Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0699 | 0.9749 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0033 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0033 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0699 | 0.9749 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0033 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0033 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0684 | 0.9524 | 0.977 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0033 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | uM | Inhibition of transcriptional activation of human Peroxisome proliferator activated receptor gamma in CHO-K1 cells;ia means inactive at 10 uM | ChEMBL. | 11738577 |
EC50 (binding) | uM | Concentration of compound that affords half-maximum transactivation of human Peroxisome proliferator activated receptor alpha in CHO-K1 cells was determined in vitro;ia means inactive at 10 microM | ChEMBL. | 11738577 |
EC50 (binding) | 0 uM | Concentration of compound that affords half-maximum transactivation of human Peroxisome proliferator activated receptor alpha in CHO-K1 cells was determined in vitro;ia means inactive at 10 microM | ChEMBL. | 11738577 |
EC50 (binding) | 0 uM | Inhibition of transcriptional activation of human Peroxisome proliferator activated receptor gamma in CHO-K1 cells;ia means inactive at 10 uM | ChEMBL. | 11738577 |
IA (functional) | In vitro effective concentration for agonist activity on human Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CHO-K1 cells at 10 microM | ChEMBL. | 12904063 | |
IA (functional) | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 12904063 | |
IA (functional) | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor delta expressed in CHO-K1 cells | ChEMBL. | 12904063 | |
IA (functional) | 0 | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor alpha expressed in CHO-K1 cells | ChEMBL. | 12904063 |
IA (functional) | 0 | In vitro effective concentration for agonist activity on human Peroxisome proliferator activated receptor gamma-Gal4 chimeric receptor in transfected CHO-K1 cells at 10 microM | ChEMBL. | 12904063 |
IA (functional) | 0 | Agonist activity on Gal4 chimeric human Peroxisome proliferator activated receptor delta expressed in CHO-K1 cells | ChEMBL. | 12904063 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.