TDR Targets

Basic information

Technical information

TDR Targets ID: 209484
Name: 6-[3-[(4-chlorophenyl)methylamino]-2-hydroxyp ropoxy]-1H-quinolin-2-one
MW: 358.819 | Formula: C19H19ClN2O3
H donors: 3 H acceptors: 3 LogP: 3.21 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(COc1ccc2c(c1)ccc(n2)O)CNCc1ccc(cc1)Cl
InChi: 1S/C19H19ClN2O3/c20-15-4-1-13(2-5-15)10-21-11-16(23)12-25-17-6-7-18-14(9-17)3-8-19(24)22-18/h1-9,16,21,23H,10-12H2,(H,22,24)
InChiKey: SWXMNPKNSIWNMZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

6-[3-[(4-chlorophenyl)methylamino]-2-hydroxy-propoxy]-1H-quinolin-2-one
6-[3-[(4-chlorobenzyl)amino]-2-hydroxy-propoxy]carbostyril

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0126	0.1286	0.2659
Schistosoma mansoni	serine/threonine protein kinase	0.0234	0.3359	0.6458
Schistosoma mansoni	cyclin B3	0.0282	0.4279	0.8228
Echinococcus multilocularis	N chimaerin	0.0074	0.0293	0.0589
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0088	0.0565	0.0565
Brugia malayi	Protein kinase c protein 2	0.0211	0.2921	0.2921
Echinococcus multilocularis	cyclin B3 1	0.0282	0.4279	0.8592
Brugia malayi	hypothetical protein	0.0068	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1286	0.1286
Brugia malayi	Protein kinase domain containing protein	0.0088	0.0565	0.0565
Schistosoma mansoni	unc-13 (munc13)	0.0081	0.0438	0.0843
Echinococcus granulosus	Cyclin L1	0.0068	0.0181	0.0363
Schistosoma mansoni	unc-13 (munc13)	0.0081	0.0438	0.0843
Echinococcus granulosus	protein kinase c iota type	0.0318	0.498	1
Trypanosoma cruzi	cdc2-related kinase 3	0.01	0.0794	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0181	0.0181
Echinococcus multilocularis	unc 13 (munc13)	0.0081	0.0438	0.088
Echinococcus granulosus	Diacylglycerol kinase theta	0.0074	0.0293	0.0589
Schistosoma mansoni	rac gtpase activating protein	0.0074	0.0293	0.0564
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0087	0.0543	0.0543
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0234	0.3359	0.6744
Echinococcus multilocularis	protein kinase c epsilon type	0.0312	0.4856	0.9751
Echinococcus multilocularis	Tolloid protein 1	0.0087	0.0543	0.109
Echinococcus multilocularis	cyclins	0.0282	0.4279	0.8592
Echinococcus multilocularis	cyclin y	0.0068	0.0181	0.0363
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0565	0.1086
Trichomonas vaginalis	cyclin B3, putative	0.0282	0.4279	1
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0234	0.3359	0.6744
Echinococcus granulosus	Rac GTPase activating protein 1	0.0074	0.0293	0.0589
Echinococcus multilocularis	cyclin G2	0.0068	0.0181	0.0363
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0238	0.344	0.7952
Echinococcus granulosus	cyclin dependent kinase	0.01	0.0794	0.1595
Brugia malayi	diacylglycerol kinase	0.0074	0.0293	0.0293
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.01	0.0794	0.0794
Echinococcus multilocularis	cyclin t1	0.0068	0.0181	0.0363
Trichomonas vaginalis	cyclin B, putative	0.0282	0.4279	1
Brugia malayi	Protein kinase domain containing protein	0.0081	0.0435	0.0435
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0074	0.0293	0.0564
Schistosoma mansoni	egf-like domain protein	0.0087	0.0543	0.1044
Onchocerca volvulus		0.0285	0.4339	1
Echinococcus multilocularis	cyclins	0.0282	0.4279	0.8592
Trypanosoma brucei	mitotic cyclin 6	0.0282	0.4279	1
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0087	0.0543	0.1616
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0234	0.3359	0.7754
Echinococcus multilocularis	cyclin dependent kinase 5	0.01	0.0794	0.1595
Entamoeba histolytica	diacylglycerol kinase, putative	0.0074	0.0293	0.0274
Schistosoma mansoni	cyclin G2	0.0068	0.0181	0.0348
Schistosoma mansoni	serine/threonine protein kinase	0.0074	0.0293	0.0564
Echinococcus granulosus	raf serine:threonine protein kinase	0.0074	0.0293	0.0589
Echinococcus multilocularis	cyclins	0.0282	0.4279	0.8592
Onchocerca volvulus	Arrow homolog	0.0087	0.0543	0.087
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0646	0.1134
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0312	0.4856	0.4856
Schistosoma mansoni	hypothetical protein	0.0068	0.0181	0.0348
Brugia malayi	cyclin fold protein 1 variant b	0.0068	0.0181	0.0181
Entamoeba histolytica	cell division protein kinase 2, putative	0.01	0.0794	0.1497
Trypanosoma cruzi	cyclin, putative	0.0282	0.4279	1
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0282	0.4279	1
Trypanosoma brucei	cdc2-related kinase 3	0.01	0.0794	0.1497
Echinococcus granulosus	cyclins	0.0282	0.4279	0.8592
Echinococcus granulosus	cdk5 and abl1 enzyme substrate 1	0.0068	0.0181	0.0363
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0282	0.4279	0.4279
Brugia malayi	Cyclin C	0.0068	0.0181	0.0181
Trypanosoma cruzi	cyclin 6, putative	0.0282	0.4279	1
Echinococcus multilocularis	oligomeric golgi complex subunit 3	0.0068	0.0181	0.0363
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0646	0.1134
Schistosoma mansoni	protein kinase C mu	0.0074	0.0293	0.0564
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0565	0.1086
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0293	0.0293
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0234	0.3359	0.3359
Loa Loa (eye worm)	hypothetical protein	0.0078	0.0375	0.0375
Giardia lamblia	Cyclin A	0.0282	0.4279	1
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.0794	0.1497
Echinococcus multilocularis	Cyclin L1	0.0068	0.0181	0.0363
Schistosoma mansoni	serine/threonine protein kinase	0.0292	0.4466	0.8588
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0234	0.3359	0.6744
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0074	0.0293	0.0589
Entamoeba histolytica	cyclin, putative	0.0282	0.4279	1
Echinococcus multilocularis	myotubularin protein 13	0.0078	0.0375	0.0752
Giardia lamblia	Kinase, CMGC CDK	0.01	0.0794	0.1497
Loa Loa (eye worm)	cyclin domain-containing protein	0.0282	0.4279	0.4279
Brugia malayi	protein kinase C3,putative	0.0238	0.3435	0.3435
Loa Loa (eye worm)	cyclin domain-containing protein	0.0068	0.0181	0.0181
Entamoeba histolytica	protein kinase, putative	0.0088	0.0565	0.0936
Schistosoma mansoni	cyclin d	0.0068	0.0181	0.0348
Onchocerca volvulus		0.02	0.2702	0.6064
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0794	0.1528
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0234	0.3359	0.7754
Trichomonas vaginalis	cyclin D, putative	0.0282	0.4279	1
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0081	0.0423	0.0591
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0234	0.3359	0.7754
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0092	0.0646	0.1134
Schistosoma mansoni	hypothetical protein	0.0074	0.0293	0.0564
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.01	0.0794	0.0794
Loa Loa (eye worm)	hypothetical protein	0.0234	0.3359	0.3359
Schistosoma mansoni	hypothetical protein	0.0068	0.0181	0.0348
Entamoeba histolytica	protein kinase, putative	0.0092	0.0646	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0543	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0293	0.0293
Loa Loa (eye worm)	raf kinase	0.0074	0.0293	0.0293
Schistosoma mansoni	cyclin B	0.0282	0.4279	0.8228
Echinococcus granulosus	cyclin t1	0.0068	0.0181	0.0363
Trichomonas vaginalis	cyclins, putative	0.0282	0.4279	1
Echinococcus granulosus	cyclin A3 4	0.0068	0.0181	0.0363
Echinococcus granulosus	laminin	0.0087	0.0543	0.109
Echinococcus granulosus	protein kinase c eta type	0.0074	0.0293	0.0589
Echinococcus granulosus	RNA directed DNA polymerase	0.0122	0.1218	0.2446
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0088	0.0565	0.0565
Brugia malayi	C1-like domain containing protein	0.0207	0.2844	0.2844
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0068	0.0181	0.0181
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0088	0.0565	0.0565
Echinococcus multilocularis	protein kinase c eta type	0.0074	0.0293	0.0589
Loa Loa (eye worm)	cyclin domain-containing protein	0.058	1	1
Echinococcus multilocularis	serine threonine protein kinase	0.0218	0.305	0.6125
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0087	0.0543	0.1044
Schistosoma mansoni	diacylglycerol kinase theta	0.0074	0.0293	0.0564
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0081	0.0435	0.0873
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0293	0.0293
Trichomonas vaginalis	cyclins, putative	0.0282	0.4279	1
Echinococcus granulosus	cyclin y	0.0068	0.0181	0.0363
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0137	0.1505	0.1505
Echinococcus granulosus	cyclin k	0.0068	0.0181	0.0363
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0074	0.0293	0.0293
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0087	0.0543	0.0543
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0234	0.3359	0.7754
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0122	0.1218	0.2446
Brugia malayi	RhoGAP domain containing protein	0.0074	0.0293	0.0293
Echinococcus granulosus	unc 13 munc13	0.0081	0.0438	0.088
Trichomonas vaginalis	cyclins, putative	0.0282	0.4279	1
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0088	0.0565	0.1134
Plasmodium vivax	protein kinase Crk2	0.01	0.0794	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0543	0.0543
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.01	0.0794	0.1497
Plasmodium falciparum	cyclin dependent kinase binding protein, putative	0.0068	0.0181	0.0423
Leishmania major	protein kinase A catalytic subunit	0.0234	0.3359	0.7754
Trichomonas vaginalis	cyclins, putative	0.0282	0.4279	1
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0068	0.0181	0.0423
Trypanosoma brucei	cdc2-related kinase 1	0.01	0.0794	0.1497
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0565	0.1086
Giardia lamblia	Hypothetical protein	0.0282	0.4279	1
Brugia malayi	Calcium binding EGF domain containing protein	0.0087	0.0543	0.0543
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0181	0.0181
Brugia malayi	diacylglycerol kinase	0.0074	0.0293	0.0293
Echinococcus granulosus	cyclins	0.0068	0.0181	0.0363
Trichomonas vaginalis	cyclins, putative	0.0282	0.4279	1
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0088	0.0565	0.1134
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0234	0.3359	0.6744
Echinococcus multilocularis	cyclin y	0.0068	0.0181	0.0363
Entamoeba histolytica	cyclin, putative	0.0282	0.4279	1
Entamoeba histolytica	cell division protein kinase 2, putative	0.01	0.0794	0.1497
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0646	0.1134
Entamoeba histolytica	cyclin family protein	0.0282	0.4279	1
Loa Loa (eye worm)	hypothetical protein	0.0282	0.4279	0.4279
Echinococcus granulosus	cyclin B	0.0282	0.4279	0.8592
Echinococcus multilocularis	cyclin k	0.0068	0.0181	0.0363
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0234	0.3359	0.7754
Toxoplasma gondii	cyclin domain protein, cyclin H family protein	0.0068	0.0181	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0282	0.4279	0.4279
Brugia malayi	RhoGAP domain containing protein	0.0074	0.0293	0.0293
Entamoeba histolytica	hypothetical protein	0.0074	0.0293	0.0274
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0068	0.0181	0.0181
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0435	0.0836
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0293	0.0293
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0088	0.0565	0.1134
Echinococcus granulosus	cyclin B3 1	0.0282	0.4279	0.8592
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0646	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0285	0.4339	0.4339
Loa Loa (eye worm)	cyclin domain-containing protein	0.0068	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0196	0.2634	0.2634
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0249	0.3655	0.3655
Trypanosoma cruzi	cyclin, putative	0.0282	0.4279	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0074	0.0293	0.0589
Toxoplasma gondii	cyclin dependent kinase binding protein	0.0068	0.0181	0.0539
Echinococcus granulosus	N chimaerin	0.0074	0.0293	0.0589
Echinococcus multilocularis	cyclin b3	0.0282	0.4279	0.8592
Plasmodium falciparum	cyclin	0.0282	0.4279	1
Echinococcus granulosus	serine:threonine protein kinase N2	0.015	0.175	0.3514
Schistosoma mansoni	g1/s-specific cyclin C	0.0068	0.0181	0.0348
Entamoeba histolytica	cyclin family protein	0.0282	0.4279	1
Trypanosoma cruzi	cdc2-related kinase 3	0.01	0.0794	0.1497
Schistosoma mansoni	diacylglycerol kinase theta	0.0074	0.0293	0.0564
Plasmodium falciparum	cyclin 1	0.0068	0.0181	0.0423
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0087	0.0543	0.1616
Toxoplasma gondii	cyclin, N-terminal domain-containing protein	0.0068	0.0181	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0653	0.0653
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0074	0.0293	0.0564
Brugia malayi	Fibulin-1 precursor	0.0087	0.0543	0.0543
Onchocerca volvulus		0.0081	0.0438	0.0619
Echinococcus granulosus	cyclin	0.0068	0.0181	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0543	0.0543
Loa Loa (eye worm)	RasGEF domain-containing protein	0.0074	0.0293	0.0293
Toxoplasma gondii	hypothetical protein	0.0214	0.2976	0.8859
Echinococcus granulosus	NDR protein kinase	0.0088	0.0565	0.1134
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0226	0.3217	0.646
Echinococcus multilocularis	cyclin G2	0.0068	0.0181	0.0363
Echinococcus granulosus	cyclin y	0.0068	0.0181	0.0363
Schistosoma mansoni	serine/threonine protein kinase	0.0292	0.4466	0.8588
Echinococcus granulosus	cyclins	0.0282	0.4279	0.8592
Loa Loa (eye worm)	hypothetical protein	0.02	0.2702	0.2702
Echinococcus granulosus	oligomeric golgi complex subunit 3	0.0068	0.0181	0.0363
Schistosoma mansoni	serine/threonine protein kinase	0.0234	0.3359	0.6458
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0234	0.3359	1
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0234	0.3359	0.3359
Schistosoma mansoni	serine/threonine protein kinase	0.0088	0.0565	0.1086
Brugia malayi	Protein kinase domain containing protein	0.0088	0.0565	0.0565
Entamoeba histolytica	protein kinase, putative	0.0092	0.0646	0.1134
Echinococcus granulosus	Tolloid protein 1	0.0087	0.0543	0.109
Brugia malayi	Protein kinase domain containing protein	0.01	0.0794	0.0794
Echinococcus multilocularis	cyclins	0.0282	0.4279	0.8592
Brugia malayi	p70 ribosomal S6 kinase beta	0.0088	0.0565	0.0565
Schistosoma mansoni	cyclin l	0.0068	0.0181	0.0348
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0088	0.0565	0.1134
Toxoplasma gondii	AGC kinase	0.0234	0.3359	1
Trichomonas vaginalis	cyclin B, putative	0.0282	0.4279	1
Onchocerca volvulus		0.0204	0.2784	0.6259
Echinococcus granulosus	G2:mitotic specific cyclin B3	0.0282	0.4279	0.8592
Echinococcus multilocularis	serine:threonine protein kinase	0.021	0.2894	0.5812
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0282	0.4279	0.4279
Trypanosoma cruzi	cdc2-related kinase 1	0.01	0.0794	0.1497
Trichomonas vaginalis	cyclin D, putative	0.0282	0.4279	1
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0081	0.0438	0.088
Trichomonas vaginalis	cyclin A, putative	0.0282	0.4279	1
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0081	0.0435	0.0873
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0133	0.1428	0.1428
Giardia lamblia	G2/mitotic-specific cyclin B	0.0282	0.4279	1
Loa Loa (eye worm)	hypothetical protein	0.0285	0.4339	0.4339
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0234	0.3359	0.6744
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0226	0.3217	0.646
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.01	0.0794	0.2365
Schistosoma mansoni	cyclin G	0.0068	0.0181	0.0348
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1218	0.1218
Schistosoma mansoni	serine/threonine protein kinase	0.0081	0.0435	0.0836
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0646	0.1134
Loa Loa (eye worm)	CYL-1 protein	0.0068	0.0181	0.0181
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.0794	0.1497
Brugia malayi	hypothetical protein	0.0068	0.0181	0.0181
Echinococcus multilocularis	G2:mitotic specific cyclin B3	0.0282	0.4279	0.8592
Loa Loa (eye worm)	cyclin C	0.0068	0.0181	0.0181
Loa Loa (eye worm)	hypothetical protein	0.0204	0.2784	0.2784
Trichomonas vaginalis	cyclin B, putative	0.0282	0.4279	1
Loa Loa (eye worm)	hypothetical protein	0.009	0.06	0.06
Schistosoma mansoni	serine/threonine protein kinase	0.0312	0.4856	0.9338
Giardia lamblia	Kinase, CMGC CDK	0.01	0.0794	0.1497
Trichomonas vaginalis	AGC family protein kinase	0.0088	0.0565	0.0936
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0074	0.0293	0.0589
Brugia malayi	cell division control protein 2 homolog	0.01	0.0794	0.0794
Echinococcus multilocularis	cyclins	0.0282	0.4279	0.8592
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0282	0.4279	1
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0646	0.1134
Echinococcus multilocularis	cyclin dependent kinase 1	0.01	0.0794	0.1595
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0092	0.0646	0.0646
Echinococcus multilocularis	fibrillin 1	0.0087	0.0543	0.109
Schistosoma mansoni	atypical protein kinase C	0.033	0.5201	1
Schistosoma mansoni	cyclins	0.0282	0.4279	0.8228
Trypanosoma cruzi	cdc2-related kinase 1	0.01	0.0794	0.1497
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.0074	0.0293	0.0293
Echinococcus multilocularis	myosin light chain kinase, smooth muscle	0.021	0.2894	0.5812
Brugia malayi	RhoGEF domain containing protein	0.0074	0.0293	0.0293
Trichomonas vaginalis	conserved hypothetical protein	0.0282	0.4279	1
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0074	0.0293	0.0589
Echinococcus multilocularis	cdk5 and abl1 enzyme substrate 1	0.0068	0.0181	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0126	0.1286	0.1286
Trichomonas vaginalis	AGC family protein kinase	0.0088	0.0565	0.0936
Entamoeba histolytica	diacylglycerol kinase, putative	0.0074	0.0293	0.0274
Echinococcus granulosus	cyclin G2	0.0068	0.0181	0.0363
Toxoplasma gondii	diacylglycerol kinase, putative	0.0074	0.0293	0.0873
Schistosoma mansoni	protein kinase C	0.0081	0.0438	0.0843
Schistosoma mansoni	vav2	0.0078	0.0375	0.072
Trichomonas vaginalis	AGC family protein kinase	0.0234	0.3359	0.7754
Echinococcus granulosus	serine:threonine protein kinase	0.021	0.2894	0.5812
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0282	0.4279	0.4279
Echinococcus granulosus	myosin light chain kinase smooth muscle	0.021	0.2894	0.5812
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0238	0.344	0.7952
Trichomonas vaginalis	cyclin B, putative	0.0282	0.4279	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0068	0.0181	0.0181
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0068	0.0181	0.0181
Echinococcus granulosus	cyclin b3	0.0282	0.4279	0.8592
Trichomonas vaginalis	cyclin B, putative	0.0282	0.4279	1
Loa Loa (eye worm)	cyclin domain-containing protein	0.0068	0.0181	0.0181
Echinococcus granulosus	cyclins	0.0282	0.4279	0.8592
Schistosoma mansoni	protein kinase C mu	0.0207	0.2844	0.5469
Echinococcus granulosus	protein kinase c epsilon type	0.0312	0.4856	0.9751
Echinococcus granulosus	Protein kinase C brain isozyme	0.0292	0.4466	0.8968
Echinococcus granulosus	myotubularin protein 13	0.0078	0.0375	0.0752
Schistosoma mansoni	cyclin k	0.0068	0.0181	0.0348
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0234	0.3359	0.7754
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0234	0.3359	1
Loa Loa (eye worm)	cyclin fold protein 1 variant b	0.0068	0.0181	0.0181
Echinococcus granulosus	cyclins	0.0282	0.4279	0.8592
Echinococcus multilocularis	Rac GTPase activating protein 1	0.0074	0.0293	0.0589
Echinococcus multilocularis	cyclin dependent kinase	0.01	0.0794	0.1595
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0234	0.3359	0.7754
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0234	0.3359	0.7754
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0088	0.0565	0.0565
Echinococcus granulosus	protein kinase C gamma type	0.0218	0.305	0.6125
Loa Loa (eye worm)	hypothetical protein	0.0359	0.5755	0.5755
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0207	0.2844	0.2844
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0074	0.0293	0.0293
Echinococcus granulosus	cyclins	0.0282	0.4279	0.8592
Echinococcus granulosus	cyclin dependent kinase 1	0.01	0.0794	0.1595
Toxoplasma gondii	hypothetical protein	0.0068	0.0181	0.0539
Loa Loa (eye worm)	hypothetical protein	0.0373	0.6026	0.6026
Schistosoma mansoni	serine/threonine protein kinase	0.0234	0.3359	0.6458
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0234	0.3359	0.3359
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0234	0.3359	0.7849
Echinococcus multilocularis	RNA directed DNA polymerase	0.0122	0.1218	0.2446
Echinococcus granulosus	serine:threonine protein kinase N2	0.0088	0.0565	0.1134
Toxoplasma gondii	AGC kinase	0.0088	0.0565	0.1681
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0154	0.1831	0.4026
Schistosoma mansoni	serine/threonine kinase	0.0088	0.0565	0.1086
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0088	0.0565	0.1134
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0088	0.0565	0.1134
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0088	0.0565	0.0565
Echinococcus multilocularis	cyclin A3 4	0.0068	0.0181	0.0363
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.01	0.0794	0.1595
Echinococcus multilocularis	cyclins	0.0282	0.4279	0.8592
Loa Loa (eye worm)	cyclin domain-containing protein	0.0068	0.0181	0.0181
Trichomonas vaginalis	AGC family protein kinase	0.0088	0.0565	0.0936
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0292	0.4466	0.8968
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0207	0.2844	0.2844
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0646	0.1134
Echinococcus multilocularis	cyclin dependent kinase 1	0.01	0.0794	0.1595
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0234	0.3359	0.6744
Trichomonas vaginalis	AGC family protein kinase	0.0092	0.0646	0.1134
Echinococcus multilocularis	cyclin B	0.0282	0.4279	0.8592
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0088	0.0565	0.1134
Echinococcus granulosus	cyclin G2	0.0068	0.0181	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0285	0.4339	0.4339
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0068	0.0181	0.0181
Brugia malayi	protein kinase C II.	0.0312	0.4856	0.4856
Schistosoma mansoni	Cyclin fold protein	0.0068	0.0181	0.0348
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0081	0.0438	0.088
Brugia malayi	Hr1 repeat family protein	0.0088	0.0565	0.0565
Entamoeba histolytica	protein kinase, putative	0.0088	0.0565	0.0936
Echinococcus granulosus	G1:S specific cyclin D1	0.0068	0.0181	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0543	0.0543
Onchocerca volvulus		0.0282	0.4279	0.9856
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.01	0.0794	0.0794
Trichomonas vaginalis	CMGC family protein kinase	0.01	0.0794	0.1497
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0293	0.0293
Echinococcus multilocularis	cyclin	0.0068	0.0181	0.0363
Toxoplasma gondii	cyclin 4, putative	0.0068	0.0181	0.0539
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0231	0.3295	0.6617
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0234	0.3359	0.6744
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0068	0.0181	0.0348
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0087	0.0543	0.0543
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0068	0.0181	0.0181
Schistosoma mansoni	serine/threonine protein kinase	0.01	0.0794	0.1528
Brugia malayi	Protein kinase domain containing protein	0.0092	0.0646	0.0646
Brugia malayi	Pleckstrin Homology Domain	0.0078	0.0375	0.0375
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0088	0.0565	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0293	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0438	0.0438
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0234	0.3359	0.7754
Plasmodium falciparum	protein kinase 5	0.01	0.0794	0.1857
Echinococcus multilocularis	cyclins	0.0282	0.4279	0.8592
Toxoplasma gondii	AGC kinase	0.0234	0.3359	1
Echinococcus granulosus	cyclin dependent kinase 5	0.01	0.0794	0.1595
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0088	0.0565	0.1134
Echinococcus multilocularis	protein kinase c iota type	0.0318	0.498	1
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.01	0.0794	0.1497
Leishmania major	cyclin	0.0282	0.4279	1
Brugia malayi	Variant SH3 domain containing protein	0.0074	0.0293	0.0293
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0087	0.0543	0.0543
Echinococcus multilocularis	G1:S specific cyclin D1	0.0068	0.0181	0.0363
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0068	0.0181	0.0181
Echinococcus multilocularis	laminin	0.0087	0.0543	0.109
Giardia lamblia	Kinase, AGC PKA	0.0234	0.3359	0.7754
Brugia malayi	Ras association domain family 1 isoform A	0.0074	0.0293	0.0293

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0	The chronotropic effect tested in vitro by using isolated blood-perfused dog heart preparations	ChEMBL.	1331445
Activity (functional)	= 4.9	The inotropic effect tested in vitro by using isolated blood-perfused dog heart preparations	ChEMBL.	1331445

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL120597
PubChem: 10247856

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 209484