Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acidic alpha-glucosidase | Starlite/ChEMBL | References |
Sus scrofa | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Starlite/ChEMBL | References |
Rattus norvegicus | Sucrase-isomaltase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.2938 | 1 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.2938 | 0.2938 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0082 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.2938 | 1 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.2938 | 0.2938 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.2938 | 1 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0082 | 0 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.2938 | 0.2938 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0366 | 1 | 1 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0082 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0 | 0.5 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.2938 | 0.334 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0 | 0.5 |
Schistosoma mansoni | alpha-glucosidase | 0.0332 | 0.8796 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0082 | 0 | 0.5 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0082 | 0 | 0.5 |
Entamoeba histolytica | glycosyl hydrolase, family 31 protein | 0.0082 | 0 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0082 | 0 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0366 | 1 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0 | 0.5 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0082 | 0 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0366 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.2938 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.2938 | 0.2938 |
Onchocerca volvulus | 0.0332 | 0.8796 | 0.5 | |
Schistosoma mansoni | alpha-glucosidase | 0.0332 | 0.8796 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0366 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.2938 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.1 uM | Inhibition of maltase in rat intestinal mucosa pre-incubated for 40 mins using maltose substrate | ChEMBL. | 26287401 |
IC50 (binding) | = 8.4 uM | Inhibition of sucrase in rat intestinal mucosa pre-incubated for 40 mins using sucrose substrate | ChEMBL. | 26287401 |
IC50 (binding) | = 18.9 uM | Inhibition of pig liver microsomes HMG-CoA reductase incubated for 5 mins in using HMG-CoA and NADPH by colorimetric method | ChEMBL. | 26287401 |
IC50 (functional) | = 48.6 uM | Cytotoxicity against human K562 cells by MTT method | ChEMBL. | 26287401 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.