TDR Targets

Basic information

Technical information

TDR Targets ID: 209915
Name: N-[2-[[2-hydroxy-3-[2-[2-(2-hydroxyethylamino )-2-oxoethoxy]phenoxy]propyl]amino]propyl]-2- phenylacetamide
MW: 459.535 | Formula: C24H33N3O6
H donors: 5 H acceptors: 4 LogP: 0.82 Rotable bonds: 17
Rule of 5 violations (Lipinski): 1
SMILES: OCCNC(=O)COc1ccccc1OCC(CNC(CNC(=O)Cc1ccccc1)C)O
InChi: 1S/C24H33N3O6/c1-18(14-27-23(30)13-19-7-3-2-4-8-19)26-15-20(29)16-32-21-9-5-6-10-22(21)33-17-24(31)25-11-12-28/h2-10,18,20,26,28-29H,11-17H2,1H3,(H,25,31)(H,27,30)
InChiKey: KJSHRXWCJLNNSW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-[2-[[2-hydroxy-3-[2-[2-(2-hydroxyethylamino)-2-oxo-ethoxy]phenoxy]propyl]amino]propyl]-2-phenyl-acetamide
N-[2-[[2-hydroxy-3-[2-[2-(2-hydroxyethylamino)-2-oxo-ethoxy]phenoxy]propyl]amino]propyl]-2-phenyl-ethanamide
N-[2-[[2-hydroxy-3-[2-[2-(2-hydroxyethylamino)-2-keto-ethoxy]phenoxy]propyl]amino]propyl]-2-phenyl-acetamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.0644	0.2638
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	hypothetical protein	0.0011	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	glutaminase	0.0264	0.6372	0.6372
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.0656	0.0656
Brugia malayi	Serotonin receptor	0.0034	0.0656	0.0972
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	amine GPCR	0.0034	0.0656	0.0656
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.0644	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0034	0.0656	0.0972
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0034	0.0656	0.0656
Brugia malayi	G-protein coupled receptor	0.0034	0.0656	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Entamoeba histolytica	hypothetical protein	0.0036	0.0718	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus multilocularis	survival motor neuron protein 1	0.0228	0.5488	0.5488
Entamoeba histolytica	hypothetical protein	0.0036	0.0718	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0034	0.0656	0.0656
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0034	0.0656	0.0968
Schistosoma mansoni	opsin-like receptor	0.0034	0.0656	0.0656
Onchocerca volvulus		0.0034	0.0656	0.2707
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	neuropeptide F receptor	0.0034	0.0656	0.0968
Echinococcus multilocularis	cpg binding protein	0.003	0.0578	0.0578
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0034	0.0656	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Onchocerca volvulus		0.0034	0.0656	0.2707
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0034	0.0656	0.2707
Onchocerca volvulus		0.0034	0.0656	0.2707
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0718	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	g-protein coupled receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	TAR-binding protein	0.0127	0.2975	0.4632
Brugia malayi	neuropeptide F receptor	0.0034	0.0656	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	myosin xvIII	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0034	0.0656	0.0972
Echinococcus multilocularis	dnaJ subfamily B	0.041	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0034	0.0656	0.0656
Brugia malayi	RNA recognition motif domain containing protein	0.0127	0.2975	0.4634
Onchocerca volvulus		0.0034	0.0656	0.2707
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.2975	0.2975
Echinococcus multilocularis	neuropeptide receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	adenoreceptor	0.0034	0.0656	0.0656
Schistosoma mansoni	opsin-like receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	histamine h1 receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0537	0.078
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0968	0.1461
Loa Loa (eye worm)	RNA binding protein	0.0127	0.2975	0.4632
Brugia malayi	Dopamine receptor protein 1	0.0034	0.0656	0.0972
Toxoplasma gondii	Erv1 / Alr family protein	0.0033	0.0644	0.2638
Brugia malayi	AKH receptor	0.0034	0.0656	0.0972
Echinococcus granulosus	neuropeptide FF receptor 2	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	neuropeptide receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0011	0.0106	0.0106
Brugia malayi	G protein-coupled receptor F59B2.13	0.0034	0.0656	0.0972
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0034	0.0656	0.0656
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0656	0.0656
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0034	0.0656	0.0656
Brugia malayi	GnHR receptor homolog	0.0034	0.0656	0.0972
Loa Loa (eye worm)	hepatopoietin HPO2	0.0033	0.0644	0.0949
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	hypothetical protein	0.0034	0.0656	0.0656
Onchocerca volvulus		0.0034	0.0656	0.2707
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0034	0.0656	0.0972
Onchocerca volvulus		0.0034	0.0656	0.2707
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Brugia malayi	Dopamine receptor	0.0034	0.0656	0.0972
Trypanosoma cruzi	Present in the outer mitochondrial membrane proteome 4	0.0033	0.0644	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Loa Loa (eye worm)	G-protein coupled receptor	0.0034	0.0656	0.0968
Schistosoma mansoni	amine GPCR	0.0034	0.0656	0.0656
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Echinococcus multilocularis	serotonin receptor	0.0034	0.0656	0.0656
Brugia malayi	hypothetical protein	0.0036	0.0718	0.1069
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0968	0.0968
Brugia malayi	G protein-coupled receptor	0.0034	0.0656	0.0972
Plasmodium vivax	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.0644	1
Onchocerca volvulus		0.0034	0.0656	0.2707
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0656	0.0656
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0968	0.0968
Brugia malayi	follicle stimulating hormone receptor	0.0034	0.0656	0.0972
Echinococcus granulosus	FAD linked sulfhydryl oxidase ALR	0.0033	0.0644	0.0644
Trypanosoma brucei	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.0644	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0656	0.0656
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	hypothetical protein	0.0034	0.0656	0.0656
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.0656	0.0656
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0968	0.0968
Brugia malayi	Serotonin receptor	0.0034	0.0656	0.0972
Brugia malayi	putative neuropeptide receptor NPR1	0.0034	0.0656	0.0972
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0034	0.0656	0.0656
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Schistosoma mansoni	cpg binding protein	0.0029	0.0537	0.0537
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.2975	0.2975
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0656	0.0656
Brugia malayi	neuropeptide F receptor	0.0034	0.0656	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0034	0.0656	0.0656
Schistosoma mansoni	hypothetical protein	0.0034	0.0656	0.0656
Loa Loa (eye worm)	neuropeptide F receptor	0.0034	0.0656	0.0968
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.2975	0.2975
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Echinococcus granulosus	dro:myosuppressin receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	orexin receptor type 2	0.0034	0.0656	0.0656
Entamoeba histolytica	hypothetical protein	0.0036	0.0718	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0656	0.0656
Brugia malayi	sulfakinin receptor protein	0.0034	0.0656	0.0972
Echinococcus multilocularis	neuropeptide receptor A26	0.0034	0.0656	0.0656
Echinococcus granulosus	neuropeptide receptor A26	0.0034	0.0656	0.0656
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Loa Loa (eye worm)	glutaminase	0.0264	0.6372	1
Echinococcus granulosus	tar DNA binding protein	0.0127	0.2975	0.2975
Echinococcus multilocularis	somatostatin receptor	0.0034	0.0656	0.0656
Entamoeba histolytica	hypothetical protein	0.0036	0.0718	0.5
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0228	0.5488	0.8603
Onchocerca volvulus		0.0034	0.0656	0.2707
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	cpg binding protein	0.003	0.0578	0.0578
Schistosoma mansoni	amine GPCR	0.0034	0.0656	0.0656
Onchocerca volvulus		0.0034	0.0656	0.2707
Schistosoma mansoni	hypothetical protein	0.0047	0.0978	0.0978
Brugia malayi	hypothetical protein	0.0025	0.0454	0.0653
Echinococcus granulosus	neuropeptide s receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0718	0.0718
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0034	0.0656	0.0656
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0034	0.0656	0.0972
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0034	0.0656	0.0968
Trypanosoma cruzi	ERV/ALR sulfhydryl oxidase domain-containing protein	0.0033	0.0644	1
Brugia malayi	putative neuropeptide receptor	0.0034	0.0656	0.0972
Mycobacterium ulcerans	glutaminase	0.0264	0.6372	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0968	0.0968
Brugia malayi	G-protein coupled receptor	0.0034	0.0656	0.0972
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0968	0.0968
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0034	0.0656	0.0656
Echinococcus granulosus	tm gpcr rhodopsin	0.0034	0.0656	0.0656
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0034	0.0656	0.0656
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0011	0.0106	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus multilocularis	serotonin receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0656	0.0656
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0537	0.0784
Loa Loa (eye worm)	TYRA-2 protein	0.0034	0.0656	0.0968
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Echinococcus multilocularis	neuropeptide s receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0034	0.0656	0.0656
Onchocerca volvulus		0.0034	0.0656	0.2707
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.2975	0.2975
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Echinococcus multilocularis	allatostatin A receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	allatostatin A receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	amine GPCR	0.0034	0.0656	0.0656
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0127	0.2975	0.4632
Loa Loa (eye worm)	glutaminase 2	0.0264	0.6372	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0034	0.0656	0.0656
Schistosoma mansoni	hypothetical protein	0.0034	0.0656	0.0656
Schistosoma mansoni	hypothetical protein	0.0036	0.0718	0.0718
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Schistosoma mansoni	neuropeptide f receptor 76f	0.0034	0.0656	0.0656
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0044	0.0044
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0034	0.0656	0.0968
Echinococcus granulosus	serotonin receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0034	0.0656	0.0968
Brugia malayi	hypothetical protein	0.0228	0.5488	0.8604
Schistosoma mansoni	growth hormone secretagogue receptor	0.0034	0.0656	0.0656
Brugia malayi	Melatonin receptor type 1A	0.0034	0.0656	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.1338	0.1338
Echinococcus granulosus	somatostatin receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	G protein coupled receptor 139	0.0034	0.0656	0.0656
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	7tm_1 domain containing protein	0.0034	0.0656	0.0656
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0718	0.0718
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Onchocerca volvulus		0.0034	0.0656	0.2707
Schistosoma mansoni	neuropeptide F-like receptor	0.0034	0.0656	0.0656
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.1176	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0034	0.0656	0.0656
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Brugia malayi	ORL1-like opioid receptor	0.0034	0.0656	0.0972
Echinococcus granulosus	g protein coupled receptor	0.0034	0.0656	0.0656
Leishmania major	hypothetical protein, conserved	0.0033	0.0644	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0968	0.0968
Echinococcus multilocularis	dro:myosuppressin receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	g-protein coupled receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0034	0.0656	0.2707
Brugia malayi	Augmenter of liver regeneration	0.0033	0.0644	0.0953
Echinococcus multilocularis	neuropeptide Y receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	opsin-like receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	cpg binding protein	0.003	0.0578	0.0578
Brugia malayi	RNA binding protein	0.0127	0.2975	0.4634
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0454	0.0648
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	fmrfamide receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	hypothetical protein	0.041	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0127	0.2975	0.2975
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0034	0.0656	0.0656
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0034	0.0656	0.0656
Onchocerca volvulus		0.0047	0.0978	1
Onchocerca volvulus		0.0034	0.0656	0.2707
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0034	0.0656	0.0656
Echinococcus multilocularis	orexin receptor type 2	0.0034	0.0656	0.0656
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0034	0.0656	0.0656
Brugia malayi	larval opioid receptor	0.0034	0.0656	0.0972
Brugia malayi	RE15519p	0.0034	0.0656	0.0972
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	cpg binding protein	0.003	0.0578	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus multilocularis	sex peptide receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0034	0.0656	0.0656
Echinococcus multilocularis	fmrfamide receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	sex peptide receptor	0.0034	0.0656	0.0656
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0978	0.1481
Echinococcus granulosus	survival motor neuron protein 1	0.0228	0.5488	0.5488
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0034	0.0656	0.0656
Brugia malayi	TAR-binding protein	0.0127	0.2975	0.4634
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Schistosoma mansoni	hypothetical protein	0.0034	0.0656	0.0656
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0034	0.0656	0.0972
Brugia malayi	glutaminase DH11.1	0.0264	0.6372	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Echinococcus multilocularis	g protein coupled receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	amine GPCR	0.0034	0.0656	0.0656
Echinococcus multilocularis	FAD linked sulfhydryl oxidase ALR	0.0033	0.0644	0.0644
Plasmodium falciparum	FAD-linked sulfhydryl oxidase ERV1, putative	0.0033	0.0644	1
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.2975	0.2975
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0034	0.0656	0.0656
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Schistosoma mansoni	neuropeptide receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	biogenic amine receptor	0.0034	0.0656	0.0656
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0034	0.0656	0.0656
Brugia malayi	hypothetical protein	0.0016	0.023	0.0299
Trichomonas vaginalis	glutaminase, putative	0.0264	0.6372	0.5
Onchocerca volvulus		0.0034	0.0656	0.2707
Echinococcus multilocularis	neuropeptides capa receptor	0.0034	0.0656	0.0656
Loa Loa (eye worm)	G-protein coupled receptor	0.0034	0.0656	0.0968
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	biogenic amine 5HT receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	rhodopsin orphan GPCR	0.0034	0.0656	0.0656
Brugia malayi	hypothetical protein	0.0034	0.0656	0.0972
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0034	0.0656	0.0656
Brugia malayi	Dopamine receptor protein 2	0.0034	0.0656	0.0972
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0968	0.0968
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0968	0.1465
Onchocerca volvulus		0.0034	0.0656	0.2707
Onchocerca volvulus		0.0034	0.0656	0.2707
Onchocerca volvulus		0.0034	0.0656	0.2707
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0978	0.0978
Echinococcus granulosus	neuropeptides capa receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	neuropeptide receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	G protein coupled receptor 139	0.0034	0.0656	0.0656
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0656	0.0968
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0034	0.0656	0.0656
Echinococcus granulosus	neuropeptide Y receptor	0.0034	0.0656	0.0656
Onchocerca volvulus		0.0034	0.0656	0.2707

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	= 5 mg kg-1	Beta-adrenergic blocking potency of the compound to inhibit tachycardia in anesthetized cats	ChEMBL.	6131134
ED50 (functional)	= 5 mg kg-1	Beta-adrenergic blocking potency of the compound to inhibit tachycardia in anesthetized cats	ChEMBL.	6131134
Inhibition (functional)	= 33 %	In vivo beta-adrenergic blocking potency to inhibit vasodepressor response in anesthetized cats	ChEMBL.	6131134
Inhibition (functional)	= 33 %	In vivo beta-adrenergic blocking potency to inhibit vasodepressor response in anesthetized cats	ChEMBL.	6131134

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 12841739

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 209915