Detailed information for compound 2096340

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.617 | Formula: C28H40O
  • H donors: 0 H acceptors: 1 LogP: 6.8 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC([C@@H](/C=C/[C@H]([C@H]1CCC2=C3[C@H](CC[C@]12C)[C@@]1(C)CCC(=O)C=C1C=C3)C)C)C
  • InChi: 1S/C28H40O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,17-20,24,26H,11-16H2,1-6H3/b8-7+/t19-,20-,24-,26+,27+,28-/m1/s1
  • InChiKey: OIMXTYUHMBQQJM-RUEXCWEXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis inositol monophosphatase, putative 0.008 0.0828 0.5931
Echinococcus granulosus high affinity choline transporter 1 0.0404 0.4809 0.4808
Brugia malayi Calcitonin receptor-like protein seb-1 0.0209 0.2412 0.2711
Echinococcus multilocularis cpg binding protein 0.0061 0.0593 0.0592
Echinococcus granulosus survival motor neuron protein 1 0.0737 0.8898 0.8897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0333 0.3927 0.3927
Echinococcus multilocularis pyruvate kinase 0.0035 0.0274 0.0273
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0016 0.0015
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0274 0.1619
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0127 0.1395 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0084 0.0868 0.0975
Schistosoma mansoni hypothetical protein 0.0091 0.0956 0.0955
Brugia malayi MH2 domain containing protein 0.0253 0.2952 0.3317
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.005 0.0056
Brugia malayi Smad1 0.0017 0.005 0.0056
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.008 0.0828 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0333 0.3927 0.3927
Loa Loa (eye worm) hypothetical protein 0.0127 0.14 0.1572
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.1217 0.1127
Echinococcus multilocularis pyruvate kinase 0.0028 0.0182 0.0181
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0014 0.01
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0828 0.1921
Loa Loa (eye worm) hypothetical protein 0.0112 0.1217 0.1367
Echinococcus multilocularis muscleblind protein 0.0329 0.3876 0.3876
Schistosoma mansoni cpg binding protein 0.0061 0.0593 0.0592
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0014 0.0013
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0197 0.0221
Plasmodium vivax hypothetical protein, conserved 0.0112 0.1217 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0014 0.0013
Schistosoma mansoni sodium/solute symporter 0.0084 0.0868 0.0867
Echinococcus granulosus expressed protein 0.0014 0.0014 0.0013
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0056 0.0062
Mycobacterium tuberculosis Conserved protein 0.0112 0.1217 0.1127
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0127 0.1395 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0274 0.0307
Echinococcus granulosus pyruvate kinase 0.0018 0.0062 0.0061
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0014 0.0013
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.008 0.0828 0.1921
Brugia malayi MH2 domain containing protein 0.0017 0.005 0.0056
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.005 0.005
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0653 0.0652
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0653 0.0733
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.027 0.3157 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0014 0.0013
Echinococcus granulosus lamin dm0 0.0029 0.0197 0.0196
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0072 0.0724 0.0538
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.2952 0.3317
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.008 0.0828 0.6631
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0014 0.0013
Echinococcus granulosus smad 0.0017 0.005 0.005
Onchocerca volvulus 0.0029 0.0197 0.1165
Schistosoma mansoni survival motor neuron protein 0.015 0.1686 0.1686
Loa Loa (eye worm) hypothetical protein 0.0111 0.1205 0.1353
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0014 0.0015
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0111 0.1205 0.1353
Schistosoma mansoni patched 1 0.0111 0.1205 0.1204
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0014 0.0014 0.0015
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0014 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0029 0.0197 0.0221
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.027 0.3157 0.3548
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0014 0.0013
Mycobacterium leprae Probable lipase LipE 0.0112 0.1217 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.1217 0.1367
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0014 0.0013
Schistosoma mansoni lamin 0.0029 0.0197 0.0196
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.1217 0.1127
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0014 0.0014 0.0013
Onchocerca volvulus 0.0014 0.0014 0.0079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0015
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0014 0.0014 0.0013
Echinococcus granulosus lamin 0.0029 0.0197 0.0196
Echinococcus granulosus cpg binding protein 0.0061 0.0593 0.0592
Echinococcus granulosus sodium:glucose cotransporter 0.0084 0.0868 0.0867
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.1205 0.1204
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0091 0.0956 0.1073
Echinococcus multilocularis lamin dm0 0.0029 0.0197 0.0196
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0091 0.0956 0.0955
Schistosoma mansoni pyruvate kinase 0.0035 0.0274 0.0273
Brugia malayi hypothetical protein 0.0127 0.14 0.1572
Loa Loa (eye worm) hypothetical protein 0.0014 0.0011 0.0012
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0197 0.0221
Echinococcus granulosus muscleblind protein 0.0329 0.3876 0.3876
Schistosoma mansoni lamin 0.0029 0.0197 0.0196
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0014 0.0014 0.0015
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.005 0.005
Echinococcus granulosus pyruvate kinase 0.0018 0.0062 0.0061
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0828 0.1921
Echinococcus granulosus pyruvate kinase 0.0035 0.0274 0.0273
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0014 0.0014 0.0015
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.1205 0.1204
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0014 0.0014 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0333 0.3927 0.4413
Toxoplasma gondii ABC1 family protein 0.0112 0.1217 1
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0091 0.0956 0.0955
Brugia malayi CXXC zinc finger family protein 0.0058 0.0552 0.0619
Loa Loa (eye worm) hypothetical protein 0.0404 0.4809 0.5404
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.027 0.3157 1
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0014 0.0013
Onchocerca volvulus 0.0112 0.1217 0.7214
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0014 0.0014 0.0015
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0014 0.0014 0.01
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0127 0.1395 1
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0274 0.1619
Echinococcus multilocularis dnaJ subfamily B 0.0827 1 1
Brugia malayi beta-lactamase family protein 0.0112 0.1217 0.1367
Schistosoma mansoni pyruvate kinase 0.0035 0.0274 0.0273
Mycobacterium ulcerans hypothetical protein 0.0112 0.1217 0.3271
Onchocerca volvulus 0.015 0.1686 1
Echinococcus granulosus sodium:myo inositol cotransporter 0.0084 0.0868 0.0867
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0274 0.0307
Schistosoma mansoni hypothetical protein 0.0066 0.0653 0.0652
Echinococcus multilocularis musashi 0.0029 0.0197 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0333 0.3927 0.3927
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0016 0.0015
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1217 0.1216
Schistosoma mansoni GTP-binding protein alpha subunit 0.0014 0.0014 0.0013
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.1205 0.8634
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.1217 0.1127
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0274 0.0307
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0084 0.0868 0.6979
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0274 0.1962
Leishmania major hypothetical protein, conserved 0.0112 0.1217 0.3271
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0015
Echinococcus multilocularis protein patched 0.0111 0.1205 0.1204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0059 0.0058
Brugia malayi MH1 domain containing protein 0.0017 0.005 0.0056
Onchocerca volvulus 0.0112 0.1217 0.7214
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0091 0.0956 0.0955
Loa Loa (eye worm) hypothetical protein 0.0112 0.1217 0.1367
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0011 0.0011
Onchocerca volvulus Huntingtin homolog 0.0127 0.14 0.83
Entamoeba histolytica hypothetical protein 0.0076 0.0775 0.9358
Loa Loa (eye worm) hypothetical protein 0.0127 0.14 0.1572
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1217 0.872
Onchocerca volvulus 0.0112 0.1217 0.7214
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.1217 0.872
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0209 0.2412 0.2711
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0274 0.1619
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0142 0.0159
Onchocerca volvulus 0.0029 0.0197 0.1165
Loa Loa (eye worm) Smad1 0.0017 0.005 0.0056
Brugia malayi MH2 domain containing protein 0.0017 0.005 0.0056
Loa Loa (eye worm) hypothetical protein 0.0209 0.2412 0.2711
Brugia malayi GH02984p 0.0404 0.4809 0.5404
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0014 0.0014 0.0013
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0717 0.8644 1
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1217 0.3271
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0014 0.0014 0.0015
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0828 0.1921
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0084 0.0868 0.0867
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0552 0.0619
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0016 0.0015
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0014 0.0015
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0653 0.0733
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0014 0.0014 0.01
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.003 0.0033
Schistosoma mansoni hypothetical protein 0.0066 0.0653 0.0652
Schistosoma mansoni inositol transporter 0.0084 0.0868 0.0867
Schistosoma mansoni hypothetical protein 0.0091 0.0956 0.0955
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.027 0.3157 1
Loa Loa (eye worm) hypothetical protein 0.027 0.3157 0.3548
Loa Loa (eye worm) hypothetical protein 0.0029 0.019 0.0213
Mycobacterium leprae conserved hypothetical protein 0.0112 0.1217 1
Chlamydia trachomatis pyruvate kinase 0.0035 0.0274 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0112 0.1217 0.1367
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0014 0.0013
Schistosoma mansoni Smad4 0.0017 0.005 0.005
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0091 0.0956 0.0955
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0112 0.1217 0.1367
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1352 0.1351
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.1217 0.1216
Schistosoma mansoni smad1 5 8 and 0.0017 0.005 0.005
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.027 0.3157 0.3156
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0014 0.0014 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0016 0.0015
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0111 0.1205 0.1204
Schistosoma mansoni hypothetical protein 0.0091 0.0956 0.0955
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0653 0.0652
Schistosoma mansoni inositol monophosphatase 0.008 0.0828 0.0827
Brugia malayi hypothetical protein 0.0076 0.0775 0.0871
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0014 0.01
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0775 0.0775
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.1217 0.1216
Brugia malayi Inositol-1 0.008 0.0828 0.0929
Schistosoma mansoni hypothetical protein 0.0076 0.0775 0.0775
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1217 0.872
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0091 0.0956 0.0955
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0775 0.0775
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.9606 0.9606
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0014 0.0013
Echinococcus multilocularis muscleblind protein 1 0.0329 0.3876 0.3876
Brugia malayi intermediate filament protein 0.0029 0.0197 0.0221
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0828 0.5931
Loa Loa (eye worm) beta-lactamase 0.0112 0.1217 0.1367
Echinococcus granulosus GPCR family 2 0.0066 0.0653 0.0652
Echinococcus multilocularis inositol monophosphatase 1 0.008 0.0828 0.0827
Schistosoma mansoni high-affinity choline transporter 0.0404 0.4809 0.4808
Loa Loa (eye worm) hypothetical protein 0.0329 0.3876 0.4356
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0014 0.0014 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0333 0.3927 0.3927
Loa Loa (eye worm) G protein alpha subunit 3 0.0014 0.0014 0.0015
Schistosoma mansoni hypothetical protein 0.0066 0.0653 0.0652
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0653 0.0733
Brugia malayi Sodium:solute symporter family protein 0.0084 0.0868 0.0975
Echinococcus multilocularis survival motor neuron protein 1 0.0737 0.8898 0.8897
Giardia lamblia Pyruvate kinase 0.0035 0.0274 0.1589
Loa Loa (eye worm) hypothetical protein 0.0112 0.1217 0.1367
Schistosoma mansoni cpg binding protein 0.0058 0.0552 0.0551
Schistosoma mansoni hypothetical protein 0.0143 0.1598 0.1597
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.1217 0.1127
Echinococcus granulosus sterol regulatory element binding protein 0.0111 0.1205 0.1204
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.1217 0.1127
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0014 0.0014 0.0013
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0014 0.0014 0.0015
Echinococcus granulosus Smad4 0.0017 0.005 0.005
Entamoeba histolytica myo-inositol monophosphatase, putative 0.008 0.0828 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0084 0.0868 0.0867
Mycobacterium tuberculosis Conserved protein 0.0112 0.1217 0.1127
Echinococcus multilocularis protein dispatched 1 0.0111 0.1205 0.1204
Loa Loa (eye worm) apoptosis regulator protein 0.0091 0.0956 0.1073
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.027 0.3157 0.3156
Onchocerca volvulus 0.0014 0.0014 0.0079
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0333 0.3927 0.3927
Schistosoma mansoni hypothetical protein 0.0066 0.0653 0.0652
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0274 0.0307
Schistosoma mansoni intermediate filament proteins 0.0029 0.0197 0.0196
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0014 0.0014 0.0013
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0014 0.0014 0.01
Echinococcus multilocularis GPCR, family 2 0.0066 0.0653 0.0652
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0014 0.01
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.1217 0.1127
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0014 0.0014 0.0015
Schistosoma mansoni apoptosis regulator bax 0.0091 0.0956 0.0955
Echinococcus granulosus sodium:glucose cotransporter 2 0.0084 0.0868 0.0867
Entamoeba histolytica pyruvate kinase, putative 0.0025 0.0142 0.1573
Onchocerca volvulus 0.0014 0.0014 0.0079
Echinococcus granulosus Protein patched homolog 1 0.0111 0.1205 0.1204
Onchocerca volvulus 0.0058 0.0552 0.327
Echinococcus multilocularis pyruvate kinase 0.0018 0.0062 0.0061
Schistosoma mansoni hypothetical protein 0.0827 1 1
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0014 0.0014 0.0013
Echinococcus granulosus intermediate filament protein 0.0029 0.0197 0.0196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0333 0.3927 0.3927
Loa Loa (eye worm) hypothetical protein 0.0025 0.0142 0.0159
Loa Loa (eye worm) hypothetical protein 0.0014 0.0005 0.0005
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0014 0.0014 0.0013
Schistosoma mansoni smad1 5 8 and 0.0017 0.005 0.005
Echinococcus multilocularis pyruvate kinase 0.0035 0.0274 0.0273
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0072 0.0724 0.4775
Brugia malayi Muscleblind-like protein 0.0329 0.3876 0.4356
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0653 0.0652
Echinococcus granulosus pyruvate kinase 0.0018 0.0062 0.0061
Brugia malayi CHE-14 protein 0.0111 0.1205 0.1353
Entamoeba histolytica hypothetical protein 0.0076 0.0775 0.9358
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.027 0.3157 1
Mycobacterium tuberculosis Conserved protein 0.0112 0.1217 0.1127
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0059 0.0058
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0011 0.0011
Entamoeba histolytica hypothetical protein 0.0076 0.0775 0.9358
Loa Loa (eye worm) hypothetical protein 0.0091 0.0956 0.1073
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.1217 0.3271
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0014 0.0014 0.01
Trichomonas vaginalis esterase, putative 0.0112 0.1217 0.872
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0014 0.0014 0.01
Loa Loa (eye worm) inositol-1 0.008 0.0828 0.0929
Schistosoma mansoni smad 0.0017 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0329 0.3876 0.4356
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.1598 0.1795
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0274 0.1962
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.015 0.1686 0.1894
Echinococcus multilocularis sterol regulatory element binding protein 0.0111 0.1205 0.1204
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0016 0.0015
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.005 0.005
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0274 0.1835
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.1217 0.3271
Echinococcus multilocularis pyruvate kinase 0.0018 0.0062 0.0061
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0014 0.0014 0.0015
Trichomonas vaginalis myo inositol monophosphatase, putative 0.008 0.0828 0.5931
Onchocerca volvulus Huntingtin homolog 0.0127 0.14 0.83
Echinococcus granulosus pyruvate kinase 0.0035 0.0274 0.0273
Loa Loa (eye worm) hypothetical protein 0.0066 0.0653 0.0733
Echinococcus multilocularis high affinity choline transporter 1 0.0404 0.4809 0.4808
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1217 0.872
Echinococcus multilocularis Smad4 0.0017 0.005 0.005
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0127 0.1395 1
Loa Loa (eye worm) hypothetical protein 0.0737 0.8898 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0333 0.3927 0.4413
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0014 0.0014 0.0015
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0274 0.0307
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0084 0.0868 0.0867
Schistosoma mansoni hypothetical protein 0.015 0.1686 0.1686
Echinococcus multilocularis expressed protein 0.0014 0.0014 0.0013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.008 0.0828 0.1921
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0084 0.0868 0.0867
Echinococcus multilocularis lamin 0.0029 0.0197 0.0196
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0653 0.0652
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0333 0.3927 0.3927
Brugia malayi beta-lactamase family protein 0.0112 0.1217 0.1367
Echinococcus granulosus solute carrier family 5 0.0084 0.0868 0.0867
Schistosoma mansoni inositol monophosphatase 0.008 0.0828 0.0827
Plasmodium falciparum pyruvate kinase 0.0035 0.0274 1
Schistosoma mansoni smad1 5 8 and 0.0017 0.005 0.005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.1217 0.1367
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0775 0.0775
Schistosoma mansoni inositol transporter 0.0084 0.0868 0.0867
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.1217 0.1367
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.003 0.0033
Echinococcus granulosus inositol monophosphatase 1 0.008 0.0828 0.0827
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0059 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.1217 0.872
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0015
Entamoeba histolytica hypothetical protein 0.0076 0.0775 0.9358
Echinococcus multilocularis pyruvate kinase 0.0018 0.0062 0.0061
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.2952 0.3317
Onchocerca volvulus 0.0084 0.0868 0.5144
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.1217 0.1127
Brugia malayi hypothetical protein 0.0014 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0035 0.0274 0.0307
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.027 0.3157 0.3156
Echinococcus multilocularis solute carrier family 5 0.0084 0.0868 0.0867
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.1217 0.3271
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.1217 0.1216
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0014 0.0014 0.0013
Schistosoma mansoni pyruvate kinase 0.0018 0.0062 0.0061
Schistosoma mansoni cpg binding protein 0.0061 0.0593 0.0592
Mycobacterium ulcerans lipase LipD 0.0112 0.1217 0.3271
Echinococcus multilocularis smad 0.0017 0.005 0.005
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.005 0.005
Brugia malayi beta-lactamase 0.0112 0.1217 0.1367
Mycobacterium ulcerans beta-lactamase 0.0112 0.1217 0.3271
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0209 0.2412 0.2711
Brugia malayi hypothetical protein 0.0737 0.8898 1
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0274 0.1835
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.1217 0.3271
Brugia malayi G-protein alpha subunit 0.0014 0.0014 0.0015
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0197 0.0221
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0014 0.0014 0.0015
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.027 0.3157 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.119 0.977
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0014 0.0014 0.0013
Loa Loa (eye worm) hypothetical protein 0.0143 0.1598 0.1795
Loa Loa (eye worm) hypothetical protein 0.0014 0.0014 0.0015
Brugia malayi MH1 domain containing protein 0.0017 0.005 0.0056

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) Antimicrobial activity against Escherichia coli after 5 to 12 hrs by micro broth dilution assay ChEMBL. 25981689

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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