Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.266 | 0.4573 | 1 |
Echinococcus granulosus | geminin | 0.0172 | 0.0238 | 0.0238 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.266 | 0.4573 | 1 |
Onchocerca volvulus | 0.0361 | 0.0567 | 0.5 | |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0147 | 0.0195 | 0.0195 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.266 | 0.4573 | 1 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.004 | 0.0007 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0147 | 0.0195 | 0.0195 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.266 | 0.4573 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.5774 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.0238 | 0.0238 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0043 | 0.0014 | 0.003 |
Loa Loa (eye worm) | thymidylate synthase | 0.0361 | 0.0567 | 0.0567 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.004 | 0.0007 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.5774 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.5774 | 1 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0043 | 0.0014 | 0.003 |
Schistosoma mansoni | dihydrofolate reductase | 0.5774 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.5774 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.5774 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.5774 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.5774 | 1 | 1 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0147 | 0.0195 | 0.0195 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0147 | 0.0195 | 0.0195 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0172 | 0.0237 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0143 | 0.0188 | 0.0188 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.266 | 0.4573 | 1 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.004 | 0.0007 | 0.0016 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0172 | 0.0237 | 0.0519 |
Echinococcus multilocularis | geminin | 0.0172 | 0.0238 | 0.0238 |
Echinococcus multilocularis | thymidylate synthase | 0.0361 | 0.0567 | 0.0567 |
Schistosoma mansoni | hypothetical protein | 0.0172 | 0.0238 | 0.0238 |
Echinococcus granulosus | thymidylate synthase | 0.0361 | 0.0567 | 0.0567 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0043 | 0.0014 | 0.0572 |
Brugia malayi | thymidylate synthase | 0.0361 | 0.0567 | 0.0567 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0361 | 0.0567 | 0.0567 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0361 | 0.0567 | 0.0338 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0043 | 0.0014 | 0.0014 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0043 | 0.0014 | 0.0572 |
Brugia malayi | hypothetical protein | 0.0172 | 0.0237 | 0.0237 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0043 | 0.0014 | 0.003 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.266 | 0.4573 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.5774 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.7 nM | Tested for the binding affinity of A2a receptor by displacing the [3H]-CGS- 21680 in rat striatal membranes | ChEMBL. | 7932588 |
Ki (binding) | = 5.7 nM | Binding affinity for adenosine A2 receptor using [3H]- NECA | ChEMBL. | 1738138 |
Ki (binding) | = 50 nM | Tested for the binding affinity of A3 receptor by displacing N6-[[125I]-4-amino-3-iodobenzyl]-adenosine-5''-N-methyluronamide from membranes of CHO cells transfected with rat A3-cDNA | ChEMBL. | 7932588 |
Ki (binding) | = 240 nM | Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]-PIA as radioligand | ChEMBL. | 1738138 |
Ki (binding) | = 400 nM | Tested for the binding affinity of A1 receptor by displacing the [3H]-PIA in rat brain membranes | ChEMBL. | 7932588 |
Ratio (binding) | = 0.024 | Ratio of A2 to A1. | ChEMBL. | 1738138 |
Ratio (binding) | = 0.11 | Ratio of Ki for A2a and A3 receptors | ChEMBL. | 7932588 |
Ratio (binding) | = 8 | Ratio of Ki for A1 and A3 receptors | ChEMBL. | 7932588 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.