Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0726 | 0.2228 | 0.2941 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.0915 | 0.3311 | 0.4398 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.0915 | 0.3311 | 0.443 |
Onchocerca volvulus | 0.1026 | 0.3948 | 0.388 | |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.1065 | 0.4168 | 0.5576 |
Echinococcus granulosus | c src tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0422 | 0.0481 | 0.5 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.1026 | 0.3948 | 0.4247 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1099 | 0.4361 | 0.5834 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0625 | 0.1644 | 0.2199 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1167 | 0.4752 | 0.6357 |
Echinococcus multilocularis | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable fatty acid synthase Fas (fatty acid synthetase) | 0.0345 | 0.0042 | 0.0056 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.1642 | 0.7476 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | hypothetical protein | 0.1845 | 0.8643 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.1167 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1099 | 0.4361 | 0.5834 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | polyketide synthase | 0.1167 | 0.4752 | 0.6357 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0422 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.1167 | 0.4752 | 0.6357 |
Mycobacterium ulcerans | polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0726 | 0.2228 | 0.2981 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.1167 | 0.4752 | 1 |
Mycobacterium ulcerans | fatty acid synthase Fas | 0.0345 | 0.0042 | 0.0056 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.1167 | 0.4752 | 0.6337 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.1099 | 0.4361 | 0.5834 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0884 | 0.3131 | 0.4188 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.1099 | 0.4361 | 0.581 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | hypothetical protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.1099 | 0.4361 | 0.581 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0789 | 0.2588 | 0.3461 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0422 | 0.0481 | 0.0481 |
Brugia malayi | AMP-binding enzyme family protein | 0.1026 | 0.3948 | 0.3948 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.1026 | 0.3948 | 0.528 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0884 | 0.3131 | 0.4155 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.1065 | 0.4168 | 0.5576 |
Brugia malayi | SRC-1 | 0.0422 | 0.0481 | 0.0481 |
Loa Loa (eye worm) | fatty acid synthase | 0.1084 | 0.4277 | 0.4651 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.1167 | 0.4752 | 0.6357 |
Echinococcus granulosus | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.0898 | 0.3214 | 0.4299 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0422 | 0.0481 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0782 | 0.2547 | 0.3708 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.1167 | 0.4752 | 0.6337 |
Mycobacterium ulcerans | thioesterase | 0.0915 | 0.3311 | 0.443 |
Mycobacterium ulcerans | polyketide synthase Pks9 | 0.0726 | 0.2228 | 0.2981 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0422 | 0.0481 | 0.5 |
Mycobacterium tuberculosis | Polyketide synthetase MbtC (polyketide synthase) | 0.0378 | 0.0229 | 0.0306 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.1099 | 0.4361 | 0.5834 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0884 | 0.3131 | 0.4188 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.1099 | 0.4361 | 0.5834 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0422 | 0.0481 | 0.5 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0713 | 0.2149 | 0.2574 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0422 | 0.0481 | 0.5 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.198 | 0.9416 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Mycobacterium ulcerans | thioesterase TesA | 0.0915 | 0.3311 | 0.443 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0422 | 0.0481 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0615 | 0.1592 | 0.1361 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.1167 | 0.4752 | 0.6357 |
Onchocerca volvulus | 0.1912 | 0.9025 | 0.9562 | |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.1099 | 0.4361 | 0.4361 |
Schistosoma mansoni | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.1642 | 0.7476 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0422 | 0.0481 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0422 | 0.0481 | 0.0481 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0422 | 0.0481 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0422 | 0.0481 | 0.5 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.1167 | 0.4752 | 0.6337 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks15 | 0.0444 | 0.061 | 0.0817 |
Loa Loa (eye worm) | acyl carrier protein | 0.0505 | 0.096 | 0.0587 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0422 | 0.0481 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.