Detailed information for compound 209308

Basic information

Technical information
  • TDR Targets ID: 209308
  • Name: phenylsulfanylsulfonylbenzene
  • MW: 250.337 | Formula: C12H10O2S2
  • H donors: 0 H acceptors: 2 LogP: 3.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=S(=O)(c1ccccc1)Sc1ccccc1
  • InChi: 1S/C12H10O2S2/c13-16(14,12-9-5-2-6-10-12)15-11-7-3-1-4-8-11/h1-10H
  • InChiKey: ATKJLMWDXASAJA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (phenylthio)sulfonylbenzene
  • 1212-08-4
  • Phenyl benzenethiolsulfonate
  • Phenyl benzenethiosulfonate
  • Phenyl disulfoxide
  • Phenyl phenylthio sulfone
  • S-Phenyl benzenethiolsulfonate
  • WLN: WSR&SR
  • S-Phenyl benzenesulfonothioate
  • EINECS 214-919-1
  • NSC 74657
  • S-Phenyl benzenethiosulphonate
  • ZINC00156081
  • AIDS-032889
  • 390267_ALDRICH
  • Benzenethiosulfonic acid S-phenyl ester
  • S-Phenyl benzenethiosulfonate
  • AIDS032889
  • Aromatic thiosulfone analog
  • Benzenesulfonic acid, thio-, S-phenyl ester
  • Benzenesulfonothioic acid, S-phenyl ester
  • NSC74657

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0031 0.0278 0.0334
Brugia malayi RNA recognition motif domain containing protein 0.0256 0.3083 0.3728
Onchocerca volvulus 0.0044 0.0439 0.0236
Loa Loa (eye worm) glutaminase 2 0.0265 0.3192 0.3859
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Schistosoma mansoni cpg binding protein 0.003 0.027 0.0326
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.047 0.0568
Echinococcus multilocularis tissue type plasminogen activator 0.0176 0.2089 0.2089
Brugia malayi TAR-binding protein 0.0256 0.3083 0.3728
Toxoplasma gondii microneme protein MIC4 0.0044 0.0439 0.0081
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0139 0.1626 0.1967
Loa Loa (eye worm) acetyltransferase 0.0142 0.1657 0.2002
Toxoplasma gondii microneme protein MIC17B 0.0044 0.0439 0.0081
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0411 0.1065
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0727 0.0878
Loa Loa (eye worm) hypothetical protein 0.0672 0.8267 1
Echinococcus multilocularis fibropellin Ia 0.0132 0.1536 0.1536
Echinococcus granulosus protein jagged 1 0.0132 0.1536 0.3984
Echinococcus multilocularis enteropeptidase 0.0257 0.3087 0.3087
Loa Loa (eye worm) hypothetical protein 0.0139 0.1626 0.1965
Loa Loa (eye worm) PAN domain-containing protein 0.0044 0.0439 0.0528
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0651 0.0787
Echinococcus granulosus glycoprotein Antigen 5 0.0257 0.3087 0.8008
Giardia lamblia High cysteine protein 0.0132 0.1536 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.047 0.047
Schistosoma mansoni hypothetical protein 0.0132 0.1536 0.1858
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.1657 0.2004
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0139 0.1626 0.4219
Schistosoma mansoni cpg binding protein 0.0029 0.0249 0.0302
Echinococcus multilocularis protein jagged 1 0.0132 0.1536 0.1536
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.016 0.1888 0.5915
Echinococcus granulosus fibropellin Ia 0.0132 0.1536 0.3984
Brugia malayi EGF-like domain containing protein 0.0132 0.1536 0.1857
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0176 0.2089 1
Echinococcus granulosus GPCR family 2 0.0031 0.0278 0.0722
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.047 0.0566
Brugia malayi EGF-like domain containing protein 0.0132 0.1536 0.1857
Onchocerca volvulus 0.0044 0.0439 0.0236
Brugia malayi notch-like transmembrane receptor 0.0132 0.1536 0.1857
Loa Loa (eye worm) hypothetical protein 0.0139 0.1626 0.1965
Loa Loa (eye worm) hypothetical protein 0.0318 0.3854 0.4661
Onchocerca volvulus 0.0132 0.1536 0.1604
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.0671 0.2103
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Echinococcus granulosus neurogenic locus notch protein 0.0132 0.1536 0.3984
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Onchocerca volvulus 0.0533 0.6533 0.7837
Echinococcus granulosus Tolloid protein 1 0.0318 0.3854 1
Brugia malayi Protein kinase domain containing protein 0.0176 0.2089 0.2526
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0044 0.0439 0.0081
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Echinococcus granulosus neural cadherin 0.0132 0.1536 0.3984
Schistosoma mansoni tar DNA-binding protein 0.0256 0.3083 0.3729
Echinococcus multilocularis neurogenic locus notch protein 4 0.0132 0.1536 0.1536
Treponema pallidum bacterioferrin (TpF1) 0.0009 0 0.5
Brugia malayi Cadherin domain containing protein 0.0132 0.1536 0.1857
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0063 0.0671 0.1741
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0006
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.1657 0.2004
Brugia malayi Calcium binding EGF domain containing protein 0.0318 0.3854 0.4662
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.016 0.1888 0.8587
Schistosoma mansoni hypothetical protein 0.0132 0.1536 0.1858
Echinococcus multilocularis neurogenic locus notch protein 0.0132 0.1536 0.1536
Plasmodium falciparum cysteine repeat modular protein 1 0.0176 0.2089 1
Schistosoma mansoni egf-like domain protein 0.0318 0.3854 0.4662
Onchocerca volvulus 0.0044 0.0439 0.0236
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Echinococcus multilocularis neurogenic locus protein delta 0.0132 0.1536 0.1536
Loa Loa (eye worm) TAR-binding protein 0.0256 0.3083 0.3727
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Toxoplasma gondii PAN domain-containing protein 0.0044 0.0439 0.0081
Echinococcus granulosus protein jagged 1 0.0132 0.1536 0.3984
Brugia malayi RNA binding protein 0.0256 0.3083 0.3728
Toxoplasma gondii microneme protein, putative 0.0044 0.0439 0.0081
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0132 0.1536 0.1857
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.047 0.0569
Loa Loa (eye worm) hypothetical protein 0.0139 0.1626 0.1965
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.016 0.1888 0.8806
Loa Loa (eye worm) hypothetical protein 0.0176 0.2089 0.2524
Toxoplasma gondii PAN domain-containing protein 0.0044 0.0439 0.0081
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Schistosoma mansoni hypothetical protein 0.0132 0.1536 0.1858
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0318 0.3854 0.4662
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.047 0.122
Schistosoma mansoni notch 0.0132 0.1536 0.1858
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Schistosoma mansoni hypothetical protein 0.0132 0.1536 0.1858
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0411 0.1287
Brugia malayi EGF-like domain containing protein 0.0132 0.1536 0.1857
Schistosoma mansoni glutaminase 0.0265 0.3192 0.3861
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0139 0.1626 0.1967
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.0671 0.2103
Loa Loa (eye worm) PAN domain-containing protein 0.0044 0.0439 0.0528
Toxoplasma gondii EGF family domain-containing protein 0.0132 0.1536 0.3267
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Schistosoma mansoni hypothetical protein 0.0132 0.1536 0.1858
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0139 0.1626 0.1967
Schistosoma mansoni hypothetical protein 0.0031 0.0278 0.0336
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0063 0.0671 0.1741
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0278 0.0722
Echinococcus multilocularis Tolloid protein 1 0.0318 0.3854 0.3854
Onchocerca volvulus 0.0672 0.8267 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0139 0.1626 0.1966
Schistosoma mansoni notch 0.0132 0.1536 0.1858
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.047 0.047
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.0671 0.2103
Schistosoma mansoni cpg binding protein 0.003 0.027 0.0326
Schistosoma mansoni septate junction protein 0.0132 0.1536 0.1858
Onchocerca volvulus Arrow homolog 0.0318 0.3854 0.4496
Loa Loa (eye worm) hypothetical protein 0.0044 0.0439 0.0528
Brugia malayi EGF-like domain containing protein 0.0132 0.1536 0.1857
Trichomonas vaginalis glutaminase, putative 0.0265 0.3192 1
Onchocerca volvulus 0.0139 0.1626 0.1717
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0139 0.1626 0.1967
Onchocerca volvulus 0.0044 0.0439 0.0236
Echinococcus granulosus neurogenic locus notch protein 0.0132 0.1536 0.3984
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.0671 0.2103
Onchocerca volvulus 0.0044 0.0439 0.0236
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0278 0.0335
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Schistosoma mansoni hypothetical protein 0.0139 0.1626 0.1967
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0139 0.1626 0.1626
Toxoplasma gondii subtilisin SUB12 0.0044 0.0439 0.0081
Brugia malayi EGF-like domain containing protein 0.0132 0.1536 0.1857
Brugia malayi Calcium binding EGF domain containing protein 0.0132 0.1536 0.1857
Brugia malayi Fibulin-1 precursor 0.0318 0.3854 0.4662
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0318 0.3854 0.4661
Schistosoma mansoni notch 0.0132 0.1536 0.1858
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.016 0.1888 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Brugia malayi MH2 domain containing protein 0.0117 0.1346 0.1627
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0318 0.3854 0.4661
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Schistosoma mansoni laminin gamma-3 chain 0.0132 0.1536 0.1858
Schistosoma mansoni tar DNA-binding protein 0.0256 0.3083 0.3729
Brugia malayi Delta serrate ligand family protein 0.0132 0.1536 0.1857
Onchocerca volvulus 0.0132 0.1536 0.1604
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.016 0.1888 0.8587
Brugia malayi Trypsin family protein 0.0672 0.8267 1
Brugia malayi EGF-like domain containing protein 0.0132 0.1536 0.1857
Schistosoma mansoni hypothetical protein 0.0031 0.0278 0.0336
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0132 0.1536 0.1604
Schistosoma mansoni hypothetical protein 0.0031 0.0278 0.0336
Loa Loa (eye worm) hypothetical protein 0.0318 0.3854 0.4661
Onchocerca volvulus Putative cubilin 0.0132 0.1536 0.1604
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Onchocerca volvulus 0.0132 0.1536 0.1604
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Onchocerca volvulus Neurogenic locus notch homolog 0.0132 0.1536 0.1604
Echinococcus multilocularis slit 2 protein 0.0132 0.1536 0.1536
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0672 0.8267 1
Brugia malayi EGF-like domain containing protein 0.0132 0.1536 0.1857
Echinococcus granulosus cpg binding protein 0.003 0.027 0.07
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.016 0.1888 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Echinococcus multilocularis transmembrane protease serine 3 0.0139 0.1626 0.1626
Onchocerca volvulus 0.0044 0.0439 0.0236
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.016 0.1888 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0002
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0063 0.0671 0.0671
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Brugia malayi GCC2 and GCC3 family protein 0.0132 0.1536 0.1857
Brugia malayi Trypsin family protein 0.0139 0.1626 0.1966
Brugia malayi glutaminase DH11.1 0.0265 0.3192 0.386
Echinococcus granulosus Mastin 0.0257 0.3087 0.8008
Onchocerca volvulus 0.0139 0.1626 0.1717
Echinococcus multilocularis neurogenic locus protein delta 0.0132 0.1536 0.1536
Mycobacterium ulcerans glutaminase 0.0265 0.3192 1
Toxoplasma gondii hypothetical protein 0.0044 0.0439 0.0081
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.1657 0.1657
Trypanosoma cruzi hypothetical protein, conserved 0.0176 0.2089 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.016 0.1888 0.2283
Onchocerca volvulus 0.0044 0.0439 0.0236
Onchocerca volvulus 0.0044 0.0439 0.0236
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0278 0.0334
Schistosoma mansoni notch 0.0132 0.1536 0.1858
Echinococcus multilocularis cpg binding protein 0.003 0.027 0.027
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Echinococcus granulosus laminin 0.0318 0.3854 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0139 0.1626 0.1626
Onchocerca volvulus 0.0044 0.0439 0.0236
Schistosoma mansoni notch 0.0132 0.1536 0.1858
Brugia malayi Calcium binding EGF domain containing protein 0.0132 0.1536 0.1857
Loa Loa (eye worm) PAN domain-containing protein 0.0044 0.0439 0.0528
Schistosoma mansoni hypothetical protein 0.0132 0.1536 0.1858
Loa Loa (eye worm) hypothetical protein 0.0044 0.0439 0.0528
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1114 0.1345
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0063 0.0671 1
Echinococcus multilocularis neurogenic locus notch protein 0.0132 0.1536 0.1536
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0256 0.3083 0.3727
Leishmania major hypothetical protein, conserved 0.0176 0.2089 1
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.016 0.1888 0.2283
Onchocerca volvulus 0.0139 0.1626 0.1717
Schistosoma mansoni tar DNA-binding protein 0.0256 0.3083 0.3729
Loa Loa (eye worm) hypothetical protein 0.0318 0.3854 0.4661
Onchocerca volvulus 0.0044 0.0439 0.0236
Toxoplasma gondii PAN domain-containing protein 0.0044 0.0439 0.0081
Loa Loa (eye worm) hypothetical protein 0.0044 0.0439 0.0528
Plasmodium falciparum dihydroorotate dehydrogenase 0.016 0.1888 0.8836
Brugia malayi Trypsin family protein 0.0139 0.1626 0.1966
Loa Loa (eye worm) Notch2 0.0132 0.1536 0.1855
Loa Loa (eye worm) TK/ROR protein kinase 0.0176 0.2089 0.2524
Echinococcus multilocularis tar DNA binding protein 0.0256 0.3083 0.3083
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0139 0.1626 0.4219
Echinococcus multilocularis neural cadherin 0.0132 0.1536 0.1536
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Echinococcus granulosus transmembrane protease serine 3 0.0139 0.1626 0.4219
Echinococcus granulosus notch 0.0132 0.1536 0.3984
Brugia malayi Trypsin-like protease protein 5 0.0139 0.1626 0.1966
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Toxoplasma gondii PAN domain-containing protein 0.0044 0.0439 0.0081
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.047 0.0569
Schistosoma mansoni hypothetical protein 0.0139 0.1626 0.1967
Echinococcus granulosus protein jagged 2 0.0132 0.1536 0.3984
Echinococcus multilocularis protein jagged 1 0.0132 0.1536 0.1536
Onchocerca volvulus 0.0132 0.1536 0.1604
Schistosoma mansoni hypothetical protein 0.0176 0.2089 0.2526
Echinococcus granulosus tar DNA binding protein 0.0256 0.3083 0.7998
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.016 0.1888 0.4291
Toxoplasma gondii PAN domain-containing protein 0.0044 0.0439 0.0081
Echinococcus multilocularis laminin 0.0318 0.3854 0.3854
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0063 0.0671 0.0671
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0139 0.1626 0.1967
Echinococcus granulosus neurogenic locus notch protein 4 0.0132 0.1536 0.3984
Echinococcus granulosus slit 2 protein 0.0132 0.1536 0.3984
Toxoplasma gondii kringle domain-containing protein 0.0176 0.2089 0.4872
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0672 0.8267 1
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Schistosoma mansoni cell polarity protein 0.0132 0.1536 0.1858
Loa Loa (eye worm) hypothetical protein 0.0318 0.3854 0.4661
Onchocerca volvulus 0.0139 0.1626 0.1717
Brugia malayi Trypsin family protein 0.0139 0.1626 0.1966
Loa Loa (eye worm) hypothetical protein 0.0044 0.0439 0.0528
Toxoplasma gondii calcium binding egf domain-containing protein 0.0318 0.3854 1
Loa Loa (eye worm) PAN domain-containing protein 0.0044 0.0439 0.0528
Loa Loa (eye worm) hypothetical protein 0.0044 0.0439 0.0528
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0278 0.0335
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.016 0.1888 0.5
Echinococcus multilocularis Mastin 0.0257 0.3087 0.3087
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0318 0.3854 0.4661
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1114 0.1346
Loa Loa (eye worm) PAN domain-containing protein 0.0044 0.0439 0.0528
Echinococcus multilocularis fat cadherin tumor suppressor 0.0132 0.1536 0.1536
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0249 0.0299
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1346 0.1626
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Onchocerca volvulus 0.0044 0.0439 0.0236
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.047 0.0569
Echinococcus granulosus protein jagged 2 0.0132 0.1536 0.3984
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Onchocerca volvulus 0.0132 0.1536 0.1604
Schistosoma mansoni hypothetical protein 0.0067 0.0727 0.0879
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0278 0.0278
Onchocerca volvulus 0.0176 0.2089 0.2294
Brugia malayi Calcium binding EGF domain containing protein 0.0132 0.1536 0.1857
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0063 0.0671 0.2103
Loa Loa (eye worm) notch protein 0.0132 0.1536 0.1855
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Toxoplasma gondii hypothetical protein 0.0044 0.0439 0.0081
Loa Loa (eye worm) hypothetical protein 0.0067 0.0727 0.0877
Loa Loa (eye worm) hypothetical protein 0.0139 0.1626 0.1965
Loa Loa (eye worm) trypsin family protein 0.0139 0.1626 0.1965
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0411 0.1287
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.016 0.1888 0.8587
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Brugia malayi CXXC zinc finger family protein 0.0029 0.0249 0.0301
Schistosoma mansoni cercarial elastase (S01 family) 0.0139 0.1626 0.1967
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1114 0.1346
Loa Loa (eye worm) RNA binding protein 0.0256 0.3083 0.3727
Echinococcus granulosus enteropeptidase 0.0257 0.3087 0.8008
Loa Loa (eye worm) hypothetical protein 0.0098 0.1114 0.1345
Loa Loa (eye worm) hypothetical protein 0.0044 0.0439 0.0528
Brugia malayi hypothetical protein 0.0139 0.1626 0.1966
Echinococcus multilocularis glycoprotein Antigen 5 0.0257 0.3087 0.3087
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0132 0.1536 0.1858
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0278 0.0722
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1346 0.1626
Schistosoma mansoni hypothetical protein 0.0031 0.0278 0.0336
Toxoplasma gondii microneme protein MIC17C 0.0044 0.0439 0.0081
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Brugia malayi Cadherin domain containing protein 0.0132 0.1536 0.1857
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.047 0.122
Loa Loa (eye worm) glutaminase 0.0265 0.3192 0.3859
Schistosoma mansoni hypothetical protein 0.0132 0.1536 0.1858
Schistosoma mansoni slit 0.0132 0.1536 0.1858
Echinococcus multilocularis GPCR, family 2 0.0031 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0139 0.1626 0.1965
Brugia malayi Zinc finger, C2H2 type family protein 0.0063 0.0671 0.0811
Toxoplasma gondii calcium binding egf domain-containing protein 0.0318 0.3854 1
Schistosoma mansoni notch 0.0132 0.1536 0.1858
Schistosoma mansoni tar DNA-binding protein 0.0256 0.3083 0.3729
Echinococcus granulosus delta-like protein 1 0.0132 0.1536 0.3984
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0613 0.0587
Mycobacterium ulcerans hypothetical protein 0.0139 0.1626 0.5094
Loa Loa (eye worm) hypothetical protein 0.0044 0.0439 0.0528
Echinococcus multilocularis protein jagged 2 0.0132 0.1536 0.1536
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053
Loa Loa (eye worm) hypothetical protein 0.0318 0.3854 0.4661
Toxoplasma gondii microneme protein MIC17A 0.0044 0.0439 0.0081
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0257 0.3087 0.3733
Schistosoma mansoni dihydroorotate dehydrogenase 0.016 0.1888 0.2284
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0063 0.0671 0.2103
Toxoplasma gondii PAN/Apple domain-containing protein 0.0044 0.0439 0.0081
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Echinococcus granulosus tissue type plasminogen activator 0.0176 0.2089 0.5419
Onchocerca volvulus 0.0139 0.1626 0.1717
Echinococcus granulosus neurogenic locus protein delta 0.0132 0.1536 0.3984
Toxoplasma gondii PAN domain-containing protein 0.0044 0.0439 0.0081
Brugia malayi Muscle positioning protein 4 0.0132 0.1536 0.1857
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0318 0.3854 0.4662
Onchocerca volvulus Slit protein homolog 0.0132 0.1536 0.1604
Schistosoma mansoni tar DNA-binding protein 0.0256 0.3083 0.3729
Loa Loa (eye worm) hypothetical protein 0.0132 0.1536 0.1855
Loa Loa (eye worm) hypothetical protein 0.0672 0.8267 1
Echinococcus multilocularis fibrillin 1 0.0318 0.3854 0.3854
Echinococcus multilocularis notch 0.0132 0.1536 0.1536
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.1608 0.4171
Brugia malayi Kringle domain containing protein 0.0176 0.2089 0.2526
Brugia malayi PAN domain containing protein 0.0044 0.0439 0.053

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Inhibition of HIV-1 replication in human T-cell by using XTT assay; Inactive ChEMBL. 8809151
IC50 (functional) = 13.1 Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay. ChEMBL. 8809151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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