Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thioesterase | 0.0915 | 0.3311 | 0.443 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.1912 | 0.9025 | 0.9562 | |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0422 | 0.0481 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0782 | 0.2547 | 0.3708 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0444 | 0.061 | 0.0817 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Loa Loa (eye worm) | acyl carrier protein | 0.0505 | 0.096 | 0.0587 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0884 | 0.3131 | 0.4188 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1167 | 0.4752 | 0.6337 |
Loa Loa (eye worm) | hypothetical protein | 0.1845 | 0.8643 | 1 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0422 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0884 | 0.3131 | 0.4188 |
Brugia malayi | SRC-1 | 0.0422 | 0.0481 | 0.0481 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.1026 | 0.3948 | 0.528 |
Echinococcus multilocularis | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0789 | 0.2588 | 0.3461 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1167 | 0.4752 | 0.6357 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1167 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1167 | 0.4752 | 0.6357 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1167 | 0.4752 | 0.6357 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0898 | 0.3214 | 0.4299 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1099 | 0.4361 | 0.581 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0422 | 0.0481 | 0.5 |
Loa Loa (eye worm) | fatty acid synthase | 0.1084 | 0.4277 | 0.4651 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1099 | 0.4361 | 0.5834 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1592 | 0.1361 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.1026 | 0.3948 | 0.4247 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0726 | 0.2228 | 0.2981 |
Brugia malayi | SH2 domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1099 | 0.4361 | 0.4361 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0713 | 0.2149 | 0.2574 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0884 | 0.3131 | 0.4155 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0625 | 0.1644 | 0.2199 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.1065 | 0.4168 | 0.5576 |
Brugia malayi | AMP-binding enzyme family protein | 0.1026 | 0.3948 | 0.3948 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1167 | 0.4752 | 1 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1642 | 0.7476 | 1 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1167 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | polyketide synthase | 0.1167 | 0.4752 | 0.6357 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0378 | 0.0229 | 0.0306 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0915 | 0.3311 | 0.443 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Brugia malayi | protein-tyrosine kinase | 0.0422 | 0.0481 | 0.0481 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1167 | 0.4752 | 0.6357 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0726 | 0.2228 | 0.2941 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0422 | 0.0481 | 0.5 |
Onchocerca volvulus | 0.1026 | 0.3948 | 0.388 | |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0422 | 0.0481 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.198 | 0.9416 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0726 | 0.2228 | 0.2981 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0915 | 0.3311 | 0.4398 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0915 | 0.3311 | 0.443 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1099 | 0.4361 | 0.581 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0345 | 0.0042 | 0.0056 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1167 | 0.4752 | 0.6357 |
Echinococcus granulosus | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | hypothetical protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0345 | 0.0042 | 0.0056 |
Echinococcus granulosus | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.1065 | 0.4168 | 0.5576 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1099 | 0.4361 | 0.5834 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.