brugia malayi beta-lactamase family protein 0.0072 0.0164 0.0638
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0061 0.0396
Loa Loa (eye worm) hypothetical protein 0.0192 0.0509 0.2028
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0071 0.3119
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0199 0.2374
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0019 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Echinococcus multilocularis GPCR, family 2 0.0068 0.0153 0.0288
Brugia malayi hypothetical protein 0.0037 0.0063 0.0243
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0058 0.0186
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0023 0.003
Loa Loa (eye worm) MH2 domain-containing protein 0.0625 0.1757 0.6994
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Onchocerca volvulus 0.0023 0.0022 0.0068
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.015 0.0389 0.0376
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.015 0.0389 0.0748
Echinococcus multilocularis isocitrate dehydrogenase 0.0066 0.0147 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0019 0.0073
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0019 0.0073
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0164 0.7168
Onchocerca volvulus 0.0031 0.0045 0.0219
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0023 0.0036
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0038 0.1664
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0164 0.0397
Echinococcus granulosus GPCR family 2 0.0068 0.0153 0.0358
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.015 0.0389 0.0941
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0151
Loa Loa (eye worm) hypothetical protein 0.0068 0.0153 0.0608
Onchocerca volvulus 0.0086 0.0204 0.1273
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0117
Trypanosoma brucei glucose transporter, putative 0.0067 0.0151 0.6596
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0164 0.0641
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0151 0.6596
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0027 0.0122
Brugia malayi Sugar transporter family protein 0.0031 0.0045 0.0175
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0071 0.0242
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3203 0.9175 0.9174
Echinococcus multilocularis BC026374 protein (S09 family) 0.015 0.0389 0.0748
Loa Loa (eye worm) apoptosis regulator protein 0.0085 0.0203 0.0807
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0184
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0164 0.0151
Trypanosoma brucei glucose transporter, putative 0.0067 0.0151 0.6596
Leishmania major hypothetical protein, conserved 0.0072 0.0164 0.7168
Trichomonas vaginalis glucosylceramidase, putative 0.0826 0.2334 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0043 0.008 0.0146
Trypanosoma cruzi DNA repair protein, putative 0.0034 0.0056 0.2434
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0048 0.029
Entamoeba histolytica CAAX prenyl protease family 0.0094 0.0229 0.2188
Brugia malayi beta-lactamase 0.0072 0.0164 0.0638
Brugia malayi MH2 domain containing protein 0.0019 0.0012 0.0047
Brugia malayi Bromodomain containing protein 0.0075 0.0172 0.0669
Loa Loa (eye worm) hypothetical protein 0.0094 0.0229 0.0911
Trichomonas vaginalis glucosylceramidase, putative 0.0571 0.1601 0.6837
Trypanosoma brucei glucosidase, putative 0.0035 0.0058 0.2547
Loa Loa (eye worm) hypothetical protein 0.0027 0.0036 0.0142
Onchocerca volvulus 0.015 0.0389 0.2504
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0045 0.0128
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0061 0.2664
Trypanosoma cruzi hexose transporter, putative 0.0031 0.0045 0.1969
Onchocerca volvulus 0.015 0.0389 0.2504
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.0582 0.1397
Schistosoma mansoni smad1 5 8 and 0.0043 0.008 0.0193
Brugia malayi MH2 domain containing protein 0.0043 0.008 0.0311
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Schistosoma mansoni neuroligin 3 (S09 family) 0.015 0.0389 0.0941
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0019 0.0075
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0039 0.007 0.0237
Loa Loa (eye worm) hypothetical protein 0.008 0.0188 0.0749
Onchocerca volvulus 0.0031 0.0045 0.0219
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0019 0.0034
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0019 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0215 0.0575 0.229
Plasmodium falciparum protein kinase 7 0.0291 0.0795 0.6501
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0217 0.0582 0.1124
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0164 0.0638
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Schistosoma mansoni acetylcholinesterase 0.015 0.0389 0.0941
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0019 0.0075
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0071 0.3119
Leishmania major hypothetical protein, conserved 0.0031 0.0045 0.1969
Brugia malayi CAAX amino terminal protease family protein 0.0094 0.0229 0.089
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0153 0.0358
Echinococcus granulosus microtubule associated protein 2 0.1451 0.4134 1
Trypanosoma brucei CAAX amino terminal protease, putative 0.0094 0.0229 1
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0048 0.029
Trypanosoma brucei glucose transporter, putative 0.0067 0.0151 0.6596
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0097 0.0237 0.0572
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0048 0.0141
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0084
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0023 0.1024
Echinococcus granulosus General substrate transporter 0.0186 0.0494 0.1184
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0071 0.0533
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0888 0.2512 0.6075
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0058 0.0104
Entamoeba histolytica hypothetical protein 0.0023 0.0023 0.0103
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0019 0.0034
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.0582 0.1397
Trypanosoma cruzi metacaspase, putative 0.0028 0.0038 0.1664
Treponema pallidum recombinase A 0.0111 0.0277 0.2422
Echinococcus multilocularis cpg binding protein 0.0034 0.0056 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0826 0.2334 1
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0048 0.029
Chlamydia trachomatis recombinase RecA 0.0111 0.0277 0.2422
Chlamydia trachomatis replicative DNA helicase 0.0398 0.1102 1
Schistosoma mansoni hypothetical protein 0.0085 0.0203 0.049
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0027 0.0013
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0022 0.0034
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0023 0.0045
Toxoplasma gondii facilitative glucose transporter GT1 0.0217 0.0582 0.7272
Mycobacterium leprae Conserved hypothetical protein 0.1173 0.3334 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0204 0.0481
Schistosoma mansoni caspase-3 (C14 family) 0.0028 0.0038 0.0092
Brugia malayi Carboxylesterase family protein 0.0888 0.2512 0.9774
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0038 0.0317
Loa Loa (eye worm) hypothetical protein 0.0037 0.0064 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0045 0.0128
Brugia malayi Doublecortin family protein 0.0023 0.0022 0.0086
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0027 0.116
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.0436 0.3519
Trypanosoma cruzi metacaspase, putative 0.0028 0.0038 0.1664
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0111 0.0277 0.2328
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0061 0.2664
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0199 0.1601
Schistosoma mansoni hypothetical protein 0.002 0.0015 0.0036
Trypanosoma cruzi glucose transporter, putative 0.0031 0.0045 0.1969
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0413 0.0987
Brugia malayi Sugar transporter family protein 0.0031 0.0045 0.0175
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0199 0.1704
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Brugia malayi Carboxylesterase family protein 0.015 0.0389 0.1513
Echinococcus multilocularis musashi 0.0028 0.0037 0.0063
Echinococcus granulosus transient receptor potential gamma protein 0.0194 0.0515 0.1234
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0028 0.0038 0.008
Entamoeba histolytica hypothetical protein 0.0037 0.0063 0.05
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0158 0.0297
Echinococcus multilocularis para nitrobenzyl esterase 0.015 0.0389 0.0748
Loa Loa (eye worm) hypothetical protein 0.0019 0.0012 0.0048
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Loa Loa (eye worm) hypothetical protein 0.0023 0.0023 0.0093
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0061 0.0396
Entamoeba histolytica protein kinase, putative 0.0032 0.0048 0.0353
Brugia malayi Sugar transporter family protein 0.0217 0.0582 0.2264
Loa Loa (eye worm) hypothetical protein 0.0069 0.0155 0.0617
Schistosoma mansoni BC026374 protein (S09 family) 0.015 0.0389 0.0941
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Echinococcus granulosus CAAX prenyl protease 2 0.0094 0.0229 0.0542
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0398 0.1102 0.328
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Loa Loa (eye worm) MH1 domain-containing protein 0.0043 0.008 0.0318
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0022 0.0075
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0027 0.017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0007 0.0017
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0116 0.0216
Schistosoma mansoni glucose transport protein 0.0217 0.0582 0.1407
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0075
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0045 0.0175
Onchocerca volvulus 0.0031 0.0045 0.0219
Echinococcus multilocularis carboxylesterase 5A 0.0888 0.2512 0.4884
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0023 0.1024
Loa Loa (eye worm) inositol-1 0.004 0.0071 0.0284
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0058 0.0103
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0085 0.0203 0.049
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0204 0.0387
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0158 0.1324
Onchocerca volvulus 0.0028 0.0037 0.0167
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0019 0.0073
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0027
Schistosoma mansoni hypothetical protein 0.0068 0.0153 0.037
Entamoeba histolytica hypothetical protein 0.0037 0.0063 0.05
Trypanosoma cruzi metacaspase 5, putative 0.0028 0.0038 0.1664
Onchocerca volvulus 0.0031 0.0045 0.0219
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0031 0.0045 0.1969
Echinococcus multilocularis synaptic vesicle 2 protein 0.0031 0.0045 0.0078
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0038 0.0206
Brugia malayi nuclear receptor NHR-88 0.0021 0.0019 0.0073
Loa Loa (eye worm) hypothetical protein 0.004 0.0071 0.0283
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0019 0.0045
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0066 0.0147 0.1111
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0038 0.0092
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0027 0.011
Schistosoma mansoni sugar transporter 0.0031 0.0045 0.0109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0019 0.0046
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0023 0.0093
Leishmania major glucose transporter, lmgt2 0.0067 0.0151 0.6596
Toxoplasma gondii sugar transporter ST2 0.0031 0.0045 0.0406
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.004 0.0226
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0071 0.0129
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0031 0.0045 0.0109
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0037 0.0144
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0019 0.0027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0164 0.0151
Echinococcus granulosus RUN 0.0023 0.0022 0.0042
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0071 0.0417
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0023 0.0057
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0085 0.0203 0.0385
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0023 0.013
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Trypanosoma brucei metacaspase 5, putative 0.0028 0.0038 0.1664
Brugia malayi Carboxylesterase family protein 0.015 0.0389 0.1513
Trichomonas vaginalis glucosylceramidase, putative 0.0826 0.2334 1
Echinococcus multilocularis lamin 0.0028 0.0037 0.0063
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0039 0.007 0.0273
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0153 0.0594
Loa Loa (eye worm) sugar transporter 0.0217 0.0582 0.2316
Entamoeba histolytica hypothetical protein 0.0037 0.0063 0.05
Schistosoma mansoni caspase-7 (C14 family) 0.0028 0.0038 0.0092
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0039 0.007 0.028
Loa Loa (eye worm) hypothetical protein 0.0031 0.0046 0.0184
Brugia malayi Inositol-1 0.004 0.0071 0.0277
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0058 0.0186
Onchocerca volvulus 0.0053 0.011 0.0651
Trypanosoma cruzi DNA repair protein, putative 0.0034 0.0056 0.2434
Schistosoma mansoni transient receptor potential channel 4 0.0194 0.0515 0.1245
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0199 0.047
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.18 0.5137 1
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Brugia malayi major facilitator superfamily protein 0.0031 0.0045 0.0175
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0075
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0019 0.0075
Schistosoma mansoni Smad4 0.0043 0.008 0.0193
Schistosoma mansoni glucose transport protein 0.0217 0.0582 0.1407
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0459 0.1278 0.1266
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.0582 0.1124
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0066 0.0147 0.0134
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0053 0.011 0.0438
Loa Loa (eye worm) acetylcholinesterase 1 0.0888 0.2512 1
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0019 0.0046
Trichomonas vaginalis glucosylceramidase, putative 0.0542 0.1517 0.6475
Trichomonas vaginalis Clan U, family U48, CaaX prenyl peptidase 2-like 0.0094 0.0229 0.0921
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0019 0.0046
Echinococcus multilocularis solute carrier family 22 0.0031 0.0045 0.0078
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.0653
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0012 0.0048
Onchocerca volvulus 0.0023 0.0022 0.0068
Echinococcus granulosus solute carrier family 22 0.0031 0.0045 0.0097
Schistosoma mansoni cpg binding protein 0.0034 0.0056 0.0136
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0048 0.029
Trypanosoma brucei glucose transporter, putative 0.0067 0.0151 0.6596
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0023 0.0057
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0043 0.008 0.0193
Echinococcus multilocularis RUN 0.0023 0.0022 0.0034
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0147 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0019 0.0073
Onchocerca volvulus 0.015 0.0389 0.2504
Onchocerca volvulus Cell death protein 3 homolog 0.0028 0.0038 0.0173
Brugia malayi hypothetical protein 0.0031 0.0045 0.0175
Trichomonas vaginalis glucosylceramidase, putative 0.0542 0.1517 0.6475
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0116 0.0102
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0147 0.6421
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0104
Leishmania major glucose transporter, lmgt1 0.0067 0.0151 0.6596
Entamoeba histolytica protein kinase, putative 0.0032 0.0048 0.0353
Loa Loa (eye worm) hypothetical protein 0.0194 0.0515 0.2049
Schistosoma mansoni glucose transporter 0.0031 0.0045 0.0109
Schistosoma mansoni hypothetical protein 0.0217 0.0582 0.1407
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0147 0.6421
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0028 0.0038 0.0065
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.0139 0.0326
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0058 0.0186
Schistosoma mansoni hypothetical protein 0.0068 0.0153 0.037
Schistosoma mansoni alpha-glucosidase 0.0136 0.0349 0.0845
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.0098
Brugia malayi Carboxylesterase family protein 0.015 0.0389 0.1513
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0085 0.0203 0.0385
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0048 0.21
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0331 0.091 0.2201
Brugia malayi steroid hormone receptor 0.0021 0.0019 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0045 0.0128
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0007 0.0026
Loa Loa (eye worm) hypothetical protein 0.0084 0.0199 0.0791
Echinococcus multilocularis solute carrier family 22 0.0031 0.0045 0.0078
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0023 0.1024
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0058 0.0186
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0164 0.0385
Loa Loa (eye worm) Smad1 0.0043 0.008 0.0318
Trypanosoma cruzi hexose transporter, putative 0.0037 0.0063 0.2758
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0019 0.0027
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0066 0.0147 0.0277
Brugia malayi Probable ClpP-like protease 0.0084 0.0199 0.0774
Echinococcus granulosus acetylcholinesterase 0.0888 0.2512 0.6071
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0031 0.0045 0.0032
Loa Loa (eye worm) carboxylesterase 0.0888 0.2512 1
Schistosoma mansoni hypothetical protein 0.0147 0.038 0.0918
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0061 0.2664
Echinococcus granulosus caspase 8 0.0028 0.0038 0.008
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0028 0.0038 0.0092
Brugia malayi Trypsin family protein 0.0097 0.0237 0.092
Echinococcus multilocularis acetylcholinesterase 0.0888 0.2512 0.4884
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0542 0.1517 0.6475
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0031 0.0045 0.0078
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0071 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0007 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0217 0.0582 0.2443
Loa Loa (eye worm) beta-lactamase 0.0072 0.0164 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0045 0.0128
Loa Loa (eye worm) twinkle helicase 0.0114 0.0284 0.1132
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0039 0.007 0.3072
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Brugia malayi Carboxylesterase family protein 0.015 0.0389 0.1513
Schistosoma mansoni smad 0.0019 0.0012 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0019 0.0046
Schistosoma mansoni protein kinase 0.0032 0.0048 0.0116
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.004 0.0226
Onchocerca volvulus 0.0021 0.0019 0.0045
Trypanosoma brucei glucose transporter, putative 0.0067 0.0151 0.6596
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.0653
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0019 0.0027
Schistosoma mansoni transient receptor potential channel 0.0194 0.0515 0.1245
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0071 0.3119
Echinococcus granulosus TRP transient receptor potential channel 0.0072 0.0165 0.0387
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0046 0.0234
Echinococcus granulosus lamin 0.0028 0.0037 0.0078
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0151 0.6596
Echinococcus multilocularis caspase 0.0028 0.0038 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0037 0.0148
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0147 0.0277
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0045 0.0175
Brugia malayi Transient-receptor-potential like protein 0.0072 0.0165 0.064
Plasmodium falciparum metacaspase-like protein 0.0028 0.0038 0.0206
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0164 0.0641
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0045 0.0179
Schistosoma mansoni lipoxygenase 0.0063 0.0139 0.0337
Toxoplasma gondii sugar transporter ST3 0.0031 0.0045 0.0406
Echinococcus multilocularis mothers against decapentaplegic 2 0.0019 0.0012 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.0098
Giardia lamblia Sugar-proton symporter 0.0031 0.0045 0.0222
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0048 0.029
Loa Loa (eye worm) hypothetical protein 0.0147 0.038 0.1512
Leishmania major CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) 0.0094 0.0229 1
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0094 0.0229 0.0553
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0058 0.0227
Echinococcus granulosus intermediate filament protein 0.0028 0.0037 0.0078
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0058 0.0232
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0164 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0019 0.0075
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0034 0.0056 0.2434
Entamoeba histolytica hypothetical protein 0.0103 0.0253 0.2438
Echinococcus granulosus TGF beta signal transducer SmadC 0.0043 0.008 0.0181
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0029 0.004 0.0081
Trichomonas vaginalis glucosylceramidase, putative 0.0542 0.1517 0.6475
Echinococcus multilocularis Smad4 0.0043 0.008 0.0146
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0164 0.0151
Trichomonas vaginalis glucosylceramidase, putative 0.0542 0.1517 0.6475
Loa Loa (eye worm) carboxylesterase 0.015 0.0389 0.1548
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0191
Brugia malayi MH1 domain containing protein 0.0024 0.0025 0.0097
Mycobacterium tuberculosis Conserved protein 0.0072 0.0164 0.0151
Brugia malayi Bromodomain containing protein 0.0037 0.0064 0.025
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0019 0.0046
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0042 0.0091
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0413 0.1605
Schistosoma mansoni protein kinase 0.0032 0.0048 0.0116
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0066 0.0147 0.0277
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0039 0.007 0.3072
Brugia malayi hypothetical protein 0.0031 0.0045 0.0175
Schistosoma mansoni protein kinase 0.0032 0.0048 0.0116
Schistosoma mansoni smad 0.0043 0.008 0.0193
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Echinococcus multilocularis microtubule associated protein 2 0.1451 0.4134 0.8046
Echinococcus granulosus caspase 2 0.0028 0.0038 0.008
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0398 0.1102 1
Trypanosoma brucei metacaspase MCA2 0.0028 0.0038 0.1664
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0058 0.0186
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0158 0.0381
Loa Loa (eye worm) transcription factor SMAD2 0.0625 0.1757 0.6994
Schistosoma mansoni intermediate filament proteins 0.0028 0.0037 0.009
Brugia malayi MH1 domain containing protein 0.0043 0.008 0.0311
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0015 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0042 0.0073
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0145 0.0352
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0164 0.1253
Loa Loa (eye worm) hypothetical protein 0.0097 0.0237 0.0941
Leishmania major myo-inositol/proton symporter (MIT) 0.0031 0.0045 0.1969
Schistosoma mansoni cpg binding protein 0.0031 0.0046 0.0111
Onchocerca volvulus 0.0028 0.0037 0.0167
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0019 0.0027
Brugia malayi nuclear hormone receptor 0.0021 0.0019 0.0073
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0066 0.0147 0.1111
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Trypanosoma cruzi metacaspase, putative 0.0028 0.0038 0.1664
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0129 0.0242
Toxoplasma gondii sugar transporter ST1 0.0031 0.0045 0.0406
Schistosoma mansoni Replicative DNA helicase 0.0398 0.1102 0.2667
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0104
Schistosoma mansoni inositol monophosphatase 0.004 0.0071 0.0173
Onchocerca volvulus 0.0072 0.0164 0.101
Echinococcus multilocularis caspase 2 0.0028 0.0038 0.0065
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Echinococcus granulosus carboxylesterase 5A 0.0888 0.2512 0.6071
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Echinococcus multilocularis mothers against decapentaplegic 6 0.0019 0.0012 0.0014
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0039 0.007 0.017
Giardia lamblia DNA repair protein RAD52 0.0362 0.0998 1
Brugia malayi MH1 domain containing protein 0.0043 0.008 0.0311
Onchocerca volvulus 0.0031 0.0045 0.0219
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0075
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0084
Trichomonas vaginalis glucosylceramidase, putative 0.0826 0.2334 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0058 0.0576
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0048 0.029
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0048 0.0191
Treponema pallidum replicative DNA helicase (dnaB) 0.0398 0.1102 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0031 0.0045 0.0292
Loa Loa (eye worm) hypothetical protein 0.0066 0.0146 0.0581
Echinococcus granulosus solute carrier family 22 0.0031 0.0045 0.0097
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Schistosoma mansoni lipoxygenase 0.0023 0.0022 0.0054
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Echinococcus multilocularis CAAX prenyl protease 2 0.0094 0.0229 0.0436
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0025 0.0049
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Onchocerca volvulus 0.0072 0.0164 0.101
Loa Loa (eye worm) MH2 domain-containing protein 0.0043 0.008 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0019 0.0073
Brugia malayi latrophilin 2 splice variant baaae 0.0147 0.038 0.1477
Echinococcus granulosus mothers against decapentaplegic 2 0.0019 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0075
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0048 0.029
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0031 0.0045 0.0264
Onchocerca volvulus 0.0097 0.0237 0.1492
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0005 0.0012
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0071 0.0242
Brugia malayi Major Facilitator Superfamily protein 0.0031 0.0045 0.0175
Echinococcus multilocularis acetylcholinesterase 0.0888 0.2512 0.4884
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0085 0.0203 0.0788
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.004 0.025
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0039 0.007 0.0273
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0071 0.0161
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0058 0.2547
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0058 0.0186
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0031 0.0045 0.0292
Schistosoma mansoni gliotactin 0.015 0.0389 0.0941
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0048 0.0445
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0028 0.0038 0.0098
Schistosoma mansoni lamin 0.0028 0.0037 0.009
Onchocerca volvulus 0.0031 0.0045 0.0219
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0023 0.0093
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0158 0.1324
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0199 0.1704
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0037 0.0148
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0019 0.0027
Schistosoma mansoni alpha glucosidase 0.0035 0.0058 0.0141
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0019 0.0034
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0048 0.0191
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0019 0.0075
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0058 0.2547
Loa Loa (eye worm) hypothetical protein 0.015 0.0389 0.1548
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.015 0.0389 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0888 0.2512 1
Echinococcus granulosus lamin dm0 0.0028 0.0037 0.0078
Schistosoma mansoni smad1 5 8 and 0.0043 0.008 0.0193
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0022 0.0088
Mycobacterium ulcerans integral membrane transport protein 0.0031 0.0045 0.0292
Onchocerca volvulus 0.0072 0.0164 0.101
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0024 0.0027 0.0122
Onchocerca volvulus 0.0091 0.0218 0.1371
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0058 0.0457
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0048 0.029
Leishmania major glucose transporter/membrane transporter D2, putative 0.0067 0.0151 0.6596
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0027 0.0039
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0151 0.0585
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0046 0.0112
Trypanosoma cruzi peptidase with unknown catalytic mechanism (family U48) 0.0094 0.0229 1
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0023 0.0084
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0061 0.2664
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0164 0.0151
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0075
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0061 0.2664
Plasmodium vivax metacaspase 1, putative 0.0028 0.0038 0.0206
Trypanosoma brucei metacaspase 0.0028 0.0038 0.1664
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0025 0.004
Plasmodium falciparum hexose transporter 0.0217 0.0582 0.4727
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0153 0.0594
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0046 0.0112
Leishmania major metacaspase, putative 0.0028 0.0038 0.1664
Schistosoma mansoni zinc finger protein 0.0021 0.0017 0.0041
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0104
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0066 0.0147 0.6421
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0164 0.031
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0066 0.0147 0.6421
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0217 0.0582 0.1397
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0164 0.0641
Echinococcus granulosus neuroligin 0.015 0.0389 0.093
Trichomonas vaginalis glucosylceramidase, putative 0.0571 0.1601 0.6837
Trichomonas vaginalis spcc417.12 protein, putative 0.015 0.0389 0.1611
Trichomonas vaginalis glucosylceramidase, putative 0.0542 0.1517 0.6475
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0046 0.008
Onchocerca volvulus 0.015 0.0389 0.2504
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.015 0.0389 0.0941
Entamoeba histolytica hypothetical protein 0.0024 0.0027 0.0135
Loa Loa (eye worm) hypothetical protein 0.0715 0.2016 0.8026
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0153 0.0288
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0147 0.1709
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0158 0.1845
Schistosoma mansoni family U48 unassigned peptidase (U48 family) 0.0094 0.0229 0.0553
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0097 0.0237 0.0572
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0204 0.0792
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.015 0.0389 0.0941
Echinococcus granulosus mothers against decapentaplegic 5 0.0043 0.008 0.0181
Schistosoma mansoni glucose transport protein 0.0217 0.0582 0.1407
Loa Loa (eye worm) hypothetical protein 0.0028 0.0038 0.0151
Trypanosoma cruzi CAAX prenyl protease 2, putative 0.0094 0.0229 1
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0061 0.061
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0028 0.0038 0.0148
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0058 0.0457
Brugia malayi major facilitator superfamily protein 0.0031 0.0045 0.0175
Onchocerca volvulus 0.0031 0.0045 0.0219
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0826 0.2334 0.9293
Schistosoma mansoni apoptosis regulator bax 0.0085 0.0203 0.049
Brugia malayi Cell death protein 3 precursor 0.0028 0.0038 0.0148
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0071 0.059
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0039 0.007 0.0127
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0025 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0164 0.0641
Schistosoma mansoni hypothetical protein 0.0085 0.0203 0.049
Loa Loa (eye worm) nuclear factor I 0.0024 0.0025 0.01
Loa Loa (eye worm) carboxylesterase 0.015 0.0389 0.1548
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0019 0.0046
Mycobacterium tuberculosis Conserved protein 0.0072 0.0164 0.0151
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0071 0.3119
Trypanosoma brucei THT1 - hexose transporter, putative 0.0067 0.0151 0.6596
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0019 0.0073
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0151 0.6596
Plasmodium vivax sugar transporter, putative 0.0031 0.0045 0.0264
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0158 0.1324
Entamoeba histolytica hypothetical protein 0.0037 0.0063 0.05
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0058 0.0128
Trypanosoma brucei glucose transporter 2A 0.0067 0.0151 0.6596
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0027 0.0122
Echinococcus granulosus transient receptor potential ion channel A 0.0187 0.0496 0.1189
Brugia malayi hypothetical protein 0.015 0.0389 0.1513
Brugia malayi mothers against decapentaplegic homolog 3 0.0019 0.0012 0.0047
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0005 0.0012
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0088
Echinococcus granulosus caspase 0.0028 0.0038 0.008
Mycobacterium ulcerans lipase LipD 0.0072 0.0164 0.1384
Echinococcus multilocularis short transient receptor potential channel 6 0.0128 0.0326 0.0625
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0413 0.0794
Trypanosoma brucei glucose transporter, putative 0.0067 0.0151 0.6596
Schistosoma mansoni rab6-interacting 0.0023 0.0022 0.0054
Echinococcus granulosus solute carrier family 22 0.0031 0.0045 0.0097
Mycobacterium tuberculosis Carboxylesterase LipT 0.015 0.0389 0.0376
Echinococcus granulosus Smad4 0.0043 0.008 0.0181
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0022 0.0034
Mycobacterium ulcerans sugar transporter 0.0031 0.0045 0.0292
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0129 0.0301
Loa Loa (eye worm) sugar transporter 0.0031 0.0045 0.0179
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0019 0.0046
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0019 0.0073
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0039 0.007 0.0158
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.0653
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.0098
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0019 0.0046
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0039 0.007 0.0729
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0039 0.007 0.0474
Echinococcus granulosus tumor protein p63 0.0363 0.1001 0.2413
Schistosoma mansoni cpg binding protein 0.0034 0.0056 0.0136
Leishmania major protein kinase, putative 0.0032 0.0048 0.21
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0019 0.0073
Loa Loa (eye worm) major facilitator superfamily transporter 0.0031 0.0045 0.0179
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0075
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0164 0.0151
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0012 0.0048
Trichomonas vaginalis esterase, putative 0.0072 0.0164 0.0641
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0116 0.0102
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0164 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0019 0.0075
Echinococcus multilocularis neuropeptide s receptor 0.0534 0.1494 0.2901
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0217 0.0582 0.1124
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.0436 0.3519
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0019 0.0034
Echinococcus granulosus neuropeptide s receptor 0.0534 0.1494 0.3606
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0019 0.0073
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0164 0.1384
Toxoplasma gondii ABC1 family protein 0.0072 0.0164 0.1928
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0059 0.0046
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0022 0.0034
Trypanosoma brucei glucose transporter 1E 0.0067 0.0151 0.6596
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0048 0.0187
Trichomonas vaginalis conserved hypothetical protein 0.0067 0.0151 0.0585
Echinococcus granulosus short transient receptor potential channel 6 0.0128 0.0326 0.0777
Schistosoma mansoni transient receptor potential channel 0.0128 0.0326 0.0788
Loa Loa (eye worm) hypothetical protein 0.0888 0.2512 1
Brugia malayi isocitrate dehydrogenase 0.0066 0.0147 0.0571
Onchocerca volvulus 0.0031 0.0045 0.0219
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Echinococcus multilocularis transient receptor potential ion channel A 0.0187 0.0496 0.0957
Loa Loa (eye worm) hypothetical protein 0.015 0.0389 0.1548
Schistosoma mansoni polycystin 1-related 0.0023 0.0022 0.0054
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0027 0.017
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0039 0.007 0.3072
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0151 0.0585
Giardia lamblia Hypothetical protein 0.0094 0.0229 0.2106
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0048 0.0445
Trichomonas vaginalis glucosylceramidase, putative 0.0826 0.2334 1
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0164 0.7168
Brugia malayi Smad1 0.0043 0.008 0.0311
Loa Loa (eye worm) isocitrate dehydrogenase 0.0066 0.0147 0.0585
Schistosoma mansoni coup transcription factor 0.0021 0.0019 0.0046
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0023 0.0035
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0199 0.0558
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0066 0.0147 0.6421
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0164 0.0641
Schistosoma mansoni transient receptor potential channel 0.0128 0.0326 0.0788
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0164 0.0653
Onchocerca volvulus 0.0031 0.0045 0.0219
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0039 0.007 0.0237
Loa Loa (eye worm) hypothetical protein 0.015 0.0389 0.1548
Echinococcus granulosus acetylcholinesterase 0.0888 0.2512 0.6071
Onchocerca volvulus 0.015 0.0389 0.2504
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0046 0.018
Onchocerca volvulus 0.0031 0.0045 0.0219
Schistosoma mansoni hypothetical protein 0.0068 0.0153 0.037
Echinococcus granulosus cpg binding protein 0.0034 0.0056 0.0125
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0058 0.2547
Schistosoma mansoni hypothetical protein 0.0068 0.0153 0.037
Trypanosoma cruzi sugar transporter, putative 0.0031 0.0045 0.1969
Brugia malayi MH1 domain containing protein 0.0024 0.0025 0.0097
Brugia malayi ecdysteroid receptor 0.0021 0.0019 0.0073
Trypanosoma cruzi hexose transporter, putative 0.0067 0.0151 0.6596
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0037 0.0148
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0058 0.0186
Trichomonas vaginalis glucosylceramidase, putative 0.0542 0.1517 0.6475
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.011 0.0266
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0058 0.0186
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0075
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0046 0.0183
Schistosoma mansoni Smad4 0.0019 0.0012 0.0029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0019 0.0034
Echinococcus multilocularis tumor protein p63 0.0363 0.1001 0.1941
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.008 0.0188 0.1774
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0019 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0019 0.0073
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0199 0.1704
Loa Loa (eye worm) hypothetical protein 0.015 0.0389 0.1548
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0048 0.0084
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0038 0.0317
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0204 0.0493
Echinococcus multilocularis solute carrier family 22 0.0031 0.0045 0.0078
Schistosoma mansoni inositol monophosphatase 0.004 0.0071 0.0173
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0151 0.0585
Loa Loa (eye worm) hypothetical protein 0.0024 0.0025 0.01
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0019 0.0073
Mycobacterium tuberculosis Conserved protein 0.0072 0.0164 0.0151
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0027 0.116
Echinococcus multilocularis solute carrier family 22 0.0031 0.0045 0.0078
Schistosoma mansoni sugar transporter 0.0031 0.0045 0.0109
Trypanosoma cruzi metacaspase, putative 0.0028 0.0038 0.1664
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.0098
Brugia malayi intermediate filament protein 0.0028 0.0037 0.0144
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0046 0.0133
Mycobacterium ulcerans recombinase A 0.0111 0.0277 0.2422
Trypanosoma brucei glucose transporter, putative 0.0067 0.0151 0.6596
Echinococcus granulosus zinc finger protein 0.0021 0.0017 0.0029
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Mycobacterium ulcerans beta-lactamase 0.0072 0.0164 0.1384
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0007 0.0004
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.015 0.0389 0.1611
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0039 0.007 0.0474
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0164 0.0397
Plasmodium vivax CDK-related protein kinase 6, putative 0.0437 0.1216 1
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0023 0.0084
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0023 0.0091
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0019 0.0034
Loa Loa (eye worm) hypothetical protein 0.0072 0.0165 0.0655
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0022 0.0042
Echinococcus multilocularis neuroligin 0.015 0.0389 0.0748
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0153 0.0608
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0028 0.0038 0.0317
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.0653
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0019 0.0027
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0413 0.0794
Trichomonas vaginalis glucose transporter, putative 0.0067 0.0151 0.0585
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0019 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0019 0.0073
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0066 0.0147 0.0355
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0019 0.0027
Trichomonas vaginalis sugar transport protein, putative 0.0031 0.0045 0.0128
Loa Loa (eye worm) hypothetical protein 0.0072 0.0164 0.0653
Brugia malayi MH2 domain containing protein 0.0043 0.008 0.0311
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0132 0.1518
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0031 0.0045 0.0172
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0151 0.0585
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0022 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0019 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Schistosoma mansoni hypothetical protein 0.0037 0.0063 0.0151
Loa Loa (eye worm) hypothetical protein 0.015 0.0389 0.1548
Mycobacterium ulcerans carboxylesterase, LipT 0.015 0.0389 0.3448
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0199 0.1704
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0019 0.0045
Echinococcus granulosus smad 0.0043 0.008 0.0181
Onchocerca volvulus 0.0031 0.0045 0.0219
Trichomonas vaginalis sugar transporter, putative 0.0067 0.0151 0.0585
Brugia malayi Cam kinase protein 1 0.0032 0.0048 0.0187
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0046 0.01
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0111 0.0277 0.0794
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0085 0.0203 0.0479
Onchocerca volvulus Glucosylceramidase homolog 0.0542 0.1517 1
Schistosoma mansoni microtubule-associated protein tau 0.1451 0.4134 1
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0022 0.0042
Loa Loa (eye worm) hypothetical protein 0.015 0.0389 0.1548
Echinococcus multilocularis zinc finger protein 0.0021 0.0017 0.0024
Schistosoma mansoni sugar transporter 0.0031 0.0045 0.0109
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0048 0.0104
Plasmodium falciparum metacaspase 1 0.0028 0.0038 0.0206
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0019 0.0046
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0362 0.0998 1
Mycobacterium ulcerans hypothetical protein 0.0072 0.0164 0.1384
Echinococcus granulosus Sugar transporter ERD6 protein 0.0031 0.0045 0.0097
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0158 0.6885
Onchocerca volvulus 0.0031 0.0045 0.0219
Trypanosoma brucei sugar transporter, putative 0.0031 0.0045 0.1969
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0158 0.0144
Toxoplasma gondii transporter, major facilitator family protein 0.0031 0.0045 0.0406
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0038 0.0098
Brugia malayi hypothetical protein 0.0031 0.0045 0.0175
Brugia malayi PHD-finger family protein 0.0026 0.0032 0.0124
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0046 0.0334
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0153 0.0358
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0116 0.0308
Loa Loa (eye worm) hypothetical protein 0.0384 0.1063 0.4233
Schistosoma mansoni lamin 0.0028 0.0037 0.009
Echinococcus multilocularis lamin dm0 0.0028 0.0037 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0045 0.0179
Schistosoma mansoni bromodomain containing protein 0.0063 0.0139 0.0337
Echinococcus granulosus BC026374 protein S09 family 0.015 0.0389 0.093
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0063 0.014
Schistosoma mansoni hypothetical protein 0.0085 0.0203 0.049
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0826 0.2334 0.9083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0019 0.0073
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0398 0.1102 1
Echinococcus multilocularis caspase 8 0.0028 0.0038 0.0065
Schistosoma mansoni Smad4 0.0019 0.0012 0.0029
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0199 0.1543
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0046 0.0099
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.0139 0.0262
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128
Echinococcus granulosus short transient receptor potential channel 6 0.0128 0.0326 0.0777
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0072 0.0165 0.0311
Loa Loa (eye worm) hypothetical protein 0.0097 0.0237 0.0941
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0058 0.0186
Toxoplasma gondii isocitrate dehydrogenase 0.0066 0.0147 0.1709
Brugia malayi MH2 domain containing protein 0.0625 0.1757 0.6836
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0019 0.0073
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0019 0.0045
Onchocerca volvulus 0.0031 0.0045 0.0219
Loa Loa (eye worm) hypothetical protein 0.0086 0.0204 0.0811
Loa Loa (eye worm) hypothetical protein 0.0023 0.0022 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0019 0.0075
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0085 0.0203 0.0479
Trichomonas vaginalis sugar transporter, putative 0.0031 0.0045 0.0128

Activities

Activity type Activity value Assay description Source Reference
FC (functional) = 2 Bactericidal activity against replicating Mycobacterium tuberculosis assessed as log reduction CFU at 1 to 10 times MIC after 21 days ChEMBL. 26295286
FC (functional) > 3 Bactericidal activity against nonreplicating Mycobacterium tuberculosis assessed as log reduction CFU at MIC after 21 days ChEMBL. 26295286
FC (functional) > 3 Bactericidal activity against nonreplicating Mycobacterium tuberculosis assessed as log reduction CFU at 1 to 10 times MIC after 21 days ChEMBL. 26295286
MIC (functional) = 3.4 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv ChEMBL. 26295286
MIC (functional) = 5.2 uM Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 25618 under aerobic condition after 5 days ChEMBL. 26295286
Ratio (functional) > 4 Ratio of MBC to MIC for replicating Mycobacterium tuberculosis at 1 to 10 times MIC after 21 days ChEMBL. 26295286

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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