Detailed information for compound 2097987

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.662 | Formula: C28H46O5
  • H donors: 1 H acceptors: 3 LogP: 6.19 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)CC[C@H]([C@H]1CC[C@@H]2[C@]1(C)CC[C@H]1[C@H]2[C@H](O)C[C@H]2[C@]1(C)CC[C@H](C2)OC(=O)C)C
  • InChi: 1S/C28H46O5/c1-6-32-25(31)10-7-17(2)21-8-9-22-26-23(12-14-28(21,22)5)27(4)13-11-20(33-18(3)29)15-19(27)16-24(26)30/h17,19-24,26,30H,6-16H2,1-5H3/t17-,19+,20-,21-,22+,23+,24-,26+,27+,28-/m1/s1
  • InChiKey: STIZBCZNDJIKQQ-XPIXAVGJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi intermediate filament protein 0.0059 0.0122 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0764 0.2911
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1284 0.5616 1
Onchocerca volvulus 0.0287 0.1144 0.2013
Plasmodium vivax multidomain scavenger receptor, putative 0.0047 0.0069 0.0101
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0174 0.0221
Onchocerca volvulus 0.018 0.0666 0.1158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0045 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0017 0.0017
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0041 0.004
Giardia lamblia Tenascin-37 0.0073 0.0185 0.5
Loa Loa (eye worm) hypothetical protein 0.0344 0.1399 0.1399
Echinococcus granulosus lipoxygenase domain containing protein 0.0047 0.0069 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1238 0.4746
Brugia malayi hypothetical protein 0.0047 0.0069 0.0057
Echinococcus granulosus microtubule associated protein 2 0.0823 0.3546 0.4803
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0017 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0017 0.0017
Brugia malayi Matrixin family protein 0.007 0.0172 0.016
Onchocerca volvulus Matrilysin homolog 0.0155 0.0555 0.096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0017 0.0008
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0174 0.0295
Loa Loa (eye worm) doublecortin family protein 0.0047 0.0069 0.0069
Schistosoma mansoni intermediate filament proteins 0.0059 0.0122 0.019
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1284 0.5616 1
Schistosoma mansoni lipoxygenase 0.0122 0.0404 0.0675
Loa Loa (eye worm) hypothetical protein 0.0073 0.0185 0.0185
Echinococcus multilocularis integrin alpha ps 0.0071 0.0178 0.0226
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0051 0.0053
Brugia malayi hypothetical protein 0.0344 0.1399 0.1389
Schistosoma mansoni integrin alpha-ps 0.0071 0.0178 0.0286
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0174 0.0279
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0017 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0017 0.0005
Echinococcus multilocularis lipoxygenase domain containing protein 0.0047 0.0069 0.0078
Echinococcus multilocularis neuropeptide s receptor 0.1051 0.457 0.6193
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.1284 0.5616 1
Brugia malayi nuclear receptor NHR-88 0.0036 0.0017 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1238 0.4746
Trypanosoma cruzi DNA polymerase eta, putative 0.0048 0.0072 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0045 0.0132
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Brugia malayi hypoxia-induced factor 1 0.0179 0.0663 0.0651
Onchocerca volvulus 0.0108 0.0342 0.0579
Loa Loa (eye worm) MH2 domain-containing protein 0.0142 0.0496 0.0496
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0018 0.0011
Schistosoma mansoni hypothetical protein 0.055 0.2325 0.3976
Schistosoma mansoni hypothetical protein 0.0047 0.0069 0.0099
Echinococcus granulosus survival motor neuron protein 1 0.0486 0.2036 0.2752
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0045 0.0065
Brugia malayi EGF-like domain containing protein 0.0073 0.0185 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0017 0.0005
Loa Loa (eye worm) integrin alpha pat-2 0.0245 0.0957 0.0957
Brugia malayi Matrixin family protein 0.007 0.0172 0.016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0017 0.0005
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0174 0.0288
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.0045 0.0058
Brugia malayi EGF-like domain containing protein 0.0073 0.0185 0.0173
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0764 0.2911
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0128 0.0128
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.0045 0.0058
Brugia malayi hypothetical protein 0.0036 0.0018 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1238 0.4746
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Brugia malayi EGF-like domain containing protein 0.0073 0.0185 0.0173
Brugia malayi hypothetical protein 0.0611 0.2597 0.2588
Schistosoma mansoni rab6-interacting 0.0047 0.0069 0.0099
Schistosoma mansoni integrin beta subunit 0.1332 0.583 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0044 0.0054 0.0006
Brugia malayi Integrin alpha pat-2 precursor 0.0159 0.0571 0.0559
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0017 0.0008
Loa Loa (eye worm) hypothetical protein 0.0125 0.0418 0.0418
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0041 0.004
Echinococcus granulosus snurportin 1 0.0367 0.1503 0.2027
Brugia malayi follicle stimulating hormone receptor 0.0239 0.093 0.0919
Schistosoma mansoni hypothetical protein 0.0041 0.0043 0.0054
Loa Loa (eye worm) hypoxia-induced factor 1 0.0179 0.0663 0.0663
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0122 0.0122
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0206 0.0784 0.1049
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0174 0.0295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0017 0.0017
Giardia lamblia Tenascin precursor 0.0073 0.0185 0.5
Echinococcus multilocularis integrin beta 2 0.1676 0.7371 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0128 0.0116
Loa Loa (eye worm) transcription factor SMAD2 0.0142 0.0496 0.0496
Loa Loa (eye worm) hypothetical protein 0.0059 0.0122 0.0122
Brugia malayi Matrixin family protein 0.007 0.0172 0.016
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0017 0.0005
Schistosoma mansoni lamin 0.0059 0.0122 0.019
Echinococcus granulosus lamin 0.0059 0.0122 0.015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0017 0.0005
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0017 0.001
Echinococcus multilocularis tumor protein p63 0.0737 0.3161 0.4279
Giardia lamblia High cysteine protein 0.0073 0.0185 0.5
Giardia lamblia High cysteine protein 0.0073 0.0185 0.5
Giardia lamblia Tenascin-like 0.0073 0.0185 0.5
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0022 0.0014
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0255 0.1001 0.1344
Brugia malayi hypothetical protein 0.018 0.0666 0.0654
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0017 0.0008
Loa Loa (eye worm) hypothetical protein 0.018 0.0666 0.0666
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0195 0.073 0.073
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0017 0.0008
Echinococcus granulosus importin subunit beta 1 0.0034 0.0012 0.0001
Echinococcus multilocularis geminin 0.055 0.2325 0.3143
Mycobacterium tuberculosis Hypothetical protein 0.0611 0.2597 0.4384
Onchocerca volvulus 0.0073 0.0185 0.0299
Brugia malayi Hemopexin family protein 0.0099 0.0304 0.0292
Schistosoma mansoni polycystin 1-related 0.0047 0.0069 0.0099
Leishmania major cytochrome p450-like protein 0.0044 0.0054 0.0081
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0174 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0174 0.0295
Loa Loa (eye worm) hypothetical protein 0.0041 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0017 0.0008
Echinococcus granulosus integrin alpha 3 0.0122 0.0405 0.0534
Loa Loa (eye worm) matrixin family protein 0.0155 0.0555 0.0555
Schistosoma mansoni hypothetical protein 0.0099 0.0304 0.0502
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0764 0.2911
Echinococcus multilocularis Polycystic kidney disease protein 0.0047 0.0069 0.0078
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1284 0.5616 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0117 0.0117
Trichomonas vaginalis hypothetical protein 0.0073 0.0185 0.0674
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1238 0.4746
Schistosoma mansoni DNA polymerase eta 0.0048 0.0072 0.0105
Echinococcus multilocularis thymidylate synthase 0.1284 0.5616 0.7615
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0017 0.0008
Onchocerca volvulus 0.0059 0.0122 0.0186
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0017 0.0008
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.007 0.0172 0.0277
Schistosoma mansoni single-minded 0.0058 0.0118 0.0184
Onchocerca volvulus Glucosylceramidase homolog 0.0202 0.0764 0.1333
Echinococcus granulosus tumor protein p63 0.0737 0.3161 0.4279
Brugia malayi thymidylate synthase 0.1284 0.5616 0.561
Loa Loa (eye worm) hypothetical protein 0.007 0.0172 0.0172
Echinococcus granulosus neuropeptide s receptor 0.1051 0.457 0.6193
Echinococcus granulosus lipoxygenase domain containing protein 0.0047 0.0069 0.0078
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1284 0.5616 1
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0045 0.0132
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0017 0.001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0017 0.0005
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0051 0.0038
Loa Loa (eye worm) hypothetical protein 0.0085 0.0241 0.0241
Brugia malayi beta-NAC-like protein 0.0042 0.0045 0.0033
Loa Loa (eye worm) integrin beta-2 0.2262 1 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0073 0.0185 0.0185
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0017 0.0008
Echinococcus granulosus transcription factor btf3 0.0042 0.0045 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0022 0.0014
Schistosoma mansoni survival motor neuron protein 0.0099 0.0302 0.05
Echinococcus multilocularis lamin 0.0059 0.0122 0.015
Brugia malayi nuclear hormone receptor 0.0036 0.0017 0.0005
Echinococcus multilocularis fibrillin 1 0.0073 0.0185 0.0236
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0017 0.0005
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0017 0.0005
Onchocerca volvulus 0.0043 0.0051 0.0059
Brugia malayi Doublecortin family protein 0.0047 0.0069 0.0057
Schistosoma mansoni hypothetical protein 0.0036 0.0018 0.0011
Brugia malayi PAS domain containing protein 0.0058 0.0118 0.0106
Echinococcus multilocularis neuropeptide receptor A26 0.1051 0.457 0.6193
Giardia lamblia hypothetical protein 0.0073 0.0185 0.5
Schistosoma mansoni hypothetical protein 0.0099 0.0302 0.05
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0611 0.2597 0.4617
Loa Loa (eye worm) hypothetical protein 0.0073 0.0185 0.0185
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0017 0.001
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0239 0.093 0.093
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0764 0.2911
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0073 0.0185 0.0674
Brugia malayi Cytochrome P450 family protein 0.007 0.0172 0.016
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0017 0.001
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0302 0.0291
Leishmania major basic transcription factor 3a, putative 0.0042 0.0045 0.0065
Echinococcus granulosus geminin 0.055 0.2325 0.3143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0128 0.0116
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0085 0.0241 0.0229
Echinococcus multilocularis lamin dm0 0.0059 0.0122 0.015
Echinococcus multilocularis musashi 0.0059 0.0122 0.015
Echinococcus multilocularis microtubule associated protein 2 0.0823 0.3546 0.4803
Schistosoma mansoni transcription factor btf3 0.0042 0.0045 0.0058
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0017 0.0008
Echinococcus multilocularis RUN 0.0047 0.0069 0.0078
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0037 0.0043
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0017 0.001
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0017 0.001
Brugia malayi hypothetical protein 0.0486 0.2036 0.2027
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0206 0.0784 0.1049
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0022 0.0009
Leishmania major DNA polymerase eta, putative 0.0048 0.0072 0.0113
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1284 0.5616 1
Echinococcus multilocularis protein jagged 2 0.0073 0.0185 0.0236
Echinococcus granulosus neuropeptide receptor A26 0.1051 0.457 0.6193
Giardia lamblia Neurogenic locus Notch protein precursor 0.0073 0.0185 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0017 0.0005
Onchocerca volvulus 0.0099 0.0304 0.0511
Echinococcus granulosus Polycystic kidney disease protein 0.0047 0.0069 0.0078
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0017 0.001
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0174 0.0221
Loa Loa (eye worm) ICD-1 protein 0.0042 0.0045 0.0045
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0017 0.0005
Echinococcus granulosus single minded 2 0.0046 0.0066 0.0074
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0017 0.0005
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0012 0.0001
Brugia malayi Cytochrome P450 family protein 0.0044 0.0054 0.0042
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0967 0.4192 0.568
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0017 0.0017
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0017 0.0017
Schistosoma mansoni importin beta-1 0.0034 0.0012 0.0002
Brugia malayi hypothetical protein 0.0195 0.073 0.0719
Loa Loa (eye worm) CYP4Cod1 0.0044 0.0054 0.0054
Echinococcus granulosus thymidylate synthase 0.1284 0.5616 0.7615
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0344 0.1399 0.1399
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0812 0.31
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0122 0.011
Giardia lamblia Tenascin-X 0.0073 0.0185 0.5
Trypanosoma brucei DNA polymerase eta, putative 0.0048 0.0072 0.0107
Onchocerca volvulus Matrix metalloproteinase homolog 0.0155 0.0555 0.096
Plasmodium falciparum LCCL domain-containing protein 0.0047 0.0069 0.0101
Loa Loa (eye worm) hypothetical protein 0.0047 0.0069 0.0069
Echinococcus granulosus integrin beta 2 0.1676 0.7371 1
Loa Loa (eye worm) pax transcription factor protein 2 0.0287 0.1144 0.1144
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0308 0.1238 0.1228
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1238 0.4746
Loa Loa (eye worm) hypothetical protein 0.006 0.0128 0.0128
Echinococcus granulosus fibrillin 2 0.0073 0.0185 0.0236
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0764 0.2911
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0017 0.0005
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0017 0.0008
Loa Loa (eye worm) matrixin family protein 0.0169 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.0088 0.0251 0.0251
Entamoeba histolytica transcription factor BTF3, putative 0.0042 0.0045 0.1758
Loa Loa (eye worm) hypothetical protein 0.0073 0.0185 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0017 0.0005
Loa Loa (eye worm) hypothetical protein 0.0047 0.0069 0.0069
Brugia malayi Integrin alpha cytoplasmic region family protein 0.012 0.0397 0.0386
Echinococcus granulosus fibrillin 1 0.0073 0.0185 0.0236
Schistosoma mansoni rab6-interacting 0.0047 0.0069 0.0099
Loa Loa (eye worm) hypothetical protein 0.0108 0.0342 0.0342
Echinococcus multilocularis fibrillin 2 0.0073 0.0185 0.0236
Brugia malayi ecdysteroid receptor 0.0036 0.0017 0.0005
Echinococcus granulosus lamin dm0 0.0059 0.0122 0.015
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0017 0.0008
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0122 0.0122
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0017 0.0008
Brugia malayi ImpB/MucB/SamB family protein 0.0048 0.0072 0.006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0017 0.0008
Brugia malayi MH2 domain containing protein 0.0142 0.0496 0.0485
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0022 0.0022
Mycobacterium ulcerans thymidylate synthase 0.1284 0.5616 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.007 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.1284 0.5616 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0367 0.1503 0.1503
Loa Loa (eye worm) hypothetical protein 0.0037 0.0025 0.0025
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0018 0.0008
Echinococcus multilocularis transcription factor btf3 0.0042 0.0045 0.0046
Trypanosoma brucei cytochrome P450, putative 0.0044 0.0054 0.0075
Echinococcus multilocularis integrin alpha 3 0.0122 0.0405 0.0534
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0764 0.2911
Echinococcus granulosus RUN 0.0047 0.0069 0.0078
Trichomonas vaginalis glucosylceramidase, putative 0.0213 0.0812 0.31
Schistosoma mansoni hypothetical protein 0.0367 0.1503 0.2564
Onchocerca volvulus 0.007 0.0172 0.0277
Schistosoma mansoni thyroid hormone receptor 0.0036 0.0017 0.001
Toxoplasma gondii NAC domain-containing protein 0.0042 0.0045 0.0065
Schistosoma mansoni lipoxygenase 0.0206 0.0784 0.1327
Schistosoma mansoni cellular tumor antigen P53 0.0108 0.0342 0.0568
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0308 0.1238 0.1238
Echinococcus multilocularis thyroid hormone receptor alpha 0.0036 0.0017 0.0008
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.1284 0.5616 0.9631
Brugia malayi Matrixin family protein 0.007 0.0172 0.016
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0017 0.0008
Loa Loa (eye worm) hypothetical protein 0.0486 0.2036 0.2036
Echinococcus granulosus integrin alpha ps 0.0071 0.0178 0.0226
Echinococcus multilocularis adam 0.0073 0.0185 0.0236
Brugia malayi Pax transcription factor protein 2 0.0287 0.1144 0.1134
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0037 0.0043
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0034 0.0011 0.0011
Brugia malayi hypothetical protein 0.0047 0.0069 0.0057
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1284 0.5616 1
Loa Loa (eye worm) thymidylate synthase 0.1284 0.5616 0.5616
Onchocerca volvulus 0.1284 0.5616 1
Echinococcus granulosus dna polymerase eta 0.0048 0.0072 0.0083
Echinococcus multilocularis snurportin 1 0.0367 0.1503 0.2027
Onchocerca volvulus Matrilysin homolog 0.007 0.0172 0.0277
Echinococcus multilocularis lipoxygenase domain containing protein 0.0047 0.0069 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0611 0.2597 1
Echinococcus granulosus intermediate filament protein 0.0059 0.0122 0.015
Onchocerca volvulus 0.0059 0.0122 0.0186
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0174 0.0162
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0043 0.003
Schistosoma mansoni integrin alpha-ps 0.0037 0.0025 0.0023
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.0045 0.0058
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0017 0.0008
Entamoeba histolytica hypothetical protein 0.0042 0.0045 0.1758
Brugia malayi Matrixin family protein 0.0169 0.0618 0.0606
Schistosoma mansoni loxhd1 0.0047 0.0069 0.0099
Trichomonas vaginalis glucosylceramidase, putative 0.0308 0.1238 0.4746
Loa Loa (eye worm) matrix metalloproteinase 0.007 0.0172 0.0172
Loa Loa (eye worm) hypothetical protein 0.0034 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Trypanosoma cruzi cytochrome P450, putative 0.0044 0.0054 0.0081
Onchocerca volvulus 0.0099 0.0302 0.0509
Brugia malayi steroid hormone receptor 0.0036 0.0017 0.0005
Schistosoma mansoni microtubule-associated protein tau 0.0823 0.3546 0.6075
Echinococcus multilocularis dna polymerase eta 0.0048 0.0072 0.0083
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0054 0.0054
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0012 0.0007
Schistosoma mansoni hypothetical protein 0.055 0.2325 0.3976
Echinococcus granulosus adam 0.0073 0.0185 0.0236
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Brugia malayi RNA, U transporter 1 0.0098 0.0296 0.0284
Brugia malayi Kelch motif family protein 0.0344 0.1399 0.1389
Brugia malayi Cytochrome P450 family protein 0.0044 0.0054 0.0042
Giardia lamblia Neurogenic locus notch-like protein 0.0073 0.0185 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0017 0.0005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0018 0.0008
Onchocerca volvulus 0.0047 0.0069 0.0092
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.007 0.0172 0.0172
Schistosoma mansoni lamin 0.0059 0.0122 0.019
Echinococcus multilocularis survival motor neuron protein 1 0.0486 0.2036 0.2752
Onchocerca volvulus 0.0047 0.0069 0.0092
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0255 0.1001 0.1344
Toxoplasma gondii hypothetical protein 0.0073 0.0185 0.0315
Brugia malayi EGF-like domain containing protein 0.0073 0.0185 0.0173
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.0045 0.0065
Schistosoma mansoni aryl hydrocarbon receptor 0.0058 0.0118 0.0184
Mycobacterium ulcerans hydrolase 0.0085 0.0241 0.0342
Echinococcus multilocularis integrin alpha ps 0.0071 0.0178 0.0226
Schistosoma mansoni coup transcription factor 0.0036 0.0017 0.001
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0054 0.0054
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0036 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.012 0.0397 0.0397
Trypanosoma cruzi cytochrome P450, putative 0.0044 0.0054 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0017 0.0008
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0202 0.0764 0.2911
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0017 0.0008
Schistosoma mansoni integrin alpha 0.0159 0.0571 0.0962

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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