Detailed information for compound 209364

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 339.711 | Formula: C13H12ClN4O5-
  • H donors: 3 H acceptors: 4 LogP: 1.86 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](c1ccccc1)C(=O)NNC(=O)c1ccc(o1)[N+](=O)[O-].[Cl-]
  • InChi: 1S/C13H12N4O5.ClH/c14-11(8-4-2-1-3-5-8)13(19)16-15-12(18)9-6-7-10(22-9)17(20)21;/h1-7,11H,14H2,(H,15,18)(H,16,19);1H/p-1/t11-;/m1./s1
  • InChiKey: YOKUDHKJDWZAFR-RFVHGSKJSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0016 0.0016
Brugia malayi hypothetical protein 0.0656 0.0898 0.0898
Brugia malayi nuclear receptor NHR-88 0.0021 0.0014 0.0014
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.0164 0.0164
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0004 0.0004
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.004 0.0058
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.0248 0.0244
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0008
Echinococcus multilocularis musashi 0.0057 0.0064 0.0064
Echinococcus granulosus pyruvate kinase 0.0033 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0014 0.0014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0103 0.0127 0.0127
Schistosoma mansoni lamin 0.0057 0.0064 0.0064
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.7192 1 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0014 0.0014
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0104 0.0128 0.0125
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1379 0.1904 0.1904
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.7192 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0021
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0189 0.0248 0.0248
Chlamydia trachomatis pyruvate kinase 0.0033 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0017 0.0008 0.0008
Plasmodium vivax pyruvate kinase, putative 0.0033 0.003 0.0042
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.003 0.0042
Plasmodium vivax glutathione reductase, putative 0.0041 0.0041 0.006
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.4476 0.6217 1
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0014 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0014 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0014 0.0014
Plasmodium falciparum glutathione reductase 0.0041 0.0041 0.006
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0014 0.0014
Echinococcus multilocularis lamin dm0 0.0057 0.0064 0.0064
Leishmania major pyruvate kinase 0.0033 0.003 0.0042
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0008
Echinococcus multilocularis pyruvate kinase 0.0026 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0093 0.0114 0.011
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.003 0.0085
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0189 0.0248 0.0244
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0008
Echinococcus granulosus neuropeptide receptor A26 0.0501 0.0682 0.0682
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0014 0.0014
Plasmodium falciparum thioredoxin reductase 0.0041 0.0041 0.006
Loa Loa (eye worm) hypothetical protein 0.0054 0.0059 0.0059
Toxoplasma gondii thioredoxin reductase 0.0041 0.0041 0.006
Echinococcus granulosus pyruvate kinase 0.0033 0.003 0.003
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0014 0.0014
Echinococcus granulosus pyruvate kinase 0.0017 0.0008 0.0008
Treponema pallidum NADH oxidase 0.0014 0.0004 0.5
Loa Loa (eye worm) hypothetical protein 0.0056 0.0063 0.0063
Toxoplasma gondii aldehyde dehydrogenase 0.0189 0.0248 0.0392
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0093 0.0114 0.011
Loa Loa (eye worm) glutathione reductase 0.0041 0.0041 0.0041
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0004 0.0004
Echinococcus multilocularis GPCR, family 2 0.0017 0.0008 0.0008
Plasmodium vivax thioredoxin reductase, putative 0.0041 0.0041 0.006
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0014 0.0014
Loa Loa (eye worm) dihydrofolate reductase 0.7192 1 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0034 0.003
Echinococcus granulosus survival motor neuron protein 1 0.0503 0.0685 0.0685
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.0164 0.0164
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.004 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0014 0.0014
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0008 0.0008
Echinococcus multilocularis neuropeptide receptor A26 0.0501 0.0682 0.0682
Echinococcus multilocularis survival motor neuron protein 1 0.0503 0.0685 0.0685
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0034 0.0004
Loa Loa (eye worm) hypothetical protein 0.0057 0.0064 0.0064
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0093 0.0114 0.011
Echinococcus granulosus lamin 0.0057 0.0064 0.0064
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.0064 0.0064
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.003 0.0085
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.003 0.0294
Loa Loa (eye worm) hypothetical protein 0.0037 0.0035 0.0035
Mycobacterium tuberculosis Hypothetical protein 0.0656 0.0898 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0014 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0016 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0014 0.0014
Loa Loa (eye worm) thioredoxin reductase 0.0041 0.0041 0.0041
Brugia malayi Dihydrofolate reductase 0.7192 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0014 0.0014
Echinococcus multilocularis pyruvate kinase 0.0033 0.003 0.003
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0014 0.0014
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.0064 0.0064
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0014 0.0014
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0023 0.0023
Brugia malayi ecdysteroid receptor 0.0021 0.0014 0.0014
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1379 0.1904 0.188
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0656 0.0898 0.1438
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.4476 0.6217 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0023 0.0023
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0014 0.0014
Schistosoma mansoni lamin 0.0057 0.0064 0.0064
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0014 0.0014
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.4476 0.6217 1
Brugia malayi MH2 domain containing protein 0.0129 0.0164 0.0164
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0014 0.0014
Schistosoma mansoni coup transcription factor 0.0021 0.0014 0.0014
Brugia malayi intermediate filament protein 0.0057 0.0064 0.0064
Chlamydia trachomatis dihydrofolate reductase 0.7192 1 1
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.003 0.0085
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0014 0.0014
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0042 0.0042
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.004 0.0401
Brugia malayi Thioredoxin reductase 0.0041 0.0041 0.0041
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.003 0.0042
Loa Loa (eye worm) hypothetical protein 0.0027 0.0021 0.0021
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0004 0.0004
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.003 0.0042
Brugia malayi hypothetical protein 0.0503 0.0685 0.0685
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.004 0.0036
Echinococcus granulosus inositol monophosphatase 1 0.004 0.004 0.004
Echinococcus granulosus thymidylate synthase 0.1379 0.1904 0.1904
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0014 0.0014
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0008 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0014 0.0014
Leishmania major pyruvate kinase 0.0033 0.003 0.0042
Schistosoma mansoni inositol monophosphatase 0.004 0.004 0.004
Brugia malayi steroid hormone receptor 0.0021 0.0014 0.0014
Echinococcus granulosus pyruvate kinase 0.0017 0.0008 0.0008
Plasmodium falciparum pyruvate kinase 0.0033 0.003 0.0042
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0014 0.0014
Echinococcus multilocularis dihydrofolate reductase 0.7192 1 1
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.004 0.004
Echinococcus multilocularis pyruvate kinase 0.0017 0.0008 0.0008
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0008 0.0006
Echinococcus multilocularis thymidylate synthase 0.1379 0.1904 0.1904
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0656 0.0898 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0008 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0014 0.0014
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0014 0.0014
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.004 0.0058
Echinococcus multilocularis neuropeptide s receptor 0.0501 0.0682 0.0682
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.0017 0.0008 0.0008
Loa Loa (eye worm) inositol-1 0.004 0.004 0.004
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0014 0.0014
Mycobacterium ulcerans pyruvate kinase 0.0033 0.003 0.0026
Onchocerca volvulus 0.0057 0.0064 0.0264
Mycobacterium tuberculosis Probable reductase 0.0093 0.0114 0.011
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1379 0.1904 0.1901
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0014 0.0014
Echinococcus multilocularis pyruvate kinase 0.0017 0.0008 0.0008
Schistosoma mansoni pyruvate kinase 0.0033 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0014 0.0014
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0014 0.0014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.004 0.0401
Brugia malayi thymidylate synthase 0.1379 0.1904 0.1904
Schistosoma mansoni inositol monophosphatase 0.004 0.004 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0014 0.0014
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.4476 0.6217 1
Loa Loa (eye worm) pyruvate kinase 0.0033 0.003 0.003
Echinococcus granulosus lamin dm0 0.0057 0.0064 0.0064
Brugia malayi follicle stimulating hormone receptor 0.0253 0.0336 0.0336
Schistosoma mansoni survival motor neuron protein 0.0103 0.0127 0.0127
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0014 0.0014
Echinococcus granulosus dihydrofolate reductase 0.7192 1 1
Leishmania major trypanothione reductase 0.0041 0.0041 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0033 0.003 0.003
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.0248 0.0244
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0093 0.0114 0.0084
Onchocerca volvulus 0.1379 0.1904 1
Giardia lamblia Pyruvate kinase 0.0017 0.0008 0.1481
Loa Loa (eye worm) intermediate filament protein 0.0057 0.0064 0.0064
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0014 0.0014
Trypanosoma brucei trypanothione reductase 0.0041 0.0041 0.006
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0035 0.0035
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0042 0.0042
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0014 0.0014
Loa Loa (eye worm) pyruvate kinase 0.0033 0.003 0.003
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0008 0.0008
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.004 0.0058
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0059 0.0059
Schistosoma mansoni intermediate filament proteins 0.0057 0.0064 0.0064
Giardia lamblia Pyruvate kinase 0.0033 0.003 1
Schistosoma mansoni hypothetical protein 0.0103 0.0127 0.0127
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0014 0.0014
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0104 0.0128 0.0125
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0189 0.0248 0.0392
Mycobacterium tuberculosis Probable dehydrogenase 0.0093 0.0114 0.011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0014 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0041 0.0041 0.006
Onchocerca volvulus 0.0057 0.0064 0.0264
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0014 0.0014
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0008 0.0008
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.4476 0.6217 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0189 0.0248 0.0244
Trypanosoma brucei pyruvate kinase 1 0.0033 0.003 0.0042
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.003 0.003
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0041 0.0041 0.0037
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.7192 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0014 0.0014
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0014 0.0014
Loa Loa (eye worm) pyruvate kinase 0.0033 0.003 0.003
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0014 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0014 0.0014
Schistosoma mansoni dihydrofolate reductase 0.7192 1 1
Mycobacterium ulcerans thymidylate synthase 0.1379 0.1904 0.1901
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.0248 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0014 0.0014
Leishmania major dihydrofolate reductase-thymidylate synthase 0.4476 0.6217 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0023
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0014 0.0014
Onchocerca volvulus 0.0103 0.0127 0.0598
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.003 0.0294
Echinococcus multilocularis pyruvate kinase 0.0033 0.003 0.003
Schistosoma mansoni aldehyde dehydrogenase 0.0189 0.0248 0.0248
Loa Loa (eye worm) thymidylate synthase 0.1379 0.1904 0.1904
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0014 0.0014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.004 0.0058
Mycobacterium tuberculosis Probable oxidoreductase 0.0104 0.0128 0.0125
Echinococcus granulosus intermediate filament protein 0.0057 0.0064 0.0064
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0027 0.0027
Schistosoma mansoni pyruvate kinase 0.0017 0.0008 0.0008
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.085 0.1167 0.1167
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0014 0.0014
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.004 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0008 0.0008
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.003 0.003
Brugia malayi nuclear hormone receptor 0.0021 0.0014 0.0014
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0104 0.0128 0.0099
Echinococcus multilocularis pyruvate kinase 0.0017 0.0008 0.0008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0059 0.0059
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0008 0.0008
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0503 0.0685 0.0685
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0027 0.0027
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.0336 0.0336
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0014 0.0014
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0014 0.0014
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.004 0.0058
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0189 0.0248 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0014 0.0014
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.004 0.0401
Schistosoma mansoni hypothetical protein 0.0037 0.0035 0.0035
Echinococcus granulosus neuropeptide s receptor 0.0501 0.0682 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0014 0.0014
Echinococcus multilocularis lamin 0.0057 0.0064 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0059 0.0059
Brugia malayi glutathione reductase 0.0041 0.0041 0.0041
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0014 0.0014
Brugia malayi Inositol-1 0.004 0.004 0.004
Schistosoma mansoni pyruvate kinase 0.0033 0.003 0.003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0014 0.0014
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.003 0.0042
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.003 0.0026
Echinococcus granulosus GPCR family 2 0.0017 0.0008 0.0008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0093 0.0114 0.011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0014 0.0014

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 14 uM Tested for cytotoxicity towards human MRC-5 cells ChEMBL. 12443785
CC50 (functional) = 32 uM Tested for cytotoxicity towards mouse peritoneal macrophages (MPM) ChEMBL. 12443785
ED50 (functional) = 2 uM Evaluated in vitro for antitrypanosomal activity against Trypanosoma cruzi ChEMBL. 12443785
ED50 (functional) = 2 uM Evaluated in vitro for antitrypanosomal activity against Trypanosoma brucei ChEMBL. 12443785
ED50 (functional) > 32 uM Evaluated in vitro for antitrypanosomal activity against Leishmania infantum ChEMBL. 12443785

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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