TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 476.658 | Formula: C22H32N6O2S2
H donors: 2 H acceptors: 4 LogP: 3.26 Rotable bonds: 14
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCC(=O)Nc1sc2c(n1)cc1c(c2)sc(n1)NC(=O)CCN(CC)CC)CC
InChi: 1S/C22H32N6O2S2/c1-5-27(6-2)11-9-19(29)25-21-23-15-13-16-18(14-17(15)31-21)32-22(24-16)26-20(30)10-12-28(7-3)8-4/h13-14H,5-12H2,1-4H3,(H,23,25,29)(H,24,26,30)
InChiKey: GJESPANXIWLZAG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.066	0.8287	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0121	0.1431	0.1641
Echinococcus granulosus	fibropellin Ia	0.0121	0.1431	0.4002
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.1586	0.1831
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Schistosoma mansoni	notch	0.0121	0.1431	0.1641
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Brugia malayi	EGF-like domain containing protein	0.0121	0.1431	0.1641
Onchocerca volvulus		0.0176	0.2122	0.2332
Echinococcus multilocularis	protein jagged 1	0.0121	0.1431	0.1431
Schistosoma mansoni	hypothetical protein	0.0133	0.1586	0.1831
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Toxoplasma gondii	calcium binding egf domain-containing protein	0.029	0.3575	1
Brugia malayi	Fibulin-1 precursor	0.029	0.3575	0.4255
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0084	0.0084
Echinococcus multilocularis	laminin	0.029	0.3575	0.3575
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0568	0.0391
Echinococcus granulosus	laminin	0.029	0.3575	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0506	0.061
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0468	0.0468
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0468	0.0468
Echinococcus multilocularis	neurogenic locus protein delta	0.0121	0.1431	0.1431
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0468	0.0565
Onchocerca volvulus		0.0044	0.0445	0.0246
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0121	0.1431	0.1431
Echinococcus multilocularis	Tolloid protein 1	0.029	0.3575	0.3575
Onchocerca volvulus		0.0121	0.1431	0.1472
Loa Loa (eye worm)	hypothetical protein	0.066	0.8287	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.1586	0.1831
Loa Loa (eye worm)	Notch2	0.0121	0.1431	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Brugia malayi	Calcium binding EGF domain containing protein	0.0121	0.1431	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0445	0.0537
Echinococcus multilocularis	slit 2 protein	0.0121	0.1431	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2122	0.2561
Echinococcus granulosus	protein jagged 1	0.0121	0.1431	0.4002
Loa Loa (eye worm)	hypothetical protein	0.029	0.3575	0.4314
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0468	0.0468
Toxoplasma gondii	EGF family domain-containing protein	0.0121	0.1431	0.3149
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Echinococcus multilocularis	cpg binding protein	0.003	0.0268	0.0268
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0468	0.131
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Loa Loa (eye worm)	hypothetical protein	0.029	0.3575	0.4314
Echinococcus granulosus	neural cadherin	0.0121	0.1431	0.4002
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Echinococcus granulosus	slit 2 protein	0.0121	0.1431	0.4002
Brugia malayi	EGF-like domain containing protein	0.0121	0.1431	0.1641
Echinococcus multilocularis	glycoprotein Antigen 5	0.025	0.307	0.307
Onchocerca volvulus		0.0044	0.0445	0.0246
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0133	0.1586	0.4436
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0506	0.061
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Schistosoma mansoni	notch	0.0121	0.1431	0.1641
Brugia malayi	Trypsin family protein	0.066	0.8287	1
Schistosoma mansoni	cell polarity protein	0.0121	0.1431	0.1641
Schistosoma mansoni	hypothetical protein	0.0033	0.0311	0.0276
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.006	0.0649	0.0688
Brugia malayi	EGF-like domain containing protein	0.0121	0.1431	0.1641
Brugia malayi	RNA binding protein	0.0251	0.308	0.3653
Brugia malayi	Trypsin family protein	0.0133	0.1586	0.1831
Loa Loa (eye worm)	PAN domain-containing protein	0.0044	0.0445	0.0537
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0084	0.0236
Brugia malayi	Muscle positioning protein 4	0.0121	0.1431	0.1641
Schistosoma mansoni	hypothetical protein	0.0121	0.1431	0.1641
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Onchocerca volvulus		0.0044	0.0445	0.0246
Loa Loa (eye worm)	PAN domain-containing protein	0.0044	0.0445	0.0537
Onchocerca volvulus		0.0044	0.0445	0.0246
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Schistosoma mansoni	notch	0.0121	0.1431	0.1641
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Echinococcus multilocularis	enteropeptidase	0.025	0.307	0.307
Onchocerca volvulus		0.0121	0.1431	0.1472
Brugia malayi	EGF-like domain containing protein	0.0121	0.1431	0.1641
Brugia malayi	Cadherin domain containing protein	0.0121	0.1431	0.1641
Echinococcus multilocularis	neurogenic locus protein delta	0.0121	0.1431	0.1431
Schistosoma mansoni	hypothetical protein	0.0121	0.1431	0.1641
Schistosoma mansoni	cpg binding protein	0.0028	0.0247	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Brugia malayi	GCC2 and GCC3 family protein	0.0121	0.1431	0.1641
Schistosoma mansoni	notch	0.0121	0.1431	0.1641
Mycobacterium ulcerans	hypothetical protein	0.0133	0.1586	0.5
Brugia malayi	EGF-like domain containing protein	0.0121	0.1431	0.1641
Toxoplasma gondii	calcium binding egf domain-containing protein	0.029	0.3575	1
Brugia malayi	hypothetical protein	0.0133	0.1586	0.1831
Schistosoma mansoni	cpg binding protein	0.003	0.0268	0.0224
Echinococcus granulosus	Tolloid protein 1	0.029	0.3575	1
Schistosoma mansoni	cpg binding protein	0.003	0.0268	0.0224
Echinococcus granulosus	tissue type plasminogen activator	0.0176	0.2122	0.5936
Echinococcus multilocularis	tar DNA binding protein	0.0251	0.308	0.308
Echinococcus multilocularis	notch	0.0121	0.1431	0.1431
Schistosoma mansoni	slit	0.0121	0.1431	0.1641
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.1586	0.1831
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0121	0.1431	0.1431
Onchocerca volvulus	Arrow homolog	0.029	0.3575	0.4139
Echinococcus multilocularis	neurogenic locus notch protein	0.0121	0.1431	0.1431
Schistosoma mansoni	tar DNA-binding protein	0.0251	0.308	0.3653
Onchocerca volvulus		0.0044	0.0445	0.0246
Onchocerca volvulus		0.0121	0.1431	0.1472
Echinococcus granulosus	protein jagged 2	0.0121	0.1431	0.4002
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1586	0.1914
Echinococcus granulosus	protein jagged 2	0.0121	0.1431	0.4002
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.066	0.8287	1
Echinococcus granulosus	neurogenic locus notch protein 4	0.0121	0.1431	0.4002
Onchocerca volvulus		0.0133	0.1586	0.1665
Onchocerca volvulus		0.0121	0.1431	0.1472
Schistosoma mansoni	hypothetical protein	0.0176	0.2122	0.2484
Onchocerca volvulus		0.0133	0.1586	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Schistosoma mansoni	tar DNA-binding protein	0.0251	0.308	0.3653
Loa Loa (eye worm)	hypothetical protein	0.029	0.3575	0.4314
Echinococcus multilocularis	fibropellin Ia	0.0121	0.1431	0.1431
Echinococcus granulosus	neurogenic locus notch protein	0.0121	0.1431	0.4002
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Toxoplasma gondii	kringle domain-containing protein	0.0176	0.2122	0.5358
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.029	0.3575	0.4255
Brugia malayi	Calcium binding EGF domain containing protein	0.0121	0.1431	0.1641
Brugia malayi	Cadherin domain containing protein	0.0121	0.1431	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Echinococcus granulosus	enteropeptidase	0.025	0.307	0.8588
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0251	0.308	0.3717
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.1586	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0445	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0084	0.0102
Brugia malayi	Delta serrate ligand family protein	0.0121	0.1431	0.1641
Echinococcus granulosus	protein jagged 1	0.0121	0.1431	0.4002
Brugia malayi	Protein kinase domain containing protein	0.0176	0.2122	0.2484
Onchocerca volvulus		0.0044	0.0445	0.0246
Echinococcus multilocularis	protein jagged 1	0.0121	0.1431	0.1431
Onchocerca volvulus		0.066	0.8287	1
Brugia malayi	CXXC zinc finger family protein	0.0028	0.0247	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Loa Loa (eye worm)	hypothetical protein	0.029	0.3575	0.4314
Echinococcus granulosus	neurogenic locus notch protein	0.0121	0.1431	0.4002
Echinococcus multilocularis	neural cadherin	0.0121	0.1431	0.1431
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0506	0.0514
Loa Loa (eye worm)	notch protein	0.0121	0.1431	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0445	0.0537
Onchocerca volvulus		0.0044	0.0445	0.0246
Echinococcus granulosus	notch	0.0121	0.1431	0.4002
Brugia malayi	EGF-like domain containing protein	0.0121	0.1431	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1586	0.1914
Loa Loa (eye worm)	TAR-binding protein	0.0251	0.308	0.3717
Schistosoma mansoni	tar DNA-binding protein	0.0251	0.308	0.3653
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.025	0.307	0.364
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0506	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Schistosoma mansoni	hypothetical protein	0.0121	0.1431	0.1641
Onchocerca volvulus		0.0044	0.0445	0.0246
Trypanosoma cruzi	hypothetical protein, conserved	0.0176	0.2122	0.5
Onchocerca volvulus		0.0121	0.1431	0.1472
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0445	0.0537
Onchocerca volvulus	Slit protein homolog	0.0121	0.1431	0.1472
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.029	0.3575	0.4314
Brugia malayi	Trypsin-like protease protein 5	0.0133	0.1586	0.1831
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Onchocerca volvulus		0.0133	0.1586	0.1665
Echinococcus multilocularis	tissue type plasminogen activator	0.0176	0.2122	0.2122
Echinococcus granulosus	delta-like protein 1	0.0121	0.1431	0.4002
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Echinococcus multilocularis	transmembrane protease serine 3	0.0133	0.1586	0.1586
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1586	0.1914
Echinococcus granulosus	neurogenic locus protein delta	0.0121	0.1431	0.4002
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1586	0.1914
Giardia lamblia	High cysteine protein	0.0121	0.1431	0.5
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.029	0.3575	0.4314
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0311	0.0375
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0133	0.1586	0.1831
Echinococcus multilocularis	Mastin	0.025	0.307	0.307
Brugia malayi	Trypsin family protein	0.0133	0.1586	0.1831
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Brugia malayi	TAR-binding protein	0.0251	0.308	0.3653
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Onchocerca volvulus		0.0044	0.0445	0.0246
Echinococcus multilocularis	neurogenic locus notch protein	0.0121	0.1431	0.1431
Echinococcus multilocularis	fibrillin 1	0.029	0.3575	0.3575
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0176	0.2122	0.5
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.0247	0.0298
Loa Loa (eye worm)	PAN domain-containing protein	0.0044	0.0445	0.0537
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0445	0.0537
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Onchocerca volvulus	Neurogenic locus notch homolog	0.0121	0.1431	0.1472
Echinococcus multilocularis	protein jagged 2	0.0121	0.1431	0.1431
Schistosoma mansoni	hypothetical protein	0.0121	0.1431	0.1641
Loa Loa (eye worm)	trypsin family protein	0.0133	0.1586	0.1914
Schistosoma mansoni	tar DNA-binding protein	0.0251	0.308	0.3653
Brugia malayi	Kringle domain containing protein	0.0176	0.2122	0.2484
Schistosoma mansoni	septate junction protein	0.0121	0.1431	0.1641
Loa Loa (eye worm)	PAN domain-containing protein	0.0044	0.0445	0.0537
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0311	0.0276
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0084	0.0084
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0468	0.0468
Echinococcus granulosus	cpg binding protein	0.003	0.0268	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0084	0.0102
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.066	0.8287	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0468	0.0468
Brugia malayi	EGF-like domain containing protein	0.0121	0.1431	0.1641
Brugia malayi	RNA recognition motif domain containing protein	0.0251	0.308	0.3653
Echinococcus granulosus	glycoprotein Antigen 5	0.025	0.307	0.8588
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Schistosoma mansoni	hypothetical protein	0.0133	0.1586	0.1831
Echinococcus granulosus	tar DNA binding protein	0.0251	0.308	0.8617
Schistosoma mansoni	egf-like domain protein	0.029	0.3575	0.4255
Leishmania major	hypothetical protein, conserved	0.0176	0.2122	0.5
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0121	0.1431	0.1641
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Schistosoma mansoni	notch	0.0121	0.1431	0.1641
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0133	0.1586	0.4436
Loa Loa (eye worm)	PAN domain-containing protein	0.0044	0.0445	0.0537
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0133	0.1586	0.1831
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0121	0.1431	0.1641
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0445	0.0537
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Onchocerca volvulus		0.0527	0.659	0.789
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0468	0.131
Schistosoma mansoni	tar DNA-binding protein	0.0251	0.308	0.3653
Brugia malayi	Calcium binding EGF domain containing protein	0.029	0.3575	0.4255
Echinococcus granulosus	transmembrane protease serine 3	0.0133	0.1586	0.4436
Onchocerca volvulus	Putative cubilin	0.0121	0.1431	0.1472
Loa Loa (eye worm)	RNA binding protein	0.0251	0.308	0.3717
Onchocerca volvulus		0.0133	0.1586	0.1665
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Schistosoma mansoni	laminin gamma-3 chain	0.0121	0.1431	0.1641
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0121	0.1431	0.1472
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.029	0.3575	0.4314
Loa Loa (eye worm)	hypothetical protein	0.0133	0.1586	0.1914
Echinococcus granulosus	Mastin	0.025	0.307	0.8588
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0445	0.0537
Loa Loa (eye worm)	TK/ROR protein kinase	0.0176	0.2122	0.2561
Onchocerca volvulus		0.0044	0.0445	0.0246
Brugia malayi	Trypsin family protein	0.0133	0.1586	0.1831
Schistosoma mansoni	hypothetical protein	0.0121	0.1431	0.1641
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Schistosoma mansoni	notch	0.0121	0.1431	0.1641
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0133	0.1586	0.1831
Schistosoma mansoni	hypothetical protein	0.0121	0.1431	0.1641
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0084	0.0084
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.029	0.3575	0.4255
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0084	0.0236
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0133	0.1586	0.1586
Onchocerca volvulus		0.0133	0.1586	0.1665
Schistosoma mansoni	hypothetical protein	0.0121	0.1431	0.1641
Schistosoma mansoni	cercarial elastase (S01 family)	0.0133	0.1586	0.1831
Brugia malayi	notch-like transmembrane receptor	0.0121	0.1431	0.1641
Brugia malayi	PAN domain containing protein	0.0044	0.0445	0.044
Loa Loa (eye worm)	hypothetical protein	0.029	0.3575	0.4314
Onchocerca volvulus		0.0044	0.0445	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Echinococcus granulosus	GPCR family 2	0.0015	0.0084	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0121	0.1431	0.1726
Plasmodium falciparum	cysteine repeat modular protein 1	0.0176	0.2122	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Body weight change (functional)	= -5 %	Antiinflammatory activity of the compound dosed orally against D-adjuvant arthiritis in rat.	ChEMBL.	1732553
Inhibition (functional)	= 16 %	Antiinflammatory activity of the compound dosed orally against carragenian induced rat paw edema(CPE)	ChEMBL.	1732553
Inhibition (functional)	= 29 %	Antiinflammatory activity against D-adjuvant arthiritis in injected rat paw at the dose of 50 mg/kg by oral administration	ChEMBL.	1732553
Inhibition (functional)	= 48 %	Antiinflammatory activity against D-adjuvant arthiritis in uninjected rat paw at the dose of 50 mg/kg by oral administration	ChEMBL.	1732553

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL120223

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 209438