Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Percentage of inhibition of Prostaglandin G/H synthase 1 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 0 % | Percentage of inhibition of Prostaglandin G/H synthase 1 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (functional) | = 20.2 % | In vivo inhibition of Carrageenan-induced rat paw edema was determined in male Sprague-Dawley rat at a dose of 30 mg/kg | ChEMBL. | 11462976 |
Inhibition (binding) | = 40.5 % | Percentage of inhibition of Prostaglandin G/H synthase 2 activity in human whole blood (HWB) at 1 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 40.5 % | Percentage of inhibition of Prostaglandin G/H synthase 2 activity in human whole blood (HWB) at 1 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 100 % | Percentage inhibition of Prostaglandin G/H synthase 2 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Inhibition (binding) | = 100 % | Percentage inhibition of Prostaglandin G/H synthase 2 activity in human whole blood (HWB) at 10 microM | ChEMBL. | 11462976 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.