Detailed information for compound 209683

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 256.344 | Formula: C10H12N2O2S2
  • H donors: 2 H acceptors: 4 LogP: 1.6 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(nc1)SSc1ccccn1.O.O
  • InChi: 1S/C10H8N2S2.2H2O/c1-3-7-11-9(5-1)13-14-10-6-2-4-8-12-10;;/h1-8H;2*1H2
  • InChiKey: LMWUMNZKXKJASI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1549 0.1307
Brugia malayi Tachykinin-like peptides receptor 99D 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0165 0.4313 0.753
Schistosoma mansoni opsin-like receptor 0.0165 0.4313 0.4243
Brugia malayi Heterochromatin protein 1 0.0084 0.1549 0.1444
Loa Loa (eye worm) TK/ROR protein kinase 0.0076 0.1282 0.1175
Onchocerca volvulus 0.0165 0.4313 0.7246
Brugia malayi neuropeptide F receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0165 0.4313 0.7246
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.1156 0.1046
Brugia malayi larval opioid receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0165 0.4313 0.753
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.2527 0.9579
Brugia malayi Dopamine receptor protein 1 0.0165 0.4313 0.4243
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0165 0.4313 0.753
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2582 0.2369
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1286 0.1179
Echinococcus multilocularis rhodopsin orphan GPCR 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0113 0.2527 0.1523
Trypanosoma brucei polo-like protein kinase 0.0114 0.2582 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0401 0.0221
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1286 0.1179
Schistosoma mansoni amine GPCR 0.0165 0.4313 0.4243
Echinococcus multilocularis g protein coupled receptor 0.0165 0.4313 0.753
Onchocerca volvulus 0.0165 0.4313 0.7246
Echinococcus granulosus chromobox protein 1 0.0084 0.1549 0.2563
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0341 0.0394
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0165 0.4313 0.4243
Echinococcus granulosus somatostatin receptor 0.0165 0.4313 0.753
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0165 0.4313 0.4243
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1286 0.1179
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2582 0.2369
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0165 0.4313 0.4243
Loa Loa (eye worm) neuropeptide F receptor 0.0165 0.4313 0.4243
Brugia malayi Serotonin receptor 0.0165 0.4313 0.4243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Schistosoma mansoni hypothetical protein 0.0205 0.5689 0.5635
Loa Loa (eye worm) glutaminase 0.033 1 1
Brugia malayi hypothetical protein 0.0182 0.4927 0.4865
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Echinococcus multilocularis G protein coupled receptor 139 0.0165 0.4313 0.753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0165 0.4313 0.753
Echinococcus granulosus neuropeptide receptor 0.0165 0.4313 0.753
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0165 0.4313 0.4243
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0123 0.2871 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.2871 0.2667
Onchocerca volvulus 0.0182 0.4927 0.8348
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.2582 1
Echinococcus granulosus g protein coupled receptor 0.0165 0.4313 0.753
Echinococcus multilocularis somatostatin receptor 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0039 0 0.5
Echinococcus granulosus g protein coupled receptor 0.0165 0.4313 0.753
Onchocerca volvulus 0.0165 0.4313 0.7246
Brugia malayi RNA binding protein 0.0076 0.1286 0.1179
Onchocerca volvulus 0.0165 0.4313 0.7246
Echinococcus granulosus sex peptide receptor 0.0165 0.4313 0.753
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0401 0.0127
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Brugia malayi Serotonin receptor 0.0165 0.4313 0.4243
Echinococcus multilocularis neuropeptide receptor A26 0.0165 0.4313 0.753
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0165 0.4313 0.753
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0401 0.0127
Echinococcus granulosus hypothetical protein 0.0165 0.4313 0.753
Brugia malayi sulfakinin receptor protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.006 0.0732 0.0617
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0165 0.4313 0.753
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0113 0.2527 0.9579
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0165 0.4313 0.4243
Schistosoma mansoni neuropeptide receptor 0.0165 0.4313 0.4243
Schistosoma mansoni opsin-like receptor 0.0165 0.4313 0.4243
Echinococcus granulosus orexin receptor type 2 0.0165 0.4313 0.753
Brugia malayi TAR-binding protein 0.0076 0.1286 0.1179
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0165 0.4313 0.4243
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0341 0.0394
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0165 0.4313 0.4243
Loa Loa (eye worm) G-protein coupled receptor 0.0165 0.4313 0.4243
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Echinococcus multilocularis g protein coupled receptor 0.0165 0.4313 0.753
Schistosoma mansoni chromobox protein 0.0084 0.1549 0.1444
Echinococcus multilocularis G-protein coupled receptor, putative 0.0165 0.4313 0.753
Onchocerca volvulus 0.0165 0.4313 0.7246
Brugia malayi G-protein coupled receptor 0.0165 0.4313 0.4243
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0123 0.2871 0.2667
Brugia malayi chromobox protein homolog 3 0.0047 0.0278 0.0158
Echinococcus multilocularis neuropeptide FF receptor 2 0.0165 0.4313 0.753
Onchocerca volvulus 0.0165 0.4313 0.7246
Echinococcus granulosus 7TM GPCR rhodopsin 0.0165 0.4313 0.753
Echinococcus multilocularis allatostatin A receptor 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.2582 0.4419
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0165 0.4313 0.753
Schistosoma mansoni opsin-like receptor 0.0165 0.4313 0.4243
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0165 0.4313 0.753
Echinococcus granulosus 7tm_1 domain containing protein 0.0165 0.4313 0.753
Brugia malayi Dopamine receptor protein 2 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus multilocularis neuropeptides capa receptor 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus rhodopsin orphan GPCR 0.0165 0.4313 0.753
Brugia malayi GnHR receptor homolog 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0209 0.5847 0.5796
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0165 0.4313 0.4243
Schistosoma mansoni adenoreceptor 0.0165 0.4313 0.4243
Brugia malayi putative neuropeptide receptor 0.0165 0.4313 0.4243
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1805 0.1704
Brugia malayi Trypsin family protein 0.0209 0.5847 0.5796
Echinococcus multilocularis tissue type plasminogen activator 0.0076 0.1282 0.2085
Echinococcus multilocularis sex peptide receptor 0.0165 0.4313 0.753
Echinococcus granulosus tar DNA binding protein 0.0076 0.1286 0.2091
Echinococcus multilocularis neuropeptides capa receptor 0.0165 0.4313 0.753
Echinococcus multilocularis dro:myosuppressin receptor 0.0165 0.4313 0.753
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0123 0.2871 1
Schistosoma mansoni neuropeptide receptor 0.0165 0.4313 0.4243
Echinococcus multilocularis neuropeptide s receptor 0.0165 0.4313 0.753
Schistosoma mansoni amine GPCR 0.0165 0.4313 0.4243
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0113 0.2527 0.432
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2582 0.2369
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0603 0.0334
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1286 0.1179
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0165 0.4313 0.4243
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0113 0.2527 0.5
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1286 0.1179
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni histamine h1 receptor 0.0165 0.4313 0.4243
Echinococcus multilocularis neuropeptide receptor 0.0165 0.4313 0.753
Echinococcus granulosus tachykinin peptides receptor 99D 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni hypothetical protein 0.0205 0.5689 0.5635
Brugia malayi follicle stimulating hormone receptor 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0165 0.4313 0.7246
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.2582 0.249
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0165 0.4313 0.7246
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.2582 0.249
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.2582 0.5
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1549 0.1444
Echinococcus granulosus neuropeptides capa receptor 0.0165 0.4313 0.753
Echinococcus multilocularis orexin receptor type 2 0.0165 0.4313 0.753
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Mycobacterium ulcerans glutaminase 0.033 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0165 0.4313 0.753
Brugia malayi AKH receptor 0.0165 0.4313 0.4243
Echinococcus granulosus G protein coupled receptor 139 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Brugia malayi neuropeptide F receptor 0.0165 0.4313 0.4243
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0165 0.4313 0.753
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0165 0.4313 0.4243
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0113 0.2527 0.2435
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni kinase 0.0058 0.0654 0.0539
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0182 0.4927 0.4865
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2582 1
Schistosoma mansoni biogenic amine receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0165 0.4313 0.7246
Onchocerca volvulus 0.0165 0.4313 0.7246
Loa Loa (eye worm) G-protein coupled receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) RNA binding protein 0.0076 0.1286 0.1179
Brugia malayi jmjC domain containing protein 0.0115 0.262 0.2528
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus g-protein coupled receptor 0.0165 0.4313 0.753
Echinococcus multilocularis fmrfamide receptor 0.0165 0.4313 0.753
Echinococcus granulosus tm gpcr rhodopsin 0.0165 0.4313 0.753
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.2582 0.4136
Schistosoma mansoni biogenic amine (5HT) receptor 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0165 0.4313 0.7246
Brugia malayi glucose-6-phosphate dehydrogenase 0.0113 0.2527 0.2435
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0165 0.4313 0.4243
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2582 0.2369
Onchocerca volvulus 0.0181 0.4874 0.8253
Schistosoma mansoni hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus chromobox protein 1 0.0084 0.1549 0.2563
Onchocerca volvulus 0.0165 0.4313 0.7246
Schistosoma mansoni glutaminase 0.033 1 1
Brugia malayi RE15519p 0.0165 0.4313 0.4243
Echinococcus granulosus neuropeptide s receptor 0.0165 0.4313 0.753
Echinococcus granulosus dro:myosuppressin receptor 0.0165 0.4313 0.753
Onchocerca volvulus 0.0076 0.1282 0.1803
Schistosoma mansoni hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0165 0.4313 0.4243
Echinococcus granulosus fmrfamide receptor 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0113 0.2527 0.2435
Schistosoma mansoni amine GPCR 0.0165 0.4313 0.4243
Brugia malayi G protein-coupled receptor 0.0165 0.4313 0.4243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0165 0.4313 0.7246
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2582 0.2369
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0165 0.4313 0.7246
Echinococcus granulosus serotonin receptor 0.0165 0.4313 0.753
Echinococcus granulosus biogenic amine 5HT receptor 0.0165 0.4313 0.753
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.2582 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1286 0.1179
Echinococcus granulosus tissue type plasminogen activator 0.0076 0.1282 0.2085
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0123 0.2871 1
Loa Loa (eye worm) TYRA-2 protein 0.0165 0.4313 0.4243
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus rhodopsin orphan GPCR 0.0165 0.4313 0.753
Brugia malayi Melatonin receptor type 1A 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0165 0.4313 0.7246
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.2582 0.4419
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0076 0.1282 0.1175
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0165 0.4313 0.753
Echinococcus multilocularis fmrfamide receptor 0.0165 0.4313 0.753
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0123 0.2871 0.2667
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus rhodopsin orphan GPCR 0.0165 0.4313 0.753
Echinococcus granulosus rhodopsin orphan GPCR 0.0165 0.4313 0.753
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0165 0.4313 0.4243
Schistosoma mansoni amine GPCR 0.0165 0.4313 0.4243
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0165 0.4313 0.4243
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2582 0.2369
Schistosoma mansoni biogenic amine receptor 0.0165 0.4313 0.4243
Schistosoma mansoni biogenic amine receptor 0.0165 0.4313 0.4243
Schistosoma mansoni neuropeptide receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Schistosoma mansoni neuropeptide F-like receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) neuropeptide F receptor 0.0165 0.4313 0.4243
Trichomonas vaginalis glutaminase, putative 0.033 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1286 0.1179
Echinococcus multilocularis rhodopsin orphan GPCR 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni neuropeptide F-like receptor 0.0165 0.4313 0.4243
Schistosoma mansoni myosin xvIII 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0209 0.5847 0.5796
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0165 0.4313 0.4243
Brugia malayi Dopamine receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni hypothetical protein 0.0165 0.4313 0.4243
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0209 0.5847 0.5796
Echinococcus multilocularis serotonin receptor 0.0165 0.4313 0.753
Loa Loa (eye worm) melatonin receptor type 1A 0.0165 0.4313 0.4243
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus neuropeptide Y receptor 0.0165 0.4313 0.753
Echinococcus multilocularis chromobox protein 1 0.0084 0.1549 0.2563
Echinococcus multilocularis geminin 0.0205 0.5689 1
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0113 0.2527 0.432
Schistosoma mansoni neuropeptide receptor 0.0165 0.4313 0.4243
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.262 0.4487
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0165 0.4313 0.753
Onchocerca volvulus 0.0165 0.4313 0.7246
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0165 0.4313 0.753
Schistosoma mansoni chromobox protein 0.0084 0.1549 0.1444
Schistosoma mansoni biogenic amine (5HT) receptor 0.0165 0.4313 0.4243
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0165 0.4313 0.753
Schistosoma mansoni neuropeptide f receptor 76f 0.0165 0.4313 0.4243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0165 0.4313 0.753
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0165 0.4313 0.4243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Echinococcus granulosus allatostatin A receptor 0.0165 0.4313 0.753
Echinococcus multilocularis chromobox protein 1 0.0084 0.1549 0.2563
Schistosoma mansoni growth hormone secretagogue receptor 0.0165 0.4313 0.4243
Schistosoma mansoni hypothetical protein 0.0165 0.4313 0.4243
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0123 0.2871 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0165 0.4313 0.753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0165 0.4313 0.753
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.2582 0.249
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus neuropeptide receptor 0.0165 0.4313 0.753
Echinococcus granulosus rhodopsin orphan GPCR 0.0165 0.4313 0.753
Brugia malayi G protein-coupled receptor F59B2.13 0.0165 0.4313 0.4243
Echinococcus multilocularis g protein coupled receptor 0.0165 0.4313 0.753
Onchocerca volvulus Neuropeptide F receptor homolog 0.0165 0.4313 0.7246
Echinococcus multilocularis neuropeptide receptor 0.0165 0.4313 0.753
Brugia malayi Kringle domain containing protein 0.0076 0.1282 0.1175
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0165 0.4313 0.753
Echinococcus multilocularis g-protein coupled receptor 0.0165 0.4313 0.753
Echinococcus granulosus alpha 1A adrenergic receptor 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) glutaminase 2 0.033 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0165 0.4313 0.4243
Echinococcus multilocularis neuropeptide Y receptor 0.0165 0.4313 0.753
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0113 0.2527 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0165 0.4313 0.753
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.262 0.4487
Echinococcus granulosus rhodopsin orphan GPCR 0.0165 0.4313 0.753
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1549 0.1307
Brugia malayi Protein kinase domain containing protein 0.0076 0.1282 0.1175
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus multilocularis serotonin receptor 0.0165 0.4313 0.753
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Trichomonas vaginalis CAMK family protein kinase 0.0057 0.0603 0.0334
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Schistosoma mansoni amine GPCR 0.0165 0.4313 0.4243
Schistosoma mansoni hypothetical protein 0.0076 0.1282 0.1175
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0165 0.4313 0.7246
Echinococcus granulosus g protein coupled receptor 0.0165 0.4313 0.753
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1286 0.2091
Brugia malayi hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus neuropeptide receptor A26 0.0165 0.4313 0.753
Brugia malayi putative neuropeptide receptor NPR1 0.0165 0.4313 0.4243
Loa Loa (eye worm) hypothetical protein 0.0047 0.0278 0.0158
Echinococcus multilocularis neuropeptide Y receptor 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus peptide allatostatin:somatostatin 0.0165 0.4313 0.753
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1286 0.1179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Onchocerca volvulus 0.0209 0.5847 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus neuropeptide FF receptor 2 0.0165 0.4313 0.753
Brugia malayi ORL1-like opioid receptor 0.0165 0.4313 0.4243
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0209 0.5847 0.5796
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0165 0.4313 0.753
Echinococcus granulosus rhodopsin orphan GPCR 0.0165 0.4313 0.753
Echinococcus multilocularis rhodopsin orphan GPCR 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.2582 0.2369
Schistosoma mansoni alpha-1 adrenergic receptor 0.0165 0.4313 0.4243
Toxoplasma gondii kringle domain-containing protein 0.0076 0.1282 0.0579
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0165 0.4313 0.4243
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0165 0.4313 0.4243
Echinococcus granulosus geminin 0.0205 0.5689 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0165 0.4313 0.753
Loa Loa (eye worm) hypothetical protein 0.0165 0.4313 0.4243
Echinococcus multilocularis rhodopsin orphan GPCR 0.0165 0.4313 0.753
Echinococcus granulosus neuropeptides capa receptor 0.0165 0.4313 0.753
Echinococcus granulosus neuropeptide Y receptor 0.0165 0.4313 0.753
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0165 0.4313 0.753
Brugia malayi G-protein coupled receptor 0.0165 0.4313 0.4243
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0165 0.4313 0.4243

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Inhibition of HIV-1 replication in human T-cell by using XTT assay; Inactive ChEMBL. 8809151
IC50 (functional) = 0.2 Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay. ChEMBL. 8809151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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