Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | activin A receptor, type IB | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 14 | Starlite/ChEMBL | References |
Homo sapiens | thyroid hormone receptor, beta | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 14 | 360 aa | 336 aa | 33.3 % |
Brugia malayi | photoreceptor-specific nuclear receptor | thyroid hormone receptor, beta | 461 aa | 414 aa | 24.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0191 | 0.9921 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0152 | 0.6218 | 0.6188 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0164 | 0.7371 | 0.735 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.6249 | 0.6219 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.7371 | 0.7371 |
Schistosoma mansoni | hypothetical protein | 0.0152 | 0.6218 | 0.6218 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0152 | 0.6249 | 0.5 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0152 | 0.6249 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0152 | 0.6249 | 0.6219 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0152 | 0.6249 | 0.6219 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.6249 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.6249 | 0.6219 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0152 | 0.6249 | 0.6219 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0191 | 0.9921 | 1 |
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0192 | 1 | 1 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0192 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0152 | 0.6249 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0152 | 0.6249 | 0.6219 |
Schistosoma mansoni | protein kinase | 0.0192 | 1 | 1 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0152 | 0.6218 | 0.6188 |
Schistosoma mansoni | thyroid hormone receptor | 0.0164 | 0.7371 | 0.7371 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 104 nM | Inhibition of TGFR1 | ChEMBL. | 19640613 |
IC50 (binding) | = 0.104 uM | Inhibitory activity against TGF-beta type I receptor | ChEMBL. | 15177480 |
IC50 (binding) | = 0.104 uM | Inhibitory activity against TGF-beta type I receptor | ChEMBL. | 15177480 |
IC50 (functional) | = 0.345 uM | Inhibitory activity against TGF-beta dependentluciferase production in mink lung cells p3TP Lux | ChEMBL. | 15177480 |
IC50 (binding) | = 7.9 uM | Inhibitory activity against Mitogen-activated protein kinase p38 | ChEMBL. | 15177480 |
IC50 (binding) | = 7.9 uM | Inhibitory activity against Mitogen-activated protein kinase p38 | ChEMBL. | 15177480 |
IC50 (functional) | = 51 uM | Inhibitory activity tested in NIH 3T3 cells | ChEMBL. | 15177480 |
IC50 (functional) | = 51 uM | Inhibitory activity tested in NIH 3T3 cells | ChEMBL. | 15177480 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.