Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0021 | 0.001 | 0.001 |
Onchocerca volvulus | Putative folylpolyglutamate synthase | 0.0197 | 0.0352 | 1 |
Mycobacterium ulcerans | folylpolyglutamate synthase protein FolC | 0.0197 | 0.0352 | 0.0352 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0018 | 0.0002 | 0.0002 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.0016 | 0 | 0.5 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0021 | 0.001 | 0.001 |
Plasmodium vivax | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0197 | 0.0352 | 0.0856 |
Brugia malayi | FolC bifunctional protein | 0.0197 | 0.0352 | 0.0352 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0021 | 0.001 | 0.0024 |
Trypanosoma brucei | pteridine reductase 1 | 0.0382 | 0.0714 | 0.1738 |
Onchocerca volvulus | 0.0021 | 0.001 | 0.0281 | |
Trypanosoma brucei | oxidoreductase-like protein | 0.0021 | 0.001 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Brugia malayi | Dihydrofolate reductase | 0.5137 | 1 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.0156 | 0.0273 | 0.0273 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0197 | 0.0352 | 0.0352 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0156 | 0.0273 | 0.0273 |
Trypanosoma cruzi | folylpolyglutamate synthetase | 0.0197 | 0.0352 | 0.0856 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0016 | 0 | 0.5 |
Echinococcus multilocularis | folylpolyglutamate synthase, mitochondrial | 0.0197 | 0.0352 | 0.0352 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Onchocerca volvulus | 0.0018 | 0.0002 | 0.0064 | |
Leishmania major | oxidoreductase-like protein | 0.0021 | 0.001 | 0.0024 |
Brugia malayi | Matrixin family protein | 0.0018 | 0.0002 | 0.0002 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2121 | 0.4109 | 1 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0113 | 0.0113 |
Loa Loa (eye worm) | matrixin family protein | 0.0043 | 0.0051 | 0.0051 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0021 | 0.001 | 0.001 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.001 | 0.001 |
Toxoplasma gondii | bifunctional protein FolC subfamily protein | 0.0197 | 0.0352 | 0.0856 |
Leishmania major | folylpolyglutamate synthetase | 0.0197 | 0.0352 | 0.0856 |
Echinococcus multilocularis | dihydrofolate reductase | 0.5137 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.5137 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.5137 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.5137 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.5137 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0039 | 0.0044 | 0.1252 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0021 | 0.001 | 0.001 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0074 | 0.0113 | 0.0275 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0156 | 0.0273 | 0.0273 |
Plasmodium falciparum | dihydrofolate synthase/folylpolyglutamate synthase | 0.0197 | 0.0352 | 0.0856 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2121 | 0.4109 | 1 |
Trypanosoma cruzi | folylpolyglutamate synthase, putative | 0.0197 | 0.0352 | 0.0856 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0074 | 0.0113 | 0.0113 |
Schistosoma mansoni | folylpolyglutamate synthase | 0.0197 | 0.0352 | 0.0352 |
Loa Loa (eye worm) | matrixin family protein | 0.0039 | 0.0044 | 0.0044 |
Loa Loa (eye worm) | FolC protein | 0.0197 | 0.0352 | 0.0352 |
Trypanosoma brucei | folylpolyglutamate synthase, putative | 0.0197 | 0.0352 | 0.0856 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0039 | 0.0044 | 0.1252 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0064 | 0.0093 | 0.0093 |
Brugia malayi | Matrixin family protein | 0.0018 | 0.0002 | 0.0002 |
Mycobacterium leprae | PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) | 0.0197 | 0.0352 | 0.0352 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0074 | 0.0113 | 0.3217 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0021 | 0.001 | 0.001 |
Toxoplasma gondii | 2,4-dienoyl CoA reductase 2, peroxisomal family protein | 0.0021 | 0.001 | 0.0024 |
Echinococcus granulosus | folylpolyglutamate synthase mitochondrial | 0.0197 | 0.0352 | 0.0352 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0018 | 0.0002 | 0.0002 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2121 | 0.4109 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0021 | 0.001 | 0.001 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0016 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0025 | 0.0017 | 0.0017 |
Brugia malayi | thymidylate synthase | 0.0156 | 0.0273 | 0.0273 |
Trichomonas vaginalis | dihydrofolate synthase/folylpolyglutamate synthase, putative | 0.0197 | 0.0352 | 1 |
Mycobacterium ulcerans | 3-alpha-hydroxysteroid dehydrogenase | 0.0021 | 0.001 | 0.001 |
Brugia malayi | Matrixin family protein | 0.0018 | 0.0002 | 0.0002 |
Leishmania major | pteridine reductase 1 | 0.0387 | 0.0724 | 0.1762 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2121 | 0.4109 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0021 | 0.001 | 0.001 |
Treponema pallidum | folylpolyglutamate synthetase (folC) | 0.0197 | 0.0352 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2121 | 0.4109 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2121 | 0.4109 | 1 |
Brugia malayi | Matrixin family protein | 0.0018 | 0.0002 | 0.0002 |
Echinococcus granulosus | folylpolyglutamate synthase, mitochondrial | 0.0197 | 0.0352 | 0.0352 |
Chlamydia trachomatis | dihydrofolate reductase | 0.5137 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0018 | 0.0002 | 0.0064 |
Loa Loa (eye worm) | thymidylate synthase | 0.0156 | 0.0273 | 0.0273 |
Echinococcus multilocularis | thymidylate synthase | 0.0156 | 0.0273 | 0.0273 |
Onchocerca volvulus | 0.0025 | 0.0017 | 0.0472 | |
Mycobacterium tuberculosis | Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate synthetase) (FPGS) | 0.0197 | 0.0352 | 0.0352 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.0021 | 0.001 | 0.001 |
Echinococcus granulosus | dihydrofolate reductase | 0.5137 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0002 | 0.0002 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0064 | 0.0093 | 0.0093 |
Onchocerca volvulus | 0.0156 | 0.0273 | 0.7768 | |
Echinococcus granulosus | thymidylate synthase | 0.0156 | 0.0273 | 0.0273 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0042 | 0.0049 | 0.0049 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.5137 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0043 | 0.0051 | 0.0051 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0156 | 0.0273 | 0.0273 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0017 | 0.0017 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.