Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0769 | 0.9405 | 0.971 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0165 | 0.1548 | 0.3088 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0141 | 0.1233 | 0.2461 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0431 | 0.5011 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0431 | 0.5011 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0791 | 0.9686 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0431 | 0.5011 | 0.5011 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0431 | 0.5011 | 0.5174 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0791 | 0.9686 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0431 | 0.5011 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0431 | 0.5011 | 0.5174 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0165 | 0.1548 | 0.3088 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 8 nM | Transcriptional activation in CV-1 cells expressing RAR-gamma receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 8 nM | Transcriptional activation in CV-1 cells expressing RAR-gamma receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 1000 nM | Transcriptional activation in CV-1 cells expressing RAR-alpha receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 1000 nM | Transcriptional activation in CV-1 cells expressing RAR-alpha receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 1200 nM | Transcriptional activation in CV-1 cells expressing RAR-beta receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 1200 nM | Transcriptional activation in CV-1 cells expressing RAR-beta receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 2600 nM | Transcriptional activation in CV-1 cells expressing RAR-alpha receptor | ChEMBL. | 9733501 |
EC50 (binding) | = 2600 nM | Transcriptional activation in CV-1 cells expressing RAR-alpha receptor | ChEMBL. | 9733501 |
Relative activity (functional) | = 50 | Relative transcriptional activation activity of the compound relative to t-RA | ChEMBL. | 9357524 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.