Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.0026 | 0.0755 | 0.1553 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0068 | 0.2799 | 0.2799 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0026 | 0.0755 | 0.1132 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0026 | 0.0755 | 0.1132 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0949 | 0.0949 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.003 | 0.0949 | 0.1423 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.011 | 0.4858 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1569 | 0.2353 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0026 | 0.0755 | 0.0755 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0026 | 0.0755 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.0026 | 0.0755 | 0.1553 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.2799 | 0.2799 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2948 | 0.4422 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0026 | 0.0755 | 0.0755 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0026 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.003 | 0.0949 | 0.0949 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.6667 | 0.6667 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.7961 | 0.7961 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.6667 | 1 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0173 | 0.7961 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0146 | 0.6667 | 0.6667 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2948 | 0.4422 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0068 | 0.2799 | 0.5762 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0026 | 0.0755 | 0.0755 |
Plasmodium falciparum | carbonic anhydrase | 0.0026 | 0.0755 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0755 | 0.0755 |
Toxoplasma gondii | hypothetical protein | 0.0026 | 0.0755 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0026 | 0.0755 | 0.1553 |
Brugia malayi | Matrixin family protein | 0.003 | 0.0949 | 0.0949 |
Brugia malayi | TAR-binding protein | 0.0071 | 0.2948 | 0.2948 |
Echinococcus granulosus | carbonic anhydrase | 0.0026 | 0.0755 | 0.1553 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2948 | 0.4422 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2948 | 0.4422 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0026 | 0.0755 | 0.0755 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0068 | 0.2799 | 0.5762 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2799 | 0.4198 |
Schistosoma mansoni | tar DNA-binding protein | 0.0071 | 0.2948 | 0.4422 |
Brugia malayi | Hemopexin family protein | 0.0043 | 0.1569 | 0.1569 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0214 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0755 | 0.0755 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0026 | 0.0755 | 0.5 |
Brugia malayi | RNA binding protein | 0.0071 | 0.2948 | 0.2948 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0072 | 0.2988 | 0.4482 |
Leishmania major | carbonic anhydrase-like protein | 0.0026 | 0.0755 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0073 | 0.3052 | 0.3052 |
Loa Loa (eye worm) | TAR-binding protein | 0.0071 | 0.2948 | 0.2948 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0755 | 0.0755 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0026 | 0.0755 | 0.0755 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2799 | 0.4198 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0067 | 0.2755 | 0.3461 |
Brugia malayi | Matrixin family protein | 0.003 | 0.0949 | 0.0949 |
Onchocerca volvulus | Matrilysin homolog | 0.0067 | 0.2755 | 0.3461 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0026 | 0.0755 | 0.1132 |
Loa Loa (eye worm) | hypothetical protein | 0.0214 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0068 | 0.2799 | 0.5762 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0026 | 0.0755 | 0.1132 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.011 | 0.4858 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0068 | 0.2799 | 0.2799 |
Mycobacterium ulcerans | hydrolase | 0.0037 | 0.1272 | 0.5 |
Brugia malayi | N-terminal motif family protein | 0.0173 | 0.7961 | 0.7961 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0026 | 0.0755 | 0.0755 |
Echinococcus granulosus | carbonic anhydrase | 0.0026 | 0.0755 | 0.1553 |
Brugia malayi | Matrixin family protein | 0.003 | 0.0949 | 0.0949 |
Onchocerca volvulus | 0.0043 | 0.1569 | 0.1971 | |
Onchocerca volvulus | 0.003 | 0.0949 | 0.1192 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0026 | 0.0755 | 0.1553 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0214 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0949 | 0.0949 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0068 | 0.2799 | 0.2799 |
Echinococcus multilocularis | GPCR, family 2 | 0.0068 | 0.2799 | 0.5762 |
Loa Loa (eye worm) | matrixin family protein | 0.0073 | 0.3052 | 0.3052 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0068 | 0.2799 | 0.5762 |
Loa Loa (eye worm) | matrixin family protein | 0.0067 | 0.2755 | 0.2755 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0755 | 0.1132 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0037 | 0.1272 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0026 | 0.0755 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0071 | 0.2948 | 0.6069 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0037 | 0.1272 | 0.1272 |
Schistosoma mansoni | carbonic anhydrase | 0.0026 | 0.0755 | 0.1132 |
Echinococcus multilocularis | tar DNA binding protein | 0.0071 | 0.2948 | 0.6069 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0026 | 0.0755 | 0.0755 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0026 | 0.0755 | 0.1553 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0026 | 0.0755 | 0.0755 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1272 | 0.1272 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0068 | 0.2799 | 0.5762 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0037 | 0.1272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0949 | 0.0949 |
Loa Loa (eye worm) | RNA binding protein | 0.0071 | 0.2948 | 0.2948 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0026 | 0.0755 | 0.0755 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2799 | 0.4198 |
Onchocerca volvulus | Matrilysin homolog | 0.003 | 0.0949 | 0.1192 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.2799 | 0.4198 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0071 | 0.2948 | 0.2948 |
Brugia malayi | Matrixin family protein | 0.003 | 0.0949 | 0.0949 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0026 | 0.0755 | 0.1132 |
Echinococcus multilocularis | carbonic anhydrase | 0.0026 | 0.0755 | 0.1553 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0071 | 0.2948 | 0.2948 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.