Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cyclin b3 | 0.0271 | 0.3992 | 0.87 |
Onchocerca volvulus | 0.0271 | 0.3992 | 0.9114 | |
Trichomonas vaginalis | cyclins, putative | 0.0271 | 0.3992 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0297 | 0.4568 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0271 | 0.3992 | 1 |
Brugia malayi | Protein kinase c protein 2 | 0.0204 | 0.2531 | 0.2426 |
Echinococcus multilocularis | G2:mitotic specific cyclin B3 | 0.0271 | 0.3992 | 0.87 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.4299 | 0.4299 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0212 | 0.2717 | 0.5822 |
Entamoeba histolytica | cyclin family protein | 0.0271 | 0.3992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0354 | 0.5791 | 0.5791 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0212 | 0.2717 | 0.6692 |
Schistosoma mansoni | cyclin B3 | 0.0271 | 0.3992 | 0.87 |
Trichomonas vaginalis | cyclins, putative | 0.0271 | 0.3992 | 1 |
Trypanosoma cruzi | cyclin, putative | 0.0271 | 0.3992 | 1 |
Onchocerca volvulus | 0.0199 | 0.2421 | 0.4576 | |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0277 | 0.4126 | 0.9002 |
Onchocerca volvulus | 0.0285 | 0.4299 | 1 | |
Toxoplasma gondii | hypothetical protein | 0.0206 | 0.2572 | 0.9436 |
Brugia malayi | C1-like domain containing protein | 0.0201 | 0.2468 | 0.2362 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0277 | 0.4126 | 0.9002 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0271 | 0.3992 | 0.3908 |
Entamoeba histolytica | cyclin, putative | 0.0271 | 0.3992 | 1 |
Echinococcus multilocularis | cyclins | 0.0271 | 0.3992 | 0.87 |
Entamoeba histolytica | cyclin, putative | 0.0271 | 0.3992 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0271 | 0.3992 | 1 |
Echinococcus multilocularis | protein kinase c iota type | 0.0234 | 0.3181 | 0.6868 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0208 | 0.2634 | 0.5634 |
Giardia lamblia | Cyclin A | 0.0271 | 0.3992 | 1 |
Trichomonas vaginalis | cyclin D, putative | 0.0271 | 0.3992 | 1 |
Echinococcus granulosus | cyclins | 0.0271 | 0.3992 | 0.87 |
Echinococcus granulosus | cyclin B3 1 | 0.0271 | 0.3992 | 0.87 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 1 | 0.0212 | 0.2717 | 0.6692 |
Trichomonas vaginalis | cyclin B, putative | 0.0271 | 0.3992 | 1 |
Brugia malayi | protein kinase C3,putative | 0.016 | 0.1586 | 0.1468 |
Echinococcus granulosus | cyclins | 0.0271 | 0.3992 | 0.87 |
Leishmania major | protein kinase A catalytic subunit isoform 1 | 0.0212 | 0.2717 | 0.6692 |
Echinococcus multilocularis | cyclins | 0.0271 | 0.3992 | 0.87 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0277 | 0.4126 | 0.9002 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0297 | 0.4568 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0297 | 0.4568 | 0.4568 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0297 | 0.4568 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.4299 | 0.4299 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0212 | 0.2717 | 0.5822 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0271 | 0.3992 | 0.3908 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0212 | 0.2717 | 0.5822 |
Trichomonas vaginalis | cyclin B3, putative | 0.0271 | 0.3992 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0212 | 0.2717 | 0.6692 |
Loa Loa (eye worm) | hypothetical protein | 0.0194 | 0.2329 | 0.2329 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0135 | 0.1039 | 0.1039 |
Toxoplasma gondii | AGC kinase | 0.0212 | 0.2717 | 1 |
Brugia malayi | Cyclin, N-terminal domain containing protein | 0.0271 | 0.3992 | 0.3908 |
Schistosoma mansoni | atypical protein kinase C | 0.024 | 0.3317 | 0.7174 |
Loa Loa (eye worm) | hypothetical protein | 0.0285 | 0.4299 | 0.4299 |
Trypanosoma cruzi | CYC2-like cyclin, putative | 0.0271 | 0.3992 | 1 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 1 | 0.0212 | 0.2717 | 0.6692 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0222 | 0.2936 | 0.6315 |
Schistosoma mansoni | protein kinase C mu | 0.0201 | 0.2468 | 0.5258 |
Echinococcus multilocularis | cyclins | 0.0271 | 0.3992 | 0.87 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0271 | 0.3992 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0201 | 0.2468 | 0.2468 |
Trichomonas vaginalis | cyclin D, putative | 0.0271 | 0.3992 | 1 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0122 | 0.076 | 0.1404 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0212 | 0.2717 | 0.5822 |
Schistosoma mansoni | cyclin B | 0.0271 | 0.3992 | 0.87 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0216 | 0.2809 | 0.6931 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0212 | 0.2717 | 0.5822 |
Echinococcus granulosus | cyclin b3 | 0.0271 | 0.3992 | 0.87 |
Entamoeba histolytica | cyclin family protein | 0.0271 | 0.3992 | 1 |
Echinococcus granulosus | G2:mitotic specific cyclin B3 | 0.0271 | 0.3992 | 0.87 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0838 | 0.0838 |
Loa Loa (eye worm) | hypothetical protein | 0.0365 | 0.6032 | 0.6032 |
Trypanosoma brucei | protein kinase A catalytic subunit, putative | 0.0212 | 0.2717 | 0.6692 |
Onchocerca volvulus | 0.0194 | 0.2329 | 0.431 | |
Brugia malayi | cAMP-dependent protein kinase catalytic subunit, putative | 0.0212 | 0.2717 | 0.2615 |
Schistosoma mansoni | cyclins | 0.0271 | 0.3992 | 0.87 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0271 | 0.3992 | 0.3992 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0212 | 0.2717 | 0.2717 |
Leishmania major | cyclin | 0.0271 | 0.3992 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0212 | 0.2717 | 0.5822 |
Plasmodium vivax | cAMP-dependent protein kinase catalytic subunit, putative | 0.0212 | 0.2717 | 1 |
Echinococcus multilocularis | cyclin B | 0.0271 | 0.3992 | 0.87 |
Echinococcus multilocularis | cyclins | 0.0271 | 0.3992 | 0.87 |
Toxoplasma gondii | protein kinase, cAMP-dependent, catalytic chain | 0.0212 | 0.2717 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0234 | 0.3181 | 0.6868 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0132 | 0.0976 | 0.0976 |
Trypanosoma brucei | mitotic cyclin 6 | 0.0271 | 0.3992 | 1 |
Echinococcus granulosus | cyclins | 0.0271 | 0.3992 | 0.87 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0277 | 0.4126 | 0.9002 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0153 | 0.1433 | 0.3359 |
Trypanosoma brucei | cAMP-dependent protein kinase catalytic subunit 2 | 0.0212 | 0.2717 | 0.6692 |
Loa Loa (eye worm) | hypothetical protein | 0.0126 | 0.0838 | 0.0838 |
Echinococcus granulosus | enhancer of mRNA decapping protein 4 | 0.0206 | 0.2579 | 0.551 |
Leishmania major | CYC2-like cyclin, putative,cyclin 6, putative | 0.0271 | 0.3992 | 1 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0122 | 0.076 | 0.1404 |
Trypanosoma cruzi | cyclin 6, putative | 0.0271 | 0.3992 | 1 |
Trichomonas vaginalis | cyclin A, putative | 0.0271 | 0.3992 | 1 |
Echinococcus multilocularis | cyclins | 0.0271 | 0.3992 | 0.87 |
Echinococcus granulosus | cyclin B | 0.0271 | 0.3992 | 0.87 |
Leishmania major | protein kinase A catalytic subunit isoform 2 | 0.0212 | 0.2717 | 0.6692 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0201 | 0.2468 | 0.2362 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.2421 | 0.2421 |
Trichomonas vaginalis | cyclin B, putative | 0.0271 | 0.3992 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0271 | 0.3992 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDK5 protein kinase | 0.0094 | 0.0138 | 0.0138 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0271 | 0.3992 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.3992 | 0.3992 |
Brugia malayi | protein kinase C II. | 0.0297 | 0.4568 | 0.4492 |
Echinococcus multilocularis | enhancer of mRNA decapping protein 4 | 0.0206 | 0.2579 | 0.551 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.2252 | 0.2252 |
Echinococcus granulosus | cyclins | 0.0271 | 0.3992 | 0.87 |
Echinococcus multilocularis | cyclins | 0.0271 | 0.3992 | 0.87 |
Leishmania major | protein kinase A catalytic subunit | 0.0212 | 0.2717 | 0.6692 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 2 | 0.0212 | 0.2717 | 0.6692 |
Trichomonas vaginalis | cyclins, putative | 0.0271 | 0.3992 | 1 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0094 | 0.0138 | 0.0138 |
Trichomonas vaginalis | cyclin B, putative | 0.0271 | 0.3992 | 1 |
Loa Loa (eye worm) | AGC/PKA protein kinase | 0.0212 | 0.2717 | 0.2717 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0122 | 0.076 | 0.1404 |
Toxoplasma gondii | AGC kinase | 0.0212 | 0.2717 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.076 | 0.076 |
Plasmodium falciparum | cAMP-dependent protein kinase catalytic subunit | 0.0212 | 0.2717 | 0.6692 |
Echinococcus multilocularis | cyclin B3 1 | 0.0271 | 0.3992 | 0.87 |
Plasmodium falciparum | cyclin | 0.0271 | 0.3992 | 1 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0166 | 0.1722 | 0.1722 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0216 | 0.2809 | 0.6931 |
Loa Loa (eye worm) | cyclin domain-containing protein | 0.0547 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0271 | 0.3992 | 0.3992 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0149 | 0.1341 | 0.2715 |
Echinococcus multilocularis | cyclins | 0.0271 | 0.3992 | 0.87 |
Trypanosoma cruzi | cyclin, putative | 0.0271 | 0.3992 | 1 |
Giardia lamblia | Hypothetical protein | 0.0271 | 0.3992 | 1 |
Echinococcus granulosus | cyclins | 0.0271 | 0.3992 | 0.87 |
Trichomonas vaginalis | cyclins, putative | 0.0271 | 0.3992 | 1 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0212 | 0.2717 | 0.5822 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0212 | 0.2717 | 0.5822 |
Echinococcus granulosus | protein kinase C gamma type | 0.0208 | 0.2634 | 0.5634 |
Loa Loa (eye worm) | hypothetical protein | 0.0212 | 0.2717 | 0.2717 |
Trypanosoma cruzi | cAMP-dependent protein kinase catalytic subunit 3 | 0.0212 | 0.2717 | 0.6692 |
Echinococcus multilocularis | cAMP dependent protein kinase catalytic subunit | 0.0212 | 0.2717 | 0.5822 |
Echinococcus granulosus | cAMP dependent protein kinase catalytic subunit | 0.0212 | 0.2717 | 0.5822 |
Loa Loa (eye worm) | CMGC/CDK/CDC2 protein kinase | 0.0094 | 0.0138 | 0.0138 |
Trichomonas vaginalis | AGC family protein kinase | 0.0212 | 0.2717 | 0.6692 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | 0 | Inhibition of HIV-1 replication in human T-cell by using XTT assay; Inactive | ChEMBL. | 8809151 |
IC50 (functional) | > 200 | Inhibition of HIV-1 replication in a proliferating human T-cell line assayed using an XTT assay. | ChEMBL. | 8809151 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.