Detailed information for compound 2096643

Basic information

Technical information
  • TDR Targets ID: 2096643
  • Name: N-(2-methylpropyl)butanamide
  • MW: 143.227 | Formula: C8H17NO
  • H donors: 1 H acceptors: 1 LogP: 1.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCC(=O)NCC(C)C
  • InChi: 1S/C8H17NO/c1-4-5-8(10)9-6-7(2)3/h7H,4-6H2,1-3H3,(H,9,10)
  • InChiKey: PZDWBPCVLDKVPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-isobutylbutanamide
  • N-isobutylbutyramide
  • 7476-94-0
  • Butanamide, N-(2-methylpropyl)-
  • Butyramide, N-isobutyl-
  • NSC404417

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0265
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0171 0.0041
Schistosoma mansoni jumonji domain containing protein 0.0081 0.0213 0.0427
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0376 0.079
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0631 0.1323
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0052 0.0097
Plasmodium vivax glycogen synthase kinase 3, putative 0.0048 0.0079 0.0144
Brugia malayi Bromodomain containing protein 0.0147 0.0482 0.1016
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0171 0.0337
Schistosoma mansoni hypothetical protein 0.0453 0.1721 0.3536
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0265
Loa Loa (eye worm) hypothetical protein 0.0092 0.0259 0.0539
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0393 0.148 0.314
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.002 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.0837 0.0832
Trichomonas vaginalis chromobox protein, putative 0.0043 0.006 0.0126
Schistosoma mansoni chromobox protein 0.0072 0.0176 0.0351
Brugia malayi PHD-finger family protein 0.0031 0.0011 0.0011
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0049 0.0082 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0182 0.0177
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0088 0.0174
Entamoeba histolytica acyl-CoA synthetase, putative 0.0092 0.0259 0.7641
Loa Loa (eye worm) hypothetical protein 0.0031 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.021 0.0734 0.1553
Onchocerca volvulus 0.0071 0.0171 0.2818
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0088 0.0174
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0082 0.0164
Echinococcus multilocularis transcription factor eb 0.0326 0.1207 0.1202
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.006 0.0116
Loa Loa (eye worm) bromodomain containing protein 0.0035 0.0025 0.0042
Schistosoma mansoni hypothetical protein 0.0041 0.0049 0.009
Brugia malayi Muscleblind-like protein 0.0599 0.2314 0.4916
Brugia malayi jmjC domain containing protein 0.0102 0.0298 0.0623
Echinococcus multilocularis geminin 0.1226 0.4857 0.4855
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0171 0.0341
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0064 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0593 0.1243
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0011 0.0005
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0066 0.0152 0.0427
Brugia malayi hypothetical protein 0.005 0.0088 0.0176
Loa Loa (eye worm) hypothetical protein 0.0139 0.0448 0.0943
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.0837 0.1713
Brugia malayi hypothetical protein 0.0032 0.0016 0.0022
Loa Loa (eye worm) hypothetical protein 0.0353 0.1316 0.2792
Loa Loa (eye worm) latrophilin receptor protein 2 0.021 0.0734 0.1553
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0088 0.0162
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0171 0.0358
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1205 0.4769 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.021 0.0734 0.1553
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0964 0.2022
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0171 0.0351
Entamoeba histolytica hypothetical protein 0.0073 0.0182 0.438
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.021 0.0734 0.073
Brugia malayi RNA binding protein 0.0062 0.0134 0.0274
Brugia malayi chromobox protein homolog 3 0.004 0.0048 0.009
Echinococcus granulosus transcription factor btf3 0.0106 0.0314 0.0636
Echinococcus granulosus high affinity choline transporter 1 0.0353 0.1316 0.2702
Brugia malayi hypothetical protein 0.0039 0.0043 0.008
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0088 0.0162
Trichomonas vaginalis esterase, putative 0.0071 0.0171 0.0358
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0171 0.1771
Loa Loa (eye worm) hypothetical protein 0.0325 0.1201 0.2546
Echinococcus granulosus zinc finger protein 0.0038 0.004 0.0072
Brugia malayi hypothetical protein 0.0039 0.0043 0.008
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0663 0.2571 0.5465
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0085 0.0163
Echinococcus multilocularis solute carrier family 5 0.0039 0.0042 0.0037
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0176 0.0368
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0082 0.0162
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0593 0.1243
Echinococcus multilocularis chromobox protein 1 0.0072 0.0176 0.017
Mycobacterium tuberculosis Conserved protein 0.0071 0.0171 0.0543
Schistosoma mansoni bromodomain containing protein 0.0124 0.0389 0.079
Onchocerca volvulus 0.0071 0.0171 0.2818
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.1188 0.47 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0092 0.0259 0.0537
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.002 0.0015
Entamoeba histolytica acyl-coA synthetase, putative 0.0092 0.0259 0.7641
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0145 0.0297
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0259 0.0234
Echinococcus granulosus transcription factor eb 0.0326 0.1207 0.2477
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0082 0.0077
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0182 0.0364
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0048 0.01
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0171 0.0351
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.1205 0.4769 1
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.1188 0.47 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0082 0.0164
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0964 0.2022
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.1188 0.47 0.4697
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0116
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0265
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0134 0.0129
Echinococcus granulosus geminin 0.1226 0.4857 1
Leishmania major hypothetical protein, conserved 0.0071 0.0171 0.0351
Brugia malayi beta-NAC-like protein 0.0106 0.0314 0.0658
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0134 0.0274
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0052 0.01
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.002 0.0031
Brugia malayi AMP-binding enzyme family protein 0.0092 0.0259 0.0539
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0134 0.0274
Trypanosoma brucei protein kinase, putative 0.0048 0.0079 0.0155
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0171 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0314 0.0658
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.006 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0092 0.0259 0.0537
Onchocerca volvulus 0.0048 0.0079 0.1253
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.0042 0.0076
Brugia malayi PHD-finger family protein 0.0049 0.0083 0.0165
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0171 0.0353
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0149 0.0407
Giardia lamblia Kinase, CMGC GSK 0.0048 0.0079 0.0144
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.1188 0.47 0.9676
Loa Loa (eye worm) hypothetical protein 0.0071 0.0171 0.0353
Echinococcus multilocularis transcription factor btf3 0.0106 0.0314 0.0309
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0314 0.0658
Loa Loa (eye worm) hypothetical protein 0.0599 0.2314 0.4916
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0259 0.0234
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.0837 0.1713
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.002 0.0031
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0048 0.0079 0.0144
Schistosoma mansoni hypothetical protein 0.021 0.0734 0.1503
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0092 0.0259 0.0234
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0048 0.0079 0.0155
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0176 0.0363
Schistosoma mansoni transcription factor btf3 0.0106 0.0314 0.0636
Brugia malayi TAR-binding protein 0.0062 0.0134 0.0274
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0171 0.0543
Loa Loa (eye worm) hypothetical protein 0.0599 0.2314 0.4916
Trypanosoma brucei transcription factor BTF3, putative 0.0106 0.0314 0.0655
Brugia malayi beta-lactamase 0.0071 0.0171 0.0353
Leishmania major hypothetical protein, conserved 0.005 0.0088 0.0174
Loa Loa (eye worm) hypothetical protein 0.0663 0.2571 0.5465
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0171 0.0358
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0064 0.0059
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0082 0.0162
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0171 0.0353
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.002 0.0031
Echinococcus multilocularis chromobox protein 1 0.0072 0.0176 0.017
Onchocerca volvulus 0.0071 0.0171 0.2818
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0235 0.0837 0.1713
Echinococcus granulosus chromobox protein 1 0.0072 0.0176 0.0351
Schistosoma mansoni hypothetical protein 0.1226 0.4857 1
Loa Loa (eye worm) hypothetical protein 0.0092 0.0259 0.0539
Brugia malayi jmjC domain containing protein 0.0041 0.0052 0.01
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0593 0.1243
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0171 0.0358
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0176 0.0368
Brugia malayi isocitrate dehydrogenase 0.0049 0.0082 0.0164
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0171 0.0543
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0171 0.0358
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0048 0.0079 0.0155
Echinococcus granulosus muscleblind protein 0.0599 0.2314 0.4757
Loa Loa (eye worm) hypothetical protein 0.0039 0.0042 0.0079
Toxoplasma gondii NAC domain-containing protein 0.0106 0.0314 0.0638
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0092 0.0259 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0082 0.0159
Leishmania major 4-coumarate:coa ligase-like protein 0.0092 0.0259 0.0537
Schistosoma mansoni hypothetical protein 0.021 0.0734 0.1503
Echinococcus multilocularis GPCR, family 2 0.021 0.0734 0.073
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0082 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0235 0.0837 0.0832
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0048 0.01
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.021 0.0734 0.073
Brugia malayi Sodium:solute symporter family protein 0.0039 0.0042 0.0079
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0082 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0092 0.0259 0.0539
Echinococcus multilocularis muscleblind protein 0.0599 0.2314 0.2309
Brugia malayi latrophilin 2 splice variant baaae 0.0453 0.1721 0.3654
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0149 0.0407
Brugia malayi beta-lactamase family protein 0.0071 0.0171 0.0353
Trichomonas vaginalis conserved hypothetical protein 0.0106 0.0314 0.0658
Loa Loa (eye worm) hypothetical protein 0.005 0.0088 0.0176
Schistosoma mansoni hypothetical protein 0.0073 0.0182 0.0364
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0092 0.0259 0.0234
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0082 0.0077
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0593 0.1243
Entamoeba histolytica hypothetical protein 0.0106 0.0314 1
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0137 0.0442 0.0638
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.006 0.0104
Mycobacterium tuberculosis Conserved protein 0.0071 0.0171 0.0543
Entamoeba histolytica acyl-CoA synthetase, putative 0.0092 0.0259 0.7641
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.1205 0.4769 1
Schistosoma mansoni hypothetical protein 0.021 0.0734 0.1503
Loa Loa (eye worm) hypothetical protein 0.0071 0.0171 0.0353
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0171 0.0041
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0326 0.1207 0.256
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.006 0.0055
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.1188 0.47 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.006 0.0932
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0171 0.0358
Mycobacterium ulcerans hypothetical protein 0.0071 0.0171 0.0041
Schistosoma mansoni hypothetical protein 0.021 0.0734 0.1503
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0182 0.0364
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.1205 0.4769 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0663 0.2571 0.5465
Entamoeba histolytica hypothetical protein 0.0073 0.0182 0.438
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0776 0.303 0.6345
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0069 0.0164 0.05
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0325 0.1201 0.2546
Brugia malayi Heterochromatin protein 1 0.0072 0.0176 0.0363
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0266 0.0964 0.2042
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0092 0.0259 0.1079
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0082 0.0077
Brugia malayi Latrophilin receptor protein 2 0.021 0.0734 0.1553
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0082 0.0151
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0037 0.0032
Onchocerca volvulus Glucosylceramidase homolog 0.0175 0.0593 1
Plasmodium falciparum basic transcription factor 3b, putative 0.0106 0.0314 0.0638
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0134 0.0274
Mycobacterium ulcerans hypothetical protein 0.0092 0.0259 0.0234
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0376 0.079
Toxoplasma gondii ABC1 family protein 0.0071 0.0171 0.0337
Echinococcus granulosus jumonji domain containing protein 0.0043 0.006 0.0113
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.0298 0.0602
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0117 0.036 0.0355
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0011 0.0011
Loa Loa (eye worm) beta-lactamase 0.0071 0.0171 0.0353
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0049 0.0082 0.0151
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0171 0.0543
Onchocerca volvulus 0.0092 0.0259 0.431
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0064 0.0121
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0171 0.0166
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0079 0.0165
Loa Loa (eye worm) hypothetical protein 0.0071 0.0171 0.0353
Trichomonas vaginalis chromobox protein, putative 0.0043 0.006 0.0126
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.1205 0.4769 1
Schistosoma mansoni inositol transporter 0.0039 0.0042 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0593 0.1243
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0052 0.0097
Loa Loa (eye worm) hypothetical protein 0.008 0.0209 0.0434
Loa Loa (eye worm) hypothetical protein 0.0075 0.019 0.0394
Schistosoma mansoni high-affinity choline transporter 0.0353 0.1316 0.2702
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.1205 0.4769 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0085 0.0169
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0082 0.0162
Echinococcus granulosus tar DNA binding protein 0.0062 0.0134 0.0265
Onchocerca volvulus Alhambra homolog 0.0031 0.0011 0.0089
Plasmodium falciparum acyl-CoA synthetase 0.0069 0.0164 0.0322
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.021 0.0734 0.1503
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0137 0.0442 0.2203
Echinococcus granulosus peregrin 0.0036 0.0029 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.002 0.0032
Loa Loa (eye worm) hypothetical protein 0.0069 0.0164 0.0338
Brugia malayi GH02984p 0.0353 0.1316 0.2792
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0235 0.0837 0.1771
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0048 0.0079 0.0152
Echinococcus multilocularis protein kinase shaggy 0.0048 0.0079 0.0074
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0451 0.1715 1
Schistosoma mansoni hypothetical protein 0.0043 0.006 0.0112
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.0837 0.1713
Mycobacterium ulcerans acyl-CoA synthetase 0.0092 0.0259 0.0234
Mycobacterium ulcerans lipase LipD 0.0071 0.0171 0.0041
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.1188 0.47 1
Giardia lamblia Kinase, CMGC GSK 0.0048 0.0079 0.0144
Entamoeba histolytica transcription factor BTF3, putative 0.0106 0.0314 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.1188 0.47 0.5
Trypanosoma cruzi transcription factor btf3, putative 0.0106 0.0314 0.0655
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0171 0.0351
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0048 0.0079 0.0152
Loa Loa (eye worm) hypothetical protein 0.0069 0.0164 0.0338
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0052 0.0097
Brugia malayi Bromodomain containing protein 0.0075 0.019 0.0393
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0088 0.0162
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0082 0.0077
Loa Loa (eye worm) hypothetical protein 0.0069 0.0164 0.0338
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.0042 0.0076
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0776 0.303 0.6327
Schistosoma mansoni hypothetical protein 0.0031 0.0011 0.0011
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.0042 0.0037
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0048 0.0079 0.0157
Echinococcus granulosus GPCR family 2 0.021 0.0734 0.1503
Onchocerca volvulus 0.0039 0.0042 0.063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0149 0.0407
Brugia malayi glucose-6-phosphate dehydrogenase 0.1188 0.47 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.002 0.0031
Onchocerca volvulus 0.0032 0.0012 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0235 0.0837 0.1713
Echinococcus granulosus tumor protein p63 0.0337 0.1252 0.257
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.0259 0.1079
Loa Loa (eye worm) hypothetical protein 0.0071 0.0171 0.0353
Mycobacterium tuberculosis Conserved protein 0.0071 0.0171 0.0543
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0171 0.0543
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0593 0.1243
Schistosoma mansoni hypothetical protein 0.1226 0.4857 1
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0964 0.2022
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0171 0.0341
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.002 0.0031
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.002 0.0015
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.0042 0.0076
Brugia malayi Bromodomain containing protein 0.0036 0.0029 0.0051
Loa Loa (eye worm) hypothetical protein 0.0069 0.0164 0.0338
Loa Loa (eye worm) hypothetical protein 0.0453 0.1721 0.3654
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.0298 0.0292
Echinococcus granulosus protein kinase shaggy 0.0048 0.0079 0.0152
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0048 0.0721
Schistosoma mansoni zinc finger protein 0.003 0.0006 0.0002
Trypanosoma cruzi transcription factor btf3, putative 0.0106 0.0314 0.0655
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0069 0.0164 0.0026
Echinococcus multilocularis tumor protein p63 0.0337 0.1252 0.1248
Loa Loa (eye worm) ICD-1 protein 0.0106 0.0314 0.0658
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0043 0.006 0.0104
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0082 0.0159
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0043 0.006 0.0116
Plasmodium vivax acyl-CoA synthetase, putative 0.0069 0.0164 0.0322
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0171 0.0543
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0412 0.1555 0.902
Entamoeba histolytica hypothetical protein 0.0073 0.0182 0.438
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0171 0.0341
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0964 0.2022
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0092 0.0259 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0265
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0011 0.0011
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0092 0.0259 0.0234
Loa Loa (eye worm) hypothetical protein 0.0071 0.0171 0.0353
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0092 0.0259 0.0234
Leishmania major basic transcription factor 3a, putative 0.0106 0.0314 0.0655
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.006 0.0055
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0069 0.0164 0.0338
Schistosoma mansoni zinc finger protein 0.0038 0.004 0.0072
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0048 0.0079 0.0074
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.0042 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0048 0.009
Trypanosoma brucei beta lactamase 0.0066 0.0152 0.031
Brugia malayi MH2 domain containing protein 0.0121 0.0376 0.079
Brugia malayi intracellular kinase 0.0048 0.0079 0.0157
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.0042 0.0037
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0593 0.1243
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.021 0.0734 0.1503
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0043 0.006 0.0104
Loa Loa (eye worm) RNA binding protein 0.0062 0.0134 0.0274
Plasmodium falciparum glycogen synthase kinase 3 0.0048 0.0079 0.0144
Entamoeba histolytica hypothetical protein 0.0073 0.0182 0.438
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0235 0.0837 0.1771
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0266 0.0964 0.2042
Echinococcus multilocularis peregrin 0.0036 0.0029 0.0024
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0117 0.036 0.0732
Onchocerca volvulus 0.0049 0.0085 0.1349
Echinococcus granulosus chromobox protein 1 0.0072 0.0176 0.0351
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0082 0.0162
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.1188 0.47 1
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0382 0.1434 0.3041
Brugia malayi AMP-binding enzyme family protein 0.0092 0.0259 0.0539
Loa Loa (eye worm) hypothetical protein 0.0092 0.0259 0.0539
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0088 0.0162
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0964 0.2022
Schistosoma mansoni sodium/solute symporter 0.0039 0.0042 0.0076
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0048 0.0079 0.0157
Mycobacterium leprae Probable lipase LipE 0.0071 0.0171 0.1771
Schistosoma mansoni hypothetical protein 0.003 0.0006 0.0002
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.1188 0.47 1
Echinococcus multilocularis high affinity choline transporter 1 0.0353 0.1316 0.1312
Brugia malayi hypothetical protein 0.0073 0.0182 0.0376
Mycobacterium ulcerans beta-lactamase 0.0071 0.0171 0.0041
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.1205 0.4769 1
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.1188 0.47 0.9676
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0171 0.0166
Echinococcus multilocularis muscleblind protein 1 0.0599 0.2314 0.2309
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0171 0.0543
Echinococcus multilocularis zinc finger protein 0.0038 0.004 0.0035
Brugia malayi beta-lactamase family protein 0.0071 0.0171 0.0353
Schistosoma mansoni chromobox protein 0.0072 0.0176 0.0351
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0082 0.0162
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0088 0.0174
Loa Loa (eye worm) hypothetical protein 0.0053 0.0101 0.0203
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.0042 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0184 0.0631 0.1323
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0134 0.0265
Schistosoma mansoni inositol transporter 0.0039 0.0042 0.0076
Trichomonas vaginalis glucosylceramidase, putative 0.0266 0.0964 0.2022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0171 0.0341
Echinococcus granulosus solute carrier family 5 0.0039 0.0042 0.0076
Loa Loa (eye worm) hypothetical protein 0.0084 0.0224 0.0467
Trichomonas vaginalis CMGC family protein kinase 0.0048 0.0079 0.0165
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0049 0.0093
Plasmodium vivax basic transcription factor 3b, putative 0.0106 0.0314 0.0638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0065 0.0149 0.0407
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.0042 0.0067
Loa Loa (eye worm) hypothetical protein 0.0071 0.0171 0.0353
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0663 0.2571 0.5465

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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