Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APH1B gamma secretase subunit | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Schistosoma japonicum | ko:K06172 anterior pharynx defective 1, putative | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus granulosus | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Brugia malayi | gamma-secretase subunit aph-1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | Get druggable targets OG5_130831 | All targets in OG5_130831 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | mbt repeat family protein | 0.005 | 0.0634 | 0.0489 |
Leishmania major | DNA polymerase eta, putative | 0.0043 | 0.0414 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.079 | 0.0781 |
Echinococcus granulosus | dna polymerase eta | 0.0043 | 0.0414 | 0.0283 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0238 | 0.6628 | 0.658 |
Echinococcus multilocularis | dna polymerase eta | 0.0043 | 0.0414 | 0.0283 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.2709 | 1 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.3304 | 0.3794 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0238 | 0.6628 | 0.7751 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0057 | 0.0858 | 0.0739 |
Schistosoma mansoni | DNA polymerase eta | 0.0043 | 0.0414 | 0.0279 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0231 | 0.0094 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.079 | 0.0678 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.0296 | 0.8483 | 0.8462 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.0296 | 0.8483 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0138 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0138 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0238 | 0.6628 | 0.6667 |
Echinococcus granulosus | geminin | 0.0339 | 0.9871 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.005 | 0.0634 | 0.051 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3304 | 0.321 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.3304 | 0.3724 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0138 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0138 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0115 | 0.2709 | 1 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0634 | 0.0503 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0115 | 0.2709 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0634 | 0.0489 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0238 | 0.6628 | 0.658 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.3304 | 0.3724 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0043 | 0.0414 | 0.1527 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.3304 | 0.3253 |
Schistosoma mansoni | hypothetical protein | 0.0306 | 0.8823 | 0.8806 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0057 | 0.0858 | 0.0739 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.079 | 0.0678 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0414 | 0.0222 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0634 | 0.0595 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.079 | 0.0781 |
Brugia malayi | mbt repeat family protein | 0.005 | 0.0634 | 0.0595 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3304 | 0.321 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0238 | 0.6628 | 0.6667 |
Schistosoma mansoni | sex comb on midleg homolog | 0.005 | 0.0634 | 0.0503 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0057 | 0.0858 | 0.0729 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0858 | 0.076 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.0296 | 0.8483 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0238 | 0.6628 | 0.7776 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0199 | 0.5375 | 0.5381 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0057 | 0.0858 | 0.0739 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0057 | 0.0858 | 0.0862 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.005 | 0.0634 | 0.051 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 0.9871 | 0.9869 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.0296 | 0.8483 | 0.8574 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.005 | 0.0634 | 0.051 |
Echinococcus multilocularis | geminin | 0.0339 | 0.9871 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.0296 | 0.8483 | 0.8574 |
Loa Loa (eye worm) | MBCTL1 | 0.0057 | 0.0858 | 0.076 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.005 | 0.0634 | 0.051 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.3304 | 0.3253 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3304 | 0.321 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.0231 | 0.0111 |
Schistosoma mansoni | hypothetical protein | 0.0339 | 0.9871 | 0.9869 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.005 | 0.0634 | 0.0503 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3304 | 0.321 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0043 | 0.0414 | 0.033 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0199 | 0.5375 | 0.5381 |
Brugia malayi | RNA binding protein | 0.0134 | 0.3304 | 0.3794 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.005 | 0.0634 | 0.5 |
Onchocerca volvulus | 0.005 | 0.0634 | 0.5 | |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0238 | 0.6628 | 0.6667 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.3304 | 0.3794 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3304 | 0.321 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.3304 | 0.3724 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0238 | 0.6628 | 0.6667 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0057 | 0.0858 | 0.0739 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0238 | 0.6628 | 0.658 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5 uM | Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. | ChEMBL. | 12643944 |
IC50 (functional) | = 5 uM | Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs. | ChEMBL. | 12643944 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.