Detailed information for compound 2091182

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.747 | Formula: C30H54O5
  • H donors: 5 H acceptors: 5 LogP: 5.64 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCC1[C@@]2(C)CC[C@@H](C([C@@H]2CC[C@@]1(C)[C@]1(C)C[C@@H](O)[C@@]2([C@H](C1O)CC(CC2)(C)C)CO)(C)C)O
  • InChi: 1S/C30H54O5/c1-25(2)13-14-30(18-32)19(16-25)24(35)29(7,17-23(30)34)28(6)12-8-20-26(3,4)22(33)9-11-27(20,5)21(28)10-15-31/h19-24,31-35H,8-18H2,1-7H3/t19-,20-,21?,22-,23+,24?,27-,28+,29+,30+/m0/s1
  • InChiKey: GKSNIBLANHVYKJ-IILPUIEVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.023 0.0239
Chlamydia trachomatis replicative DNA helicase 0.0378 0.085 0.2401
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0039 0.0028
Trypanosoma brucei pyruvate dehydrogenase complex E3 binding protein, putative 0.0148 0.0305 0.0294
Mycobacterium ulcerans lipase LipD 0.0036 0.0039 0.0008
Echinococcus multilocularis p2X purinoceptor 4 0.037 0.0831 0.0831
Leishmania major 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0148 0.0305 0.0294
Entamoeba histolytica hypothetical protein 0.0106 0.0205 0.0881
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0039 0.001
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0151 0.0151
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0364 0.0818 0.0818
Brugia malayi hypothetical protein 0.0238 0.0518 0.0537
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0148 0.0305 0.0476
Onchocerca volvulus 0.0049 0.0068 0.9588
Chlamydia trachomatis biotin carboxylase 0.1464 0.3428 1
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0032 0.0033
Schistosoma mansoni glutaminase 0.0267 0.0588 0.0588
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E2 0.0148 0.0305 0.0294
Trypanosoma cruzi acetyl-CoA carboxylase, putative 0.0574 0.1314 0.2115
Loa Loa (eye worm) hypothetical protein 0.0036 0.0039 0.004
Plasmodium vivax carbamoyl phosphate synthetase, putative 0.0364 0.0818 0.1132
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0064 0.0042
Schistosoma mansoni acetyl-CoA carboxylase 0.4232 1 1
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0071 0.0071
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0378 0.085 0.1809
Chlamydia trachomatis acetyl-coenzyme A carboxylase carboxyl transferase subunit beta 0.0574 0.1314 0.3769
Mycobacterium tuberculosis Conserved protein 0.0036 0.0039 0.001
Trichomonas vaginalis glutaminase, putative 0.0267 0.0588 1
Schistosoma mansoni aspartate carbamoyltransferase 0.0364 0.0818 0.0818
Onchocerca volvulus 0.0036 0.0039 0.5477
Loa Loa (eye worm) hypothetical protein 0.0036 0.0039 0.004
Mycobacterium leprae ACETYL/PROPIONYL-CoA CARBOXYLASE (BETA SUBUNIT) ACCD6 0.0574 0.1314 0.3409
Mycobacterium ulcerans hypothetical protein 0.0036 0.0039 0.0008
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.1612 0.378 0.4811
Echinococcus granulosus dihydrolipoyllysine residue succinyltransferase 0.0148 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.008 0.0144 0.0144
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0574 0.1314 0.1314
Mycobacterium tuberculosis DlaT, dihydrolipoamide acyltransferase, E2 component of pyruvate dehydrogenase 0.0148 0.0305 0.0351
Onchocerca volvulus 0.0036 0.0039 0.5477
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0069 0.0071
Leishmania major 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0574 0.1314 0.1304
Brugia malayi beta-lactamase family protein 0.0036 0.0039 0.004
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.1612 0.378 0.378
Schistosoma mansoni dihydrolipoamide S-acetyltransferase 0.0148 0.0305 0.0305
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3316 0.7823 1
Echinococcus multilocularis p2X purinoceptor 4 0.037 0.0831 0.0831
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0106 0.0205 0.0205
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0056 0.0085 0.0085
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0574 0.1314 0.2115
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0148 0.0305 0.0476
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0039 0.001
Leishmania major carbamoyl-phosphate synthase, putative 0.0364 0.0818 0.0807
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0039 0.0054
Trypanosoma brucei dihydrolipoamide acetyltransferase E2 subunit, putative 0.0148 0.0305 0.0294
Wolbachia endosymbiont of Brugia malayi branched-chain alpha-keto acid dehydrogenase subunit E2 0.0148 0.0305 0.0283
Wolbachia endosymbiont of Brugia malayi Acetyl-CoA carboxylase, carboxyltransferase component 0.0574 0.1314 0.3106
Schistosoma mansoni hypothetical protein 0.008 0.0144 0.0144
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.4084 0.9648 1
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1612 0.378 0.6116
Trypanosoma brucei 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0574 0.1314 0.1304
Loa Loa (eye worm) beta-lactamase 0.0036 0.0039 0.004
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0039 0.0039
Echinococcus multilocularis tumor protein p63 0.034 0.076 0.076
Leishmania major dihydrolipoamide acetyltransferase precursorlike protein 0.0148 0.0305 0.0294
Schistosoma mansoni hypothetical protein 0.008 0.0144 0.0144
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0148 0.0305 0.0476
Loa Loa (eye worm) glutaminase 2 0.0267 0.0588 0.0609
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1612 0.378 0.3773
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0106 0.0204 0.044
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0064 0.0067
Trypanosoma cruzi dihydrolipoamide acetyltransferase precursor, putative 0.0148 0.0305 0.0476
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0039 0.004
Onchocerca volvulus 0.005 0.0071 1
Onchocerca volvulus 0.0047 0.0064 0.9019
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.1612 0.378 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0164 0.0164
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0036 0.0006
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1612 0.378 0.378
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0148 0.0305 0.0793
Loa Loa (eye worm) hypothetical protein 0.0194 0.0415 0.043
Loa Loa (eye worm) hypothetical protein 0.0148 0.0305 0.0316
Loa Loa (eye worm) hypothetical protein 0.0047 0.0064 0.0066
Mycobacterium ulcerans pyruvate carboxylase 0.1612 0.378 1
Leishmania major acetyl-CoA carboxylase, putative 0.4232 1 1
Leishmania major dihydrolipoamide branched chain transacylase, putative 0.0148 0.0305 0.0294
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0039 0.0039
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0047 0.0064 0.0066
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0064 0.0066
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0037
Toxoplasma gondii dihydrolipoamide acyltransferase, putative 0.0148 0.0305 0.0294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0037
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0148 0.0305 0.0305
Schistosoma mansoni hypothetical protein 0.0106 0.0205 0.0205
Echinococcus multilocularis Niemann Pick C1 protein 0.0194 0.0415 0.0415
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0106 0.0205 0.0205
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1602 0.3755 0.3755
Mycobacterium ulcerans hypothetical protein 0.0148 0.0305 0.0718
Schistosoma mansoni transcription factor LCR-F1 0.0106 0.0205 0.0205
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.1612 0.378 0.4811
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0039 0.001
Entamoeba histolytica hypothetical protein 0.0106 0.0205 0.0881
Brugia malayi beta-lactamase 0.0036 0.0039 0.004
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0069 0.0071
Schistosoma mansoni P2X receptor subunit 0.037 0.0831 0.0831
Treponema pallidum replicative DNA helicase (dnaB) 0.0378 0.085 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0037
Chlamydia trachomatis dihydrolipoamide acetyltransferase 0.0148 0.0305 0.0793
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0011 0.0016
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.023 0.0239
Mycobacterium tuberculosis Conserved protein 0.0036 0.0039 0.001
Brugia malayi Niemann-Pick C1 protein precursor 0.0194 0.0415 0.043
Echinococcus granulosus Biotin lipoyl attachment 0.0148 0.0305 0.0305
Mycobacterium ulcerans branched-chain alpha-keto acid dehydrogenase subunit E2 0.0148 0.0305 0.0718
Toxoplasma gondii pyruvate carboxylase 0.1612 0.378 0.3773
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0032 0.003 0.0019
Toxoplasma gondii carbamoylphosphate synthetase 0.0364 0.0818 0.0807
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4_2 0.0574 0.1314 0.3415
Trypanosoma cruzi glutamine-dependent carbamoyl-phosphate synthetase, putative 0.0364 0.0818 0.1309
Mycobacterium tuberculosis Conserved protein 0.0036 0.0039 0.001
Treponema pallidum pyruvate carboxylase subunit B 0.0148 0.0305 0.1566
Mycobacterium ulcerans beta-lactamase 0.0036 0.0039 0.0008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0039 0.0008
Trypanosoma brucei glutamine hydrolysing (not ammonia-dependent) carbomoyl phosphate synthase, putative 0.0364 0.0818 0.0807
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0064 0.0042
Echinococcus granulosus Niemann Pick C1 protein 0.0194 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0049 0.0069 0.0071
Echinococcus granulosus dihydrolipoyllysine residue acetyltransferase 0.0148 0.0305 0.0305
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.1612 0.378 0.378
Mycobacterium leprae Conserved hypothetical protein 0.1115 0.2599 0.6843
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.4232 1 1
Brugia malayi MH2 domain containing protein 0.0117 0.023 0.0239
Chlamydia trachomatis dihydrolipoamide succinyltransferase 0.0148 0.0305 0.0793
Plasmodium vivax dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, putative 0.0148 0.0305 0.0422
Schistosoma mansoni Replicative DNA helicase 0.0378 0.085 0.085
Brugia malayi hypothetical protein 0.0106 0.0205 0.0213
Echinococcus multilocularis Niemann Pick C1 protein 0.0278 0.0613 0.0613
Entamoeba histolytica hypothetical protein 0.0106 0.0205 0.0881
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0037
Entamoeba histolytica hypothetical protein 0.0106 0.0205 0.0881
Plasmodium falciparum dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex 0.0148 0.0305 0.0422
Echinococcus multilocularis protein dispatched 1 0.0095 0.0179 0.0179
Echinococcus multilocularis protein patched 0.0083 0.0151 0.0151
Toxoplasma gondii acyl-CoA carboxyltransferase beta chain, putative 0.0574 0.1314 0.1304
Trypanosoma cruzi 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase, putative 0.0148 0.0305 0.0476
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0164 0.017
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.4232 1 1
Schistosoma mansoni P2X receptor subunit 0.037 0.0831 0.0831
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0068 0.0071
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0164 0.0164
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.1612 0.378 1
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3063 0.7224 1
Schistosoma mansoni pyruvate carboxylase 0.1612 0.378 0.378
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0164 0.017
Schistosoma mansoni P2X receptor subunit 0.037 0.0831 0.0831
Trypanosoma brucei 2-oxoglutarate dehydrogenase E2 component, putative 0.0148 0.0305 0.0294
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.1612 0.378 0.3773
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0064 0.0075
Plasmodium falciparum lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex 0.0148 0.0305 0.0422
Onchocerca volvulus 0.0036 0.0039 0.5477
Trypanosoma brucei dihydrolipoamide branched chain transacylase, putative 0.0148 0.0305 0.0294
Brugia malayi Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial precursor, puta 0.0148 0.0305 0.0316
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0039 0.0008
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0194 0.0415 0.2188
Echinococcus granulosus tumor protein p63 0.034 0.076 0.076
Brugia malayi glutaminase DH11.1 0.0267 0.0588 0.0609
Wolbachia endosymbiont of Brugia malayi carbamoyl phosphate synthase large subunit 0.0364 0.0818 0.1718
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0039 0.0045
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0039 0.001
Echinococcus granulosus expressed conserved protein 0.0183 0.0387 0.0387
Schistosoma mansoni survival motor neuron protein 0.0049 0.0068 0.0068
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0518 0.0518
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide acyltransferase E2 component 0.0148 0.0305 0.0283
Loa Loa (eye worm) hypothetical protein 0.0238 0.0518 0.0537
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0056 0.0085 0.0085
Loa Loa (eye worm) hypothetical protein 0.0148 0.0305 0.0316
Loa Loa (eye worm) twinkle helicase 0.0108 0.0209 0.0217
Mycobacterium tuberculosis Acetyl/propionyl-CoA carboxylase (beta subunit) AccD6 0.0574 0.1314 0.1647
Mycobacterium tuberculosis Probable propionyl-CoA carboxylase beta chain 5 AccD5 (pccase) (propanoyl-CoA:carbon dioxide ligase) 0.0574 0.1314 0.1647
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0039 0.0045
Echinococcus multilocularis p2X purinoceptor 4 0.037 0.0831 0.0831
Echinococcus multilocularis dihydrolipoyllysine residue succinyltransferase 0.0148 0.0305 0.0305
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0574 0.1314 0.1314
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.3063 0.7224 1
Toxoplasma gondii ABC1 family protein 0.0036 0.0039 0.0028
Brugia malayi beta-lactamase family protein 0.0036 0.0039 0.004
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0064 0.0075
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0064 0.0066
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0064 0.0067
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0378 0.085 0.2175
Mycobacterium leprae Probable propionyl-CoA carboxylase beta chain 5 AccD5 (PCCASE) (PROPANOYL-COA:CARBON DIOXIDE LIGASE) 0.0574 0.1314 0.3409
Schistosoma mansoni P2X receptor subunit 0.037 0.0831 0.0831
Mycobacterium ulcerans glutaminase 0.0267 0.0588 0.1474
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0164 0.0164
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0039 0.004
Toxoplasma gondii biotin-requiring enzyme domain-containing protein 0.0148 0.0305 0.0294
Loa Loa (eye worm) hypothetical protein 0.0035 0.0036 0.0037
Mycobacterium ulcerans recombinase A 0.0106 0.0204 0.0447
Schistosoma mansoni patched 1 0.0083 0.0151 0.0151
Trypanosoma cruzi dihydrolipoamide acetyltransferase, putative 0.0148 0.0305 0.0476
Brugia malayi Lipoamide acyltransferase component of branched-chain alpha-keto aciddehydrogenase complex, mitochondrial precursor 0.0148 0.0305 0.0316
Brugia malayi Carboxyl transferase domain containing protein 0.4084 0.9648 1
Echinococcus granulosus Niemann Pick C1 protein 0.0278 0.0613 0.0613
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0011 0.0016
Schistosoma mansoni lipoxygenase 0.0056 0.0085 0.0085
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0064 0.0075
Loa Loa (eye worm) hypothetical protein 0.0036 0.0039 0.004
Trypanosoma cruzi dihydrolipoamide branched chain transacylase, putative 0.0148 0.0305 0.0476
Loa Loa (eye worm) hypothetical protein 0.0036 0.0039 0.004
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.1612 0.378 0.378
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0064 0.0075
Trypanosoma cruzi DNA repair protein, putative 0.0032 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0033 0.0032 0.0033
Echinococcus granulosus p2X purinoceptor 4 0.037 0.0831 0.0831
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0722 0.1666 1
Schistosoma mansoni dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase 0.0148 0.0305 0.0305
Trypanosoma cruzi acetyl-CoA carboxylase 0.262 0.6173 1
Loa Loa (eye worm) hypothetical protein 0.0083 0.0151 0.0157
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0197 0.0422 0.0422
Mycobacterium ulcerans dihydrolipoamide acetyltransferase 0.0148 0.0305 0.0718
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0036 0.005
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.1612 0.378 1
Mycobacterium ulcerans carbamoyl phosphate synthase large subunit 0.0364 0.0818 0.2088
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0151 0.0151
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0574 0.1314 0.1314
Schistosoma mansoni hypothetical protein 0.0049 0.0068 0.0068
Trypanosoma brucei acetyl-CoA carboxylase 0.4232 1 1
Trypanosoma cruzi glutamine dependent carbamoyl-phosphate synthase, putative 0.0364 0.0818 0.1309
Brugia malayi hypothetical protein 0.0025 0.0011 0.0012
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.1612 0.378 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0064 0.0075
Toxoplasma gondii 2-oxo acid dehydrogenases acyltransferase (catalytic domain) domain-containing protein 0.0148 0.0305 0.0294
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0151 0.2043
Loa Loa (eye worm) hypothetical protein 0.0102 0.0196 0.0203
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0378 0.085 0.2169
Mycobacterium leprae Probable propyonyl-CoA carboxylase beta chain 4 AccD4 (Pccase) 0.0574 0.1314 0.3409
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0039 0.0039
Giardia lamblia Acetyl-CoA carboxylase/pyruvate carboxylase fusion protein, putative 0.0722 0.1666 0.5
Chlamydia trachomatis recombinase RecA 0.0106 0.0204 0.0494
Leishmania major dihydrolipoamide acetyltransferase precursor, putative 0.0148 0.0305 0.0294
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0064 0.0075
Trypanosoma brucei unspecified product 0.106 0.2469 0.246
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0064 0.0053
Echinococcus multilocularis dihydrolipoyllysine residue acetyltransferase 0.0148 0.0305 0.0305
Echinococcus multilocularis expressed conserved protein 0.0183 0.0387 0.0387
Loa Loa (eye worm) hypothetical protein 0.0148 0.0305 0.0316
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0064 0.0053
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 5 AccD5 0.0574 0.1314 0.3415
Trypanosoma cruzi DNA repair protein, putative 0.0032 0.003 0.003
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0036 0.005
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0064 0.0053
Loa Loa (eye worm) glutaminase 0.0267 0.0588 0.0609
Schistosoma mansoni carbamoyl-phosphate synthetase 0.0364 0.0818 0.0818
Echinococcus granulosus p2X purinoceptor 4 0.037 0.0831 0.0831
Mycobacterium ulcerans acetyl-/propionyl-CoA carboxylase subunit beta 0.0574 0.1314 0.3415
Schistosoma mansoni hypothetical protein 0.008 0.0144 0.0144
Chlamydia trachomatis acetyl-CoA carboxylase biotin carboxyl carrier protein 0.0148 0.0305 0.0793
Loa Loa (eye worm) hypothetical protein 0.0047 0.0064 0.0066
Plasmodium falciparum dihydrolipoamide acyltransferase component E2 0.0148 0.0305 0.0422
Mycobacterium leprae Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex SucB 0.0148 0.0305 0.0711
Schistosoma mansoni dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase 0.0148 0.0305 0.0305
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0164 0.0164
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0064 0.0075
Toxoplasma gondii dihydrolipoyllysine-residue succinyltransferase component of oxoglutarate dehydrogenase 0.0148 0.0305 0.0294
Echinococcus multilocularis Biotin lipoyl attachment 0.0148 0.0305 0.0305
Leishmania major propionyl-coa carboxylase beta chain, putative 0.0574 0.1314 0.1304
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0039 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.0025 0.0011 0.0012
Brugia malayi CHE-14 protein 0.0083 0.0151 0.0157
Trypanosoma cruzi 3-methylcrotonoyl-CoA carboxylase beta subunit, putative 0.0574 0.1314 0.2115
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0151 0.0157
Mycobacterium tuberculosis Biotinylated protein TB7.3 0.0148 0.0305 0.0351
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3043 0.7177 0.917
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.4232 1 1
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.1612 0.378 0.3773
Echinococcus granulosus p2X purinoceptor 4 0.037 0.0831 0.0831
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0064 0.0066
Schistosoma mansoni hypothetical protein 0.0033 0.0032 0.0032
Mycobacterium leprae Probable biotinylated protein homolog TB7.3 0.0148 0.0305 0.0711
Mycobacterium ulcerans propionyl-CoA carboxylase beta chain 4 AccD4 0.0574 0.1314 0.3415
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0518 0.0518
Mycobacterium tuberculosis Probable branched-chain keto acid dehydrogenase E2 component BkdC 0.0148 0.0305 0.0351
Loa Loa (eye worm) hypothetical protein 0.0036 0.0039 0.004
Leishmania major carboxylase, putative 0.1612 0.378 0.3773
Leishmania major hypothetical protein, conserved 0.0036 0.0039 0.0028
Mycobacterium ulcerans acetyl/propionyl CoA carboxylase subunit beta 0.0574 0.1314 0.3415
Mycobacterium ulcerans acetyl-coenzyme a carboxylase carboxyl transferase (subunit beta) AccD3 0.0574 0.1314 0.3415
Loa Loa (eye worm) hypothetical protein 0.005 0.0071 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0039 0.0039
Plasmodium falciparum carbamoyl phosphate synthetase 0.0364 0.0818 0.1132
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0011 0.0016
Brugia malayi dihydrolipoamide S-acetyltransferase precursor, putative 0.0148 0.0305 0.0316
Mycobacterium ulcerans hypothetical protein 0.0047 0.0064 0.0075
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0231 0.0502 0.0604
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.1612 0.378 0.6116
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0164 0.0164
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.1612 0.378 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0164 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0164 0.0164
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0039 0.001
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0039 0.001
Plasmodium vivax lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, putative 0.0148 0.0305 0.0422
Loa Loa (eye worm) hypothetical protein 0.0036 0.0039 0.004

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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