TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 327.381 | Formula: C17H21N5O2
H donors: 3 H acceptors: 5 LogP: 1.39 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H](Cn1cnc2c1ncnc2N[C@@H](Cc1ccccc1)C)O
InChi: 1S/C17H21N5O2/c1-12(7-13-5-3-2-4-6-13)21-16-15-17(19-10-18-16)22(11-20-15)8-14(24)9-23/h2-6,10-12,14,23-24H,7-9H2,1H3,(H,18,19,21)/t12-,14+/m1/s1
InChiKey: JXLMYGYJHCFSIH-OCCSQVGLSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Adenosine A2 receptor	Starlite/ChEMBL	References
Rattus norvegicus	Adenosine A1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	hypothetical protein	Adenosine A1 receptor	326 aa	305 aa	21.0 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Adenosine A1 receptor	326 aa	295 aa	28.1 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	311 aa	21.2 %
Onchocerca volvulus		Adenosine A2 receptor	410 aa	356 aa	23.9 %
Onchocerca volvulus		Adenosine A2 receptor	410 aa	337 aa	23.1 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Adenosine A2 receptor	410 aa	399 aa	28.1 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	306 aa	21.2 %
Onchocerca volvulus	Ubiquinol-cytochrome-c reductase complex assembly factor 1 homolog	Adenosine A1 receptor	326 aa	286 aa	22.7 %
Schistosoma japonicum	ko:K04136 adrenergic receptor, alpha 1b, putative	Adenosine A2 receptor	410 aa	366 aa	25.4 %
Echinococcus multilocularis	allatostatin A receptor	Adenosine A1 receptor	326 aa	303 aa	24.1 %
Loa Loa (eye worm)	neuropeptide F receptor	Adenosine A1 receptor	326 aa	316 aa	19.9 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Adenosine A1 receptor	326 aa	286 aa	26.9 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	323 aa	20.7 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Adenosine A1 receptor	326 aa	321 aa	23.1 %
Schistosoma mansoni	neuropeptide receptor	Adenosine A1 receptor	326 aa	274 aa	22.6 %
Loa Loa (eye worm)	hypothetical protein	Adenosine A1 receptor	326 aa	300 aa	24.3 %
Echinococcus multilocularis	neuropeptide receptor	Adenosine A1 receptor	326 aa	299 aa	22.4 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Adenosine A1 receptor	326 aa	327 aa	24.8 %
Onchocerca volvulus		Adenosine A1 receptor	326 aa	304 aa	21.1 %
Schistosoma mansoni	dro/myosuppressin receptor	Adenosine A1 receptor	326 aa	326 aa	22.1 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Adenosine A1 receptor	326 aa	321 aa	22.7 %
Echinococcus granulosus	neuropeptide receptor	Adenosine A1 receptor	326 aa	299 aa	22.4 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	315 aa	21.6 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Adenosine A2 receptor	410 aa	346 aa	28.3 %
Echinococcus granulosus	allatostatin A receptor	Adenosine A1 receptor	326 aa	303 aa	24.1 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Adenosine A1 receptor	326 aa	317 aa	24.6 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Adenosine A2 receptor	410 aa	340 aa	27.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	amine GPCR	0.0023	0.0308	0.0281
Brugia malayi	Smad1	0.0016	0.0114	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0232	0.6784	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0023	0.0308	0.0413
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0029	0.0494	0.0479
Mycobacterium ulcerans	multifunctional mycocerosic acid synthase membrane-associated Mas	0.0027	0.0434	0.481
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0016	0.0114	0.0099
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.2446	0.2435
Mycobacterium tuberculosis	Probable polyketide synthase Pks7	0.0027	0.0434	0.0569
Trichomonas vaginalis	set domain proteins, putative	0.0236	0.6894	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Echinococcus multilocularis	tumor protein p63	0.0336	1	1
Mycobacterium leprae	Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas	0.0027	0.0434	0.481
Echinococcus multilocularis	sex peptide receptor	0.0023	0.0308	0.0293
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0023	0.0308	0.0335
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsB	0.002	0.0234	0.172
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.0308	0.0293
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0413	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0023	0.0308	0.0413
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0308	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Brugia malayi	ORL1-like opioid receptor	0.0023	0.0308	0.0335
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.003	0.0527	0.7194
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0308	0.0281
Onchocerca volvulus		0.0027	0.0451	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0092	0.2446	0.3282
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0451	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	opsin-like receptor	0.0023	0.0308	0.0281
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.2446	0.2435
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0023	0.0308	0.0293
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0023	0.0308	0.0335
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0023	0.0308	0.0281
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0023	0.0308	0.0293
Mycobacterium ulcerans	lipase LipD	0.0036	0.0732	0.9423
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0308	0.0281
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0732	1
Echinococcus granulosus	neuropeptide s receptor	0.0023	0.0308	0.0293
Toxoplasma gondii	type I fatty acid synthase, putative	0.0027	0.0434	0.5916
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.006	0.0081
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0435	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0044	0.006
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Brugia malayi	follicle stimulating hormone receptor	0.0023	0.0308	0.0335
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0092	0.2446	0.2435
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Brugia malayi	Intermediate filament tail domain containing protein	0.0027	0.0451	0.0528
Echinococcus multilocularis	lamin dm0	0.0027	0.0451	0.0436
Mycobacterium tuberculosis	Probable multifunctional mycocerosic acid synthase membrane-associated Mas	0.0027	0.0434	0.0569
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0308	0.0281
Onchocerca volvulus		0.0036	0.0732	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0732	0.0983
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0732	0.9423
Mycobacterium tuberculosis	Probable lipase LipE	0.0036	0.0732	0.1012
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0023	0.0308	0.0293
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0308	0.0281
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.2446	0.3189
Schistosoma mansoni	lamin	0.0027	0.0451	0.0475
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.1164	0.1493
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0101	0.0086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Echinococcus multilocularis	lamin	0.0027	0.0451	0.0436
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Onchocerca volvulus		0.0036	0.0732	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Mycobacterium tuberculosis	Polyketide synthase Pks12	0.0027	0.0434	0.0569
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0023	0.0335	0.0422
Schistosoma mansoni	tar DNA-binding protein	0.0254	0.7454	1
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Mycobacterium ulcerans	thioesterase TesA	0.0021	0.0256	0.2064
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0672	0.0902
Echinococcus multilocularis	smad	0.0016	0.0114	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0308	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus granulosus	7tm_1 domain containing protein	0.0023	0.0308	0.0293
Loa Loa (eye worm)	melatonin receptor type 1A	0.0023	0.0308	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0413	0.5
Loa Loa (eye worm)	RNA binding protein	0.0254	0.7454	1
Onchocerca volvulus		0.0036	0.0732	0.0645
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0308	0.0293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0732	0.0983
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0023	0.0308	0.0335
Schistosoma mansoni	tar DNA-binding protein	0.0254	0.7454	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0023	0.0308	0.0335
Schistosoma mansoni	amine GPCR	0.0023	0.0308	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0036	0.0732	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0308	0.0413
Loa Loa (eye worm)	TAR-binding protein	0.0254	0.7454	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0092	0.2446	0.2435
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0114	0.0017
Echinococcus multilocularis	serotonin receptor	0.0023	0.0308	0.0293
Onchocerca volvulus		0.0023	0.0335	0.0041
Schistosoma mansoni	hypothetical protein	0.0169	0.4833	0.6436
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.0308	0.0293
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0023	0.0308	0.0281
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0386	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Toxoplasma gondii	beta-ketoacyl synthase, N-terminal domain-containing protein	0.0016	0.0113	0.1523
Echinococcus granulosus	smad	0.0016	0.0114	0.0099
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0308	0.0281
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0732	0.1012
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0027	0.0451	0.0605
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.003	0.0527	0.0579
Brugia malayi	AKH receptor	0.0023	0.0308	0.0335
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0732	0.9423
Brugia malayi	G protein-coupled receptor	0.0023	0.0308	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0023	0.0308	0.0293
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0308	0.0281
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0025	0.0386	0.0498
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0732	0.0983
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0308	0.0413
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0023	0.0308	0.0413
Echinococcus multilocularis	allatostatin A receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0101	0.0136
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA	0.0025	0.0386	0.4065
Brugia malayi	MH2 domain containing protein	0.0016	0.0114	0.0073
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0527	0.0579
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0732	0.0983
Brugia malayi	neuropeptide F receptor	0.0023	0.0308	0.0335
Schistosoma mansoni	hypothetical protein	0.0034	0.0672	0.0776
Brugia malayi	Serotonin receptor	0.0023	0.0308	0.0335
Echinococcus multilocularis	somatostatin receptor	0.0023	0.0308	0.0293
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0016	0.0114	0.0099
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.2446	0.3189
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Loa Loa (eye worm)	fatty acid synthase	0.0025	0.0375	0.0504
Loa Loa (eye worm)	hypothetical protein	0.0049	0.113	0.1516
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0023	0.0308	0.0293
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0254	0.7454	1
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0308	0.0293
Brugia malayi	beta-lactamase family protein	0.0036	0.0732	0.0909
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0023	0.0308	0.0281
Loa Loa (eye worm)	TYRA-2 protein	0.0023	0.0308	0.0413
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0101	0.0086
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0101	0.0056
Schistosoma mansoni	amine GPCR	0.0023	0.0308	0.0281
Loa Loa (eye worm)	hypothetical protein	0.003	0.0527	0.0708
Toxoplasma gondii	ABC1 family protein	0.0036	0.0732	1
Brugia malayi	oxidoreductase, zinc-binding dehydrogenase family protein	0.0048	0.1081	0.1381
Echinococcus granulosus	g-protein coupled receptor	0.0023	0.0308	0.0293
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0732	0.0718
Schistosoma mansoni	myosin xvIII	0.0023	0.0308	0.0281
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Loa Loa (eye worm)	Smad1	0.0016	0.0114	0.0153
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.002	0.0234	0.172
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0023	0.0308	0.0281
Brugia malayi	Melatonin receptor type 1A	0.0023	0.0308	0.0335
Mycobacterium tuberculosis	Polyketide synthase Pks13	0.0038	0.077	0.1068
Brugia malayi	Dopamine receptor	0.0023	0.0308	0.0335
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0092	0.2446	0.3227
Echinococcus multilocularis	musashi	0.0027	0.0451	0.0436
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0308	0.0293
Onchocerca volvulus		0.0027	0.0451	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0914	0.1226
Schistosoma mansoni	neuropeptide f receptor 76f	0.0023	0.0308	0.0281
Echinococcus granulosus	serotonin receptor	0.0023	0.0308	0.0293
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0023	0.0308	0.0293
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0308	0.0293
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0732	0.0858
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0023	0.0308	0.0293
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0308	0.0293
Schistosoma mansoni	opsin-like receptor	0.0023	0.0308	0.0281
Echinococcus granulosus	geminin	0.0169	0.4833	0.4825
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.0308	0.0293
Echinococcus multilocularis	neuropeptide receptor A26	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Brugia malayi	TAR-binding protein	0.0254	0.7454	1
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0732	0.1012
Echinococcus granulosus	7TM GPCR rhodopsin	0.0023	0.0308	0.0293
Plasmodium vivax	hypothetical protein, conserved	0.0036	0.0732	1
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0016	0.0114	0.0099
Echinococcus multilocularis	serotonin receptor	0.0023	0.0308	0.0293
Mycobacterium ulcerans	thioesterase	0.0021	0.0256	0.2064
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0732	0.0983
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0023	0.0308	0.0293
Echinococcus granulosus	neuropeptides capa receptor	0.0023	0.0308	0.0293
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD	0.0025	0.0386	0.4065
Mycobacterium tuberculosis	Probable membrane bound polyketide synthase Pks6	0.0038	0.077	0.1068
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0023	0.0308	0.0281
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0023	0.0335	0.0449
Schistosoma mansoni	growth hormone secretagogue receptor	0.0023	0.0308	0.0281
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0023	0.0308	0.0293
Schistosoma mansoni	tar DNA-binding protein	0.0254	0.7454	1
Brugia malayi	MH2 domain containing protein	0.0016	0.0114	0.0073
Brugia malayi	Pre-SET motif family protein	0.0207	0.6009	0.8046
Echinococcus granulosus	neuropeptide receptor	0.0023	0.0308	0.0293
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0308	0.0281
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0732	0.0858
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0114	0.0017
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Echinococcus granulosus	GPCR family 2	0.0016	0.0101	0.0086
Mycobacterium tuberculosis	Probable esterase LipL	0.0036	0.0732	0.1012
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0308	0.0293
Schistosoma mansoni	hypothetical protein	0.0023	0.0308	0.0281
Loa Loa (eye worm)	MH2 domain-containing protein	0.0239	0.7013	0.9408
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus granulosus	histone lysine methyltransferase setb	0.003	0.0527	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0413	0.0554
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0023	0.0308	0.0281
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0386	0.4065
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.0308	0.0293
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0308	0.0281
Brugia malayi	putative neuropeptide receptor NPR1	0.0023	0.0308	0.0335
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.1164	0.1493
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus granulosus	allatostatin A receptor	0.0023	0.0308	0.0293
Echinococcus granulosus	fmrfamide receptor	0.0023	0.0308	0.0293
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.005	0.1164	0.1562
Schistosoma mansoni	lamin	0.0027	0.0451	0.0475
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Brugia malayi	MH1 domain containing protein	0.0016	0.0114	0.0073
Echinococcus granulosus	intermediate filament protein	0.0027	0.0451	0.0436
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0023	0.0308	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Mycobacterium ulcerans	polyketide synthase Pks13	0.0038	0.077	1
Mycobacterium ulcerans	phenolpthiocerol synthesis type-I polyketide synthase PpsC	0.0027	0.0434	0.481
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0023	0.0308	0.0335
Echinococcus granulosus	orexin receptor type 2	0.0023	0.0308	0.0293
Echinococcus granulosus	neuropeptide receptor A26	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Brugia malayi	Pre-SET motif family protein	0.003	0.0527	0.0632
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0023	0.0308	0.0281
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.0308	0.0293
Mycobacterium tuberculosis	Probable hydrolase	0.0036	0.0732	0.1012
Leishmania major	hypothetical protein, conserved	0.0036	0.0732	1
Brugia malayi	G-protein coupled receptor	0.0023	0.0308	0.0335
Echinococcus multilocularis	g protein coupled receptor	0.0023	0.0308	0.0293
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0732	0.0909
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Loa Loa (eye worm)	G-protein coupled receptor	0.0023	0.0308	0.0413
Echinococcus granulosus	Smad4	0.0016	0.0114	0.0099
Loa Loa (eye worm)	intermediate filament protein	0.0027	0.0451	0.0605
Brugia malayi	hypothetical protein	0.0026	0.0413	0.0477
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0023	0.0308	0.0281
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsA	0.0025	0.0386	0.0498
Echinococcus granulosus	lamin dm0	0.0027	0.0451	0.0436
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0335	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	amine GPCR	0.0023	0.0308	0.0281
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0015	0.0021
Mycobacterium ulcerans	polyketide synthase	0.0025	0.0386	0.4065
Brugia malayi	intermediate filament protein	0.0027	0.0451	0.0528
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0732	0.9423
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0023	0.0308	0.0281
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0023	0.0308	0.0293
Brugia malayi	RE15519p	0.0023	0.0308	0.0335
Echinococcus granulosus	mothers against decapentaplegic 5	0.0016	0.0114	0.0099
Echinococcus multilocularis	neuropeptide receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0023	0.0308	0.0413
Echinococcus multilocularis	G protein coupled receptor 139	0.0023	0.0308	0.0293
Schistosoma mansoni	tar DNA-binding protein	0.0254	0.7454	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	cellular tumor antigen P53	0.0049	0.113	0.1399
Echinococcus multilocularis	tar DNA binding protein	0.0254	0.7454	0.745
Onchocerca volvulus		0.0236	0.6894	1
Echinococcus multilocularis	neuropeptide s receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	neuropeptide F receptor	0.0023	0.0308	0.0413
Brugia malayi	Serotonin receptor	0.0023	0.0308	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0732	1
Schistosoma mansoni	Smad4	0.0016	0.0114	0.0017
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0308	0.0293
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0732	0.9423
Plasmodium vivax	SET domain protein, putative	0.003	0.0527	0.3583
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0023	0.0308	0.0413
Schistosoma mansoni	neuropeptide receptor	0.0023	0.0308	0.0281
Brugia malayi	MH2 domain containing protein	0.0239	0.7013	0.9404
Mycobacterium tuberculosis	Probable thioesterase TesA	0.0021	0.0256	0.0305
Onchocerca volvulus		0.0049	0.113	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0732	0.0983
Echinococcus multilocularis	g-protein coupled receptor	0.0023	0.0308	0.0293
Echinococcus granulosus	neuropeptide FF receptor 2	0.0023	0.0308	0.0293
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB	0.002	0.0234	0.172
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0732	0.9423
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.0308	0.0293
Mycobacterium tuberculosis	Phenolpthiocerol synthesis type-I polyketide synthase PpsD	0.0025	0.0386	0.0498
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Brugia malayi	neuropeptide F receptor	0.0023	0.0308	0.0335
Brugia malayi	GnHR receptor homolog	0.0023	0.0308	0.0335
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.003	0.0527	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus granulosus	neuropeptide receptor	0.0023	0.0308	0.0293
Brugia malayi	MH1 domain containing protein	0.0016	0.0114	0.0073
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Echinococcus multilocularis	geminin	0.0169	0.4833	0.4825
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0092	0.2446	0.3189
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Echinococcus granulosus	somatostatin receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	hypothetical protein	0.0023	0.0308	0.0281
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0023	0.0308	0.0281
Echinococcus granulosus	G protein coupled receptor 139	0.0023	0.0308	0.0293
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0101	0.0136
Schistosoma mansoni	hypothetical protein	0.0023	0.0308	0.0281
Echinococcus granulosus	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Mycobacterium tuberculosis	Probable lipase LipD	0.0036	0.0732	0.1012
Mycobacterium leprae	Probable polyketide synthase Pks1	0.0027	0.0434	0.481
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0016	0.0114	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0413	0.5627
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0527	0.0579
Echinococcus multilocularis	dro:myosuppressin receptor	0.0023	0.0308	0.0293
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Mycobacterium ulcerans	polyketide synthase	0.0027	0.0434	0.481
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.003	0.0527	0.0579
Schistosoma mansoni	opsin-like receptor	0.0023	0.0308	0.0281
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0732	0.0983
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0101	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0732	0.9423
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0101	0.0086
Schistosoma mansoni	intermediate filament proteins	0.0027	0.0451	0.0475
Loa Loa (eye worm)	MH2 domain-containing protein	0.0016	0.0114	0.0153
Schistosoma mansoni	biogenic amine receptor	0.0023	0.0308	0.0281
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0036	0.0732	0.1012
Onchocerca volvulus		0.0044	0.0961	0.0992
Schistosoma mansoni	tar DNA-binding protein	0.0254	0.7454	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Brugia malayi	hypothetical protein	0.0017	0.0128	0.0092
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0023	0.0308	0.0281
Echinococcus multilocularis	neuropeptides capa receptor	0.0023	0.0308	0.0293
Echinococcus granulosus	sex peptide receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Mycobacterium tuberculosis	Conserved protein	0.0036	0.0732	0.1012
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.003	0.0527	0.0513
Echinococcus granulosus	hypothetical protein	0.0023	0.0308	0.0293
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0308	0.0293
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0732	0.0983
Onchocerca volvulus	Fatty acid synthase homolog	0.0045	0.1009	0.1065
Schistosoma mansoni	amine GPCR	0.0023	0.0308	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0386	0.4065
Echinococcus multilocularis	Smad4	0.0016	0.0114	0.0099
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0101	0.0086
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0023	0.0308	0.0335
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0023	0.0308	0.0281
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.0308	0.0293
Brugia malayi	G-protein coupled receptor	0.0023	0.0308	0.0335
Brugia malayi	RNA recognition motif domain containing protein	0.0254	0.7454	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0023	0.0308	0.0293
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0672	0.0828
Brugia malayi	Dopamine receptor protein 2	0.0023	0.0308	0.0335
Mycobacterium ulcerans	Type I modular polyketide synthase	0.0025	0.0386	0.4065
Mycobacterium tuberculosis	Polyketide synthase Pks2	0.0024	0.0362	0.0462
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0023	0.0308	0.0293
Brugia malayi	hypothetical protein	0.0023	0.0308	0.0335
Brugia malayi	larval opioid receptor	0.0023	0.0308	0.0335
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0023	0.0308	0.0293
Schistosoma mansoni	neuropeptide F-like receptor	0.0023	0.0308	0.0281
Mycobacterium tuberculosis	Probable polyketide synthase Pks5	0.0024	0.0362	0.0462
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0023	0.0308	0.0293
Toxoplasma gondii	type I fatty acid synthase, putative	0.0018	0.0162	0.2194
Mycobacterium leprae	PROBABLE THIOESTERASE TESA	0.0021	0.0256	0.2064
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	hypothetical protein	0.0169	0.4833	0.6436
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413
Schistosoma mansoni	histamine h1 receptor	0.0023	0.0308	0.0281
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0023	0.0308	0.0293
Loa Loa (eye worm)	MH1 domain-containing protein	0.0016	0.0114	0.0153
Brugia malayi	sulfakinin receptor protein	0.0023	0.0308	0.0335
Brugia malayi	G protein-coupled receptor F59B2.13	0.0023	0.0308	0.0335
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.1164	0.1562
Brugia malayi	Dopamine receptor protein 1	0.0023	0.0308	0.0335
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0732	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0101	0.0056
Echinococcus granulosus	lamin	0.0027	0.0451	0.0436
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0023	0.0308	0.0293
Echinococcus granulosus	tar DNA binding protein	0.0254	0.7454	0.745
Mycobacterium leprae	PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC	0.0027	0.0434	0.481
Schistosoma mansoni	hypothetical protein	0.0023	0.0308	0.0281
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0207	0.6009	0.8062
Onchocerca volvulus		0.003	0.0527	0.0334
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0732	0.0718
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0023	0.0308	0.0293
Brugia malayi	beta-lactamase family protein	0.0036	0.0732	0.0909
Brugia malayi	RNA binding protein	0.0254	0.7454	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0023	0.0308	0.0293
Schistosoma mansoni	smad	0.0016	0.0114	0.0017
Schistosoma mansoni	smad1 5 8 and	0.0016	0.0114	0.0017
Echinococcus granulosus	neuropeptide Y receptor	0.0023	0.0308	0.0293
Echinococcus granulosus	biogenic amine 5HT receptor	0.0023	0.0308	0.0293
Mycobacterium tuberculosis	Probable polyketide synthase Pks8	0.0021	0.0244	0.0287
Brugia malayi	putative neuropeptide receptor	0.0023	0.0308	0.0335
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0036	0.0732	0.1012
Echinococcus granulosus	g protein coupled receptor	0.0023	0.0308	0.0293
Echinococcus multilocularis	orexin receptor type 2	0.0023	0.0308	0.0293
Echinococcus granulosus	dro:myosuppressin receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	transcription factor SMAD2	0.0239	0.7013	0.9408
Brugia malayi	beta-lactamase	0.0036	0.0732	0.0909
Schistosoma mansoni	adenoreceptor	0.0023	0.0308	0.0281
Mycobacterium tuberculosis	Probable polyketide synthase Pks1	0.0018	0.0167	0.0173
Mycobacterium leprae	Polyketide synthase Pks13	0.0038	0.077	1
Brugia malayi	Beta-ketoacyl synthase, N-terminal domain containing protein	0.0025	0.0386	0.0441
Echinococcus multilocularis	fmrfamide receptor	0.0023	0.0308	0.0293
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0308	0.0413

Activities

Activity type	Activity value	Assay description	Source	Reference
ED20 (functional)	0 mg kg-1	Cardiovascular activity (as 20% decrease in rate) in rats; NT means not tested	ChEMBL.	3005574
ED20 (functional)	0 mg kg-1	Cardiovascular activity (as 20% decrease in blood pressure) in rats; NT means not tested	ChEMBL.	3005574
Ki (binding)	> 10000 nM	Binding affinity for adenosine A1 receptor in rat brain membranes using [3H]-CHA as radioligand	ChEMBL.	3005574
Ki (binding)	> 10000 nM	Binding affinity for adenosine A2 receptor in rat striatal membranes using [3H]-NECA as radioligand	ChEMBL.	3005574
Ki (binding)	> 10000 nM	Binding affinity for adenosine A1 receptor in rat brain membranes using [3H]-CHA as radioligand	ChEMBL.	3005574
Ki (binding)	> 10000 nM	Binding affinity for adenosine A2 receptor in rat striatal membranes using [3H]-NECA as radioligand	ChEMBL.	3005574
LAD (functional)	> 100 mg kg-1	Dose required to inhibit mouse locomotor activity by 60%	ChEMBL.	3005574
LAD (functional)	> 100 mg kg-1	CNS activity measured using screen test failure	ChEMBL.	3005574
LAD (functional)	> 100 mg kg-1	Dose required to inhibit mouse locomotor activity by 60%	ChEMBL.	3005574
LAD (functional)	> 100 mg kg-1	CNS activity measured using screen test failure	ChEMBL.	3005574

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL120075

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 209489