Detailed information for compound 209450

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 532.656 | Formula: C25H36N6O5S
  • H donors: 6 H acceptors: 6 LogP: -0.8 Rotable bonds: 18
    Rule of 5 violations (Lipinski): 3
  • SMILES: CSCC[C@@H](C(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(=O)[C@H](Cc1c[nH]cn1)N
  • InChi: 1S/C25H36N6O5S/c1-15(2)21(31-22(32)18(26)12-17-13-27-14-28-17)24(34)30-20(11-16-7-5-4-6-8-16)23(33)29-19(25(35)36)9-10-37-3/h4-8,13-15,18-21H,9-12,26H2,1-3H3,(H,27,28)(H,29,33)(H,30,34)(H,31,32)(H,35,36)/t18-,19-,20-,21-/m0/s1
  • InChiKey: MLUMSZGAWGBYFW-TUFLPTIASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens farnesyltransferase, CAAX box, alpha Starlite/ChEMBL References
Rattus norvegicus Protein farnesyltransferase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Babesia bovis prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Cryptosporidium hominis chain B, structure of fpt bound to ggpp Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote Get druggable targets OG5_128081 All targets in OG5_128081
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma mansoni protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium falciparum protein farnesyltransferase subunit alpha Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Leishmania infantum farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma mansoni protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania mexicana farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Leishmania braziliensis farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans similar to S. cerevisiae RAM1 (YDL090C) beta subunit of farnesyl transferase (Ram1p+Ram2p), involved in prenylation of RAS prote Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, alpha [EC:2.5.1.58 2.5.1.59], putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein Get druggable targets OG5_128081 All targets in OG5_128081
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium parvum farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma brucei gambiense protein farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium berghei protein farnesyltransferase subunit beta, putative Get druggable targets OG5_128081 All targets in OG5_128081
Theileria parva hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Neospora caninum protein farnesyltranstransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus multilocularis protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trypanosoma cruzi protein farnesyltransferase, putative Get druggable targets OG5_128081 All targets in OG5_128081
Theileria parva farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Neospora caninum hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Trypanosoma cruzi protein farnesyltransferase, putative Get druggable targets OG5_128081 All targets in OG5_128081
Candida albicans alpha subunit shared by C terminal CaaX Geranylgeranyltransferase I (Ram2p+Cdc43p) and farnesyltransferase (Ram2p+Ram1p) Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium knowlesi protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium parvum protein geranyl-geranyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Schistosoma japonicum ko:K05954 farnesyltransferase, CAAX box, beta [EC:2.5.1.58], putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium falciparum protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium berghei protein farnesyltransferase subunit alpha, putative Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax prenyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Leishmania major farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Giardia lamblia Rab geranylgeranyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium vivax farnesyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Babesia bovis protein prenyltransferase alpha subunit repeat domain containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Trypanosoma brucei protein farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative Get druggable targets OG5_128459 All targets in OG5_128459
Giardia lamblia Prenyltransferase Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium knowlesi protein farnesyltransferase subunit beta, putative Get druggable targets OG5_128081 All targets in OG5_128081
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative Get druggable targets OG5_128081 All targets in OG5_128081
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein Get druggable targets OG5_128459 All targets in OG5_128459
Cryptosporidium hominis farnesyltransferase Get druggable targets OG5_128459 All targets in OG5_128459
Toxoplasma gondii hypothetical protein Get druggable targets OG5_128459 All targets in OG5_128459
Leishmania donovani farnesyltransferase beta subunit Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium vivax conserved Plasmodium protein, unknown function Get druggable targets OG5_128081 All targets in OG5_128081
Plasmodium yoelii Prenyltransferase and squalene oxidase repeat, putative Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus granulosus protein farnesyltransferase subunit beta Get druggable targets OG5_128081 All targets in OG5_128081
Echinococcus multilocularis protein farnesyltransferase alpha subunit Get druggable targets OG5_128459 All targets in OG5_128459
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_128081 All targets in OG5_128081
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major farnesyltransferase beta subunit 0.0067 0.1235 0.8638
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0067 0.1235 0.2456
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0286 0.1075
Schistosoma mansoni tar DNA-binding protein 0.0251 0.5297 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.002 0.0189 0.172
Brugia malayi RNA recognition motif domain containing protein 0.0251 0.5297 0.6007
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.104 0.3522
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0026 0.0331 0.2054
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0026 0.0331 0.481
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0075 0.1406 1
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0075 0.1406 0.2843
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0331 0.481
Loa Loa (eye worm) hypothetical protein 0.0018 0.0151 0.0172
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0297 0.4065
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0067 0.1235 0.8638
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0075 0.1406 0.1808
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0286 0.1075
Brugia malayi Pre-SET motif family protein 0.0407 0.8755 1
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1406 1
Schistosoma mansoni tar DNA-binding protein 0.0251 0.5297 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0218 0.4564 0.4481
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0075 0.1406 0.2843
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0018 0.0151 0.0065
Loa Loa (eye worm) RNA binding protein 0.0251 0.5297 0.605
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.1235 0.11
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0075 0.1406 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.2378 0.2716
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0074 0.1379 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0435 0.041
Brugia malayi TAR-binding protein 0.0251 0.5297 0.6007
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0025 0.0297 0.0233
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0037 0.0568 0.3853
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0067 0.1235 0.2456
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0218 0.4564 0.4481
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.104 0.1727
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0075 0.1406 0.2438
Onchocerca volvulus 0.0043 0.0703 0.0454
Toxoplasma gondii hypothetical protein 0.0075 0.1406 0.4792
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0025 0.0297 0.4065
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0218 0.4564 0.5213
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0218 0.4564 0.516
Loa Loa (eye worm) hypothetical protein 0.0024 0.0286 0.0327
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0018 0.0151 0.0437
Mycobacterium leprae Probable polyketide synthase Pks1 0.0026 0.0331 0.481
Loa Loa (eye worm) hypothetical protein 0.0018 0.0151 0.0172
Giardia lamblia Rab geranylgeranyltransferase 0.0075 0.1406 0.2843
Schistosoma mansoni tar DNA-binding protein 0.0251 0.5297 1
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0067 0.1235 0.2106
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0218 0.4564 0.6359
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0025 0.0297 0.1795
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0297 0.4065
Schistosoma mansoni hypothetical protein 0.0031 0.0435 0.0553
Echinococcus granulosus tumor protein p63 0.0332 0.709 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1921 0.2194
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0251 0.5297 0.605
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0067 0.1235 0.1316
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0067 0.1235 0.4199
Onchocerca volvulus 0.0075 0.1406 0.1176
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1921 0.2109
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0067 0.1235 0.11
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0067 0.1235 0.141
Onchocerca volvulus 0.0058 0.104 0.08
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0075 0.1406 1
Loa Loa (eye worm) hypothetical protein 0.0098 0.1921 0.2194
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0075 0.1406 0.2843
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0261 0.0298
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0075 0.1406 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0025 0.0297 0.4065
Loa Loa (eye worm) hypothetical protein 0.0067 0.1234 0.1409
Plasmodium vivax SET domain protein, putative 0.0058 0.104 0.2014
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.1234 0.1315
Brugia malayi MH2 domain containing protein 0.0119 0.2381 0.2639
Schistosoma mansoni hypothetical protein 0.0031 0.0435 0.0553
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0026 0.0331 0.2054
Onchocerca volvulus Huntingtin homolog 0.0119 0.2378 0.2175
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0067 0.1235 0.1562
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0075 0.1406 0.1808
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0261 0.0191
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0067 0.1235 0.11
Leishmania major hypothetical protein, conserved 0.0024 0.0286 0.1075
Onchocerca volvulus 0.0049 0.0822 0.0577
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0026 0.0331 0.481
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0026 0.0331 0.2054
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.104 0.1281
Schistosoma mansoni hypothetical protein 0.0067 0.1234 0.2104
Mycobacterium ulcerans thioesterase TesA 0.0021 0.0205 0.2064
Mycobacterium leprae Polyketide synthase Pks13 0.0037 0.0568 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.104 0.1727
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0143 0.2906 0.2797
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0016 0.0104 0.0273
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0286 0.0906
Mycobacterium ulcerans polyketide synthase 0.0025 0.0297 0.4065
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0018 0.0151 0.0172
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0024 0.028 0.1668
Trypanosoma cruzi protein farnesyltransferase, putative 0.0067 0.1235 0.8638
Loa Loa (eye worm) hypothetical protein 0.0049 0.0822 0.0939
Brugia malayi Pre-SET motif family protein 0.0058 0.104 0.1091
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0026 0.0331 0.481
Loa Loa (eye worm) hypothetical protein 0.0014 0.0055 0.0063
Echinococcus granulosus tar DNA binding protein 0.0251 0.5297 0.7416
Trypanosoma cruzi lanosterol synthase, putative 0.0074 0.1379 0.9789
Giardia lamblia Prenyltransferase 0.0067 0.1235 0.2456
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0075 0.1406 0.1513
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0075 0.1406 0.1808
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0297 0.4065
Schistosoma mansoni tar DNA-binding protein 0.0251 0.5297 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0018 0.0142 0.0623
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.1235 0.11
Brugia malayi hypothetical protein 0.0024 0.0286 0.022
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.104 0.1281
Loa Loa (eye worm) TAR-binding protein 0.0251 0.5297 0.605
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0218 0.4564 1
Giardia lamblia Rab geranylgeranyltransferase 0.0218 0.4564 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0025 0.0297 0.1795
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0218 0.4564 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0024 0.028 0.1668
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0025 0.0297 0.1795
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.1406 1
Mycobacterium ulcerans thioesterase 0.0021 0.0205 0.2064
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0261 0.1522
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0407 0.8755 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0435 0.041
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0075 0.1406 0.1605
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0075 0.1406 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.104 0.1727
Trypanosoma cruzi protein farnesyltransferase, putative 0.0067 0.1235 0.8638
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0286 0.0306
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.002 0.0197 0.1037
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0286 0.0306
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0021 0.0205 0.2064
Echinococcus multilocularis tar DNA binding protein 0.0251 0.5297 0.7416
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0018 0.0151 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.2381 0.2719
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0218 0.4564 0.8575
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0037 0.0568 0.3853
Toxoplasma gondii type I fatty acid synthase, putative 0.0026 0.0331 0.1061
Loa Loa (eye worm) hypothetical protein 0.0031 0.0435 0.0497
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0435 0.0497
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0435 0.0393
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0075 0.1406 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0067 0.1235 0.11
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0067 0.1235 0.1562
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.1406 1
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0067 0.1235 0.2456
Toxoplasma gondii hypothetical protein 0.0143 0.2906 1
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0286 0.1075
Schistosoma mansoni hypothetical protein 0.0031 0.0435 0.0553
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1921 0.2109
Brugia malayi RNA binding protein 0.0251 0.5297 0.6007
Loa Loa (eye worm) hypothetical protein 0.0119 0.2378 0.2716
Schistosoma mansoni tar DNA-binding protein 0.0251 0.5297 1
Echinococcus multilocularis tumor protein p63 0.0332 0.709 1
Leishmania major lanosterol synthase, putative 0.0056 0.0976 0.6574
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0075 0.1406 0.1808
Trypanosoma brucei lanosterol synthase 0.0074 0.1379 0.9789
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0075 0.1406 1
Echinococcus granulosus GPCR family 2 0.0031 0.0435 0.041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0435 0.041
Echinococcus multilocularis GPCR, family 2 0.0031 0.0435 0.041
Mycobacterium ulcerans Type I modular polyketide synthase 0.0025 0.0297 0.4065
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0286 0.0306
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0047 0.0788 0.08
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0992 0.1212
Mycobacterium tuberculosis Probable thioesterase TesA 0.0021 0.0205 0.1102
Brugia malayi hypothetical protein 0.0119 0.2378 0.2637
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0049 0.0831 0.1542
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.002 0.0189 0.172
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.104 0.1281
Loa Loa (eye worm) hypothetical protein 0.0218 0.4564 0.5213
Toxoplasma gondii type I fatty acid synthase, putative 0.0018 0.0138 0.0393
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0067 0.1235 0.11
Trypanosoma cruzi lanosterol synthase, putative 0.0074 0.1379 0.9789
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0218 0.4564 1
Onchocerca volvulus Huntingtin homolog 0.0119 0.2378 0.2175
Trichomonas vaginalis set domain proteins, putative 0.0464 1 1
Onchocerca volvulus Fatty acid synthase homolog 0.0045 0.0737 0.049
Schistosoma mansoni hypothetical protein 0.0031 0.0435 0.0553
Mycobacterium ulcerans polyketide synthase 0.0026 0.0331 0.481
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0822 0.1304
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0018 0.0151 0.0437
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0075 0.1406 0.1274
Loa Loa (eye worm) hypothetical protein 0.0058 0.104 0.1187
Loa Loa (eye worm) hypothetical protein 0.0042 0.067 0.0765
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0435 0.041
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0218 0.4564 0.4481
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.104 0.1727
Mycobacterium ulcerans polyketide synthase Pks13 0.0037 0.0568 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.002 0.0189 0.172
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.2381 0.2719
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0435 0.0393
Loa Loa (eye worm) fatty acid synthase 0.0025 0.0289 0.033
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0218 0.4564 0.6359

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6800 nM In vitro inhibitory concentration evaluated against P21ras Farnesyl transferase ChEMBL. No reference
IC50 (binding) = 6800 nM In vitro inhibitory concentration evaluated against P21ras Farnesyl transferase ChEMBL. No reference
IC50 (binding) = 6.8 uM Inhibition of Farnesyltransferase ChEMBL. 8558502
IC50 (binding) = 6.8 uM Inhibition of Farnesyltransferase ChEMBL. 8558502

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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